Clinical trials: Therapy Strategies
Diabetes Mellitus, Type 1, Endothelial Dysfunction
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
The investigators will test the hypothesis that, in adults with type 1 diabetes (T1D), glucagon-like peptide-1 receptor agonism (GLP-1RA, i.e.
- Trial name
- MCD-1 (NCT05478707)
- Testing
- Dulaglutide
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- AdventHealth Translational Research Institute
Congenital Mitral Insufficiency
Study of Innovative Drug Strategies in Improving Left Ventricular Function After Mitral Repair
The goal of this observational study is to compare the safety and effectiveness of a modified drug therapy with traditional drug therapy in pediatric patients after mitral repair.
- Trial name
- NCT06039592
- Testing
- Captopril Tablets, Metoprolol Oral Tablet, Spironolactone Tablets
- Where
- China
- Volunteers
- 164 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Lymphoblastic Leukemia
Mercaptopurine Therapeutic Drug Monitoring to Optimize the Maintenance Phase of Childhood ALL
Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy in children (<18 years). The success of pediatric ALL therapy is remarkable but important challenges still need to be faced, including cure rates in…
- Trial name
- NCT05811845
- Where
- 4 sites in Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Burlo Garofolo
STEMI
Pharmacogenetic Approach to Anti-platelet Therapy for the Treatment of ST-segment Elevation Myocardial Infarction (STEMI)
The objective of the RAPID STEMI study is to evaluate the feasibility, efficacy, and safety of a pharmacogenetic approach to anti-platelet therapy for the treatment of ST-segment elevation myocardial infarction (STEMI) patients…
- Trial name
- RAPID STEMI (NCT01452139)
- Testing
- Point-of-Care Genetic Testing, Prasugrel
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Maxillo-Facial Surgery
RESTIT : Evaluation of Resorbable Osteosynthesis Devices Versus Titanium in Maxillofacial Surgery
Primary objective : To evaluate the quality of fractures setting and osteotomy of the facial massif osteosynthesised with resorbable device PLLA/PGA compared with usual Titanium plates.
- Trial name
- NCT00240669
- Testing
- Resorbable device PLLA/PGA, Titanium device
- Where
- France
- Volunteers
- 308 people
- Sponsor
- Hospices Civils de Lyon
Coronary Artery Ectasia, Acute Coronary Syndromes (ACS)
Multicenter Trial of Antithrombotic Strategies in Acute Coronary Syndrome With Coronary Artery Ectasia
Coronary artery ectasia (CAE) is a condition in which a coronary artery becomes abnormally dilated, measuring at least 50% larger than the adjacent normal segment.
- Conditions
- Coronary Artery Ectasia, Acute Coronary Syndromes (ACS), STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
- Trial name
- OVER-TIME II (NCT07511257)
- Testing
- Aspirin 100 mg, Clopidogrel 75 mg, Rivaroxaban 15 mg
- Where
- Mexico
- Volunteers
- 326 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Human Immunodeficiency Virus (HIV)
Antiretroviral Treatment Strategies in Relation to Adherence, Resistance and Virological Treatment Failure
This project aims to assess different antiretroviral treatment strategies, optimally controlled and conventional, in relation to drug resistance and virological treatment failure.
- Trial name
- DotArv (NCT01433601)
- Testing
- Enhanced Treatment Support (ETS)
- Where
- Vietnam
- Volunteers
- 640 people
- Sponsor
- Karolinska Institutet
Breast Cancer Early Stage Breast Cancer (Stage 1-3), Prehabilitation
Multimodal Prehabilitation Program That Combines Physical Exercise, Psychological Intervention and Nutritional Support to Improve the Response to Neoadjuvant Chemoterhapy in Early Breast Cancer Patients
The aim of this clinical trial is to evaluate whether following a multimodal prehabilitation program including physical exercise, nutritional support and psychological intervention during neoadjuvant chemotherapy in breast cancer…
- Trial name
- DIANA (NCT07107594)
- Testing
- Multimodal prehabilitation
- Where
- Spain
- Volunteers
- 214 people
- Sponsor
- Hospital Clinic of Barcelona
Purpura, Thrombocytopenic, Idiopathic
The Combination of ATRA and Eltrombopag as the Treatment of Steroid-resistant/Relapse ITP Based on MSC-C5b-9
A Prospective, Randomized, Open-Label, Multicenter Clinical Trial study to compare the efficacy and safety of ATRA plus eltrombopag compared to eltrombopag monotherapy in the treatment of steroid-resistant/relapsed immune…
- Trial name
- NCT05438875
- Testing
- all-trans retinoic acid, Eltrombopag
- Where
- 5 sites in China
- Volunteers
- 96 people
- Sponsor
- Peking University People's Hospital
Diabetes
Leveraging Interventions for Needs and Knowledge in Diabetes
Unmet social needs and economic burden persist as key reasons why one-third of people with diabetes have poor disease control. The purpose of this study is to learn whether different tools and types of support may help people…
- Trial name
- LINKD (NCT07676188)
- Testing
- FindHelp, Peer Support, Social Work
- Where
- United States
- Volunteers
- 694 people
- Sponsor
- University of Michigan
Barrett's Esophagus, Overweight and Obesity
CAlorie and Protein REstriction PROgram in Barrett's Esophagus Patients (CARE-PRO).
The increasing incidence of Esophageal Adenocarcinoma (EAC) in several Western countries can be primarily ascribed to risk factors such as obesity, chronic gastroesophageal reflux, dietary habits and alcohol intake.
- Trial name
- CARE-PRO (NCT03813381)
- Testing
- Calorie and protein restriction diet
- Volunteers
- 160 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Peripheral Artery Disease
Clinical Outcomes of Three Different Percutaneous Revascularization Strategies for the Treatment of Lifestyle Limiting Claudication: A Retrospective Analysis
To determine the effect of three different percutaneous revascularization strategies (Balloon Cryoplasty vs. Stent Placement vs. Atherectomy) in the treatment of lifestyle limiting lower extremity claudication
- Trial name
- FIX-IT Retro (NCT00512720)
- Where
- United States
- Volunteers
- 355 people
- Sponsor
- Corewell Health West
HIV-1 Infection
Lipopeptide Immunisation With GTU-multiHIV Trial
The combination of GTU-MultiHIV B DNA and LIPO-5 vaccines in a prime-boost strategy is expected to induce strong and diverse HIV-specific immune responses in HIV-infected patients.
- Trial name
- NCT01492985
- Testing
- GTU-multHIV B vaccine and LIPO-5 vaccine
- Where
- France
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Low Back Pain, Neck Pain
How Does Basic Body Awareness Therapy Effect Pain Coping Strategies in Postmenopausal Women?
Exercise interventions are deemed essential for the effective management of patients with pain. Various therapy methods have been shown in the literature for pain and coping with pain.
- Conditions
- Low Back Pain, Neck Pain, Menopause
- Trial name
- NCT05893290
- Testing
- Therapeutic Exercise Group, Therapeutic Exercise+Basic Body Awareness Therapy Group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- European University of Lefke
Bone Neoplasm of Vertebral Column, Chordoma
Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas
Rationale: Chordomas and chondrosarcomas located in the axial skeleton are malignant neoplasms of bone. These tumors share the same clinical challenges, as the effect of the disease is more a function of their local…
- Conditions
- Bone Neoplasm of Vertebral Column, Chordoma, Chondrosarcoma, Magnetic Resonance Imaging
- Trial name
- CHIPT (NCT04832620)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Leiden University Medical Center
Penile Amputation
Replantation Following Complete Penile Amputation
The goal of this observational study Replantation following Complete Penile Amputation a case series before and after study is to help andrologist and urologists deal with such rare male emergencies easily in emergency situation.
- Trial name
- NCT06244927
- Testing
- Replantation surgery
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sir Run Run Shaw Hospital
Cardiomyopathies
Risk Stratification and New Early Prevention and Treatment Strategies for Patients With Cardiomyopathy (STRENGTH）
This study will include patients with different types of cardiomyopathy from multiple centers were prospectively enrolled in a retrospective study to establish a natural population cohort of cardiomyopathy patients.
- Trial name
- NCT06352320
- Testing
- Diagnosis of HCM, Diagnosis of DCM, Diagnosis of ARVC
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Chronic Illness
Pilot Study to Improve Care Coordination
The purpose of this study is 1) to learn how VA patients can help share their health information between their VA providers and providers outside the VA and 2) if sharing this information is useful to providers and improves care…
- Trial name
- NCT02386189
- Testing
- Patient Care Coordination Training
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Papillary Thyroid Microcarcinoma
Safety and Quality of Life of Three Treatment Strategies for Low-Risk Papillary Thyroid Microcarcinoma
This is a prospective observational patient registry study designed to evaluate the safety and quality of life associated with three treatment strategies for patients diagnosed with low-risk papillary thyroid microcarcinoma…
- Trial name
- PTMC-3S (NCT07249125)
- Where
- China
- Volunteers
- 1,630 people
- Sponsor
- Xijing Hospital
Patient With Sonographically Indeterminate or Complex Adnexal Mass
ADNEXMR Scoring System: Impact of an MR Scoring System on Therapeutic Strategy of Pelvic Adnexal Masses
Background : About 25% of adnexal masses remain indeterminate after transvaginal ultrasonography, as evidenced by the published literature.
- Trial name
- ASCORDIA01 (NCT02664597)
- Testing
- ADNEXMR Scoring System, Standard strategy
- Where
- France
- Volunteers
- 377 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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