Clinical trials: Therapy Strategies
Atherosclerotic Cardiovascular Disease
A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE)
The purpose of this study was to assess the effectiveness of an "inclisiran first" implementation strategy (addition of inclisiran to maximally tolerated statin therapy immediately upon failure to achieve acceptable LDL-C with…
- Trial name
- V-INITIATE (NCT04929249)
- Testing
- Inclisiran
- Where
- 43 sites in United States
- Volunteers
- 450 people
- Sponsor
- Novartis Pharmaceuticals
Bulimia Nervosa, Binge-Eating Disorder
Bulimia Nervosa and Binge Eating Disorder: Comparing Therapeutic Strategies
This study aims to assess the effectiveness of new neurostimulation techniques in patients with eating disorders. The primary aim of our proposal is to test a reduction in symptoms of alteration of eating behaviors, such as…
- Trial name
- NCT05296915
- Testing
- tVNS, rTMS, CBT-E
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Tobacco Use Disorder, Alcohol Use Disorder
Cytisine for Smoking Cessation
The goal of this clinical trial is to evaluate the safety and effectiveness of cytisine as a smoking cessation treatment in individuals with concurrent alcohol use disorder.
- Conditions
- Tobacco Use Disorder, Alcohol Use Disorder, Smoking Cessation
- Trial name
- NCT05729243
- Testing
- Cytisine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Type 2 Diabetes
Skin Samples of Diabetic Patients and Healthy Volunteers Collection
The main objective of this study is the Obtention of skin micro-samples collected from healthy volunteers and diabetic patients (type 2 and MODY), intended to be used afterwards to obtain stem cell lines, in the framework of new…
- Trial name
- NCT01349374
- Testing
- skin biopsy
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Factor V Leiden Heterozygous Mutation, Factor II Heterozygous Mutation
Evaluation of a Preventive Therapeutic Strategy for Postpartum Venous Thromboembolism in Women With Genetic Risk Factor
Background : pregnancy and postpartum period are times of increased risk for deep vein thrombosis (DVT). The incidence of venous thromboembolic disease (VTE) during pregnancy is estimated at 1-2 per 1,000, and this risk increases…
- Conditions
- Factor V Leiden Heterozygous Mutation, Factor II Heterozygous Mutation, Pregnancy, Postpartum
- Trial name
- POSTPART AS5-2 (NCT07342127)
- Testing
- Retrospective collection of health data, Phone call to every participant
- Where
- 2 sites in France
- Volunteers
- 86 people
- Sponsor
- Hospices Civils de Lyon
Infertility Primary, Psychosocial Stressor
Psychosocial Intervention in Assisted Reproduction Treatments
The aim of the study was to evaluate and compare different strategies of psychosocial intervention for patients undergoing IVF treatment in a private fertility clinic.
- Conditions
- Infertility Primary, Psychosocial Stressor, Anxiety Depression
- Trial name
- NCT04572659
- Testing
- Group psychosocial intervention, Couple psychosocial intervention
- Volunteers
- 174 people
- Sponsor
- Vida Recoletas Sevilla
Atrial Fibrillation, Heart Failure
Ablation Strategies for Persistent Atrial Fibrillation Combined With Heart Failure
(1) To evaluate the efficacy and safety of "2C3L" strategy combined with VOM anhydrous ethanol chemical ablation for persistent atrial fibrillation complicated with heart failure; (2) To evaluate the effectiveness of…
- Trial name
- NCT06438692
- Testing
- VOM ethanol chemical ablation and 2C3L, 2C3L
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Qianfoshan Hospital
Acute Coronary Syndrome, Myocardium; Injury
Acute Myocardial Infarction: Prognostic and Therapeutic Evaluation
AMIPE is both a retrospective and prospective study which was designed in order to collect data of patients with acute coronary syndromes and myocardial injury and to improve the knowledge about these conditions.
- Trial name
- AMIPE (NCT03883711)
- Testing
- Database
- Where
- 3 sites in Italy
- Volunteers
- 11,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Thyroid Cancer, Intermediate Risk
Systematic Radioiodine Administration Versus Decision of Radioiodine Treatment Guided by a Post-operative Work-up
This trial is comparing two strategies in intermediate-risk differentiated thyroid cancer patients: Systematic radioiodine administration versus decision of radioiodine treatment guided by a post-operative work-up based on serum…
- Trial name
- INTERMEDIATE (NCT04290663)
- Testing
- Systematic RAI-treatment, Decision of RAI-treatment guided by a post-operative assessment
- Where
- 29 sites in France
- Volunteers
- 368 people
- Sponsor
- Centre Francois Baclesse
Non-small Cell Lung Cancer, Radiation Therapy
Phase 2 Study Evaluating Mid-position Strategy in Radiotherapy Treatment for Patients With a Locally Advanced Non-small Cell Lung Carcinoma
The purpose of this study is to establish on the market and to clinically evaluate a new strategy of treatment for patients with locally advanced non-small cell lung cancer using deformable repositioning of 4D imaging.
- Conditions
- Non-small Cell Lung Cancer, Radiation Therapy, Locally Advanced Disease, Non-metastatic Disease
- Trial name
- midP (NCT01635270)
- Testing
- mid-position radiation strategy, ITV
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre Leon Berard
Colorectal Cancer
PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSS
The purpose of this study is to preliminarily observe the efficacy and safety of PCSK9 inhibitors in combination with standard advanced first-line regimens in the treatment of advanced colorectal cancer with pMMR/MSS.
- Trial name
- NCT06391905
- Testing
- PCSK9 inhibitor in combination with standard advanced first-line regimen group, standard advanced first-line regimen group
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial People's Hospital
Type 2 Diabetes
Coaching of Diabetic Patients After Hospital Discharge
One third of the costs of medical care for people with diabetes are related to hospitalization." Difficult" diabetic patient, i.e.
- Trial name
- SORTIDIAB (NCT01877213)
- Testing
- Coaching with coordinate care
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis, CFTR Gene Mutation
Validation of Therapeutic Efficacy Targeting the Splicing Variants in Cystic Fibrosis and CFTR Pathologies
Cystic Fibrosis, an inherited autosomal recessive disease, arises from mutations in the CFTR gene. For intronic mutations affecting splicing events, oligonucleotides therapy has the potential to restore the production of the full…
- Trial name
- ONB-CFTR (NCT05100823)
- Testing
- Nasal cells sampling, Rectal biopsy sampling
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Montpellier
Aphasia
Incorporating Strategy Training Into Naming Treatment in Aphasia
This study incorporates metacognitive strategy training into semantic feature analysis treatment. Semantic feature analysis treatment has a strong evidence base and capacity to improve word retrieval by encouraging…
- Trial name
- NCT05307796
- Testing
- Strategy training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- MGH Institute of Health Professions
HIV Infections
Antibody Responses to Pneumococcal Vaccines Among HIV-infected Adults.
Streptococcus pneumoniae is the major cause of bacterial infection in HIV-infected patients. The current pneumococcal vaccine is poorly efficacious in patients with a CD4 cell count lower than 500/mm3.
- Trial name
- NCT00148824
- Testing
- 7-valent pneumococcal conjugate vaccine (vaccine), 23-valent pneumococcal conjugate vaccine (vaccine)
- Where
- France
- Volunteers
- 212 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Pancreatic Cancer, Periampullary Tumor
Double Bypass Versus Stent-treatment in Irresectable Pancreatic Cancer
Double bypass (hepaticojejunostomy + gastrojejunostomy) is compared to stent strategy in patients planned for curative pancreatic resection in whom peroperative findings makes resection impossible.
- Trial name
- NCT01569282
- Testing
- Hepaticojejunostomy and gastroenterostomy, Stent strategy
- Where
- 6 sites in Sweden
- Sponsor
- Göteborg University
Malignant Neoplasm of Oropharynx Stage III, Malignant Neoplasm of Larynx Stage III
Dose Escalation Versus Standard in Laryngopharyngeal Cancers
The primary objective of the study is to establish the safety of using a moderate escalation of radiotherapy dose in advanced/poor prognosis OPC and LH cancers receiving curative radiotherapy.
- Conditions
- Malignant Neoplasm of Oropharynx Stage III, Malignant Neoplasm of Larynx Stage III, Malignant Neoplasm of Hypopharynx Stage III, Malignant Neoplasm of Oropharynx Stage IVa
- Trial name
- INTELHOPE (NCT02757222)
- Testing
- Escalated Dose, Standard Dose
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Tata Medical Center
Primary Spontaneous Pneumothorax (PSP), Conservative Management (Active Observation)
Conservative Management in Primary Spontaneous Pneumothorax: a Multicenter Randomized Non-inferiority Study
The goal of this randomized clinical trial is to find out whether a conservative management strategy (active observation without an initial invasive procedure) can treat as effectively as the standard treatment with chest tube…
- Trial name
- CONNEP (NCT07331805)
- Testing
- Conservative management (active observation), Chest tube drainage
- Volunteers
- 436 people
- Sponsor
- Corporacion Parc Tauli
Lung Cancer Associated With Cystic Airspaces
Staging Strategies and Their Association With Prognosis and Therapy in Lung Cancer With Cystic Airspaces
The goal of this observational study is to determine the most accurate tumor size measurement method for T-staging and prognostic assessment in lung cancer with cystic airspaces (LCCA).
- Trial name
- NCT07066813
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Central South University
HIV Infections
Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at Birth
The purpose of this study is to compare the effects of anti-HIV drug courses of different lengths in infants who became HIV infected at birth.
- Trial name
- NCT00102960
- Testing
- Abacavir sulfate, Didanosine, Efavirenz
- Volunteers
- 377 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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