Clinical trials: Therapy Strategies
Older Adults (60 - 85 Years Old), OA Knee
Home-Based Quadriceps Isometric Exercise for Knee Osteoarthritis Pain
Knee osteoarthritis is a common cause of pain and reduced mobility in older adults. Many people have limited access to supervised rehabilitation programs, highlighting the need for simple and safe home-based treatment options.
- Trial name
- KOA-ISO01 (NCT07445568)
- Testing
- Cannabidiol (CBD) Topical Gel, Arnica montana Topical Gel, Home-based Quadriceps Isometric Exercise
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Universidad del Valle de México, Campus Cuernavaca
Liver Cancer, Liver Neoplasm
Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization
Background: Treatment for liver cancer can include surgery, transplant, and chemotherapy. It can also include other minimally invasive tumor treatments such as transarterial chemoembolization (TACE).
- Conditions
- Liver Cancer, Liver Neoplasm, Hepatocellular Carcinoma, HCC
- Trial name
- NCT02471313
- Testing
- [18F] FMISO
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Device-Related Thrombosis, Atrial Fibrillation
Efficacy of Different Anti-Thrombotic Strategies on Device-Related Thrombosis Prevention After Percutaneous Left Atrial Appendage Occlusion
Comparison among three different antithrombotic strategies after percutaneous LAA occlusion with a Watchman FLX LAAC device.
- Conditions
- Device-Related Thrombosis, Atrial Fibrillation, Left Atrial Appendage Occlusion
- Trial name
- FADE-DRT (NCT04502017)
- Testing
- ASA plus Clopidogrel, Genetic-Tailored AntiThrombotic Strategy, Half-Dose of novel OAC
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Arthritis, Arthritis, Rheumatoid
An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid Arthritis
The purpose of this study is to examine whether an magnetic resonance imaging (MRI) -guided treatment strategy based on a predefined treatment algorithm can prevent progression of erosive joint damage, increase remission rate and…
- Conditions
- Arthritis, Arthritis, Rheumatoid, Joint Diseases, Musculoskeletal Diseases
- Trial name
- IMAGINE-RA (NCT01656278)
- Testing
- Magnetic resonance imaging (MRI), Conventional biochemical and clinical examinations
- Where
- 9 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Professor of Rheumatology, MD, DMSci, Kim Horslev-Petersen
Refractory Colorectal Cancer, Radiotherapy-Induced Immune Priming
Combination of High and Low-Dose Radiotherapy With Immune Therapy and TKI in Advanced Colorectal Cancer: A Phase II Study
The goal of this clinical trial is to learn whether a high- and low-dose radiotherapy regimen followed by anti-angiogenic TKI and anti-PD-1 antibody therapy works to treat advanced metastatic colorectal cancer.
- Conditions
- Refractory Colorectal Cancer, Radiotherapy-Induced Immune Priming, Immune Response
- Trial name
- TRIUNITE-07 (NCT07467590)
- Testing
- High- and Low-Dose Radiotherapy, Anti-Angiogenic TKI and Anti-PD-1 Therapy
- Volunteers
- 33 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
COPD, COPD Exacerbation Acute
Assessing Optimal Inhaler Strategies During Acute Exacerbations of COPD (AECOPDs) Using Oscillometry
Chronic Obstructive Pulmonary Disease (COPD) is a persistent lung disease that makes it very difficult to breathe. The airways and the normally 'spongy' lungs themselves are affected.
- Trial name
- NCT06495047
- Testing
- Long-acting bronchodilator therapy (LABD), Short-acting bronchodilator therapy (SABD)
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Care Burden, Anxiety
Group Music Therapy Intervention With Informal Carers of Elderly Dependents
To evaluate the effects of a group music therapy intervention with informal caregivers of elderly people on clinical psychological symptoms, taking into account variables such as caregiver burden, anxiety and depression.
- Conditions
- Care Burden, Anxiety, Depression, Coping Strategies
- Trial name
- MUSIC CARES (NCT06028815)
- Testing
- Group music therapy
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- University of Deusto
Rheumatoid Arthritis
educAR: Improving Adherence in Rheumatoid Arthritis
Based on recent guidelines, the investigators have developed a parallel (patient and physician) educational web-based tool. To prove its effectiveness, the investigators have designed a cluster clinical trial of a 6-month…
- Trial name
- educAR (NCT05425485)
- Testing
- Multi-component intervention
- Where
- 15 sites in Spain
- Volunteers
- 142 people
- Sponsor
- María Ahijón
Migraine
The MOTS (Medication Overuse Treatment Strategy) Trial
There are two commonly used treatment strategies for treating patients who have chronic migraine with medication overuse. This study will compare the outcomes amongst patients randomized to one of the two treatment strategies.
- Trial name
- MOTS (NCT02764320)
- Testing
- Migraine Prophylactic Therapy Only, Discontinuation of Overused Medication
- Where
- 29 sites in United States
- Volunteers
- 720 people
- Sponsor
- Mayo Clinic
Recurrent High Grade Glioma
PTCs-based Precision Treatment Strategy on Recurrent High-grade Gliomas
This trial is an open-label, single-arm, phase 0/1 study of high-grade glioma that aims to evaluate the feasibility, preliminary efficacy and safety of the precision treatment strategy.
- Trial name
- NCT05473923
- Testing
- Receiving chemotherapeutic or targeted drugs recommended by molecular tumor board.
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Acute Coronary Syndrome, Percutaneous Coronary Intervention
A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk
In patients with heart attacks, the treatment of choice is to restore blood flow with percutaneous coronary intervention (PCI) (use of stents (metal meshes) to open blockages).
- Trial name
- RAPID MANAGE (NCT02044146)
- Testing
- Ticagrelor, Prasugrel, Clopidogrel
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Child Abuse, Self-control
Coaching Alternative Parenting Strategies (CAPS) Study
This is a randomized, controlled trial (RCT) of Parent-Child Interaction Therapy (PCIT) designed to test the effects of PCIT on self-regulation and behavior in child maltreating (CM) parents and their elementary-school children.
- Conditions
- Child Abuse, Self-control, Parenting
- Trial name
- CAPS (NCT02684903)
- Testing
- Parent Child Interaction Therapy
- Where
- United States
- Volunteers
- 408 people
- Sponsor
- University of Oregon
Autoimmune Diseases
Treatment Strategies in IgG4-RD Patients With Re-elevation of Serum IgG4 Level During Maintenance Remission Period
This study has been designed as a 52-week, randomized double blind placebo controlled multicenter clinical trial. The study aims to compare the efficacy and safety of two treatment strategies in IgG4-RD patients with re-elevation…
- Trial name
- NCT05974683
- Testing
- mycophenolate mofetil
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Peking Union Medical College Hospital
Antiplatelet Drug-related Gastrointestinal Injury
Long-term MOno-Antiplatelet Drug Strategy After PerCutanEous CoronAry InterveNtion
The OCEAN (long-term mOn-antiplatelet drug strategy after perCutanEous coronANy intervention) study is the largest prospective multicenter data base to investigate the long-term incidence and prognosis of the use of agents for…
- Trial name
- RESCIND-OCEAN (NCT03725800)
- Where
- 8 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Depression, Depressive Disorder
Remote Coaching for Supporting the Implementation of Depression Care in Primary Care in Rural India
This cluster-randomized hybrid type-II implementation superiority trial will include 14 rural primary care facilities in Madhya Pradesh, which will implement a collaborative depression care packaged based on the WHO mhGAP…
- Conditions
- Depression, Depressive Disorder, Psychological, Noncommunicable Diseases
- Trial name
- ESSENCE-IT (NCT05264792)
- Testing
- Enhanced Implementation Support, Routine Implementation Support
- Where
- India
- Volunteers
- 14 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Stable Angina, Unstable Angina
COMBO-Stent in Patients on Chronic Anticoagulant Therapy (COSTA) COSTA-Bleed and COSTA-Outcome Trials
Prospective, multi-centre, randomized, open-label, parallel comparisons to evaluate the incidence of bleedings (COSTA-Bleed) and the incidence of ischemic and bleeding events (COSTA-Outcome) following a therapy with the abluminal…
- Conditions
- Stable Angina, Unstable Angina, STEMI, NSTEMI
- Trial name
- COSTA (NCT02723981)
- Testing
- COMBO-Stent, Clopidogrel, Vitamin K Antagonist, Rivaroxaban, Dabigatran, Any drug eluting stent oder bare metal sent
- Where
- 10 sites in Germany
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Obesity
Refining Novel Culturally Tailored Behavioral Weight Loss Treatment Components for Sexual Minority Women With Obesity
Obesity disproportionately impacts sexual minority women. Behavioral weight loss programs are the gold standard treatment for mild to moderate obesity.
- Trial name
- NCT05036187
- Testing
- Behavioral Weight Loss Intervention, Minority Stress Intervention, Negative Body Image Intervention
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The Miriam Hospital
Pain, Acute
Therapeutic Strategies During Exposure to Pain in an Experimental Design
The goal of the present study is to compare different therapeutic strategies (according to habituation model vs. according to the inhibitory learning approach) during exposure to thermal pain in an experimental design.
- Trial name
- NCT03146832
- Testing
- Exposure therapy (according to habituation approach), Exposure therapy (according to inhibitory learning approach)
- Where
- Germany
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Hypercholesterolemia, Medication Adherence
Effectiveness of a Combined Strategy to Improve Therapeutic Compliance and Degree of Control Among Patients With Hypercholesterolaemia
Background In subjects with hypercholesterolaemia, cholesterol values remain above guideline levels. One of the limiting factors to the achievement of goals in such patients is therapeutic non-adherence.
- Conditions
- Hypercholesterolemia, Medication Adherence, Primary Health Care
- Trial name
- EFESCOM (NCT02314663)
- Testing
- "COMBINED STRATEGY"
- Volunteers
- 358 people
- Sponsor
- Gerencia de Atención Primaria, Albacete
Type 1 Diabetes
Insulin-based Strategies to Prevent Hypoglycemia During Exercise
It has been reported that insulin basal rate reduction initiated at exercise onset can reduce the hypoglycemic risk during exercise.
- Trial name
- NCT02631265
- Testing
- Exercise 1, Exercise 2, Exercise 3
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
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