Clinical trials: Therapy Strategies
Breast Cancer
Combination Chemotherapy in Treating Women With Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002696
- Testing
- CAF regimen, CMF regimen, cyclophosphamide
- Where
- 7 sites in Argentina
- Sponsor
- Grupo Oncologico Cooperativo del Sur
Stroke
Strategies of Therapy With the Exoskeleton Robot ARMin
Neurological patients (e.g., after stroke) need long-term neurorehabilitation therapy of the arm with often limited, unsatisfactory outcome.
- Trial name
- MultiVIT-ARMin (NCT03100422)
- Testing
- ARMin, Occupational Therapy
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Swiss Federal Institute of Technology
Tooth Avulsion, Dental Pulp Diseases
Optimizing Pulp Management in Autotransplantation of Mature Third Molars: A Randomized Controlled Trial
This study aims to find the best way to use your own healthy wisdom tooth to replace the bad tooth. After transplantation, how to manage the "tooth nerve" (dental pulp) inside the tooth is a key question.
- Conditions
- Tooth Avulsion, Dental Pulp Diseases, Tooth, Impacted
- Trial name
- OPuM-ATM3 (NCT07291531)
- Testing
- Postoperative Root Canal Therapy, Intraoperative Apical Surgery with Retrograde Filling, Intraoperative Root-End Resection
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Tobacco Use, Smoking Cessation
Overcoming Nicotine Dependence to Enable Quitting
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are…
- Conditions
- Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence
- Trial name
- ON-DEQ (NCT05513872)
- Testing
- Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- Rush University Medical Center
Deep Caries
Deep Caries in Mature Teeth With Reversible Pulpitis
This clinical trial will be conducted to clinical, radiographical and histological evaluation of pulp condition with reversible pulpities after total and selective removal of primary and secondary caries (randomized clinical…
- Trial name
- NCT07028905
- Testing
- Total caries removal, Partial caries removal
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Minia University
Anorexia Nervosa, Mental Health Issue
Norwegian Microbiota Study in Anorexia Nervosa
Anorexia nervosa (AN) is a serious mental disorder occurring mainly in women. AN is characterized by severely restricted food-intake and subsequent low weight.
- Conditions
- Anorexia Nervosa, Mental Health Issue, Microbiota, Diet
- Trial name
- NORMA (NCT06144905)
- Testing
- standard care treatment program
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Norwegian University of Life Sciences
Chronic Spinal Pain
Time to Step Up to Stepped Care: A Novel Strategy for Cognitive Behavioral Therapy for Insomnia in Chronic Spinal Pain
Chronic spinal pain (i.e., chronic neck pain and chronic low back pain) are highly prevalent, and are known for their immens personal and socio-economic burden.
- Trial name
- StepUp (NCT06771856)
- Testing
- Standard Care CBTi, Stepped Care CBTi
- Where
- Belgium
- Volunteers
- 129 people
- Sponsor
- Vrije Universiteit Brussel
Osteoporosis, Osteopenia, Osteoporosis
Intervention Study of Drugs in Patients Osteopenia and Osteoporosis
This is a 12 months, randomized, multicenter, open-label, parallel-group study in postmenopausal women and male aged 50 years or old with osteoporosis or osteopenia in China to evaluate the efficacy and safety of different…
- Trial name
- NCT04719572
- Testing
- Basic treatment group, Basic treatment+ anti-osteoporosis drug group, Basic treatment + non-drug treatment group
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Chinese PLA General Hospital
HIV Infections, Antiretroviral Therapy
Improving Clinic Attendance for Medication Collection Among HIV Positive Individuals in Nepal
Antiretroviral therapy (ART) has been a game changer in the context of HIV-epidemic. From 2005 to 2015, HIV-related deaths have fallen by 45% thanks to ART.
- Conditions
- HIV Infections, Antiretroviral Therapy, HIV Seropositivity
- Trial name
- NCT03367130
- Testing
- Mobile phone reminder
- Where
- Nepal
- Volunteers
- 468 people
- Sponsor
- Tokyo University
Infertility
Swanson-Based Supportive Care for Infertility Stress and Coping in Couples Undergoing ART
The goal of this clinical trial is to learn if supportive care based on Swanson's Caring Theory can reduce stress and improve coping in couples undergoing infertility treatment with assisted reproductive treatment (ART)…
- Trial name
- NCT07557069
- Testing
- Swanson Caring Theory-based supportive care
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ondokuz Mayıs University
HIV Infections
A Study of Two Adherence Plans to Help HIV-Positive Patients Take Their Medications Correctly
The purpose of this study is to look at different ways to help patients follow their anti-HIV medication schedules. It is very important that HIV-positive patients take their anti-HIV medications correctly so they get the best…
- Trial name
- NCT00001129
- Testing
- Electronic Medication Reminder System, Medication Manager
- Where
- 20 sites in United States
- Volunteers
- 1,248 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Medication Adherence
Development and Evaluation of an Electronic Health Record-based Medication Complete Communication (EMC2) Strategy
There is a well-documented need for effective interventions that can help patients understand and safely adhere to prescribed medications, particularly those with greater potential for harm if not taken correctly.
- Trial name
- NCT03652272
- Testing
- EMC2
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Foot Injuries, Posterior Tibial Tendon Dysfunction
The CurePPaC Study - Analysing Non-surgical Treatment Strategies to Cure Pes Planovalgus Associated Complaints
Pes planovalgus, also called flat foot, is a common foot deformity characterized by a flattening of the foot's longitudinal arch and is accompanied by a dysfunction of the posterior tibial tendon ("posterior tibial tendon…
- Trial name
- NCT01839669
- Testing
- Foot Orthoses Only, Foot Orthoses and Eccentric Exercise
- Where
- 6 sites in Switzerland
- Volunteers
- 7 people
- Sponsor
- Bern University of Applied Sciences
Acute Heart Failure, Diuretic Resistance
Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance
The P-VALUE-AHF trial is a multicenter, randomized, open-label, parallel-group trial on the diuretic and decongestive effects of different diuretic escalation strategies in patients with acute heart failure and diuretic…
- Trial name
- P-Value-AHF (NCT05986773)
- Testing
- Furosemide, Metolazone, Acetazolamide
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- Stadtspital Zürich
Rejection Heart Transplant, Immunosuppression
Improving Immunosuppressive Therapy in Heart Transplantation
Cardiac allograft rejection (CAR) occurs in 30% to 40% of transplant recipients within the first year post-transplant, and carries an increased risk of both acute graft failure and reduced graft longevity.
- Trial name
- NCT03932539
- Where
- 4 sites in Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
Tolerogenic Dendritic Cells as a Therapeutic Strategy for the Treatment of Multiple Sclerosis Patients (TOLERVIT-MS)
The purpose of this study is to determine the safety and tolerability of the intranodal administration of autologous monocyte-derived dendritic cells tolerised with Vitamin-D3 and pulsed with myelin peptides (tolDC-VitD3) in…
- Trial name
- TOLERVIT-MS (NCT02903537)
- Testing
- Autologous VitD3 tolerogenic monocyte-derived dendritic cells loaded with a pool of myelin peptides (tolDC-VitD3), Interferon-beta
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
End Stage Renal Disease
Research Study Evaluating Cinacalcet for Patients With End Stage Renal Disease (ESRD)
The purpose of this study is to observe the effects of a treatment strategy that incorporates cinacalcet HCl into the management of secondary hyperparathyroidism (HPT) in subjects with ESRD receiving hemodialysis, on bio-intact…
- Trial name
- NCT00113945
- Testing
- Cinacalcet
- Volunteers
- 360 people
- Sponsor
- Amgen
Ovarian Cancer, Epithelial
Two Therapeutic Strategies in First-line in Patients With Epithelial Advanced Ovarian Cancer
CHIMOVIP is a study to determine the best therapeutic strategy in patient with ovarian advanced cancer.
- Trial name
- CHIMOVIP (NCT03025477)
- Testing
- CC0 - Carboplatin (IV) - Paclitaxel (IV), CC0 - Cisplatin (IP) - Epirubicin (IV), CC>0 - Carboplatin (IV)- Paclitaxel (IV)
- Where
- 7 sites in France
- Volunteers
- 84 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Myocardial Ischemia, Myocardial Infarction
Prehospital Evaluation and Economic Analysis of Different Coronary Syndrome Treatment Strategies - PREDICT
Despite remarkable gains in treatment over the last decade short-term mortality for those who survive to hospital with AT-elevation acute myocardial infarction (STEMI) remains high (5%-10%).
- Trial name
- PREDICT (NCT00747656)
- Where
- 5 sites in Canada
- Volunteers
- 446 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Kidney Transplantation
Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation
The objective of the study will be to evaluate the effect of different therapeutic immunosuppressive strategies currently employed in common clinical practice on regulatory T lymphocytes and to verify the hypothesis that the…
- Trial name
- EVERTWIST (NCT01640743)
- Testing
- Tacrolimus + Methylprednisolone, Tacrolimus + Everolimus + Methylprednisolone
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
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