Clinical trials: Therapy Strategies
Obesity & Overweight, Cardiometabolic Health Indicators
Comparing Different Medication Regimens to Maintaining Weight Loss Among Adults With Obesity Using GLP-1s
The purpose of this research is to compare weight loss among 3 groups: 1. people who stay on a GLP-1 drug at full strength (Group 1) 2.
- Trial name
- OFF-RAMP (NCT07832084)
- Testing
- GLP-1 dose reduction, non-GLP weight loss medication, Maintenance of GLP-1 dose
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jing Luo
Ulcerative Colitis in Remission
Safety and Efficacy of a STOPping Strategy Versus Classical Maintenance Dose of JAK Inhibitors in Deep Remission Patients With Ulcerative Colitis
This phase IV, multicenter, open-label randomized controlled trial will evaluate whether a JAK inhibitor discontinuation strategy is superior to standard maintenance therapy in adult patients with ulcerative colitis who are in…
- Trial name
- STOP (NCT07718529)
- Testing
- treatment withdrawal
- Where
- 22 sites in France
- Volunteers
- 224 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Atrial Fibrillation, Coronary Artery Disease
Antithrombotic Strategy for AF Patients With High Risk CAD
Anticoagulation therapy is recommended for patients with atrial fibrillation (AF) in order to prevent ischemic stroke and systemic embolism.
- Trial name
- ADAPT AFFIRM (NCT06866665)
- Testing
- Anticoagulation Monotherapy, Combination therapy
- Volunteers
- 1,400 people
- Sponsor
- Yonsei University
HIV Infections
A Study to Evaluate the Safety and Efficacy of Adding Enfuvirtide to Oral Highly Active Antiretroviral Therapy (HAART) in Human Immunodeficiency Virus (HIV) Patients With Prior Treatment Experience
To assess the efficacy of enfuvirtide (Fuzeon) added to HAART compared to treatment with HAART alone in achieving and maintaining viral load suppression.
- Trial name
- INTENSE (NCT00487188)
- Testing
- Enfuvirtide, Highly active antiretroviral treatment (HAART)
- Where
- 39 sites in United States, Canada and 8 more
- Volunteers
- 47 people
- Sponsor
- Hoffmann-La Roche
Patients With Advanced Homogeneous Emphysema
Emphysematous Lung Sealant Therapy in Homogeneous Emphysema
This study will test that hypothesis that endoscopic lung volume reduction therapy performed using emphysematous lung sealant treatment can be improved using smaller doses delivered to more a larger number of treatment sites.
- Trial name
- NCT01728662
- Testing
- ELVR Procedure
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Rabin Medical Center
HIV Infection, Acquired Immunodeficiency Syndrome
Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT)
The PIVOT trial aims to determine whether a strategy of switching to PI monotherapy is non-inferior to continuing triple-therapy, in terms of the proportion of patients who maintain all the drug treatment options that were…
- Trial name
- PIVOT (NCT01230580)
- Testing
- Protease Inhibitor, Standard-of-care Antiretroviral therapy
- Volunteers
- 587 people
- Sponsor
- Medical Research Council
Combined Hepatocellular-cholangiocarcinoma, Combined Hepatocellular Carcinoma and Cholangiocarcinoma
Novel Subtypes and Treatment Strategies of Patients with Unresectable Combined Hepatocellular Cholangiocarcinoma Based on Multimodal Data
This study focused on exploring new comprehensive treatment strategies for patients with unresectable combined hepatocellular-cholangiocarcinoma, classifying patients with CHC subtypes based on the combination of artificial…
- Conditions
- Combined Hepatocellular-cholangiocarcinoma, Combined Hepatocellular Carcinoma and Cholangiocarcinoma, Combined Hepatocellular and Cholangiocarcinoma
- Trial name
- NCT06849180
- Testing
- Interventional therapies combined with or without systemic drugs
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Zhongda Hospital
Stable Coronary Syndrome, Percutaneous Coronary Intervention
A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND PILOT STUDY)
In patients with heart attacks, the current standard of care is to restore blood flow through percutaneous coronary intervention (PCI). This is done using stents (metal meshes) that opens up blockages.
- Conditions
- Stable Coronary Syndrome, Percutaneous Coronary Intervention, Antiplatelet Therapy, Ticagrelor
- Trial name
- NCT03224923
- Testing
- Ticagrelor 60mg, Clopidogrel 75mg, Aspirin 81 mg
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Ottawa Heart Institute Research Corporation
HIV Infections, Metabolic Syndrome X
Lifestyle Modification and Metformin Use in the Treatment of HIV
A healthy diet and exercise have improved the health of people without human immunodeficiency virus (HIV) who have Metabolic Syndrome.
- Trial name
- NCT00399360
- Testing
- Metformin, Lifestyle Modification
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Ankle Fractures
Treatment Strategy of Ankle Fracture Combined With Deltoid Ligament Rupture
Ankle fracture is very common which is often combined with deltoid ligament injury. Although the incidence of deltoid ligament injury is high, but there is no unified and effective diagnosis method.
- Trial name
- NCT02977910
- Testing
- repair of deltoid ligament
- Volunteers
- 200 people
- Sponsor
- Liming Cheng
Mitral Regurgitation (MR), Pediatric Cardiac Surgery
A Prospective Multicenter Cohort Study on Surgical Treatment Strategies for Pediatric Mitral Regurgitation
This prospective, multicenter cohort study aims to evaluate the outcomes of surgical repair for pediatric mitral regurgitation (MR) in China.
- Trial name
- NCT07284212
- Testing
- conventional mitral valve repair, standardized mitral valve repair
- Where
- China
- Volunteers
- 427 people
- Sponsor
- China National Center for Cardiovascular Diseases
Stroke, Ischemic, Intravascular Thrombosis
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET)
To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who received recanalization operation.
- Conditions
- Stroke, Ischemic, Intravascular Thrombosis, Mechanical Thrombectomy
- Trial name
- NCT04664933
- Testing
- Intra-arterial administration of neuroprotective agents
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hui-Sheng Chen
Psychological Trauma, Mental Health
Collaborative Organizational Approach to Selecting and Tailoring Implementation Strategies
The purpose of this study is to partner with the North Carolina Child Treatment Program (NC CTP) and the SAMHSA-funded National Child Traumatic Stress Network (NCTSN) to develop and pilot the Collaborative Organizational Approach…
- Trial name
- COAST-IS (NCT03799432)
- Testing
- COAST-IS, TF-CBT Learning Collaborative
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease, Percutaneous Coronary Intervention
Effect and Efficacy of Xpedition™/Alpine™, Everolimus-eluting Stent for Coronary Atherosclerosis
The objectives of this study are 1. To establish a prospective registry of the whole patients who received percutaneous coronary intervention with Xience Xpedition™/Alpine™ stent 2.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Angina Pectoris
- Trial name
- HOST-ALPINE (NCT02845804)
- Testing
- Alpine
- Where
- 20 sites in South Korea
- Volunteers
- 1,533 people
- Sponsor
- Seoul National University Hospital
Rheumatoid Arthritis
A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate Treatment
This 2 arm study will compare 2 treatment strategies based on tocilizumab in combination with methotrexate or placebo in patients with moderate to severe rheumatoid arthritis.
- Trial name
- NCT00810199
- Testing
- tocilizumab [RoActemra/Actemra], methotrexate
- Where
- 137 sites in United States, Brazil and 18 more
- Volunteers
- 556 people
- Sponsor
- Hoffmann-La Roche
Esophageal Cancer, Radiotherapy
PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy
The PROTECT trial will test the hypothesis that proton (PT) -enabled radiation dose reductions to sensitive, normal tissues will result in lower rates of treatment-related pulmonary complications in esophageal cancer compared to…
- Conditions
- Esophageal Cancer, Radiotherapy, Side Effect, Proton Therapy
- Trial name
- PROTECT (NCT05055648)
- Testing
- Photon Radiotherapy, Proton Radiotherapy
- Where
- 15 sites in Belgium, Denmark and 6 more
- Volunteers
- 396 people
- Sponsor
- University of Aarhus
Ulcerative Colitis
Strategies in Maintenance for Patients Receiving Long-term Therapy (S.I.M.P.L.E.) With MMX (Multi-Matrix System) Mesalamine for Ulcerative Colitis (UC)
To evaluate the percentage of subjects with clinical recurrence of UC at 6 months using MMX mesalamine once daily.
- Trial name
- NCT00446849
- Testing
- MMX Mesalamine
- Where
- 62 sites in United States
- Volunteers
- 290 people
- Sponsor
- Shire
Breastfeeding Education, Maternal Self-Efficacy
Mixed Reality as a Health Literacy Strategy for Breastfeeding Education
The goal of this randomized controlled trial is to evaluate whether a mixed reality-based educational strategy improves breastfeeding satisfaction and self-efficacy in pregnant women compared to traditional counseling.
- Conditions
- Breastfeeding Education, Maternal Self-Efficacy, Breastfeeding Satisfaction
- Trial name
- NCT06800521
- Testing
- Mixed Reality Breastfeeding Education, Traditional Breastfeeding Counseling
- Where
- Colombia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de la Sabana
Coronary Artery Disease
The DECISION-CTO Extended 10 Y Follow-up
The goal of this study is to compare the 10-year clinical outcomes of an initial strategy of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO-PCI) with an initial strategy of no CTO-PCI in patients with…
- Trial name
- DecisionCTO10Y (NCT06908499)
- Where
- 19 sites in India, Indonesia and 3 more
- Volunteers
- 804 people
- Sponsor
- Seung-Jung Park
Melasma, Treatment of Stable Melasma
Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of Melasma
Melasma is a common pigmentation disorder among young and middle-aged women, characterized by symmetrical brown-black patches on the face.
- Conditions
- Melasma, Treatment of Stable Melasma, Tranexamic Acid, Laurocapram
- Trial name
- NCT07530016
- Testing
- Ligustrazine - tranexamic acid - aloe polysaccharide composite gel
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
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