Clinical trials: Therapy Strategies
Hiv
Innovative Strategies to Increase ART Initiation and Viral Suppression Among HIV-positive Men in Malawi
Men in Sub-Saharan Africa are less likely to test for HIV, initiate ART, and more likely to initiate ART at later stages of disease.
- Trial name
- NCT04878601
- Testing
- Home-Based ART, Facility-Based ART
- Where
- Malawi
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Myocardial Infarction
Invasive vs. Conservative Management in Cancer Patients With Non-ST Elevation MI (CAN-NSTEMI)"
This retrospective study investigates the impact of invasive versus conservative management strategies in cancer patients presenting with non-ST elevation myocardial infarction (non-ST MI).
- Trial name
- CAN-NSTEMI (NCT06702436)
- Testing
- Observational Study
- Where
- Turkey (Türkiye)
- Volunteers
- 12,500 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Coronary Artery Disease, Myocardial Ischemia
Primary FIbrinolysis and Secondary STenting Versus immEdiate Stenting in ST-segment Elevation Myocardial Infarction
This prospective, multicenter, randomized, controlled, open-label clinical study has a target enrollment of 240 subjects. It will explore whether STEMI patients transferred to a PCI center following thrombolytic therapy and…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Acute Coronary Syndrome, Heart Diseases
- Trial name
- FISSTEMI (NCT04663932)
- Testing
- immediate stenting group(one-step strategy), deferred stenting group (two-step strategy)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Harbin Medical University
Obesity
Impact of the Residual Gastric Volume in Laparoscopic Sleeve Gastrectomy's Failure
Obesity is a worldwide health problematic whose incidence is increasing especially in developed countries. The surgical management of this illness consists in different techniques such as Laparoscopic Sleeve Gastrectomy but this…
- Trial name
- GASTROMANCH (NCT01539967)
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
HIV Disease Progression
Acceptability, Feasibility and Effectiveness of Online Peer Support Group for ART Adherence Among Youth
In Uganda, Youth living with HIV/AIDS (YLHIVA) enrolled in HIV treatment experience suboptimal treatment adherence and have lower viral load suppression (VLS) rates compared to younger children or adults.
- Trial name
- NCT05688709
- Testing
- WhatsApp peer support group
- Where
- 3 sites in Uganda
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Coronary Artery Disease
The DECISION-CTO Extended 10 Y Follow-up
The goal of this study is to compare the 10-year clinical outcomes of an initial strategy of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO-PCI) with an initial strategy of no CTO-PCI in patients with…
- Trial name
- DecisionCTO10Y (NCT06908499)
- Where
- 19 sites in India, Indonesia and 3 more
- Volunteers
- 804 people
- Sponsor
- Seung-Jung Park
Substance Use
Substance Abuse Treatment to HIV Care (SAT2HIV): The Implementation & Sustainment Facilitation Experiment
A cluster randomized experiment focused on testing the extent to which the organization-focused Implementation \& Sustainment Facilitation (ISF) strategy is an effective adjunct to the staff-focused Addiction Technology Transfer…
- Trial name
- NCT03120598
- Testing
- ATTC strategy, ISF strategy
- Where
- 39 sites in United States
- Volunteers
- 190 people
- Sponsor
- RTI International
Prostate Cancer
Strategies to Improve Bone Health in Men on ADT
This is a phase II randomized controlled trial (RCT) of 2 strategies to improve bone health in men receiving androgen deprivation therapy (ADT).
- Trial name
- NCT02043236
- Testing
- Healthy bones pamphlet, Bone Health Care Coordinator, Letter to GP
- Where
- Canada
- Volunteers
- 159 people
- Sponsor
- University Health Network, Toronto
Chronic Hepatitis b, Anti-PD-1 Antibody
A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (Sustained HBsAg Loss) (A)
Hepatitis B virus (HBV) infection is a major public health threat in China. At present, a functional cure, also known as clinical cure or sustained Hepatitis B surface antigen (HBsAg) loss, is recommended as the ideal endpoint of…
- Trial name
- NCT05769816
- Testing
- Anti-PD-1 antibody, NAs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Myocardial Infarction
Studying the Effectiveness of Early Invasive Treatment in Elderly Patients With High-risk Non-ST-segment Elevation Acute Coronary Syndrome.
The goal of this is observational study is to compare about MACE events and predisposing factors related to MACE events in elderly patients with high-risk non-ST acute coronary syndromes receiving early versus late invasive…
- Trial name
- NCT06486233
- Where
- Vietnam
- Volunteers
- 385 people
- Sponsor
- Gia Dinh People Hospital
Respiratory Distress Syndrome
Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams
The purpose of this study is to compare two different treatment strategies for RDS in preterm infants > 1500 grams and evaluate whether a selective surfactant administration would reduce the need of intubation, mechanical…
- Trial name
- NCT00277030
- Testing
- Surfactant, Nasal CPAP
- Where
- 3 sites in Chile
- Volunteers
- 110 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Breast Cancer
Optimization of Dynamic Neoadjuvant Therapy Strategies for HER2-Positive Breast Cancer Based on HER2-PET/CT Molecular Imaging
This study evaluates HER2-PET/CT-guided dynamic optimization of neoadjuvant therapy in patients with early-stage HER2-positive breast cancer.
- Trial name
- NCT07527806
- Testing
- Trastuzumab (Herceptin), Pertuzumab, Combination product: Trastuzumab + Pertuzumab
- Volunteers
- 156 people
- Sponsor
- Peking University Cancer Hospital & Institute
Transplant, Kidney
Pilot Trial for Implementation of a MPA PK Monitoring Strategy
This study is a prospective interventional trial of de novo renal transplant recipients, aiming to validate a strategy which combines the use of early post transplant MPA AUC sampling, and subsequent MPA trough level monitoring…
- Trial name
- MPA (NCT00187915)
- Testing
- Mycophenolate mofetil + Tacrolimus, Mycophenolate mofetil + Cyclosporin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Stenotrophomonas Maltophilia Infection
Alternative Treatment Strategies for Stenotrophomonas Maltophilia Pneumonia
Multi center, retrospective chart review of patients admitted to MHS hospitals from April 1, 2017 to March 31, 2022. Patients will be identified through the electronic medical record, and data from those that meet the study…
- Trial name
- NCT06112938
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Methodist Health System
Heart Failure, Heart Failure NYHA Class III
REDUCED FUNCTIONALITY AND KINESIOPHOBIA IN PATIENTS WITH HEART FAILURE: USE OF ALTERNATIVE THERAPEUTIC STRATEGIES
Introduction: Heart failure (HF) is a clinical syndrome that has advanced on a large scale concomitant with population aging and other factors.
- Conditions
- Heart Failure, Heart Failure NYHA Class III, Heart Failure NYHA Class IV, Neuromuscular Electrical Stimulation (NMES)
- Trial name
- NCT07099495
- Testing
- Low Frequency Neuromuscular Electrical Stimulation, Medium Frequency Neuromuscular Electrical Stimulation, Neuromuscular Electrical Stimulation without generating contractility
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Sepsis, Septic Shock
Molecular Subtype-Specific Mechanisms and Therapeutic Strategies in Sepsis
Sepsis is a complex syndrome that causes lethal organ dysfunction due to an abnormal host response to infection. No drug specifically targeting sepsis has been approved.
- Trial name
- MENDSEP (NCT06287684)
- Where
- Malta
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Mater Dei Hospital, Malta
Colorectal Neoplasms
Invasiveness and Chemoresistance of Cancer Stem Cells in Colon Cancer
The main objective of this study is to identify and characterize subpopulations of cells with invasive capacity in colorectal cancer from primary tumor, blood and metastatic samples.
- Trial name
- NCT01577511
- Testing
- Samples and follow up
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
A Trial of Two Daclizumab Dosing Strategies vs. No Induction Treatment With Tacrolimus, Mycophenolate Mofetil , & Steroids for the Prevention of Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
The purpose of the study is to determine the safety and efficacy of two dosing regimens of daclizumab in simultaneous kidney/pancreas transplant recipients.
- Trial name
- NCT00363116
- Testing
- Daclizumab
- Where
- 24 sites in United States, Canada
- Volunteers
- 298 people
- Sponsor
- University of Cincinnati
Coronary Disease
Different Hydration Strategies Associated With Aerobic Exercise In Coronary
The need to restore water losses resulting from physical activity has become established and diffused into international consensus for healthy individuals or high-performance athletes.
- Trial name
- NCT04977258
- Testing
- Treadmill aerobic exercise without water intake, Treadmill aerobic exercise with water intake of a predetermined amount., Treadmill aerobic exercise with water intake according to the desire to drink
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Adult Patients Ventilated More Than 48 h
Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy
Prospective, randomized clinical multicentric study in ICU during weaning from mechanical ventilation.
- Trial name
- WIN IN WEAN (NCT02123940)
- Testing
- lung ultrasound score
- Where
- France
- Volunteers
- 483 people
- Sponsor
- University Hospital, Clermont-Ferrand
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