Clinical trials: Therapy Strategies
NSCLC, Sintilimab
The Efficacy and Safety of the Combination of PD-1 With Chemotherapy and Adaptive Radiotherapy Strategy in the Treatment of Stage III Non-small Cell Lung Cancer Patients
To evaluate the Efficacy and Safety of the Combination of Sintilimab With Platinum-doublet Chemotherapy and Adaptive Radiotherapy Strategy in the Treatment of Stage III Non-small Cell Lung Cancer Patients
- Conditions
- NSCLC, Sintilimab, Adaptive Radiotherapy
- Trial name
- NCT07138755
- Testing
- Experimental
- Where
- 4 sites in China
- Volunteers
- 35 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Diagnosis, Psychiatric
Testing the Right Question Project (RQP) Health Education Strategy in a Mental Health Setting
The purpose of this pilot project is to test the effectiveness of three 20 minute health education modules on patient empowerment, patient activation and retention in care.
- Trial name
- RQP (NCT00134615)
- Testing
- RQP patient health education module
- Where
- 2 sites in United States
- Volunteers
- 231 people
- Sponsor
- Massachusetts General Hospital
Dysphagia
Efficacy of Two Interventions Increasing Sensory Stimulus in Elderly Patients With Oropharyngeal Dysphagia
This study will evaluate with videofluoroscopy (radiologic method to study the deglutitive physiology) the effect on the deglutition of two therapeutic treatments with the duration of 2 weeks, based on the increase of the…
- Trial name
- NCT01762228
- Testing
- Transcutaneous electrical stimulation, TRPV1 agonist
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Hospital de Mataró
Polycythemia Vera, Essential Thrombocythemia
Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) Patients
The purpose of the study is to isolate and characterize stem cells of patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) to find out why these cells are not working the way they should be and why they seem to…
- Trial name
- NCT01970930
- Testing
- Blood specimen
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
RDS of Prematurity
NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)
The purpose of this study is to determine whether two different strategies of Non Invasive Ventilation (NIV) have different effect on length and failure of NIV support in preterm infants with respiratory distress syndrome (RDS).
- Trial name
- NIV (NCT02259400)
- Testing
- NSIPPV, BiPAP
- Volunteers
- 280 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Chronic Total Occlusion of Coronary Artery, Angina Pectoris
Observational Registry on Clinical Outcome After Diagnosis of Chronic Total Occlusions
This registry aims at enrolling all consecutive patients presenting with at least one chronic total occlusion at coronary angiogram as diagnosed during angiography in our catheterization laboratory during 1 year.
- Trial name
- PETS-CTO (NCT04145167)
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Ziekenhuis Netwerk Antwerpen (ZNA)
Advanced Non Small Cell Lung Cancer
Strategies for Maintenance Therapies in Advanced Non Small Cell Lung Cancer
In France, lung cancer is responsible for more than 30000 each year. Progress was made in treatment of lung cancer in the last five years due to targeted therapies and to strategical evolutions consisting in a best adjustment of…
- Trial name
- NCT01631136
- Testing
- Cisplatin, Pemetrexed, Gemcitabine
- Where
- 91 sites in France
- Volunteers
- 932 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Unruptured Cerebral Aneurysm, Treatment Strategy
New Therapeutic System of Unruptured Intracranial Aneurysms Based on Big Data From Chinese Population
This is a prospective, multicenter, observational study, aiming at comparing the Safety and effectiveness among the different surgical treatment of unruptured intracranial aneurysms in China, so as to improve the diagnosis and…
- Trial name
- NATIONAL-1 (NCT03153865)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Breast Cancer
Sweden Cancerome Analysis Network - Breast (SCAN-B) Coupled to Psychological Resilience
This study aims to define the association between psychological resilience and biomolecular signatures in cancer patients and to relate psychological resilience to prognosis, as this could potentially open up a novel avenue of…
- Trial name
- NCT03430492
- Where
- 4 sites in Sweden
- Volunteers
- 985 people
- Sponsor
- Lund University
Traumatic Brain Injury, Executive Dysfunction
Online Emotion Regulation Group Intervention
This study will examine the efficacy of an emotion regulation intervention delivered online to individuals with traumatic brain injury (TBI) with deficits in emotion regulation.
- Conditions
- Traumatic Brain Injury, Executive Dysfunction, Emotion Dysfunction, Emotion Dysregulation
- Trial name
- NCT03479606
- Testing
- Online Emotion Regulation Skills-training
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Odontogenic Cysts
Risk-Adapted Treatment Strategies for Odontogenic Keratocysts: A Long-Term Randomized Clinical Trial Quantifying Recurrence Reduction
Background The odontogenic keratocysts (OKCs) have been one of the maxillofacial region's most contentious pathological phenomena.
- Trial name
- OKCs (NCT06133764)
- Testing
- Enucleation+ Peripheral Ostectomy+Carnoy's solution chemical cauterization (E+CS + PO), Decompression/ marsupialization (D/M), Enucleation (E)
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Qassim University
Diabetes, Brown Adipose Tissue
Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional Food/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE)
To examine MA (Maslinic Acid) safety and efficacy in ameliorating insulin resistance and the cardinal features of metabolic syndrome.
- Trial name
- NCT06484543
- Testing
- Maslinic Acid
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
HIV Infections
Comparison of Three Anti-HIV Regimens to Prevent Nevirapine Resistance in Women Who Take Nevirapine During Pregnancy
HIV infected pregnant women may take single-dose nevirapine (SD NVP) prior to giving birth to prevent mother-to-child transmission (MTCT) of HIV.
- Trial name
- NCT00099632
- Testing
- Emtricitabine/Tenofovir Disoproxil Fumarate, Lamivudine/Zidovudine, Lopinavir/Ritonavir
- Where
- 8 sites in Haiti, India and 4 more
- Volunteers
- 484 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Colorectal Cancer, Liver Metastases
Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases
Colorectal cancer patients with initially unresectable liver-only metastases may be cured after downsizing of metastases by neoadjuvant systemic therapy.
- Trial name
- CAIRO5 (NCT02162563)
- Testing
- FOLFOX/ FOLFIRI with bevacizumab, FOLFOXIRI with bevacizumab, FOLFOX/ FOLFIRI with panitumumab
- Where
- 56 sites in Belgium, Netherlands
- Volunteers
- 530 people
- Sponsor
- Dutch Colorectal Cancer Group
Substance Use Disorders, Opioid Use Disorder, Severe
EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy
This study is a multi-site, cluster randomized, two group implementation trial comparing a low- versus high-intensity implementation strategy for supporting hospital-based opioid use disorder treatment (HBOT) in community…
- Conditions
- Substance Use Disorders, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- EXHITENTRE (NCT04921787)
- Testing
- Low Intensity, High Intensity
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- Gavin Bart
Critical Limb Ischemia
Proteomics and Stem Cell Therapy as a New Vascularization Strategy
Neovascularization (NV) is the innate capability to enlarge collateral arteries ("arteriogenesis"), and to stimulate growth of new capillaries, arterioles and venules at the tissue level ("angiogenesis").
- Trial name
- NCT02802852
- Testing
- Pneumatic calf compression, Filgrastim
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Illinois Chicago
Eosinophilic Granulomatosis With Polyangiitis
Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients With Eosinophilic Granulomatosis With Polyangiitis (E-merge)
The purpose of this study is to compare mepolizumab-based regimen to conventional therapeutic strategy for remission induction in patients with Eosinophilic Granulomatosis with Polyangiitis.
- Trial name
- E-merge (NCT05030155)
- Testing
- Mepolizumab, cyclophosphamide/azathioprine
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Strategies to Improve Asthma and Treatment of Asthma in Canadians
Our study will enroll 644 randomly-selected Canadians who have been diagnosed with asthma by a physician within the previous five years. It will be determined what diagnostic tests were initially performed to make this diagnosis.
- Trial name
- NCT01525381
- Where
- Canada
- Volunteers
- 701 people
- Sponsor
- Ottawa Hospital Research Institute
Cervical Cancer
Strategies to Close the Gap From Cervical Cancer Diagnosis to Treatment in Botswana
Investigators will test the effectiveness of adaptive strategies on timely adoption of cervical cancer treatment in Botswana using a pragmatic trial design.
- Trial name
- NCT05952141
- Testing
- Clinic Outreach, Enhanced Outreach, Low-Touch Strategy
- Where
- 3 sites in United States, Botswana
- Volunteers
- 610 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Anemia, Sickle Cell
Therapeutic Anticoagulation Strategy for Acute Chest Syndrome
Acute Chest Syndrome (ACS) is a pulmonary complication of sickle cell disease (SCD) representing the leading cause of death and the second cause of hospitalization among adult patients.
- Conditions
- Anemia, Sickle Cell, Acute Chest Syndrome, Low-Molecular-Weight Heparin
- Trial name
- TASC (NCT02580773)
- Testing
- Prophylactic anticoagulation ( INNOHEP®), Curative anticoagulation ( INNOHEP®)
- Where
- France
- Volunteers
- 198 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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