Clinical trials: Thermogenesis
Thermogenesis by Different-dosage Mustard Flour Footbaths
Dose-response Relationship of Mustard Flour Footbaths in Healthy Volunteers
A study to explore whether different dosages of mustard flour in footbaths cause different effects on warmth development as well as on general well-being and the autonomic nervous system.
- Trial name
- NCT04321720
- Testing
- 3-g mustard footbath, 6-g mustard footbath, 12-g mustard footbath
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Energy Expenditure, Obesity
BRown Fat Activity Measurement With Infrared imaginG tHermography andThermogenesis - the BRIGHT Study
The whole body calorimeter is sensitive enough to reliably measure cold-induced thermogenesis as a surrogate marker of brown adipose tissue (BAT) activation.
- Conditions
- Energy Expenditure, Obesity, Adipose Tissue, Brown
- Trial name
- BRIGHT (NCT02790255)
- Testing
- Cold air, Cold water
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Healthy
Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis With a High Protein Very Low Calorie Diet
The study is designed to determine the effects of a non-pungent supplement from sweet chilli pepper on resting metabolic rate and diet-induced thermogenesis (DIT) after a period of very low calorie intake over 4 weeks.
- Trial name
- NCT01142687
- Testing
- dihydrocapsiate capsule
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Adipose Tissue, Brown, Insulin Resistance
Effect of Fluvastatin on Brown Fat Activity
The purpose of this study is to elucidate the effects of Fluvastatin on brown adipose tissue activity in humans.
- Conditions
- Adipose Tissue, Brown, Insulin Resistance, Clinical Trial
- Trial name
- FluvaBAT (NCT03189511)
- Testing
- Fluvastatin
- Where
- 2 sites in Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Nutrition, Mastication
Mastication and Energy Expenditure in Normal Weight and Obese People
The objective of the study is to analyze the specific role of physical properties of food and mastication in the cephalic phase reflex of thermogenesis, and the involvement of the autonomic nervous system in the implementation of…
- Trial name
- MASTICAL (NCT04050930)
- Testing
- Mastication
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity
Nutritional Restriction and Activity Thermogenesis
These studies will provide us with enormous insight regarding how obese patients adapt energetically during negative energy balance.
- Trial name
- NCT00065338
- Testing
- Exercise and behavior modification
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Overweight
Whey Protein Micelles and Thermogenesis in Overweight Subjects
The main objective of the trial is to measure the thermogenic effect of two different doses of whey protein microgels. It will be a randomized crossover double-blind design conducted in 20 subjects.
- Trial name
- Thermowhey (NCT02303080)
- Testing
- Control (WPM 0), WPM 30, WPM 50
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Rewarming by Shivering Heat Production Only, Rewarming by Arm and Leg Immersion in Warm Water
Hypothermia Rewarming With Distal Limb Warming
The study will compare the rewarming effectiveness of heat donation through the distal arms and legs during rewarming of mildly hypothermic subjects.
- Conditions
- Rewarming by Shivering Heat Production Only, Rewarming by Arm and Leg Immersion in Warm Water, Rewarming by Arm and Leg Exposure to Fluidotherapy
- Trial name
- NCT01827449
- Testing
- Fluidotherapy warming device
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Thermogenesis by Different-dosage Ginger Flour Footbaths
Dose-Response Relationship of Ginger Flour Footbaths in Healthy Volunteers
A study to explore whether different dosages of ginger flour in footbaths cause different effects on warmth development as well as on general well-being and the autonomic nervous system.
- Trial name
- NCT04051476
- Testing
- 3-g footbath, 6-g footbath, 12-g footbath
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Resting Energy Expenditure, Thermogenesis
Mirabegron and Physiological Function in Cold Environments
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal…
- Conditions
- Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
- Trial name
- NCT04766021
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Postprandial Metabolism, Healthy Volunteers
Postprandial Metabolic Responses to Sustainable and Non-Sustainable Meals in Healthy Young Men
This randomized crossover study evaluated the acute postprandial metabolic and hydration responses to two standardized lunch meals differing in nutritional quality and environmental footprint in healthy young men.
- Trial name
- THERMOS-LUNCH (NCT07808736)
- Testing
- Healthy-Sustainable Test Meal, Non-Sustainable Test Meal
- Where
- Italy
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Parma
Phenylketonuria (PKU)
Impact of Phenylketonuria-type Diet on Appetite, Appetite Hormones and Diet Induced Thermogenesis
Low-phenylalanine diets are commonly prescribed to people with phenylketonuria (PKU), an inborn disease which causes accumulation of amino acid phenylalanine (Phe) in the blood.
- Trial name
- NCT02440932
- Testing
- Phenylketonuria-type diet, Normal (control) diet
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Increased Energy Expenditure, Increased Satiety
The Effect of Hydrolyzed Casein on Energy Expenditure and Subjective Appetite
The primary aim is to examine and compare the effects of hydrolyzed casein (HC), intact casein (IC) and intact whey protein (IWP) on diet-induced thermogenesis (DIT).
- Trial name
- HerKulES (NCT01677273)
- Testing
- Hydrolyzed casein, Intact casein, Intact whey protein
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Thermogenenic Responses to Fasting and Overfeeding in Women
This study plans to learn more about why menopause increases the risk of weight gain. During and after menopause, women are prone to increased weight gain.
- Trial name
- NCT06610162
- Testing
- Eucalaloric feeding, Acute Fasting, Acute Overfeeding
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Obesity
Activation of Brown Adipose Tissue Thermogenesis in Humans Using Formoterol Fumarate (GB10)
One emerging, highly modifiable homeostatic mechanism for energy expenditure in humans is brown adipose tissue (BAT) thermogenesis.
- Trial name
- GB10 (NCT05553184)
- Testing
- Formoterol Fumarate 12 micrograms Inhalation Powder, Nicotinic Acid 50 MG Oral Tablet, Acute Cold Exposure
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cardiometabolic Diseases, Postmenopause
Exercise and Prolonged Fasting to Improve Brown Adipose Tissue Function in Postmenopausal Women
Type of Study: Clinical Trial Goal: The goal of this clinical trial is to investigate mitochondrial function in interscapular brown adipose tissue (iBAT) in postmenopausal women and determine whether aerobic exercise, prolonged…
- Trial name
- EMPOWER-BAT (NCT07837752)
- Testing
- Aerobic exercise, Prolonged fasting
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Brown Adipose Tissue, Metabolic Disease
Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis
To test the hypothesis that active BAT improves metabolic health by buffering postprandial metabolites plasma metabolites and energy expenditure will be compared in volunteers with and without active BAT.
- Trial name
- BANDIT (NCT06078345)
- Testing
- Carbohydrate, Fat, Protein
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Postprandial Hyperglycemia, Energy Expenditure
The Effect of Bread Fortification With Phosphorus and Lysine on Postprandial Glycaemia and Thermogenesis
Wheat and wheat derived products are highly consumed around the world. They constitute the major dietary source of protein and energy for many individuals.
- Trial name
- NCT03836495
- Testing
- lysine and phosphorus
- Where
- Lebanon
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Effects of; Food, Thermogenesis
Thermogenic Effect and Metabolic Responses of Durian
The primary aim of this study is to determine the effectiveness of durian on thermic effect of food (TEF), blood pressure, heart rate and postprandial glucose and lipid levels in young healthy men and women, compared to the…
- Conditions
- Effects of; Food, Thermogenesis, Blood Pressure, Heart Rate
- Trial name
- NCT06121817
- Testing
- Food/meal intervention
- Where
- Singapore
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Prevention of Obesity
The Effect of Protein and Calcium on Weight Change and Blood Lipid Profile
The primary aim is to examine the effect of a high protein intake (from soy or whey protein) on weightmaintenance after weight loss in a group of predisposed (severe) obese persons.
- Trial name
- PROKA (NCT01561131)
- Testing
- Whey protein, Whey protein enriched with calcium, Soy protein
- Where
- Denmark
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen