Clinical trials: Thermogenesis
Resting Energy Expenditure, Thermogenesis
MIrabegron and Physiological Function in Cold Environments
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal…
- Conditions
- Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
- Trial name
- NCT05990387
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Fasting
Mechanisms of Fasting Induced Reduction in Energy Expenditure
Fasting reduces the energy consumption of the human body. The extent of this adaptation varies significantly between different individuals.
- Trial name
- FIRE (NCT06134258)
- Testing
- mixed meal test
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Obesity and Overweight
How Metabolism Affects Weight Loss and Gain
This study examines why some individuals with obesity have difficulty losing weight, whereas some lean individuals struggle to gain weight.
- Trial name
- NCT06860776
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Obesity, Weight
Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate
A 4 week intake of drug to find a natural substance that may modify energy balance and may enhance health in combination with lifestyle changes with possible decrease in body weight.
- Trial name
- CAPSPAL (NCT00999297)
- Testing
- Dihydrocapsiate
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Caffeine-Induced Thermogenesis, Brown Adipose Tissue Activation
Caffeine-Induced Thermogenesis Assessed by Infrared Thermography
This study evaluated thermogenic and physiological responses to 200 mg of caffeine administered following a carbohydrate gel in healthy adults.
- Trial name
- NCT07868302
- Testing
- Carbohydrate Gel, Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Diet-induced Thermogenesis, Sensory Function
Sensory Stimulation as a Driver of Diet-induced Thermogenesis
This study aims to assess the influence of sensory stimulation on diet-induced energy expenditure by way of a clinical cross-over trial in 24 healthy participants either receiving a meal bolus with (orally) and without sensory…
- Trial name
- SENSATION (NCT07409025)
- Testing
- sensory exposure, sensory deprivation
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Diabetes
A Role for Brown Adipose Tissue in Postprandial Thermogenesis?
Brown adipose (fat) tissue (BAT) is a type of fat tissue found in certain small rodents and human babies that is capable of extremely high rates of energy burning.
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT01974778
- Testing
- Meal
- Where
- Australia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Obesity
Diet-Induced Thermogenesis: A Comparison of Whole and Processed Foods
This study will examine differences in diet-induced thermogenesis (DIT) between a meal made of processed ingredients and an equivalent, isocaloric meal made of whole ingredients.
- Trial name
- NCT02943434
- Testing
- Processed food
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Central Washington University
Thermogenesis
Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue
The purpose of the study is to asses brown adipose tissue activity in humans after intravenous administration of the selective beta-2-adrenergic agonist fenoterol as compared to the natural activator of brown adipose tissue, a…
- Trial name
- ASCENT (NCT05294965)
- Testing
- Fenoterol, Mild cold exposure
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Diet-induced Thermogenesis, Brown Adipose Tissue Activation
Creatine Effect on Brown Adipose Tissue Activation
Pre-clinical studies indicate that creatine may play a substantial role in diet-induced thermogenesis and may have a profound effect on energy balance.
- Trial name
- CreaBAT (NCT04086381)
- Testing
- Creatine monohydrate
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Healthy, Obese
Circadian Rhythmicity in Cold-induced Thermogenesis
This study aims to investigate whether maximum cold-induced non-shivering thermogenesis (e.g. thermogenesis as a consequence of BAT activity) differs between morning and evening.
- Conditions
- Healthy, Obese, Glucose Intolerance
- Trial name
- COLDR (NCT04406922)
- Testing
- Personalized cooling protocol
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Obesity, Normal Physiology
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Background: Diet-induced thermogenesis (DIT) is the amount of energy one's body uses to eat food, absorb the nutrients from the food, and process those nutrients.
- Conditions
- Obesity, Normal Physiology, Healthy Volunteers
- Trial name
- NCT05545306
- Testing
- +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy
Examination of the Effects of Four Different Spices on Energy Metabolism
The objective of this study is to examine whether four different spices (ginger, black pepper, horseradish and mustard) are able to increase energy metabolism.
- Trial name
- NCT00611156
- Testing
- ginger, black pepper, horseradish
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Effect of Asthma Medication Salbutamol on Obesity
The Regulatory Function of Inhaled Asthma Medication Salbutamol on Thermogenesis
In recent years, obesity and its complications have severely threatened human health. Given the limited options for obesity treatment currently available, there is an urgent need to develop new drugs and therapeutic methods to…
- Trial name
- NCT06319183
- Testing
- Salbutamol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tongji University
Obesity, Weight Loss
Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity
One of the major challenges for treating obesity is to maintain a weight reduced state on the long term due to the high rate of weight regain.
- Trial name
- BREAK (NCT05184361)
- Testing
- Intermittent energy restriction (IER), Continuous energy restriction (CER)
- Where
- Portugal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Obesity, Diabetes Mellitus
Activating Brown Adipose Tissue Through Exercise
The energy burning capacity of brown adipose tissue makes it an attractive target for anti-obesity therapies. Sympathetic nervous system (SNS) is the classical regulator of brown adipose tissue; however, recent findings show a…
- Conditions
- Obesity, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- ACTIBATE (NCT02365129)
- Testing
- Exercise training based on recommendations for adults (WHO)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Obesity, Weight Loss
Evaluation of Safety, Efficacy and Thermogenesis-induction of RZL-012 in Overweight and Obese Volunteers
Obesity is a direct result of food-intake in excess of body energy expenditure. Thus, induction of increased energy expenditure via the activation of thermogenesis at targeted anatomical sites can counterbalance obesity.
- Conditions
- Obesity, Weight Loss, Overweight and Obesity
- Trial name
- NCT03171415
- Testing
- RZL-012
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Raziel Therapeutics Ltd.