Clinical trials: Third Molars Extraction
Periodontal Defects After Third Molar Extraction, Periodontal Disease
Comparison of Autologous Tooth and Bovine Xenograft in Periodontal Healing After Mandibular Third Molar Extraction
This study investigates the healing of periodontal defects on the distal surface of the second lower molars after the surgical extraction of impacted third molars.
- Trial name
- NCT07824518
- Testing
- Autologous Tooth Graft
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Pain (Visceral, Somatic, or Neuropathic)
Distolingual Infiltration Verses Conventional Nerve Block in Mandibular Third Molar Extraction
This randomized controlled trial will compare the effectiveness of adding distolingual infiltration to conventional inferior alveolar and buccal nerve blocks for mandibular third molar extraction.
- Trial name
- NCT07296926
- Testing
- Conventional Inferior Alveolar and Buccal Nerve Block, Distolingual Infiltration plus Conventional Nerve Block
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Watim Medical & Dental College
Molar, Third, Periodontal Pocket
Evaluation of a New Technique for Periodontal Pocket Reduction in the Extraction of Wisdom Teeth
On many occasions, clinicians find situations in which they have to perform extractions of erupted or semi-erupted third molars or wisdom teeth where there are pre-existing periodontal pockets distal to the second molars, caused…
- Trial name
- NCT05722509
- Testing
- "Distal Flap Reduction" Group, "Only Exodontia" Group
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Oral Health Care
The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery
Introduction: The aim of this study was to determine the effects of a dietary supplement containing trypsin, chymotrypsin, and serratia peptidase (Tripser Forte N30, Incir Pharma, Turkey) on postoperative healing and to determine…
- Trial name
- Trypsin (NCT07269171)
- Testing
- Pain Assessment, Number of Analgesics Needed, Edema Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Wound Heal
Effect of A-PRF After Removal of Wisdom Teeth
To evaluate the healing effect of advanced platelet-rich fibrin (blood clot charged with growth factors) taken from the patient own blood on the extraction site.
- Trial name
- A-PRF (NCT03703479)
- Testing
- autologous blood clot made from the patient own clot without any additive
- Where
- Saudi Arabia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Impacted Third Molar Tooth
Impact of Antibiotic Treatment and Extraction on the Oral Micro Biome
This is a prospective, longitudinal, observational, cohort study investigating young adults undergoing surgical extraction of a wisdom tooth with and without antibiotics post-operatively.
- Trial name
- NCT02951676
- Testing
- Extraction
- Where
- China
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Drug Effect, Tooth Extraction
Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia
In the complexity of the Dental care the third molar surgery is one of the most common procedures, it is indicated for multiple reasons like infections in root canal, prosthetics or even esthetical purposes.
- Trial name
- ECA (NCT04166890)
- Testing
- Articaine / EPINEPHrine Cartridge
- Where
- Colombia
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Dental Pain
Study of Naproxen Capsules to Treat Dental Pain
The purpose of the study is to determine whether Naproxen Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT01229228
- Testing
- Naproxen Test, Naprosyn
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Iroko Pharmaceuticals, LLC
Class II Malocclusion
Effect of Upper Third Molar Extraction on Distalization Carriere Motion Appliance :A Prospective Clinical Study
This clinical study will be directed to compare the effect of presence or absence of third molar on distalization of the upper posterior segment by using carriere motion appliance
- Trial name
- NCT05166928
- Testing
- carriere motion appliance
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Oral Surgery
The Effect of Platelet-rich Fibrin on Clinical and Patient-centered Outcomes of Third Molar Extractions
The fear of oral surgeries is mostly dedicated to pain and swelling in the following days. It is not surprising, that it is of high interest to do anything to reduce these consequences.
- Trial name
- PRF (NCT05089812)
- Testing
- Third-molar extraction using platelet-rich fibrin as a filling of the alveolus
- Where
- Austria
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Wisdom Teeth
Evaluation of the Effect of Circadian Rhythm of Adrenal Glucocorticoids After Third Molar Extraction
This study aimed to investigate the effects of wisdom tooth surgery performed at different times of the day on pain, swelling and trismus based on changes in the circadian rhythm in the adrenal glands in patients aged between…
- Trial name
- NCT06610383
- Testing
- Surgical extraction of wisdom teeth in the morning, Surgical extraction of wisdom teeth in the afternoon
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Impacted Third Molar Tooth, Temporomandibular Joint Dysfunction Syndrome
Feasibility Testing of a New Way to Support the Jaw During 3rd Molar Extractions
Cross sectional observational study to assess the feasibility of using the functional prototype of the restful jaw support device to support the jaw when extracting mandibular 3rd molars using moderate/deep sedation.
- Trial name
- NCT03512769
- Testing
- Restful Jaw Device
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Impacted Mandibular Third Molar, Alveolar Bone Loss
Healing of Mandibular Third Molar Extraction Sockets Using Platelet Concentrates and Photobiomodulation
Surgical removal of impacted mandibular third molars is a common procedure that may be associated with postoperative pain, swelling, limited mouth opening, and delayed bone healing.
- Conditions
- Impacted Mandibular Third Molar, Alveolar Bone Loss, Impacted Mandibular Third Molar Extraction
- Trial name
- NCT07324213
- Testing
- Mandibular Third Molar Extraction With Primary Wound Closure, Autologous Platelet Concentrates, Photobiomodulation
- Where
- Poland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw
Alveolar Osteitis
Does the Use of HA Gel Following Third Molar Extraction Decrease the Incidence of Alveolar Osteitis?
The study aimed to investigate the effectiveness of Hyaluronic Acid gel on decreasing the incidence of alveolar osteitis after mandibular third molar extraction.
- Trial name
- NCT07139340
- Testing
- HA gel
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Bleeding, Tooth Extraction
Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery
Tranexamic acid (TXA) is an effective hemostatic agent used to reduce blood loss and the need for transfusion. It is a relatively safe drug with minimal significant side effects.
- Trial name
- NCT06806241
- Testing
- Tranexamic acid, saline irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Trismus, Edema
Low Laser Light Therapy After Impacted Third Molar Removal
Third molars extraction is a surgery frequently performed in dentistry. It is generally associated to a great postoperative distress rendered by pain, swelling and trismus, caused by surgical trauma inflammation.
- Conditions
- Trismus, Edema, Pain
- Trial name
- NCT02602431
- Testing
- Extra-oral laser irradiation, Intra-oral laser irradiation
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Mastication Disorder
Evaluation of Platelet Rich Fibrin on Reduction of Periodontal Problems After Surgical Removal of Mandibular Third Molar
The purpose of this study is to determine the influence of platelet rich fibrin to reduction of periodontal problems after surgical removal of third molar.
- Trial name
- NCT01583491
- Testing
- autologous platlet rich fibrin, one side in control group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Majid Eshghpour
Postoperative Pain, Postoperative Complications
Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction
The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars.
- Conditions
- Postoperative Pain, Postoperative Complications, Trismus, Periodontal Health
- Trial name
- NCT07180498
- Testing
- Chlorhexidine Gluconate 0.12% Mouthwash, Tea Tree Oil mouthwash
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Harran University
Impacted Third Molar Tooth
Effect of Using Irrigations at Different Temperatures on Postoperative Period During the Extraction of Impacted Mandibular Molars
An Evaluation of the Effect of Using Irrigations at Different Temperatures on Pain, Edema, and Trismus During the Extraction of Bilateral Impacted Mandibular Third Molars: A Randomized Split-Mouth Clinical Trial
- Trial name
- NCT06020053
- Testing
- saline irrigation at various temperatures (4°C, 25°C)
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Firat University