Clinical trials: Thoracentesis
Pleural Effusion
Thoracentesis QI Study
Researchers will compare 3 standard of care methods of pleural fluid drainage during therapeutic thoracentesis. Patients are randomized to manual aspiration, vacuum bottle drainage or wall suction methods.
- Trial name
- NCT05424120
- Testing
- Manual aspiration, Wall suction, Vacuum bottle drainage
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Minnesota
Pleural Effusion, Pleural Effusion, Malignant
Use of Guidance Videos to Increase Engagement and Decrease Anxiety in Patients Undergoing Pleural Tap
Patients planned to undergo a pleural tap will get verbal explanation or watch a personalized guidance video in addition to verbal explanation.
- Conditions
- Pleural Effusion, Pleural Effusion, Malignant, Pleural Pleurisy Effusion
- Trial name
- NCT04254445
- Testing
- Personalized training video
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- GistMed Ltd.
Pleural Effusion, Dyspnea
Thoracentesis: Symptoms and Prediction of the Need for Therapeutic Thoracentesis
Recurrent fluid surrounding the lungs is associated with poor quality of life, the main symptom being dyspnea. These patients are in need of recurrent removal of the fluid using drainage.
- Conditions
- Pleural Effusion, Dyspnea, Patient Reported Outcomes, Diaphragm Movement
- Trial name
- NCT04236934
- Testing
- Assesment of diaphragm shape and diaphragm movement (by M-mode and the AREA-method) by ultrasound before and after thoracentesis
- Where
- 2 sites in Denmark
- Volunteers
- 107 people
- Sponsor
- Naestved Hospital
Pleural Effusion, Pleural Diseases
Strategy for Prompt and Effective Thoracentesis in the Emergency Department
The SPEEDTAP-trial is a prospective, randomised, investigator-initiated, multicenter, clinical superior trial investigating two thoracentesis methods in four emergency departments (ED) in Central Denmark Region.
- Conditions
- Pleural Effusion, Pleural Diseases, Heart Failure
- Trial name
- SPEEDTAP (NCT06180603)
- Testing
- Gravity fluid drainage in the radiology department, Manual drainage in the emergency department
- Where
- 6 sites in Denmark
- Volunteers
- 188 people
- Sponsor
- University of Aarhus
Congestive Heart Failure, Transudative Pleural Effusion
Therapeutic Thoracentesis for Patients With Congestive Heart Failure and Large Pleural Effusion
Transudative pleural effusions are a common manifestation of patients with congestive heart failure. Severe dyspnea and respiratory failure may develop in those with large effusions, which in general show poor response to medical…
- Trial name
- NCT00629538
- Testing
- Therapeutic thoracentesis
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University Hospital
Pleural Effusion, Frist Time Indication to Perform a Thoracentesis
Improvement to Perform Thoracocentesis After a Specific Training in Medical Students With the Supervised Use of an Augmented Reality Simulator
Monocentric study, aiming to assess the improvement of medical students to perform a first-time thoracentesis after training using a specific training using an augmented virtual reality simulator, versus standard training.
- Conditions
- Pleural Effusion, Frist Time Indication to Perform a Thoracentesis, Medical Student Training
- Trial name
- ARPEGES (NCT05960747)
- Testing
- Simulation group
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- University Hospital, Strasbourg, France
Pleural Effusion, Malignant, Pleural Effusion
A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer.
Pleural fluid can be caused by cancer. Patients with repeated presentation of pleural fluid where initial diagnostic tests have been inconclusive are the focus of this trial.
- Conditions
- Pleural Effusion, Malignant, Pleural Effusion, Pleura; Exudate
- Trial name
- NCT04233359
- Testing
- Local anesthetic thoracoscopy, US-guided pleural biopsy
- Where
- 2 sites in Denmark
- Volunteers
- 4 people
- Sponsor
- Naestved Hospital
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Thoracocentesis of Pleural Effusion
Pleural Manometry in Thoracocentesis
The study aiming to measure the pleural pressure during thoracocentesis in patients with pleural effusion and the value of their measurement in both diagnostic and therapeutic decisions.
- Trial name
- NCT04420663
- Testing
- Pleural Manometry
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aly Sherif Hassaballa
Pleural Effusion
Comparing Active Versus Passive Aspiration in Therapeutic Thoracentesis: Efficacy, Procedure Time, and Patient Safety
This single-blind randomized controlled trial (RCT) aims to compare the efficacy and safety of active manual aspiration versus passive gravity drainage during therapeutic thoracentesis for large symptomatic pleural effusions.
- Trial name
- Thoracentesis (NCT07184736)
- Testing
- Active Manual Syringe Aspiration, Passive Gravity Drainage
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Cancer
Nuclear Matrix and Cancer: Proteomic and Genomic Analyses Using Microarray in Cells Obtained Via Thoracocentesis
Accurate characterization of malignant cells obtained via thoracocentesis is of paramount importance in the management of cancer patients.
- Trial name
- NCT01284777
- Testing
- blood sample, thoracocentesis
- Where
- 2 sites in France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion Disorder
Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]
The purpose of this protocol is to conduct a pilot prospective non-blind clinical trial to evaluate the efficacy and safety of a novel saline irrigation technique as an adjunct to standard interventions for treating retained…
- Conditions
- Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion Disorder, Pleural Effusions
- Trial name
- [LYTICS+] (NCT06713382)
- Testing
- Pleural Saline Irrigation
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hepatic Hydrothorax
Comparing Outcome of Thoracocentesis and Pigtail Catheter Drainage in Treatment of Patients With Hepatic Hydrothorax
Hepatic hydrothorax (HH) is a pleural effusion that develops in a patient with cirrhosis and portal hypertension in the absence of cardiopulmonary disease (Lv et al., 2018).
- Trial name
- NCT06319547
- Testing
- Thoracocentasis
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pleural Effusion, Cancer
Pleuroscopy First Versus Thoracentesis First in Patients With Suspected Malignant Pleural Effusions
This is a randomized control trial of patients with suspected malignant pleural effusions to compare whether patients who have a thoracentesis or pleuroscopy (pleural biopsy) obtain an adequate biopsy, achieve a diagnosis, and…
- Trial name
- PERFECT-MPE (NCT06892691)
- Testing
- Pleuroscopy first, Thoracentesis first
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pleural Effusions, Chronic, Congestive Heart Failure
Tunneled Pleural Catheters for Refractory Effusions Attributed to Congestive Heart Failure (TREAT-CHF) Trial
Congestive heart disease (CHF) can frequently cause transudative pleural effusions, some of which do not completely resolve with diuretics alone.
- Conditions
- Pleural Effusions, Chronic, Congestive Heart Failure, Shortness of Breath
- Trial name
- TREAT-CHF (NCT03696524)
- Testing
- tunneled pleural catheter
- Where
- United States
- Sponsor
- University of California, Los Angeles
Pleural Effusion
Gravity- Versus Suction-driven Large Volume Thoracentesis
Thoracentesis is a very common procedure, rarely associated with severe complications. One relatively common complication is chest discomfort, which is most of the time felt to be secondary to negative pleural pressures generated…
- Trial name
- GRAVITAS (NCT03591952)
- Testing
- Suction-Driven Thoracentesis, Gravity-Driven Thoracentesis
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Vanderbilt University Medical Center
Biopsy
Safety & Accuracy Study of the ActiSight Needle Guidance System in Patients Undergoing CT-Guided Percutaneous Chest Aspiration and Biopsy
This study is designed to evaluate preliminary safety and accuracy of the ActiSight™ Needle Guidance System in patients undergoing CT-guided lung aspiration or biopsy.
- Trial name
- NCT00819533
- Testing
- sensor (ActiSight™ Needle Guidance System)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- ActiViews Ltd.
Misadventure During Thoracentesis
Use of Simulation-Based Mastery Learning for Thoracentesis to Improve Outcomes
The goal of the proposed research is to investigate the use a medical simulation and mastery learning (where all learners must reach a high standard before completion of training) curriculum to improve internal medicine…
- Trial name
- NCT01898247
- Testing
- Simulation-based mastery learning
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Northwestern University
Pleural Effusion
Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis
The research aims to compare the efficacy of topical Pridocaine cream (lidocaine 2.5% and prilocaine 2.5%) and the standardized local lidocaine infiltration in pain management before pleurocentesis.
- Trial name
- NCT05984264
- Testing
- lidocaine 2.5% and prilocaine 2.5% cream in pain management before pleurocentesis.
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Assiut University
Bilateral Pleural Effusion
Impact of Large-Volume Pleural Effusions on Heart Function
The physiologic basis for relief from dyspnea after therapeutic thoracentesis remains poorly understood. Improvement of the heart and lung function may contribute to the dyspnea relief.
- Trial name
- TTE (NCT02548221)
- Testing
- transthoracic echocardiogram
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Chao Yang Hospital