Clinical trials: Thoracic Aortic Aneurysm
Aortic Dissection
Study to Evaluate the Clinical Performance of the Valiant Thoracic Stent Graft With the Captivia Delivery System (Valiant Captivia) for the Treatment of Acute, Complicated Type B Aortic Dissections
The purpose of this study is to determine if the Valiant stent graft is safe and effective in treating patients who have a thoracic dissection.
- Trial name
- NCT01114724
- Testing
- Valiant Thoracic Stent Graft with the Captivia Delivery System
- Where
- 17 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Cardiovascular
Thoracic or Abdominal Aortic Aneurysm With no Indication for Surgical Treatment
Follow up of Patients With Aortic Aneurysm by Dosage of Circulant Endothelial Progenitor Cells
The study aims to investigate the existence of a reliable correlation between the progression of aortic diameters and blood levels of circulant endothelial progenitor cells CD34+ in patients with not surgical aortic aneurysms.
- Trial name
- ANOPEC 3 (NCT02919709)
- Testing
- blood taking
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Patient With Ascending Aortic Aneurysm With Surgical Indication for Replacement
Prospective Evaluation of the Biomechanical Properties of the Thoracic Aorta Coupling Magnetic Resonance Imaging and In-vitro Elasticity Tests in Patients With Ascending Aortic Aneurysm
The biomechanical properties of the aorta are currently poorly understood. A better understanding would optimize surgical indications and monitoring techniques for patients with thoracic aortic aneurysms.
- Trial name
- MECATHOR (NCT03746964)
- Testing
- Cardiac MRI, in-vitro elasticity tests
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Thoracic Aortic Aneurysm, Aortic Stenosis Symptomatic
Comparison of Carbon Dioxide and Saline Flush to Saline Flush in TEVAR and TAVI Procedures to Reduce Cerebral Ischemia
Thoracic endovascular repair (TEVAR) and transcatheter aortic valve implantation (TAVI) are standard of care procedures to treat thoracic aortic aneurysm or severe aortic stenosis, respectively.
- Conditions
- Thoracic Aortic Aneurysm, Aortic Stenosis Symptomatic, Stroke, Complication
- Trial name
- NCT03998631
- Testing
- Carbon Dioxide and Saline Flush, Standard Saline Flush
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Aortic Aneurysm, Thoracic, Descending Thoracic Aortic Dissection
GORE® TAG® Thoracic Endoprosthesis French Mandatory Registry
This is a French Registry mandated by the French National Health Authority assessing long-term (5-years) safety of the GORE® TAG® Thoracic Endoprosthesis treating diseases of the thoracic aorta.
- Conditions
- Aortic Aneurysm, Thoracic, Descending Thoracic Aortic Dissection, Aortic Diseases, Aorta Thoracic; Traumatic Rupture
- Trial name
- NCT02266342
- Testing
- GORE® TAG® Thoracic Endoprostheses
- Where
- France
- Volunteers
- 154 people
- Sponsor
- W.L.Gore & Associates
Thoracic Aneurysm, Aneurysm Stent
The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.
Alzheimer's disease represents a growing public health problem in developed countries. Although the pathogenesis is not clearly defined, accumulation of extracellular amyloid, neurofibrillary tangles and neuronal loss are the…
- Conditions
- Thoracic Aneurysm, Aneurysm Stent, Cardiopulmonary Bypass, Abdominal Aneurysm
- Trial name
- NCT01772537
- Testing
- Propofol, isoflurane
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Penetrating Ulcer of Aorta, Aneurysm Aortic
Evaluation of the Valiant Captivia Physician Fenestrated Stent Graft System in Aortic Arch and Descending Thoracic Aorta Pathologies
The study objectives are to assess safety and effectiveness, measured acutely and at the 30-day visit after implantation of the Valiant Captivia physician fenestrated Stent Graft.
- Conditions
- Penetrating Ulcer of Aorta, Aneurysm Aortic, Type B Aortic Dissection, Residual Dissection After Type A Repair
- Trial name
- EVERGREEN (NCT05479305)
- Testing
- The Valiant Captivia Stent Graft
- Where
- 4 sites in France
- Volunteers
- 30 people
- Sponsor
- Ceric Sàrl
Aortic Aneurysm
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study "Micro AAA"
The objective of this study is to establish whether patients with aortic aneurysm, compared to general population, have higher levels of selected miRNAs and whether there is significant association between the level of miRNA in…
- Trial name
- NCT03090763
- Testing
- PCR and sequencing
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Thoracic Aortic Aneurysms
Post-Approval Clinical Study of the Talent Thoracic Stent Graft to Treat Thoracic Aortic Aneurysms (THRIVE)
The purpose of this study is to evaluate the long-term safety and effectiveness of the Talent Thoracic Stent Graft System for treatment of descending thoracic aneurysms (DTA)following U.S. market approval.
- Trial name
- THRIVE (NCT00805948)
- Testing
- Talent Thoracic Stent Graft System
- Where
- 26 sites in United States
- Volunteers
- 349 people
- Sponsor
- Medtronic Cardiovascular
Aneurysm, Aneurysm Abdominal
Totally Percutaneous Approach to Endovascular Treatment of Aortic Aneurysms (PEVAR-PRO)
Purpose of the study is the evaluation of the applicability of the percutaneous technique through double Proglide and Pre-Close Technique to the treatment of complex aortic aneurysms with thoracic endoprosthesis (TEVAR)…
- Conditions
- Aneurysm, Aneurysm Abdominal, Aneurysm Thoracic, Aneurysm, Thoracoabdominal Aortic
- Trial name
- PEVAR-PRO (NCT03484013)
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- IRCCS San Raffaele
Aortic Root Aneurysm, Aortic Root Dissection
Aortic Valve Sparing Root Replacement Versus Bentall
This study was designed to evaluate the hypothesis that the operative and midterm results of valve-sparing aortic root replacement are equivalent to those of the Bentall.
- Trial name
- NCT03604913
- Testing
- Aortic valve sparing operation, Bentall operation
- Where
- Egypt
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Assiut University
Abdominal Aortic Aneurysm, Coronary Heart Disease
Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study
Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease, Sudden Cardiac Death, Intracerebral Haemorrhage
- Trial name
- NCT02176174
- Volunteers
- 1,068,318 people, healthy volunteers welcome
- Sponsor
- University College, London
Aortic Aneurysm, Thoracic, Penetrating Aortic Ulcers (PAUs)
Evaluation of Thoraflex in the Treatment of Aneurysm or Penetrating Ulcer of the Descending Thoracic Aorta
ThoraflexTM is designed for the treatment of aneurysm or penetrating ulcer of the descending thoracic aorta. Each system is advanced from a transfemoral or transiliac approach over a 0.035" guidewire and positioned under…
- Trial name
- NCT01357590
- Testing
- Thoracic Endovascular Stent Graft System (ThoraflexTM)
- Where
- 28 sites in Belgium, Canada and 5 more
- Sponsor
- Vascutek Ltd.
Thoracic Aortic Aneurysm, Aortic Dissection
Biomechanical Reappraisal of Planning for Thoracic Endovascular Aortic Repair
Thoracic endovascular aortic repair (TEVAR) for disease involving the aortic arch remains complex and challenging due the angulation and tortuosity of the arch and its peculiar biomechanical environment.
- Conditions
- Thoracic Aortic Aneurysm, Aortic Dissection, Aortic Diseases
- Trial name
- MALAN (NCT03824626)
- Testing
- TEVAR patients
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Ospedale San Donato
Rare Diseases, Thoracic Aortic Aneurysm (TAA)
Fibroblasts and Thoracic Aortic Aneurysms: in Vitro Characterization in With Marfan Syndrome and Genetic Aortic Diseases
The aim of the present study is to characterise the phenotype of fibroblasts and to classify different mechanisms involved in the onset and progression of TAAD in syndromic and non-syndromic subjects in order to evaluate…
- Conditions
- Rare Diseases, Thoracic Aortic Aneurysm (TAA), Marfan Syndrome
- Trial name
- FIBRA (NCT06786754)
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Aortic Aneurysm, Thoracic
Detection of Hypoxia in Human Thoracic Aorta Using Pimonidazole Hydrochloride
This is a prospective study designed to determine the safety and value of Hypoxyprobe-1 (pimonidazole hydrochloride (-HCl)) to detect levels of tissue hypoxia in patients presenting with ascending aortic aneurysm.
- Trial name
- NCT03410420
- Testing
- Pimonidazole hydrochloride
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Thomas Gleason
Valvular Heart Disease, Aortic Arch Aneurysm
The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
The aim of the study is to evaluate the effects of intermittent hypoxic-hyperoxic training (IHHT) to protect myocardium against perioperative myocardial injury during cardiac surgery using cardiopulmonary bypass.
- Conditions
- Valvular Heart Disease, Aortic Arch Aneurysm, Surgery
- Trial name
- NCT04833283
- Testing
- ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT), ReOxy Cardio device
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Aortic Aneurysm, Thoracic
Evaluation of the GORE TAG Thoracic Endoprosthesis in the Treatment of Aneurysms
The purpose of this post-approval study is to evaluate the long-term performance of the GORE TAG® Thoracic Endoprosthesis (TAG device) in the primary treatment of descending thoracic aortic (DTA) aneurysms
- Trial name
- NCT00590759
- Testing
- GORE TAG® Thoracic Endoprosthesis
- Where
- 25 sites in United States
- Volunteers
- 150 people
- Sponsor
- W.L.Gore & Associates
Thoracoabdominal Aneurysms
Visceral Manifold and Unitary Device Study for the Repair of Thoracoabdominal Aortic Aneurysms
The primary objective of the Visceral Manifold and Unitary Device Study is to assess the use of the thoracic bifurcation and the visceral manifold or the unitary device to repair thoracoabdominal aortic aneurysms in patients…
- Trial name
- NCT02294435
- Testing
- Visceral Manifold and Thoracic Bifurcation, Unitary Manifold
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Sanford Health
Aortic Arch Aneurysm
The NEXUS™ Compassionate Use Data Collection Study
A Multicenter, observational Data Collection Study to Evaluate the Safety and Performance of the Nexus™ Aortic Arch Stent Graft System in patients that were implanted with the device as part of Compassionate Use Procedures.
- Trial name
- NCT03420066
- Testing
- Retrospective data collection
- Where
- 4 sites in Italy, New Zealand and 1 more
- Volunteers
- 7 people
- Sponsor
- Endospan Ltd.