Clinical trials: Thoracic Aortic Aneurysms
Aneurysm of Aortic Arch
Early Feasibility of the Branched TAG® Device in the Treatment of Aortic Arch Aneurysms
The purpose of this study is to assess the early feasibility of the use of the GORE® TAG® Thoracic Branch Endoprosthesis to treat aneurysms involving the aortic arch
- Trial name
- NCT02264977
- Testing
- GORE® TAG® Thoracic Branch Endoprosthesis
- Where
- 6 sites in United States
- Volunteers
- 9 people
- Sponsor
- W.L.Gore & Associates
Aortic Aneurysm
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study "Micro AAA"
The objective of this study is to establish whether patients with aortic aneurysm, compared to general population, have higher levels of selected miRNAs and whether there is significant association between the level of miRNA in…
- Trial name
- NCT03090763
- Testing
- PCR and sequencing
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Aneurysm Thoracic, Dissection of Aorta, Thoracic
TBE Zone 2 PMS in Japan
The goal of this surveillance is to confirm the TBE device's safety and efficacy in patients treated with proximal landing in Zone 2 in the post-marketing period.
- Conditions
- Aneurysm Thoracic, Dissection of Aorta, Thoracic, Trauma
- Trial name
- NCT07049913
- Testing
- Gore® TAG® Thoracic Aortic Branch Stent Graft System
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- W.L.Gore & Associates
Type A Aortic Dissection, Ascending Aortic Dissection
Outcomes of Aortic Dissection Repair
Type A aortic dissection (TAAD) is a potentially life-threatening pathology associated with significant risk of mortality and morbidity.
- Conditions
- Type A Aortic Dissection, Ascending Aortic Dissection, Aortic Diseases, Aortic Arch
- Trial name
- STAAD (NCT05927090)
- Testing
- Conservative Root- Sparing Aortic Valve Resuspension with or without Hemiarch Repair, Extensive Ascending Aorta Replacement (AAR) with Aortic Root Replacement (ARR), Extensive Ascending Aorta Replacement (AAR) with Total Arch Replacement (TARP)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Centre Cardiologique du Nord
Morality, Lung Cancer
Incidence of Mortality and Complications After Lung Surgery, Open Thoracic Aortic Repair, TEVAR, EVAR.
Lung surgery, open aortic surgery, TEVAR, and EVAR are major operations that carry a higher incidence of perioperative mortality and complications compare to other surgery.
- Conditions
- Morality, Lung Cancer, Aortic Aneurysm, Aortic Dissection
- Trial name
- NCT05073991
- Testing
- Lung surgery, Open aortic surgery, TEVAR
- Where
- Thailand
- Volunteers
- 2,224 people
- Sponsor
- Mahidol University
Complex Abdominal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm
CAAAs, TAAAs, Aortic Arch Aneurysms or Dissections With Fenestrated/Branched Stent Graft
The purpose of this study is to gather safety and effectiveness of the Zenith t-Branch and customized physician-specified stent-graft with a combination of fenestrations and/or branches to repair aortic aneurysm.
- Conditions
- Complex Abdominal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Aortic Arch Aneurysm, Aortic Arch Dissection
- Trial name
- NCT02089607
- Testing
- CAAA and TAAA Arm, Aortic Arch Aneurysm Arm
- Where
- 3 sites in United States
- Volunteers
- 760 people
- Sponsor
- Gustavo S Oderich
Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal
Effect of Remimazolam Versus Propofol Total Intravenous Anesthesia on Intraoperative Hemodynamic Stability in Patients Undergoing Thoracic or Abdominal Endovascular Aortic Repair
The purpose of this study is to compare two intravenous anesthetics, remimazolam and propofol, for their effects on intraoperative hemodynamic stability in patients undergoing thoracic or abdominal endovascular aortic repair.
- Conditions
- Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal, Intraoperative Hypotension, Hemodynamic Instability During Anesthesia
- Trial name
- NCT07806006
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Aortic Aneurysm, Thoracic
Detection of Hypoxia in Human Thoracic Aorta Using Pimonidazole Hydrochloride
This is a prospective study designed to determine the safety and value of Hypoxyprobe-1 (pimonidazole hydrochloride (-HCl)) to detect levels of tissue hypoxia in patients presenting with ascending aortic aneurysm.
- Trial name
- NCT03410420
- Testing
- Pimonidazole hydrochloride
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Thomas Gleason
Thoracic Aortic Aneurysms
Biomechanical and Microstructural Properties of Ascending Aortic Aneurysms
An aortic aneurysm (thoracic or abdominal) is a permanent dilatation of the aorta caused by weakening in the arterial wall. The feared complication is aortic rupture or dissection, leading to potentially lethal aortic bleeding…
- Trial name
- NCT03142074
- Testing
- Biomechanical and microstructural analysis of ATAA, ECG-gated CT
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Thoracic Aortic Aneurysm
Intravascular Ultrasound (IVUS) in Complex Aortic Endovascular Interventions
The study aims to investigate the applicability of intravascular ultrasound (IVUS) in the endovascular therapy of juxta-, supra- and thoracoabdominal aortic aneurysms.
- Trial name
- NCT04663074
- Testing
- IVUS control
- Where
- 6 sites in Denmark, Germany and 2 more
- Volunteers
- 80 people
- Sponsor
- University Hospital Muenster
Vascular Diseases
Prospective/Retrospective Registry of the E-vita OPEN PLUS Stent Graft System in France
The FEOR registry is undertaken to examine the real-world data of patients that were treated with the E-vita OPEN Plus Stent Graft System under routine care in France.
- Trial name
- FEOR (NCT04058691)
- Testing
- Surgical repair
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- JOTEC GmbH
Aortic Dissection
Zenith® Dissection Endovascular System
The Zenith® Dissection Clinical Trial is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® Dissection Endovascular System in the treatment of patients with aortic dissection.
- Trial name
- STABLE I (NCT02094300)
- Testing
- Zenith® Dissection Endovascular Graft
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Cook Group Incorporated
Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch
Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery
The purpose of this study is to compare remimazolam- and propofol-based anesthesia for their effects on postoperative cognitive dysfunction in patients undergoing aortic arch surgery.
- Conditions
- Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch, Aortic Arch Disease, Postoperative Delirium (POD)
- Trial name
- NCT07816068
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Aortic Aneurysm, Postoperative Nausea and Vomiting
AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair
The aim of this randomized trial is to assess the efficacy of analgesia using either thoracic epidural or intravenous infusions for open lumbar infrarenal aortic aneurys repair and compare Numerical Rating Scale (NRS) with…
- Conditions
- Aortic Aneurysm, Postoperative Nausea and Vomiting, Postoperative Pain, Haemodynamic Stability
- Trial name
- AoA-AAA (NCT06609993)
- Testing
- intravenous rescue opioid analgesia using fentanyl, intravenous rescue atropine administration, intravenous rescue urapidil administration
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Michał Stasiowski
Aortic Dissection, Left Subclavian Artery Occlusion
Endovascular Repair With In Situ nEedle feNestration of Left Subclavian Artery to Treat AoRtic Dissection(RISEN STAR):A Multicenter Prospective Trial.
Background: Aortic dissection (AD) is a common emergency in vascular surgery, which seriously threatens human life and health. The rupture of Stanford type B dissection is located in aortic arch and the dissection range is from…
- Conditions
- Aortic Dissection, Left Subclavian Artery Occlusion, Vascular Diseases, Interventional Therapy
- Trial name
- NCT05186181
- Testing
- In situ fenestration
- Where
- China
- Volunteers
- 217 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Aortic Aneurysm, Abdominal, Aortic Aneurysm, Thoracic
TOtal tRansfemoral branCHed endovasCular tHoracoabdominal Aortic Repair Registry
The purpose of the registry is to evaluate the peri-operative, short-, and mid- outcomes of endovascular treatment of thoracoabdominal aneurysms with multibranched endografts via total transfemoral approach for visceral vessels…
- Trial name
- NCT04930172
- Testing
- Steerable introducers
- Where
- 7 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Thoracic Aortic Aneurysm
HEART: Pilot Randomized Controlled Trial
The purpose of this study is to determine whether spironolactone reduces aortic stiffness, measured by carotid-femoral pulse wave velocity (cfPWV), compared with placebo, in patients with degenerative thoracic aortic aneurysms.
- Trial name
- NCT07483177
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Aorta Abdominalis; Aneurysm, Aorta Thoracic; Aneurysm
Evaluation of the Efficacy and Safety of Surgical Device "Lymphoblock" for Prevention of Lymphorrhea in Patients With Thoracoabdominal Aorta Repair.
Randomized, double-blind, placebo-controlled study will determine the clinical efficacy and safety of Lymphoblock in the prevention of postoperative retroperitoneal chylo-/lymphorrhoea in patients with open surgical treatment of…
- Trial name
- NCT06286540
- Testing
- Lymphoblock
- Where
- Russia
- Volunteers
- 138 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Aortic Aneurysm, Thoracic
Valiant Evo US Clinical Trial
The purpose of the Valiant Evo US Clinical Trial is to demonstrate the safety and effectiveness of the Valiant Evo Thoracic Stent Graft System in subjects with a descending thoracic aortic aneurysm (DTAA) who are candidates for…
- Trial name
- VEVO (NCT02652949)
- Testing
- Valiant Evo Thoracic Stent Graft System
- Where
- 21 sites in United States
- Volunteers
- 100 people
- Sponsor
- Medtronic Cardiovascular
Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm
Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used as a Bridging Stent With Branched and Fenestrated Endografts in the Treatment of Aortic Aneurysms Involving the Renal-Mesenteric Arteries
Multicenter, single-arm retrospective and prospective registry is being conducted to confirm the clinical performance and safety of GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis when used as a Bridging Stent with Branched…
- Trial name
- EMBRACE (NCT05143138)
- Testing
- GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis
- Where
- 14 sites in Denmark, Italy and 4 more
- Volunteers
- 259 people
- Sponsor
- W.L.Gore & Associates