Clinical trials: Thrombectomy, open to volunteers
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Acute Ischemic Stroke, Intracranial Atherosclerosis ICAS
Effect of Balloon Angioplasty vs Stenting Following Residual Stenosis After Endovascular Treatment of Intracranial Atherosclerotic Acute Ischemic Stroke
The ANGEL-ICAS trial is a multicenter, prospective, randomized, open-label, blinded-endpoint study designed to determine whether rescue balloon angioplasty is noninferior to rescue stenting in patients with intracranial…
- Trial name
- ANGEL-ICAS (NCT07026331)
- Testing
- balloon angioplasty, Stent
- Where
- China
- Volunteers
- 486 people
- Sponsor
- Beijing Anzhen Hospital
Deep Vein Thrombosis
ClotTriever® Thrombectomy System Use-Result Survey in Japan
The objective of this survey is to determine the safety and efficacy of the ClotTriever Thrombectomy System under daily clinical practice after marketing approval in Japan.
- Trial name
- NCT06871683
- Testing
- ClotTriever® Thrombectomy System
- Where
- 15 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Inari Medical
Stroke, Acute Ischemic, Medium Vessel Occlusion
INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
This domain will be conducted as part of ACT-GLOBAL platform trial and will have the nested domain name of IMP-ACT. Acute ischemic stroke (AIS) caused by intracranial arterial occlusion remains a major cause of disability and…
- Trial name
- IMP-ACT (NCT07906275)
- Testing
- Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre
- Where
- 4 sites in Canada
- Volunteers
- 800 people
- Sponsor
- University of Calgary
Ischemic Stroke, Acute
Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial
Several clinical trials have produced variable conclusions regarding the effects of intensive blood pressure (BP) lowering in post-EVT acute ischaemic stroke (AIS) patients.
- Trial name
- ENCHANTED3/MT (NCT06352619)
- Testing
- Conservative SBP Control, Moderate SBP Control, Intensive SBP Control
- Where
- 2 sites in Australia, Canada
- Volunteers
- 2,000 people
- Sponsor
- The George Institute
Stroke, Acute Ischemic
Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window
This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human tenecteplase (rhTNK-tPA) in acute ischemic stroke patients with large vessel…
- Trial name
- NCT06987305
- Testing
- Intravenous rhTNK-tPA, Endovascular thrombectomy
- Where
- 4 sites in China
- Volunteers
- 820 people
- Sponsor
- Xinqiao Hospital of Chongqing
Acute Ischemic Stroke
Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy
1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2.
- Trial name
- NOTICE-1 (NCT07049692)
- Testing
- Hyperbaric Oxygen Therapy, Conventional therapy group
- Where
- 2 sites in China
- Volunteers
- 424 people
- Sponsor
- Beijing Chao Yang Hospital
Stroke, Ischemic
Improving Neuroprotective Strategy for Ischemic Stroke Before Endovascular Thrombectomy by Intravenous Tirofiban
It remains uncertain whether intravenous tirofiban administered before endovascular thrombectomy could improve disability severity for patients with LVO due to intracranial atherosclerosis.The current study aimed to assess the…
- Trial name
- INSIST-IT2 (NCT07135089)
- Testing
- Intravenous tirofiban before endovascular thrombectomy
- Where
- China
- Volunteers
- 870 people
- Sponsor
- General Hospital of Shenyang Military Region
Acute Ischemic Stroke
Rescue Distal Thrombectomy in Treatment for Persistent Distal Occlusions
The goal of this clinical trial is to determine whether rescue distal mechanical thrombectomy can improve outcomes in patients with persistent distal occlusions after successful proximal mechanical thrombectomy for acute ischemic…
- Trial name
- 2BE3-PhaseII (NCT07533253)
- Testing
- Proximal mechanical thrombectomy, Rescue distal mechanical thrombectomy, Conservative management
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Stroke, Thromboses, Intracranial
Stroke Thrombectomy and Aneurysm Registry
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the…
- Conditions
- Stroke, Thromboses, Intracranial, Aneurysm, Brain
- Trial name
- STAR (NCT04994756)
- Testing
- Stroke/Thrombectomy/Aneurysm-specific surgical procedures
- Where
- 63 sites in United States, Canada and 7 more
- Volunteers
- 40,000 people
- Sponsor
- Medical University of South Carolina
Acute Ischemic Stroke
Study on Hibernation-like Therapy Based on Mechanical Thrombectomy
The goal of this clinical trial is to learn whether chlorpromazine and promethazine（C+P）is safe in Acute Ischemic Stroke（AIS) patients and determine the maximum dosage.
- Trial name
- CHILL-1 (NCT06663631)
- Testing
- chlorpromazine and promethazine, endovascular thrombectomy, rt-PA
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)
Though intravenous thrombolysis has been shown to improve symptoms in acute ischemic stroke patients, the recanalization rate remains low (22.6%) and only around 30% of patients benefit from the treatment.
- Trial name
- NCT06677970
- Testing
- BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Yonsei University
Ischemic Stroke
Reperfusion Injury After Endovascular Stroke Treatment
Endovascular stroke treatment with mechanical thrombectomy (MT) has become the standard therapy for intracranial large vessel occlusion (LVO).
- Trial name
- DYNASTROKE (NCT05273216)
- Testing
- Transcranial Duplex Sonography, Brain MRI, Blood biomarkers
- Where
- 3 sites in Austria
- Volunteers
- 600 people
- Sponsor
- Medical University of Graz
Acute Pulmonary Embolism (PE), Pulmonary Embolism
Evaluating the Efficacy, Safety and Long Term Functional Outcomes of Percutaneous Mechanical Aspiration Thrombectomy for Treatment of Acute Pulmonary Embolism Using the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 System
To evaluate the efficacy, safety, and long-term functional outcomes of percutaneous mechanical aspiration thrombectomy using the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 System for the treatment of acute pulmonary…
- Trial name
- RECOVER-AV (NCT06697314)
- Testing
- AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 System
- Where
- Poland
- Volunteers
- 256 people
- Sponsor
- Angiodynamics, Inc.
Stroke, Stroke Acute
Mechanical Thrombectomy in the Middle East and North Africa: Interim Results from the MEMENTO Registry
The MEMENTO (MEchanical thrMobectomy NETwork for MENA TOgether) Registry is a multicenter, prospective observational study aiming to evaluate the effectiveness, safety, and cost-effectiveness of mechanical thrombectomy (MT) in…
- Conditions
- Stroke, Stroke Acute, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- MEMENTO Regist (NCT06702787)
- Where
- Egypt
- Volunteers
- 1,500 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Acute Ischemic Stroke (AIS), Endovascular Thrombectomy
Exploration and Establishment of an Early Warning System for Futile Reperfusion - A I S
The goal of this prospective cohort registration study is to establish an early warning system for futile recanalization in acute ischemic stroke by analyzing multi-omics information to identify key regulatory nodes and target…
- Conditions
- Acute Ischemic Stroke (AIS), Endovascular Thrombectomy, Neurovascular Unit- Brain Lymphatic System
- Trial name
- NCT07045987
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke
Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well
SELECT LATE trial aims to evaluate if addition of endovascular thrombectomy to medical management in patients presenting with acute ischemic stroke and a proximal large vessel occlusion in the anterior circulation between 24 and…
- Trial name
- SELECT LATE (NCT07115940)
- Testing
- Endovascular Thrombectomy, Medical Management
- Where
- 6 sites in United States
- Volunteers
- 408 people
- Sponsor
- Amrou Sarraj
Stroke, Acute Ischemic
Role of Hypothermia in Endovascular Stroke Thrombectomy
Reducing or suspending the increase of the infarcted core, i.e., "freezing" the ischemic penumbra, may help improve the efficacy of mechanical thrombectomy.
- Trial name
- COOLING (NCT06109376)
- Testing
- hypothermia, thrombectomy
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Xinqiao Hospital of Chongqing
Ischemic Stroke, Stroke
Australasian Nanoparticle-mediated Magnetically Enhanced Diffusion for Ischemic Stroke
Rapidly restoring blood flow to the brain in patients with stroke caused by a blocked blood vessel in the brain is the key to reducing disability.
- Trial name
- AusNanoMED (NCT06495671)
- Testing
- Magnetically enhanced diffusion
- Where
- 7 sites in Australia
- Volunteers
- 30 people
- Sponsor
- University of Melbourne
Pulmonary Embolism, Pulmonary Embolism Acute Massive
Registry of Catheter Intervention in Pulmonary Embolism
Multicenter longitudinal observational ambispective (retrospective cases from 2014 and prospective from 2018 onwards) cohort study.
- Conditions
- Pulmonary Embolism, Pulmonary Embolism Acute Massive, Pulmonary Embolism Acute, Pulmonary Embolism and Thrombosis
- Trial name
- RiTEP (NCT06348459)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital San Carlos, Madrid