Clinical trials: Thrombocytopenia Purpura
Immune Thrombocytopenia
A Multicentre Investigation of 2 Cycles Rituximab Compared With Standard Regimen in Management of Steroid-Resistant/Relapsed Immune Thrombocytopenia （ITP）
The project was undertaking by Qilu Hospital, Shandong University and other several well-known hospitals in China. In order to report the efficacy and safety of Rituximab in different frequencies for the treatment of adults with…
- Trial name
- NCT02137681
- Testing
- Rituximab
- Where
- China
- Sponsor
- Shandong University
Primary Immune Thrombocytopenia
Safety and Efficacy Study of PF-06835375 in Primary Immune Thrombocytopenia
This is a Phase 2, open-label, multicenter, multiple subcutaneous injection, safety and efficacy study of PF-06835375 in adult participants with primary immune thrombocytopenia (ITP).
- Trial name
- NCT05070845
- Testing
- PF-06835375
- Where
- 24 sites in United States, Australia and 5 more
- Volunteers
- 61 people
- Sponsor
- Pfizer
Chronic Idiopathic Thrombocytopenic Purpura
Special Drug Use-results Survey for Long-term Use (Fostamatinib)
The purpose of this survey is evaluating the safety and efficacy of long-term administration of fostamatinib for Japanese patients with chronic idiopathic thrombocytopenic purpura under actual conditions of use.
- Trial name
- NCT06757257
- Testing
- fostamatinib
- Where
- Japan
- Volunteers
- 149 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
ITP - Immune Thrombocytopenia
TPO-RA Plus Baricitinib vs. TPO-RA for ITP
This is a prospective, randomized, controlled trial. ITP patients who failed prior full-does TPO-RA monotheray for 14 days. Patients are randomly assigned at a 1:1 ratio to receive baricitinib plus TPO-RA or TPO-RA alone.
- Trial name
- NCT07669675
- Testing
- Baricitinib, TPO-RA
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Immune Thrombocytopenia
Post IVIG Medication in Children With Immune Thrombocytopenia
This study is a single hospital system, single-arm year-long pilot to evaluate the feasibility of enrolling children with ITP who are receiving IVIG for treatment of disease to a scheduled post-infusion medication for 72 hours…
- Trial name
- NCT04741139
- Testing
- Acetaminophen and Diphenhydramine Only Product
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Purpura, Thrombocytopenic, Idiopathic
High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP)
The project was undertaking by Qilu Hospital of Shandong University and other 11 well-known hospitals in China. In order to report the efficacy and safety of high-dose dexamethasone compared to conventional dose prednisone for…
- Trial name
- NCT01356511
- Testing
- Prednisone, Dexamethasone
- Where
- China
- Volunteers
- 261 people
- Sponsor
- Shandong University
Immune Thrombocytopenia
Efficacy and Safety of Iguratimod in the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
A phase 2, open-label, single-arm study to evaluate the efficacy and safety of iguratimod for the treatment of adults with steroid-resistant/relapse immune thrombocytopenia (ITP)
- Trial name
- NCT05302024
- Testing
- Iguratimod
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Thrombotic Thrombocytopenic Purpura
ADAMTS13 in Thrombotic Thrombocytopenic Purpura
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy defined by the spontaneous formation of platelet thrombi in the microvessels.
- Trial name
- ADAMTS13 (NCT00426686)
- Where
- France
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bone Marrow Failure Syndromes, Anemia, Aplastic
Identifying Characteristics of Bone Marrow Failure Syndromes
Bone marrow failure syndromes (BMFS) are rare disorders characterized by dysfunctional hematopoietic stem cells, which give rise to all red and white blood cells.
- Conditions
- Bone Marrow Failure Syndromes, Anemia, Aplastic, Myelodysplastic Syndromes, Hemoglobinuria, Paroxysmal
- Trial name
- NCT00315419
- Where
- 4 sites in United States
- Volunteers
- 450 people
- Sponsor
- Office of Rare Diseases (ORD)
Autoimmune Thrombocytopenia
The Combination of ATRA and Danazol as Second-line Treatment in Adult Immune Thrombocytopenia
Randomized, open-label, multicentre study to compare the efficacy and safety of ATRA plus danazol with danazol monotherapy in patients with corticosteroid-resistant/relapsed ITP.
- Trial name
- NCT01667263
- Testing
- All-trans retinoic acid, Danazol
- Where
- 5 sites in China
- Volunteers
- 130 people
- Sponsor
- Peking University People's Hospital
Purpura, Thrombotic Thrombocytopenic, Von Willebrand Disease Type-2b
ARC1779 Injection in Patients With Von Willebrand Factor-Related Platelet Function Disorders
To evaluate the overall safety and tolerability of ARC1779, a therapeutic oligonucleotide ("aptamer") in patients with three types of von Willebrand Factor related platelet disorders.
- Trial name
- NCT00632242
- Testing
- ARC1779
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Archemix Corp.
Idiopathic Thrombocytopenic Purpura
Long-term Safety Study of Treatment With the Thrombopoietin Agonists Eltrombopag and Romiplostim in Patients With Immune Thrombocytopenia (ITP)
Thrombopoietin Receptor Agonists (TPO-ra) are novel treatment modalities for patients with refractory Primary Immune Thrombocytopenia (ITP), but only few data are available for long-term effects of these drugs.
- Trial name
- NCT01443351
- Where
- Denmark
- Sponsor
- Zealand University Hospital
Purpura, Thrombocytopenic, Idiopathic
The Combination of ATRA and Eltrombopag as the Treatment of Steroid-resistant/Relapse ITP Based on MSC-C5b-9
A Prospective, Randomized, Open-Label, Multicenter Clinical Trial study to compare the efficacy and safety of ATRA plus eltrombopag compared to eltrombopag monotherapy in the treatment of steroid-resistant/relapsed immune…
- Trial name
- NCT05438875
- Testing
- all-trans retinoic acid, Eltrombopag
- Where
- 5 sites in China
- Volunteers
- 96 people
- Sponsor
- Peking University People's Hospital
Chronic Immune Thrombocytopenia, Primary Immune Thrombocytopenia
Cognitive Status, Fatigue and Inflammation in Patients With Immune Thrombocytopenia (ITP)
This is a multi-center, hospital based, cross-sectional study based on data from patient medical records, including laboratory results.
- Conditions
- Chronic Immune Thrombocytopenia, Primary Immune Thrombocytopenia, Adult Immune Thrombocytopenia
- Trial name
- NCT06665308
- Testing
- No intervention
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 97 people
- Sponsor
- Sanofi
Thrombocytopenia, Purpura, Thrombocytopenic
Idiopathic Chronic Thrombocytopenia of Undetermined Significance : Pathogenesis and Biomarker
It is a translational research study with mechanistical objectives and including biological samples of patients with thrombocytopenia
- Conditions
- Thrombocytopenia, Purpura, Thrombocytopenic, Myelodysplastic Syndromes
- Trial name
- ICTUS (NCT04003220)
- Testing
- blood sample, Bone marrow sample
- Where
- 4 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Hereditary Spherocytosis, Idiopathic Thrombocytopenic Purpura
Single Incision Versus Standard Laparoscopic Splenectomy
This is a prospective trial of single incision versus standard 4-port laparoscopic splenectomy. The hypothesis is that there may be a difference in wound infection rates, operative time, doses of analgesics post-operatively, and…
- Trial name
- NCT01276561
- Testing
- Single Incision Splenectomy, Laparoscopic Splenectomy
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Purpura, Thrombocytopaenic, Idiopathic
EXTEND (Eltrombopag Extended Dosing Study)
An open-label, dose-adjustment, extension study to evaluate the safety and efficacy of eltrombopag for the treatment of subjects with idiopathic thrombocytopenic purpura (ITP) who have previously been enrolled in an eltrombopag…
- Trial name
- EXTEND (NCT00351468)
- Testing
- eltrombopag olamine (SB-497115-GR)
- Where
- 110 sites in United States, Australia and 29 more
- Volunteers
- 302 people
- Sponsor
- Novartis Pharmaceuticals
Immune Thrombocytopenia
Low-dose Baricitinib Plus Danazol for Steroid-resistant/Relapse Immune Thrombocytopenia
This is a prospective, multicenter, randomized, controlled phase 2 trial to compare the efficacy and safety profiles in ITP patients receiving baricitinib plus danazol to those receiving danazol alone.
- Trial name
- NCT05852847
- Testing
- Baricitinib 2 MG [Olumiant], Danazol
- Where
- 10 sites in China
- Volunteers
- 216 people
- Sponsor
- Peking University People's Hospital
Immune Thrombocytopenia
The Efficacy and Safety of Huaiqihuang Granule in Children With Chronic Primary Immune Thrombocytopenia
This is a multisite, double-blind, randomized, placebo-controlled, and parallel study designed to evaluate the clinical efficacy and safety of Huaiqihuang granule for treatment to children with chronic primary immune…
- Trial name
- ITP (NCT03201848)
- Testing
- Huaiqihuang Granule
- Where
- 14 sites in China
- Volunteers
- 216 people
- Sponsor
- Qidong Gaitianli Medicines Co., Ltd
Idiopathic Thrombocytopenic Purpura
Study of Platelets Sialylation by Flow Cytometry for the Differential Diagnosis of ICT
Idiopathic thrombocytopenic purpura (ITP) is the most frequent auto-immune cytopenia. There is no specific biological marker and the diagnosis often results from the exclusion of other differential diagnoses, notably inherited…
- Trial name
- SYMPATHIC (NCT03421392)
- Testing
- non interventional study
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital