Clinical trials: Thrombolysis
Thrombosis
Ex Vivo Test of New Stroke Treatment Using Magnetic Nanorobots
Tissue plasminogen activator (tPA) is the FDA approved thrombolytic drug for patients with acute ischemic stroke. While transcatheter endovascular therapy is widely accepted as an effective method for targeted blood vessels via a…
- Trial name
- NCT04644653
- Where
- 2 sites in Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Arterial Thrombosis
Study on the Thrombolytic Effect of Platelet Membrane Coated Tenecteplase on Human Arterial Thrombus
Tenecteplase (TNK) is the latest generation of specific thrombolytic drugs independently developed in China. This study aims to investigate the thrombolytic efficacy of platelet membrane-coated tenecteplase (PM-TNK) on human ex…
- Trial name
- NCT07712445
- Testing
- collection of venous blood or arterial blood
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Acute Ischemic Stroke
COOLing of the Ischemic PENumbra in Patients With Acute Ischemic Stroke.
This study will develop and validate a novel, active/conductive combined head and neck cooling system to selectively cool the ischemic penumbra during the acute phase of stroke, reducing neuronal damage and improving stroke…
- Trial name
- PEN-Cool (NCT07844096)
- Testing
- PEN-Cool Conductive Head-and-Neck Cooling System, Standard Reperfusion Therapy / Routine Care
- Where
- 5 sites in India
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Deep Vein Thrombosis (DVT)
Impedance Plethysmography Based Deep Vein Thrombosis Monitoring During Catheter-directed Thrombolysis
The purpose of this study is to collect data on blood circulation using a multi-frequency impedance plethysmography device developed in the ThrombUS+ project.
- Trial name
- NCT07665320
- Testing
- Impedance plethysmography IPG, Venous Occlusion Plethysmography VOP, Breathing and leg movement exercise
- Where
- 2 sites in Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tampere University
ST Elevation Myocardial Infarction
Cost Effectiveness if Primary PCI Versus Thrombolytic Therapy in Acute STEMI in Assiut University Hospital
Cost effectiveness between PPCI and thrombolytic therapy in STEMI patients without contraindications
- Trial name
- NCT03310437
- Testing
- Primary PCI
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nahed Sameh Zaki
Stroke, Ischemic
Differential Metabolic Signature of Stroke Patients Undergoing Thrombolysis
Currently, there is no reliable biomarker for stroke, meaning that treatment is often delayed and patients are often left with a disability.
- Trial name
- DETECT (NCT03443245)
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
STEMI
Erectile Dysfunction After Percutaneous Coronary Intervention Versus the Thrombolytic Therapy in Acute ST Elevation Myocardial Infarction
Erectile dysfunction is a common sexual problem affecting up to one-third of men throughout their life. It is now well recognized that risk factors for erectile dysfunction (ED) include the same risk factors as coronary artery…
- Trial name
- NCT03328156
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ischemic Stroke, Stroke, Acute
Tenecteplase in Wake-up Ischaemic Stroke Trial
Stroke is a leading causes of death and disability. At least 20% of strokes occur during sleep, so- called 'wake up stroke'. Thrombolysis with the clot-busting drug alteplase is effective for acute ischaemic stroke, provided that…
- Trial name
- TWIST (NCT03181360)
- Testing
- Tenecteplase, Control
- Where
- 83 sites in United States, Denmark and 9 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Acute Stroke
Neutrophil Extracellular Traps and Thrombolysis in the Acute Stroke
The purpose of the study was to investigate the correlation between the nucleosome concentration and the rate of recanalization after thrombolysis.
- Trial name
- NETs (NCT02476188)
- Testing
- Sample of Blood
- Where
- France
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Acute Ischemic Stroke
Research Into the Effect of a Clot-dissolving Agent and Its Inhibitor
Single-chain urokinase-type plasminogen activator (pro-urokinase) is a highly effective thrombolytic drug. At pharmacologic concentrations however, pro-urokinase is converted to urokinase - a non specific thrombolytic, limiting…
- Trial name
- NCT01694381
- Testing
- M5, C1-inhibitor
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- TSI, LLC
Myocardial Infarction
Senior PAMI: Primary Angioplasty Versus Thrombolytic Therapy for Acute Myocardial Infarction in the Elderly
This is a prospective, randomized, multi-center, international trial comparing two reperfusion strategies in elderly (age >= 70 years) patients with acute myocardial infarction: primary percutaneous coronary intervention (PCI)…
- Trial name
- NCT00136929
- Testing
- Thrombolytic therapy, Percutaneous coronary intervention (PCI)
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- PAMI Coordinating Center
Arterial Thrombosis
Study on the Thrombolytic Effect of Platelet Membrane Coated Recombinant Staphylokinase on Human Arterial Thrombus
Recombinant staphylokinase (r-SAK) is a third-generation thrombolytic agent produced by genetic engineering technology in 1985, which has better thrombolytic effect than streptokinase (SK) and urokinase (UK).
- Trial name
- NCT05978791
- Testing
- collection of venous blood or arterial blood
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hypertensive Intracerebral Hemorrhage
Modified Stereotactic Aspiration and Thrombolysis of Intracerebral Hemorrhage:a Multi-center Controlled Study
The purpose of this study is to evaluate the superiority of effect of the modified micro-invasive aspiration and drainage and conservative medical therapy in the treatment of ICH spontaneously hypertensive scientifically.
- Trial name
- MSATIH (NCT00940745)
- Testing
- Stereotactic Aspiration and Thrombolysis, conservative treatment
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Acute Pulmonary Embolism
Percutaneous Mechanical Thrombectomy With or Without Low-Dose Catheter-Directed Thrombolysis in Acute Intermediate-High Risk Pulmonary Embolism
Acute pulmonary embolism (PE) is the third most common cardiovascular cause of death. In patients with intermediate-high risk acute PE, percutaneous mechanical thrombectomy (PMT) using large-bore catheters achieves rapid…
- Trial name
- PMT-LDCDT-PE (NCT07865572)
- Testing
- PMT alone (percutaneous mechanical thrombectomy only), PMT plus low-dose catheter-directed thrombolysis (PMT+LDCDT)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Qiu Jipeng
ST Elevation Myocardial Infarction (STEMI)
IMPROVE-STEMI: pPCI Plus Low-dose r-SK in STEMI
This is a multicenter, prospective, pragmatic, randomized controlled trial (IMPROVE-STEMI) aiming to evaluate the efficacy and safety of intracoronary low-dose recombinant streptokinase combined with primary percutaneous coronary…
- Trial name
- IMPROVE-STEMI (NCT07875179)
- Testing
- Recombinant Streptokinase
- Where
- China
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Central Retinal Artery Occlusion
Safety and Efficacy After Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion
Central retinal artery occlusion (CRAO) is an ophthalmic emergency which leads to devastating visual function defects and poor prognosis.
- Trial name
- NCT05562284
- Testing
- intra-arterial thrombolysis, conservative treatments
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Deep Venous Thrombosis, Post Thrombotic Syndrome
Catheter-directed Thrombolysis Compared to Anticoagulation Alone for Acute Primary Iliofemoral Deep Venous Thrombosis
Post-thrombotic syndrome (PTS) is a complication that can develop after deep vein thrombosis (DVT) of the lower extremities. PTS can occur at various times after the initial episode, but usually manifests within two years of…
- Trial name
- NCT04411316
- Testing
- Catheter directed thrombolysis plus anticoagulation, Anticoagulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Ischemic Stroke
Intravenous Thrombolysis Registry for Acute Ischemic Stroke in China
To analyze the real situation of intravenous thrombolysis in acute ischemic stroke in China
- Trial name
- NCT03997292
- Testing
- Alteplase, Urokinase
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Acute
FRALYSE Trial: Comparison of the Classical Rt-PA Procedure With a Longer Procedure in Acute Ischemic Stroke
Data from the literature have suggested that a longer time of thrombolysis might be more effective in ischemic stroke. We, the investigators at Hospices Civils de Lyon, have designed a randomized protocol to test this hypothesis.
- Trial name
- NCT00132509
- Testing
- DFIL, NINDS
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Stroke
Thrombolytic Care During Inter-hospital Transfer
Evaluation of ischemic stroke patients receiving tissue plasminogen activator (rtPA) during air ambulance transfer
- Trial name
- NCT02752256
- Testing
- Tissue Plasminogen Activator
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Iowa