Clinical trials: Thymalfasin
Carcinoma, Hepatocellular
A Trial of Thymalfasin in Adult Patients With Hepatocellular Carcinoma
The objective of this Phase II trial is to compare the efficacy and safety of 6 months of treatment with thymalfasin plus trans arterial chemoembolization (TACE) with TACE alone in adult patients with non-surgical hepatocellular…
- Trial name
- NCT00082082
- Testing
- Thymalfasin (thymosin alpha-1), Trans arterial chemoembolization (TACE)
- Where
- 5 sites in United States
- Sponsor
- SciClone Pharmaceuticals
Small Cell Lung Cancer, Radiotherapy
Abscopal Effect for Metastatic Small Cell Lung Cancer
Patients with small cell lung cancer that had metastatic lesions after been treated with definitive surgery or chemoradiotherapy are being asked to participate in this study. 1.
- Conditions
- Small Cell Lung Cancer, Radiotherapy, Thymalfasin
- Trial name
- NCT02542137
- Testing
- Radiotherapy, Thymalfasin
- Sponsor
- Zhejiang Provincial People's Hospital
Covid19
Thymalfasin (Thymosin Alpha 1) to Treat COVID-19 Infection
It is our hypothesis that a course of Ta1 administered to hospitalized individuals with COVID-19 infection and lymphocytopenia will improve the time to recovery (primary objective) and severity of infection (secondary objectives)…
- Trial name
- Ta1 (NCT04487444)
- Testing
- Thymalfasin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Rhode Island Hospital
COVID-19
Thymosin Alpha 1 to Prevent COVID-19 Infection in Renal Dialysis Patients
Thymalfasin (thymosin alpha 1 or Ta1), the active pharmaceutical ingredient in ZADAXIN® injection, is a 28-amino acid synthetic peptide, identical to natural Ta1 produced by the thymus gland.
- Trial name
- Ta1 (NCT04428008)
- Testing
- Thymalfasin
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- William B. Ershler, MD
Chronic Hepatitis B
Efficacy Study of Thymosin alpha1 & Pegylated Interferon-alpha2a to Treat Chronic Hepatitis B
The purpose of this study is to determine the optimal treatment duration of antiviral therapy for chronic hepatitis B.
- Trial name
- NCT00291616
- Testing
- Pegylated Interferon-alpha2a, Thymosin alpha1 & Pegylated Interferon-alpha2a
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Hospital
Hematological Malignancy, Lymphocytopenia
Thymalfasin and Recombinant Human IL-2 Injections in Treating Lymphocytopenia for Patients With Malignant Hematological Tumors
To evaluate the efficacy and safety of Thymalfasin for injection in combination with Recombinant Human Interleukin-2 Injections in the treatment of lymphocytopenia in patients with malignant hematological tumors
- Trial name
- NCT06584006
- Testing
- Thymalfasin for injection in combination with Recombinant Human Interleukin-2 Injections, Recombinant Human Interleukin-2 Injections
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Non-small Cell Lung Cancer, Metastatic Non-small Cell Lung Cancer
Abscopal Effect for Metastatic Non-small Cell Lung Cancer.
Patients with Non-small cell lung cancer that had metastatic lesions after been treated with definitive surgery or chemoradiotherapy are being asked to participate in this study. 1.
- Conditions
- Non-small Cell Lung Cancer, Metastatic Non-small Cell Lung Cancer, Radiotherapy, Thymalfasin
- Trial name
- NCT02542930
- Testing
- Radiotherapy, Thymalfasin
- Sponsor
- Zhejiang Provincial People's Hospital
Pancreatitis, Acute Necrotizing
Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis
Infected pancreatic necrosis and its related septic complications are the major cause of death in patients with acute pancreatitis, therefore prevention of pancreatic infection is of great clinical value in the treatment of AP.
- Trial name
- TRACE (NCT02473406)
- Testing
- Thymosin Alpha 1, normal saline
- Where
- 2 sites in China
- Volunteers
- 508 people
- Sponsor
- Weiqin Li
Long-term Effects of Thymosin Alpha 1 Treatment
Long-term Prognosis of Patients With Sepsis After Immunotherapy
Current clinical studies of thymosin α1 for sepsis have focused on short-term outcomes (28-day or 90-day mortality), and lack of clinical data on long-term outcomes (3 year mortality) of patients with sepsis after immunotherapy.
- Trial name
- NCT04901104
- Testing
- Thymosin Alpha1
- Volunteers
- 900 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer
Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment of Esophageal Cancer
This is a prospective, single-arm, multicenter clinical study conducted in China. Patients with pathologically or cytologically confirmed resectable esophageal squamous cell carcinoma will be enrolled to explore the efficacy and…
- Trial name
- NCT07780721
- Testing
- Adebrelimab, Thymalfasin, Chemotherapy
- Where
- China
- Volunteers
- 31 people
- Sponsor
- The Affiliated Hospital of Putian University
Curable Hepatitis B Virus-Related Hepatocellular Carcinoma
Thymalfasin Adjuvant Therapy in Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (HCC) After Curative Resection
Efficacy and safety of Thymalfasin adjuvant therapy in HBV-related HCC after curative resection.
- Trial name
- NCT02281266
- Testing
- curative resection, thymalfasin, nucleoside analog (suggest to use entecavir)
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Jia Fan
HIV-1-infection
Zadaxin and HIV-positive Patients With Immune Reconstitution Disorder
The purpose of this study is to evaluate the safety and efficacy of Zadaxin® in the treatment of HIV-positive patients with immune reconstitution disorders.
- Trial name
- NCT04963712
- Testing
- Zadaxin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Public Health Clinical Center
Breast Cancer
Dendritic Cell Based Therapy for Breast Cancer Patients
The primary aim of this study is to investigate time to progression in breast cancer patients vaccinated with autologous dendritic cells pulsed with peptides in combination with adjuvant aromatase inhibitor (AI), Thymosin 1 alpha…
- Trial name
- NCT00935558
- Testing
- DC vaccine, aromatase inhibitor
- Where
- Denmark
- Sponsor
- Inge Marie Svane
Melanoma, Immune-related Adverse Event
Thymosin Alpha 1 Combined With Anti-PD-1 Monoclonal Antibody in Elderly Patients With Advanced Melanoma
Primary Objective: To evaluate the effectiveness of Thymosin Alpha-1 combined with PD-1 monoclonal antibody in elderly patients with advanced melanoma .
- Conditions
- Melanoma, Immune-related Adverse Event, Immune Checkpoint Inhibitor
- Trial name
- NCT07644897
- Testing
- Thymosin Alpha 1 and Anti-PD-1 monoclonal antibody
- Where
- 2 sites in China
- Volunteers
- 55 people
- Sponsor
- Sun Yat-sen University
MCRC
"Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
This is a multicenter, open-label, prospective, randomized controlled Phase II clinical study. All eligible subjects will be randomly assigned in a 1:1 ratio to either the triple therapy group or the double therapy group.
- Trial name
- THYMI (NCT06829355)
- Testing
- Thymalfasin (Thymosin alpha 1, Ta1), Regorafenib (BAY 73-4506), Tislelizumab (BGB-A317)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Beijing Friendship Hospital
Malignant Melanoma
Thymosin Alpha 1, Interferon Alpha, or Both, in Combination With Dacarbazine in Patients With Malignant Melanoma
The purpose of the study is to test safety and efficacy of different doses of thymosin alpha 1 (1.6 mg, 3.2 mg, and 6.4 mg) in combination with dacarbazine and with or without Interferon alpha in treating patients affected by…
- Trial name
- NCT00911443
- Testing
- Dacarbazine + Interferon alpha + Thymosin-alpha-1 1.6 mg, Dacarbazine + Interferon alpha + Thymosin-alpha-1 3.2 mg, Dacarbazine + Interferon alpha + Thymosin-alpha-1 6.4 mg
- Where
- 64 sites in France, Germany and 6 more
- Volunteers
- 488 people
- Sponsor
- sigma-tau i.f.r. S.p.A.
Osteoporotic Pain
Immunotherapy for Elderly Patients With Chronic Osteoporotic Pain
Osteoporotic pain is the most common clinical symptom in elderly patients. The course of pain is prolonged and the effect of clinical treatment is limited.
- Trial name
- NCT04524169
- Testing
- Thymosin Alpha1
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Sepsis
The Efficacy and Safety of Ta1 for Sepsis
The purpose of this study is to determine whether thymalfasin is safe and effective in patients who have sepsis
- Trial name
- TESTS (NCT02867267)
- Testing
- Thymosin alpha 1
- Where
- 22 sites in China
- Volunteers
- 1,106 people
- Sponsor
- Sun Yat-sen University
Lung Adenocarcinoma
Radiotherapy Combined With Thymosin for Metastatic NSCLC Patients Who Showed Stable Disease After First Line TKI Therapy
The investigators postulated that the exploitation of the pro-immunogenic effects of radiotherapy with thymosin might result in abscopal responses among patients with metastatic cancer.
- Trial name
- NCT02787447
- Testing
- TKI, Thoracic Hypofractionated Radiotherapy, Thymosin Alpha 1
- Where
- China
- Volunteers
- 46 people
- Sponsor
- First People's Hospital of Hangzhou
Locally Advanced Rectal Cancer
Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-low Rectal Cancer
This is an open, prospective, multi-center, single-arm phase II clinical study assessing the efficacy and safety of neoadjuvant chemoradiotherapy combined with PD-1 inhibitor and thymalfasin in patients with pMMR/MSS locally…
- Trial name
- NCT06056804
- Testing
- capecitabine, tislelizumab, thymalfasin
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Beijing Friendship Hospital