Clinical trials: Thyroid Cancers
Thyroid Nodule
Multiparameter Ultrasound Based-AI for the Diagnosis of Thyroid Nodules
The cases that fulfill the inclusion criteria will be enrolled with written informed consent. Images and videos will be collected in accordance with the procedure, uploaded to Ruiying Cloud, followed up, and registered with basic…
- Trial name
- AI (NCT05816629)
- Testing
- Multiparameter ultrasound based-AI
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thermal Ablation, Fine Needle Aspiration Biopsy
Ultrasound and Cytological Evaluation 3 Years After Radiofrequency Thermal Ablation of Benign Thyroid Nodules : a Prospective Exploratory Cohort of 180 Nodules
There is no scientific data on post-thermal ablation cytological aspects, but treated nodules that grow back significantly after a procedure justify a new cytology in order not to ignore a neoplastic process.
- Conditions
- Thermal Ablation, Fine Needle Aspiration Biopsy, Thyroid Nodules
- Trial name
- CYTOTHYRAF (NCT05726981)
- Testing
- Fine needle aspiration biopsy (FNAB)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thyroid Cancer
The Role of Midkine in Diagnosis of Thyroid Cancer
1. Evaluation of the role of serum midkine in differentiating malignant from benign thyroid nodule 2. studying the level of serum midkine in relation to different thyroid cancer stages
- Trial name
- NCT03978351
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assiut University
Fine Needle Aspiration Cytology, Thyroid Diseases
Accuracy of FNAC in Thyroid Nodules Compared to to Surgical Specimen : QOC Experience
Thyroid gland diseases are the second most common endocrine disease following diabetes mellitus(1). Thyroid nodules are common disorders with a prevalence ranged from 4 to 7% in adult population, 5%-30% are malignant…
- Trial name
- Thyroid FNAC (NCT05521594)
- Testing
- Fine Needle Aspiration Cytology
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Qena Oncology Center
Hypothyroidism
Effects of Thyroid Hormone Withdrawal on Metabolic Parameters During Radioactive Iodine Therapy in Thyroid Cancer
1. The incidence of differentiated thyroid cancer is increasing in Korea. A significant number of them experience severe hypothyroidism in preparation for radioactive iodine (RAI) therapy after total thyroidectomy. 2.
- Trial name
- NCT01744769
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Konkuk University Medical Center
Low Risk Differentiated Thyroid Cancer
Differentiated Thyroid Cancer: is There a Need for Radioiodine Ablation in Low Risk Patients?
Open-label randomized phase III trial, using a non-inferiority comparison design. After randomization,patients will receive either post-operative radioiodine ablation with an activity of 1.1 GBq (30 mCi) after stimulation by…
- Trial name
- ESTIMABL2 (NCT01837745)
- Testing
- rhTSH stimulation, I131, Follow up
- Where
- France
- Volunteers
- 776 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Head and Neck Cancer, Spinal Accessory Nerve Injury
Investigation of Effects of Physiotherapy Interventions on Mechanical Properties of Muscle in Head and Neck Cancer
As the head and neck cancer (HNC) survival rate has increased and therefore, the focus of post-treatments is to improve the quality of patients' life by decreasing the side effects.
- Conditions
- Head and Neck Cancer, Spinal Accessory Nerve Injury, Thyroid Cancer, Scapular Dyskinesis
- Trial name
- NCT05399953
- Testing
- Myofascial Release Technique, Exercise, Scar Tissue Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Yeditepe University
Thyroid Neoplasm Follicular, Bone Metastases
Efficacy of Sr-89 for Differentiated Thyroid Cancer With Bone Metastases
Using sensitive markers (such as thyroglobulin, etc) to evaluate the efficacy of strontium-89 chloride (Sr-89) in differentiated thyroid cancer with bone metastases with an aim to breaking out of its palliation effect for bone…
- Trial name
- NCT05466812
- Testing
- Sr-89
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Thyroid Cancer, Medullary, Neuroendocrine Tumor of the Lung Grade 1 and 2
177Lu-PP-F11N for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer.
The purpose of this study is to determine the use of 177Lu-PP-F11N for imaging and therapy of patients with advanced medullary thyroid carcinoma (MTC). 177Lu-PP-F11N is a gastrin analogon, binding to cholecystokinin-2 receptors.
- Conditions
- Thyroid Cancer, Medullary, Neuroendocrine Tumor of the Lung Grade 1 and 2, Neuroendocrine Tumor of the Thymus Grade 1 and 2, Neuroendocrine Tumor GEP Grade 1-3
- Trial name
- Lumed (NCT02088645)
- Testing
- 177Lu-PP-F11N
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Papillary Thyroid Cancer
Concordance of Molecular Classification Based on Fine Needle Biopsy (FNB) and Surgical Samples
The purpose of this study is to determine whether results from a fine needle biopsy are the same as results from a larger sample that is acquired from the surgical pathology using the Thyroid GuidePx® test in patients with…
- Trial name
- NCT06133374
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- University of Calgary
Iodine-resistant Thyroid Cancer, Meningioma
A Dual-targeting Tracer TATE-RGD for the Diagnosis of SSTR- and RGD- Positive Tumors
The US FDA approved a targeted somatostatin receptor 2 imaging agent, 68Ga-DOTATATE, in 2016. It has higher uptake in small cell lung cancer, pulmonary carcinoid, and medullary thyroid cancer.
- Conditions
- Iodine-resistant Thyroid Cancer, Meningioma, NETs
- Trial name
- NCT06632860
- Testing
- 68Ga-TATE-RGD, 18-FDG
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Thyroid Neoplasms
Testing a Web-based Intervention for Radioactive Iodine Symptom Management to Improve Health-related Quality of Life Among Differentiated Thyroid Cancer Patients
The goal of this clinical trial is to learn if adult patients diagnosed with differentiated thyroid cancer can easily use and benefit from an online tool aimed to provide patients with educational resources and symptom management…
- Trial name
- NCT06853925
- Testing
- Radioactive Iodine Support (RAI Support), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Georgetown University
Ovarian, Melanoma
Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.
The present clinical trial is a dose comparison of a multi-component active immunotherapy designed to stimulate an immune reaction to specific tumor associated antigens which are highly expressed on a large number of solid…
- Conditions
- Ovarian, Melanoma, Renal, Prostate
- Trial name
- NCT00423254
- Testing
- PSMA/PRAME
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mannkind Corporation
Carcinoma of Head/Neck
Observational Study on Thyroid Tumors and EvaLuation of the roLe of New pOntential Predictive/Prognostic Factors
The OTELLO Study is a monocentric, ambispective observational study that systematically analyzes the clinical, laboratory, anatomopathological, and molecular characteristics of patients with thyroid neoplasms treated at the…
- Trial name
- OTELLO (NCT07064369)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Papillary Thyroid Cancer
Prediction of Lymph Node Metastasis in Patients With Thyroid Malignancy by a New Scale
The incidence of papillary thyroid cancer (PTC) has been on the rise in recent years, and 20%-50% of PTC patients will have lymph node metastasis.
- Trial name
- NCT06286631
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Cancer, Non-small-cell Lung Cancer
Study of XL281 in Adults With Solid Tumors
The purpose of this study is to determine the safest dose of the multiple Raf kinase inhibitor (including c-Raf, B-Raf, and the activated mutant B-RafV600E) XL281, how often it should be taken, and how well subjects with cancer…
- Conditions
- Cancer, Non-small-cell Lung Cancer, Colorectal Cancer, Papillary Thyroid Cancer
- Trial name
- NCT00451880
- Testing
- XL281, famotidine
- Where
- 6 sites in United States
- Volunteers
- 180 people
- Sponsor
- Exelixis
Differentiated Thyroid Cancer (DTC)
The EMIRATES Study
This pilot study will take place in thyroid outpatient clinics. It will have two study arms running in consecutive order: first, a Control arm where standard care will take place without PDA-TC, then a Patient Decision Aid (PDA)…
- Trial name
- NCT06855680
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Renal Cell Carcinoma, Hepatocellular Carcinoma
Post-marketing Surveillance on the Safety of CabometyxTM in Korean Patients
The objective of this Post Marketing Surveillance (PMS) is to collect and describe safety and effectiveness profile of Cabometyx™ in real clinical practice setting, according to the approved labelling after the approval of…
- Conditions
- Renal Cell Carcinoma, Hepatocellular Carcinoma, Differentiated Thyroid Carcinoma
- Trial name
- NCT03776123
- Where
- 47 sites in South Korea
- Volunteers
- 347 people
- Sponsor
- Ipsen
Locally Advanced or Metastatic Medullary Thyroid Cancer, Medullary Thyroid Cancer
Study to Determine if Contacting Patients With MTC More Frequently Results in Earlier Detection and Treatment of Signs and Symptoms of AEs and Thus a Decrease in the Percentage of Time Patients Experience AEs During First 12 Months on Vandetanib Treatment
The purpose of this study is to evaluate the effect of patient outreach program on the proportion of time patients with MTC experience moderate or severe AEs during first 12 months of treatment with vandetanib
- Trial name
- NCT01298323
- Testing
- Patient outreach, Vandetanib
- Where
- 66 sites in Australia, Austria and 18 more
- Volunteers
- 205 people
- Sponsor
- Sanofi
Malignant Struma Ovarii, Papillary Thyroid Cancer
Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment
Background: Thyroid hormone is produced by the thyroid gland, an organ at the base of the neck. Thyroid hormone controls the body's metabolism and the function of many organs.
- Conditions
- Malignant Struma Ovarii, Papillary Thyroid Cancer, Hurthle Cell Thyroid Cancer, Follicular Thyroid Cancer
- Trial name
- NCT01441154
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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