Clinical trials: Thyroid Diseases
Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS)
Efficacy of Lavender Aromatherapy on Anxiety and Pain Reduction During Awake Otolaryngologic Procedures
The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting.
- Conditions
- Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS), Rhinitis, Vasomotor, Thyroid Nodules
- Trial name
- NCT07299474
- Testing
- Lavender Aromatherapy
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Thyroid Gland; Node, Lactation
Iodine Status in Swedish Lactating Women - Effect of Iodine Supplementation in the Thyroid Function of Mother and Infant
The aim of the study is to measure urinary milk iodine concentration (MIC), iodine concentration (UIC), thyroid hormones (TSH, FT4) and thyroperoxidase antibodies (TPOab) in breast-feeding women, and UIC in their nursing infants…
- Trial name
- NCT02378233
- Testing
- iodine
- Where
- Sweden
- Volunteers
- 77 people
- Sponsor
- Göteborg University
Thyroid Eye Disease
A Study of TEPEZZA® Treatment in Participants With Thyroid Eye Disease
The main goal of this study is to learn how teprotumumab will be processed in the body (Pharmacokinetics) subcutaneously and whether it is safe and tolerable after administration into adult patients with thyroid eye disease.
- Trial name
- NCT06389578
- Testing
- Teprotumumab
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Amgen
FNA, microRNA
microRNA in Thyroid Cancer
Thyroid cancer is the most common endocrine malignancy and its incidence is rapidly increasing. Palpable thyroid nodules are very common, affecting up to 5% of the general population.
- Conditions
- FNA, microRNA, Thyroid Cancer, Thyroid Nodule
- Trial name
- NCT01964508
- Testing
- Fine needle aspiration
- Where
- Israel
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Hypothyroidism, Anesthesia, General
Effect of Brain GABA Metabolite Amount to Propofol Utilisation Under TIVA in Hypothyroid Patient
Introduction: GABAergic synaptic transmigration in the anterior cingulate (ACC) cortex of hypothyroid rats has been demonstrated by electrophysiologic recordings.
- Conditions
- Hypothyroidism, Anesthesia, General, Propofol Dosage, Magnetic Resonance Imaging (MRI)
- Trial name
- BrainGABA (NCT06649318)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Medullary Thyroid Carcinoma
Research on the Application of 68Ga-DOTA-CCK-FS PET/CT in MTC
This study explores the clinical application of 68Ga-DOTA-CCK-FS PET/CT in detecting cholecystokinin-2 receptor (CCK-2R)-positive tumors, particularly medullary thyroid cancer (MTC) and other malignancies. Led by Prof.
- Trial name
- NCT07138716
- Testing
- 68Ga-DOTA-CCK-FS PET/CT
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Luo Yaping
Thyroid Cancer
Dental Safety Profile of High-Dose Radioiodine Therapy
We aim to assess the incidence of oral and dental adverse events after high-dose radioiodine therapy for differentiated thyroid cancer.
- Trial name
- NCT00439478
- Testing
- Radioiodine
- Where
- Switzerland
- Volunteers
- 202 people
- Sponsor
- University Hospital, Basel, Switzerland
Pregnancy Related, Thyroid
Safety and Efficacy of Empiric Levothyroxine (LT4) Dose Increase Versus Individualized LT4 Dose Increase in Hypothyroid Women During Pregnancy
In women who require thyroid hormone replacement medication, the investigators will compare 2 ways to adjust thyroid medication during pregnancy to determine superiority in maintaining optimal blood levels of thyroid hormone.
- Trial name
- NCT03115515
- Testing
- levothyroxine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Thyroidectomy, Postoperative Neck Pain
Neck Exercises After Thyroid Surgery
Postoperative neck pain is common after thyroidectomy and may impair early recovery. This prospective randomized controlled study aimed to evaluate the effects of postoperative neck range-of-motion (ROM) and isometric…
- Conditions
- Thyroidectomy, Postoperative Neck Pain, Quality of Life (QOL), Cervical Range of Motion
- Trial name
- NCT07415174
- Testing
- Postoperative Neck Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Istanbul University - Cerrahpasa
Head and Neck Cancer, Lung Cancer
Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00021333
- Testing
- filgrastim, cisplatin, paclitaxel
- Where
- 18 sites in United States
- Volunteers
- 29 people
- Sponsor
- Fox Chase Cancer Center
Anaplastic Thyroid Cancer
Review of Multimodality Management of Anaplastic Thyroid Cancer
To describe the outcome of patients with anaplastic thyroid cancer treated with hyperfractionated radiotherapy and concomitant chemotherapy
- Trial name
- NCT00280852
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Alberta Health services
Breast Carcinoma, Prostate Cancer Surgery
High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins
These are patients in whom a benign or malignant tumor was recorded requiring surgery. During that surgery, the surgeon will cut away the tumor as part of the treatment of the disease.
- Conditions
- Breast Carcinoma, Prostate Cancer Surgery, Thyroid Cancer, Parathyroid Adenomas
- Trial name
- NCT06835426
- Testing
- Single intravenous injection of the radiotracer, Imaging resected specimen using the high-resolution PET-CT specimen imager
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Goiter
Subtotal Versus Total Thyroidectomy for Benign Goiter
The extent of thyroid resection in benign goiter is controversial. Potential advantages of TT over BST may include: one-stage removal of incidental thyroid cancer reported in up to 10% of operatively treated benign thyroid…
- Trial name
- NCT01273714
- Testing
- thyroid resection
- Where
- Poland
- Volunteers
- 8,006 people
- Sponsor
- Jagiellonian University
Thyroid Diseases
Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy
Hypoparathyroidism is the most common complication after a total thyroidectomy surgery. It becomes permanent after 6 months. Untreated permanent hypoparathyroidism is a source of numerous complications in general and therefore…
- Trial name
- HYPOCAAVI (NCT04785443)
- Testing
- ICG, Control group
- Where
- France
- Volunteers
- 242 people
- Sponsor
- University Hospital, Brest
Non Small Cell Lung Cancer, Medullary Thyroid Cancer
Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations
A phase 1/2, first-in-human, open-label study to determine the safety, tolerability, PK, and preliminary efficacy of the novel RET/SRC inhibitor TPX-0046 in adult subjects with advanced or metastatic solid tumors harboring RET…
- Conditions
- Non Small Cell Lung Cancer, Medullary Thyroid Cancer, RET Gene Mutation, Metastatic Solid Tumor
- Trial name
- NCT04161391
- Testing
- TPX-0046
- Where
- 21 sites in United States, South Korea
- Volunteers
- 41 people
- Sponsor
- Turning Point Therapeutics, Inc.
Thyroid Gland Nodule
Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules
This trial studies how well the diagnostic deoxyribonucleic acid (DNA) methylation signature works in detecting thyroid cancer in patients with thyroid nodules.
- Trial name
- NCT03676647
- Testing
- Diagnostic DNA Methylation Signature
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- City of Hope Medical Center
Osteoporosis
Diagnosis of Decreased Bone Density by Dental Cone Beam Computed Tomography
The purpose of this study is to elucidate the role of Dental Cone Beam Computed Tomography (CBCT) in assessment of bone density.
- Trial name
- NCT02303340
- Testing
- Dual Energy X-ray Absorptiometry
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Hypothyroidism
Study of Dose Adjustment From Levothyroxine to a New Levothyroxine Sodium Test Formulation
The purpose of this study is to investigate the effect of switching participants taking levothyroxine to a new sodium formulation.
- Trial name
- NCT01916304
- Testing
- Levothyroxine sodium new formulation
- Where
- Belgium
- Volunteers
- 101 people
- Sponsor
- Takeda
Thyroid Nodule, Thyroid Diseases
Fusion UltraSound Imaging Of the Thyroid GlaNd With I-124 PET. Evaluation of Nodule Allocation.
Regular thyroid diagnostics versus augmented thyroid work-up with additional I-124 PET/US fusion for metabolic-sonographic nodule allocation in patients with benign thyroid diseases
- Conditions
- Thyroid Nodule, Thyroid Diseases, Thyroid Goitre
- Trial name
- FUSION iENA (NCT03128255)
- Testing
- Assessment of already preacquired I-124 PET/US
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Jena University Hospital
Solid Tumor, Adult, Non-small Cell Lung Cancer
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of KIN-2787 in adults with BRAF/NRAS-mutated advanced or metastatic solid tumors.
- Conditions
- Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma
- Trial name
- NCT04913285
- Testing
- KIN-2787, KIN-2787 and binimetinib
- Where
- 48 sites in United States, Australia and 5 more
- Volunteers
- 400 people
- Sponsor
- Pierre Fabre Medicament
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