Clinical trials: Thyroid Disorders
Papillary Thyroid Microcarcinoma
Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis
In this study, the investigators look at the genetic expressional alteration which influenced on the early lateral neck node metastasis in thyroid papillary microcarcinoma.
- Trial name
- NCT01384669
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Yonsei University
Advanced Solid Tumor
HEC169096 in Participants With Advanced Solid Tumors
An Open, Multi-Center Phase I/II Clinical Study To Evaluate The Safety, Tolerability, Pharmacokinetic Characteristics And Effectiveness Of HEC169096 In Patients With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced…
- Trial name
- NCT05451602
- Testing
- HEC169096
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Pancreatic Cancer, Thyroid Nodule
A Study of Multiparametric Ultrasound Imaging Methods
The researchers are doing this study to see how well a type of ultrasound imaging called multiparametric ultrasound (mpUS), can be used to examine, evaluate, and provide information about different cancerous and non-cancerous…
- Trial name
- NCT07270237
- Testing
- Multiparametric ultrasound (mpUS) imaging
- Where
- 7 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Safety, Tolerability
A Study of GensSci098 in Subjects With Graves' Disease
To evaluate the safety and tolerability of single ascending subcutaneous doses of GenSci098 in patients with Graves' Disease
- Conditions
- Safety, Tolerability, GenSci098, Graves Disease
- Trial name
- NCT07286656
- Testing
- GenSci098
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Thyroid Eye Disease
Twenty-four Hour Intraocular Pressure Patterns in Patients With Uncontrolled Thyroid Eye Disease
Patients with Thyroid Eye Disease (TED) often have enlarged extraocular muscles and higher orbital fat contents due to their disease process.
- Trial name
- NCT01798966
- Testing
- SENSIMED Triggerfish
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sensimed AG
Thyroidectomy
Purse String Suture for the Closure of Large Thyroidectomy Resulted in Better Cosmetics
Thyroidectomy for large thyroid tumor poses a problem of cosmetics, especially in terms of wide post-operative scar and prominent neck wrinkles.
- Trial name
- NCT03035383
- Testing
- Purse string technique, Conventional technique
- Volunteers
- 30 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Tratment of Multinodular Goitre
Three-Year Follow-up of Radioiodine Therapy for Goitre
Background: Preadministration of recombinant human thyrotropin (rhTSH) increases the amount and homogeneity of thyroid radioiodine uptake, and when used as an adjuvant can augment the efficiency of 131I therapy by allowing…
- Trial name
- NCT00509483
- Testing
- Radioactive iodine
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Patients With Papillary Thyroid Cancer and N1b Status
Fascial Versus Standard Neck Dissection in Patients With N1b Papillary Thyroid Carcinoma
Optimal surgical technique for neck dissection (LND) in thyroid carcinoma remains a subject of debate. Fascial ND (FND) implies the removal of the superficial and middle layers of the deep cervical fascia en bloc with lymph-nodes…
- Trial name
- FADO (NCT05804682)
- Testing
- Fascial Neck Dissection, Standard Neck Dissection
- Where
- Italy
- Volunteers
- 195 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Thyroid Nodular Disease
Thyroid Fine Needle Biopsy and Impact on Pain and Diagnostic Adequacy
This randomized study compares patient pain and comfort during ultrasound-guided thyroid fine needle biopsy using 21-gauge versus 27-gauge needles. Patients with thyroid nodules were randomly assigned to one of two needle sizes.
- Trial name
- THY-BPSY (NCT07683039)
- Testing
- Thyroid fine needle biopsy with 21-gauge needle, Thyroid fine needle biopsy with 27-gauge needle
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Thyroid Cancer, Hypoparathyroidism
Near-Infrared Autofluorescence With PTH Test Strip as an SOP of Parathyroid in Thyroid Surgery
This is a prospective study aiming to establish near-infrared autofluorescence technology and PTH test strip as a standardized process for finding and identifying parathyroid glands in thyroid surgery.
- Conditions
- Thyroid Cancer, Hypoparathyroidism, Optical Imaging
- Trial name
- PTFINDER (NCT05684029)
- Testing
- Near-infrared devices, PTH test strip
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Fujian Medical University
Keratoconus in Thyroid Gland Dysfunction
Prevalence Of Keratoconus Among Patients With Thyroid Gland Dysfunction
Hormonal imbalances are likely to affect the corneal metabolism and may be also associated with Keratoconus. Among the various endocrinologic dysfunctions assumed so far, thyroid gland dysfunction (TGD) (hypo- or hyperthyroidism…
- Trial name
- NCT04346992
- Testing
- no intervention
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Fayoum University
Advanced Solid Tumor, BRAF V600 Mutation
Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors
This is a Phase I, First-In-Human, open label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-cancer activity of ABM-1310 in adult patients with locally…
- Trial name
- NCT04190628
- Testing
- ABM-1310, Cobimetinib
- Where
- 8 sites in United States
- Volunteers
- 53 people
- Sponsor
- ABM Therapeutics Corporation
Papillary Thyroid Carcinoma, Thermal Ablation
A Study of Factors Influencing Recurrence After Thermal Ablation of Papillary Thyroid Carcinoma
A prospective cohort of papillary thyroid carcinoma(PTC), patients who received thermal ablation in our hospital since February 2023 was established as the study object.
- Trial name
- NCT05962892
- Testing
- No Intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Friendship Hospital
Hypoparathyroidism Postprocedural
Autofluorescence vs Clinical Assessment of Parathyroid Glands During Thyroid Surgery
The purpose of the investigation is to study if the use of Fluobeam®-LX to identify parathyroid glands through autofluorescence during thyroid surgery, may reduce the risk of postoperative hypoparathyroidism, defined as low PTH…
- Trial name
- NCT04509011
- Testing
- Fluobeam® LX
- Where
- 5 sites in Austria, Norway and 2 more
- Volunteers
- 516 people
- Sponsor
- Region Skane
Metastatic Thyroid Papillary Carcinoma, Metastatic Thyroid Follicular Carcinoma
Durvalumab Plus Tremelimumab for the Treatment of Patients With Progressive, Refractory Advanced Thyroid Carcinoma -The DUTHY Trial
This is a prospective, multi-centre, open label, stratified, exploratory phase II study evaluating the efficacy and safety of durvalumab plus tremelimumab in different cohorts of patients with thyroid cancers.
- Conditions
- Metastatic Thyroid Papillary Carcinoma, Metastatic Thyroid Follicular Carcinoma, Metastatic Thyroid Cancer
- Trial name
- DUTHY (NCT03753919)
- Testing
- Durvalumab, Tremelimumab
- Where
- 15 sites in Spain
- Volunteers
- 79 people
- Sponsor
- Grupo Espanol de Tumores Neuroendocrinos
Surgery, Thyroid
The Effects of Different Degrees of Head-of-bed Elevation
The patient's position is important for ensuring patient comfort and preventing complications after thyroidectomy. This study was carried out to determine the effects of different degrees of head-of-bed elevation on the…
- Conditions
- Surgery, Thyroid, Nursing Caries
- Trial name
- NCT03816371
- Testing
- Head-of-bed elevation
- Volunteers
- 114 people
- Sponsor
- Necmettin Erbakan University
Diarrhea, Medullary Thyroid Cancer
The Efficacy of CASAD in Patients With Diarrhea Related to Medullary Thyroid Cancer
Diarrhea in patients with MTC (Medullary Thyroid Cancer) can be debilitating and, in some cases life threatening. Findings in such patients include volume depletion, renal insufficiency, and electrolyte disorders.
- Trial name
- NCT01739634
- Testing
- CASAD
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Salient Pharmaceuticals Incorporated
Indeterminate Bethesda III Thyroid Nodules
Radiofrequency Ablation for BIII Thyroid Nodules
The purpose of this observational chart review study is to evaluate the efficacy and safety of Radiofrequency Ablation (RFA) for treatment of indeterminate thyroid nodules before and after RFA procedure.
- Trial name
- NCT05189808
- Testing
- Radiofrequency Ablation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Columbia University
Ultrasound
Prospective Multicenter Study on Clinical Application of Sonozoid in Thyroid Tumor
Sonazoid as a new generation of ultrasound contrast agent. This study based on the features of Sonazoid specific angiography and high mechanical index, the role of Sonazoid in the differential diagnosis of thyroid benign and…
- Trial name
- NCT04574258
- Where
- China
- Volunteers
- 371 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Cancer
Molecular Testing to Direct Extent of Initial Thyroid Surgery
The research study consists of the participant agreeing to 1) the use of preoperative molecular testing (ThyroSeq) to guide extent of initial surgery and 2) the prospective collection of medical record data related to treatment…
- Trial name
- NCT02947035
- Testing
- Thyroid lobectomy, Total thyroidectomy with CCND
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh