Clinical trials: Thyroid Surgery
Thyrotoxicosis
Therapeutic Plasma Exchange in Thyrotoxicosis
Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of…
- Trial name
- NCT04485975
- Testing
- Therapeutic plasma exchange
- Volunteers
- 27 people
- Sponsor
- Baskent University
Thyroid; Wound, Parathyroid Diseases
Comparing the Impact of AMNIOEFFECT Application vs Standard of Care on Post-Operative Healing in Patients Who Have Undergone Thyroid and Parathyroid Surgery Via the Transcutaneous Approach
The purpose of this study is to understand how placing Amnioeffect on patients having transcutaneous thyroid or parathyroid surgery affects surgery scar appearance, pain, and the ability to swallow and compare it to patients who…
- Conditions
- Thyroid; Wound, Parathyroid Diseases, Surgical Incision, Incision
- Trial name
- NCT07173621
- Testing
- Amnioeffect
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- Sarasota Memorial Health Care System
Thyroidectomy, Goiter
Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid Surgery
Despite use of meticulous surgical techniques and regardless of surgical access via conventional open or endoscopy, postoperative adhesions develop in the vast majority of patients undergoing neck surgery.
- Conditions
- Thyroidectomy, Goiter, Thyroid Cancer
- Trial name
- NCT05851560
- Testing
- Oxidized regenerated cellulose(ORC), Hyaluronic acid(HA)
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- National Taiwan University Hospital
Thyroidectomy, Postoperative Neck Pain
Neck Exercises After Thyroid Surgery
Postoperative neck pain is common after thyroidectomy and may impair early recovery. This prospective randomized controlled study aimed to evaluate the effects of postoperative neck range-of-motion (ROM) and isometric…
- Conditions
- Thyroidectomy, Postoperative Neck Pain, Quality of Life (QOL), Cervical Range of Motion
- Trial name
- NCT07415174
- Testing
- Postoperative Neck Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Istanbul University - Cerrahpasa
Intermediate-to-High Risk Differentiated Thyroid Cancer
Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC
The global incidence of Differentiated Thyroid Cancer (DTC) is rising. While surgery followed by TSH suppression is the standard of care, achieving target TSH levels with levothyroxine (L-T4) monotherapy remains challenging, with…
- Trial name
- DELTA (NCT07239674)
- Testing
- desiccated thyroid extract (DTE)+levothyroxine (L-T4)
- Volunteers
- 646 people
- Sponsor
- West China Hospital
Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia
Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery
Research indicates that hypothyroidism decreases heart contractility, reduces stroke volume and rate, affects the vascular endothelium, and increases the risk of atherosclerosis, systemic vascular resistance, hypertension…
- Conditions
- Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia, Euthyroid Sick Syndrome, Cardiac Surgery Requiring Cardiopulmonary Bypass
- Trial name
- L-Thyroxine (NCT06660823)
- Testing
- L-thyroxine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Thyroid Diseases, Thyroid Cancer
Effectiveness of WeChat-Supported Neck Rehabilitation Exercises on Early Recovery After Thyroidectomy
This study aimed to evaluate the effectiveness, safety, and implementation outcomes of a WeChat mini program-supported tele-neck rehabilitation exercises for improving early postoperative neck recovery after thyroidectomy.
- Conditions
- Thyroid Diseases, Thyroid Cancer, Surgery, Postoperative Pain
- Trial name
- NCT07707401
- Testing
- WeChat-supported Neck Rehabilitation Exercise, Standardized Postoperative Care and Video Education
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai 6th People's Hospital
Anesthesia, Thyroid
Analgesic Efficacy of an Intermediate CPB in Neck Surgeries.
This study aims to investigate the analgesic efficacy of Intermediate Cervical Plexus Block combined with GA using two bupivacaine concentrations in patients undergoing neck surgeries (total thyroidectomy or total laryngectomy)
- Conditions
- Anesthesia, Thyroid, Neck, Bupivacaine
- Trial name
- NCT06419556
- Testing
- Cervical Plexus Block
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Cairo University
Thyroid Surgery Intraoperative Nerve Monitoring (IONM) Recurrent Laryngeal Nerve Function Dexmedetomidine vs Midazolam (Anesthetic Agents)
EFFECT OF DEXMEDETOMİDİNE ON RECURRENT LARYNGEAL NERVE MONİTORİNG: A COMPARATİVE STUDY WİTH MİDAZOLAM
This prospective observational study evaluated the effect of dexmedetomidine compared with midazolam on intraoperative monitoring of the recurrent laryngeal nerve during thyroid surgery.
- Trial name
- DEX-RLN (NCT07195214)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Amasya University
Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative
Peri-operative BiPAP to Prevent Tracheostomy in High-Risk Bilateral Vocal-Cord Paralysis (BVCP)
Why: After thyroid or neck surgery, some patients can lose movement of both vocal cords (bilateral vocal-cord paralysis, BVCP). This can make breathing difficult and often leads to an emergency or preventive tracheostomy…
- Conditions
- Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative, Thyroid Neoplasms, Sleep Apnea, Obstructive
- Trial name
- BVCP-BiPAP (NCT07042971)
- Testing
- Pre-operative BiPAP Training, Post-extubation BiPAP Support, Standard Peri-operative Care
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Fujian Medical University
Thyroid,, Goiter,
Visualization Versus Neuromonitoring of the External Branch of the Superior Laryngeal Nerve During Thyroidectomy.
Injury to the external branch of the superior laryngeal nerve (EBSLN) during thyroidectomy results in lowered fundamental frequency of the voice and worsened voice performance in producing high-frequency sounds.
- Trial name
- NCT01395134
- Testing
- Neuromonitoring
- Where
- Poland
- Volunteers
- 210 people
- Sponsor
- Jagiellonian University
Thyroid Neoplasms, Thyroid Carcinoma
Influence of Thyroid Hormones on the Woundhealing Process
Main goal of this clinical investigation is to investigate different cytokines in wound fluids of euthyroid vs. hypothyroid patients. As a primary endpoint we want to evaluate if different cytokine levels in euthyroid vs.
- Trial name
- NCT00929318
- Testing
- blood sampling
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Hannover Medical School
Thyroid, Parathyroid Adenoma
Exparel Injection Effect on Postoperative Opioid Usage
The question proposed by this study, is one of patient outcomes. Does intraoperative injection of Exparel decrease postoperative use of opioid pain medications in patients undergoing thyroid and parathyroid surgery? The trial…
- Trial name
- NCT04085913
- Testing
- Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine, Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Thyroidectomy, Voice Alteration
Impact of Total Thyroidectomy on Voice and Swallowing
Purpose of this study is to evaluate the outcome of total thyroidectomy on vocal and swallowing function.
- Conditions
- Thyroidectomy, Voice Alteration, Swallowing Alteration
- Trial name
- NCT01607242
- Testing
- Endoscopy of larynx, Voice Handicap Index, Swallowing Assesment
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Thessaly
Thyroid Gland Resection
Tele-Anesthesia - Trans-Continental Anesthesia Compared to Standard Practice
Patients in Pisa will undergo thyroid gland surgery. In the protocol group anesthesia will be performed using an automated anesthesia delivery system; preoperative and intra-operative assessment of patients will be performed via…
- Trial name
- NCT01331096
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Thyroid, Papillary Thyroid Cancer
A Study of Online Follow-up in Patients With Papillary Thyroid Cancer
The randomized, actively controlled, non-inferiority trial is scheduled to begin in August 2024 and run through August 2026. Inclusion criteria: (1) has undergone microwave ablation of thyroid or thyroidectomy (including…
- Trial name
- NCT06800482
- Testing
- online outpatient follow-up
- Where
- China
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Thyroidectomy
Dysfunction Following Thyroid Surgery
Voice plays a crucial role in human communication and function. Voice production is multidimensional, involving physiologic, biomechanical, and aerodynamic mechanisms that produce an acoustic output that is perceived by the…
- Trial name
- NCT04087447
- Testing
- Thyroidectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Postoperative Sore Throat, Cough, Hoarseness, Thyroid and Parathyroid Surgery
Sore Throat After Open Neck Elective Surgery
This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough…
- Trial name
- STONES (NCT07124650)
- Testing
- Hydrocortisone Acetate 1% Ointment, Lidocaine hydrochloride 0,05% with chlorhexidine
- Where
- Russia
- Volunteers
- 764 people
- Sponsor
- Saint Petersburg State University, Russia
Medullary Thyroid Carcinoma
CTR-FAPI-guided Precision Surgery for Newly Diagnosed MTC
This is a multicenter, randomized, open-label, non-inferiority Phase III clinical trial, aims to compare 68Ga-CTR-FAPI PET-CT-guided surgery to investigator-chosen surgical approaches to evaluate its efficacy in treating newly…
- Trial name
- CAST-MTC (NCT07383246)
- Testing
- 68Ga-CTR-FAPI PET-CT guided surgery, investigator choice of surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Hemithyroidectomy, Outpatient
Randomized Investigation of Thyroid Operation as Day Surgery
hemithyroidectomy as a outpatient procedure is performed in some countries, it has never been done a RCT whether it is feasible
- Conditions
- Hemithyroidectomy, Outpatient, Hemmorhage
- Trial name
- NCT02891252
- Testing
- outpatient procedure
- Where
- Denmark
- Volunteers
- 86 people
- Sponsor
- Zealand University Hospital