Clinical trials: Tidal Volume
Preoxygenation, Anaesthesia Induction
An Algorithmic Approach to Preoxygenation
The aim of this randomized controlled trial is to evaluate an algorithmic approach to gradually adding pressure-supported ventilation and end-tidal positive pressure when conventional tidal volume breathing is insufficient for…
- Conditions
- Preoxygenation, Anaesthesia Induction, Non-invasive Positive Pressure Ventilation
- Trial name
- NCT06736197
- Testing
- Group TVB, Group PSV, Group PSV+PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 378 people
- Sponsor
- Pamukkale University
Development of Pulmonary Dysfunction Following Open Abdominal Surgery
Protective Variable Ventilation for Open Abdominal Surgery
Variable ventilation has been shown to improve lung function and reduce lung damage as well as inflammation in different models of the acute respiratory distress syndrome. Also, variable ventilation is able to recruit lungs.
- Trial name
- PROVAR (NCT01683578)
- Testing
- Variable Ventilation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technische Universität Dresden
Ventilator-Induced Diaphragmatic Dysfunction
Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients
The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on…
- Trial name
- NCT06515600
- Testing
- Practice flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment.
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- South Valley University
Cervical Spinal Cord Injury
A Comparative Study of High and Low Tidal Volume in Preventing Hypoxemia in Patients With Mechanical Ventilation After Cervical Spinal Cord Injury
This study in order to best tidal volume mechanical ventilation in patients with cervical spinal cord injury (sci) as the research point, through higher low volume Settings to find the difference of two groups of patients to…
- Trial name
- NCT04949971
- Testing
- High volume group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
ARDS
Driving Pressure Guided VT in ARDS Patients
A prospective physiologic study, in participants with COVID-19 related or non-COVID-19 related acute respiratory distress syndrome (ARDS) requiring mechanical ventilation less than 48 hours.
- Trial name
- NCT05207267
- Testing
- driving pressure guided tidal volume
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Southeast University, China
Hypoxemia, Pulmonary Sepsis
Lung Protective One-lung Ventilation With Fix and Variable Tidal Volume
During One-lung ventilation, the use of lower tidal volumes (VT) is helpful to avoid over-distension, provide sufficient oxygenation, but can result in increased atelectasis.
- Conditions
- Hypoxemia, Pulmonary Sepsis, ARDS, Human, Pneumonia
- Trial name
- NCT03364465
- Testing
- change of ventilatory settings
- Where
- Hungary
- Volunteers
- 140 people
- Sponsor
- University of Debrecen
To Assess the Ability of PI to Detect Preload Responsiveness
Changes in Pulse-Oximetry Perfusion Index Induced by Tidal Volume Challenge Versus Fluid Volume Challenge to Detect Preload Responsiveness in Mechanically Ventilated Patients With Low Tidal Volume
The primary goal of this study was to assess the ability of PI changes induced by a Vt challenge or fluid challenge test to detect preload responsiveness in critically ill adult patients on mechanical ventilation with low-tidal…
- Trial name
- NCT06673862
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Benha University
End Tidal Carbon Dioxide, Cardiometry
Correlation Between Changes in End-Tidal Carbon Dioxide and Stroke Volume Variation Detected by Electrical Cardiometry as A Predictor of Fluid Volume Responsiveness in Hemodynamically Unstable Patients in the Intensive Care
This study will be conducted to assess the role of end-tidal carbon dioxide (PETCO2) monitoring to predict the fluid volume responsiveness in correlation with stroke volume variation detected by electrical cardiometry in patients…
- Conditions
- End Tidal Carbon Dioxide, Cardiometry, Fluid Responsiveness, Shock
- Trial name
- NCT03932617
- Testing
- end tidal carbon dioxide by capnography
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Tidal Volume
Use of Ulna Length to Predict Tidal Volume in Adult Egyptians
The aim of the study is to evaluate the ability of ulna length to predict accurate protective lung tidal volume in Egyptian people in reference to their standing height.
- Trial name
- NCT04644458
- Testing
- Measuring the ulna length using meauring tape
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Ventilation, End-Tidal Carbon Dioxide
End-tidal Carbon Dioxide Monitoring in Low Tidal Volume Ventilation
In cases where there is no ventilation-perfusion problem, the end-tidal carbon dioxide (ETCO2) value is closely associated with partial arterial carbon dioxide pressure (PaCO2); therefore, the PaCO2 value can be estimated using…
- Trial name
- ETCO2 (NCT04281589)
- Testing
- if the ventilation parameter caused desaturation or hypercapnia we will change the parameter
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Acute Respiratory Distress Syndrome
Effects of End-inspiratory Pause on Ventilation
This study aims to evaluate the effect of reducing tidal volume and respiratory rate together with an end-inspiratory pause setting on ventilatory efficiency and the distribution of inspired gas within the lungs in ARDS patients.
- Trial name
- NCT06692634
- Testing
- mechanical ventilation setting
- Where
- 2 sites in Chile
- Volunteers
- 20 people
- Sponsor
- Clinica las Condes, Chile
ARDS (Acute Respiratory Distress Syndrome)
CUrrent Practices of Intensive Care for the Management of Acute Respiratory Distress Syndrome in EurOpe.
This study seeks to gain a comprehensive understanding of current ARDS management practices across European ICUs, with a particular focus on the use of LTV and PP therapy, which have been shown to improve outcomes in ARDS…
- Trial name
- CUPIDO (NCT06714201)
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Complications
The Effect of Continuous Low Tidal Volume Ventilation During Cardiopulmonary Bypass on Renal Resistive Index
Postoperative acute kidney injury following cardiopulmonary bypass surgery represents a significant barrier to patient recovery and is closely associated with increased postoperative morbidity and mortality.
- Trial name
- NCT07044102
- Testing
- Patients Undergoing Low Tidal Volume Ventilation During CABG, Patients Undergoing Apneic Ventilation During CABG
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Acute Respiratory Failure
Variable Ventilation During Acute Respiratory Failure
Acute respiratory failure requiring support with mechanical ventilation occurs with an incidence of 77-100 per 100,000 person-years and accounts for half of all patients admitted to the intensive care unit.
- Trial name
- NCT01083277
- Testing
- variable ventilation, Conventional ventilation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Boston Medical Center
Postoperative Atelectasis, Ventilator Lung
Ventilator-driven Alveolar Recruitment Maneuver
During laparoscopic surgery, gas infiltration and head down position cause pulmonary atelectasis. Alveolar recruitment maneuvers are beneficial in reopening collapsed alveoli and improving lung mechanics.
- Conditions
- Postoperative Atelectasis, Ventilator Lung, Atelectasis, Recruitment
- Trial name
- NCT04258202
- Testing
- Alveolar recruitment maneuver
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Samsung Medical Center
Pulmonary Atelectasis
Ventilation During Cardiopulmonary Bypass (CPB) for Cardiac Surgery
During most types of heart surgery cardiopulmonary bypass (CPB) is used. CPB enables blood to be directed away from the heart and the lungs and pumped through the body while the heart is not beating.
- Trial name
- NCT02070445
- Where
- Canada
- Sponsor
- McMaster University
Circulatory Failure (Shock)
Fluid-responsiveness in Children Ventilated With LOW Tidal Volume - The FLOW Study.
In this study of diagnostic accuracy, the investigators aim to validate a fluid-responsiveness test in critically ill children mechanically ventilated with low tidal volume.
- Trial name
- FLOW (NCT07494643)
- Testing
- Echocardiographic
- Where
- 6 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Ventilator Lung, Liver Cirrhosis
Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy
This randomized controlled study's objective is to find a safer mechanical ventilation strategy to reduce intraoperative bleeding in liver cancer patients undergoing laparoscopic major liver resection.
- Conditions
- Ventilator Lung, Liver Cirrhosis, Hepatocellular Carcinoma, Blood Loss, Surgical
- Trial name
- NCT05490147
- Testing
- conventional tidal volume (tidal volume [ml]= ideal body weight [kg]* 10~12) group, low tidal (tidal volume [ml]= ideal body weight [kg] * 6~8) volume
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Acute Respiratory Distress Syndrome ARDS
Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is associated with high mortality, some of which can be attributed to ventilator-induced lung injury (VILI) when artificial ventilation is not customized to the severity of lung injury.
- Trial name
- DRIVENT (NCT06322758)
- Testing
- Tidal volume customization in the acute respiratory distress syndrome
- Volunteers
- 750 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilation Therapy; Complications
Amflow-device Can Help Proper Ambu-bag Ventilation
This is a simulation study with a prospective randomized cross-over design. The aim of this study is to evaluate whether Amflow-assisted ambu-bag can delivery the accurate tidal volume compare to ordinary ambu-bag
- Trial name
- NCT03119935
- Testing
- Amflow, Ambu bag
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center