Clinical trials: Tissue Damage
Muscle Damage
Heat Therapy to Accelerate Muscle Recovery
The use of cold on muscle (Ice, Cold Water Immersion - CWI or cryotherapy) is a widespread practice used by health professionals, athletes or non-athletic population in the treatment of muscle soreness and soft tissue injuries.
- Trial name
- NCT05506514
- Testing
- Water immersion
- Where
- Qatar
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Aspetar
Preterm Labor, Cerebral Palsy
Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow
The aim of this study is to investigate the possible use of calcium channel as a neuroprotectant in cases with PTL. This will be done by comparing the effect they have on cerebral blood vessels with the already established MgSo4.
- Trial name
- NCT02591004
- Testing
- Magesium sulphate, Nifedipine, Doppler on fetal middle cerebral artery
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Traumatic and/or Non-traumatic Brain Injury
Assessing Special Features of Impaired Gait After Acquired Brain Injury With an Instrumented Treadmill
Hemiparetic gait following acquired brain injury (ABI) is grossly characterized by decreased speed of walking, increased stance time on the unaffected side, and decreased stance time on the affected side.These abnormalities are…
- Trial name
- NCT01413321
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cerebral Palsy, Rehabilitation
The Effect of Tactile Deficit on Motor Function in Unilateral Cerebral Palsy
Cerebral palsy(CP) is the most common cause of disability in childhood. The motor spectrum of disorders is characterized by abnormal muscle tone, posture, and movement.
- Conditions
- Cerebral Palsy, Rehabilitation, Tactile Perception
- Trial name
- NCT05013814
- Testing
- Semmes-Weinstein monofilament test, Box and Block Test, 9-Hole Peg Test
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Oxidative DNA Damage
Biological Functions of Carotenoids in Humans
This study will examine the the efficiency fo absorption of major plant pigments, carotenoids, (lutein, beta-carotene and lycopene)and will measure the biological functions of carotenoids in healthy women in response to an 8-week…
- Trial name
- NCT00356252
- Testing
- mixed carotenoids
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tufts University
Skeletal Muscle Damage
Recovery Kinetics Following a Soccer Training in Middle-aged Males
This study aims at investigating the recovery kinetics of skeletal muscle damage, neuromuscular fatigue and performance following a single soccer trainning session in middle aged males.
- Trial name
- NCT06260215
- Testing
- ST
- Where
- Greece
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Cerebral Palsy
Urdu Translation Of Pediatric Version Of Eating Assessment Tool
Dysphagia encompasses challenges encountered during the many stages of swallowing, including the oral phase, commencement of the swallow, pharyngeal phase, and esophageal phase.
- Trial name
- NCT06407908
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Unilateral Cerebral Palsy
Multi Sensory Stimulation And Priming (MuSSAP) in Infants at Risk of Unilateral Cerebral Palsy
A pilot randomized clinical trial exploring the effect of a Multi Sensory Stimulation And Priming (MuSSAP) training on improving manual ability in infants at risk of developing unilateral Cerebral Palsy.
- Trial name
- MuSSAP (NCT05533476)
- Testing
- Multi Sensory Stimulation and Priming, Intensive Usual Care (Upper Limb)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sint Maartenskliniek
Cerebral Palsy, Neurologic Disorder
Whole-Body Vibration Therapy in the Gait of Children With Cerebral Palsy
Observation of the effect of vibration therapy on the gait of children with cerebral palsy and the analysis of their functional evolution
- Conditions
- Cerebral Palsy, Neurologic Disorder, Gait Disorders in Children, Hemiplegia
- Trial name
- NCT06314776
- Testing
- Usual physiotherapy without Whole-Body Vibration, Pre-Usual physiotherapy, Post-Usual physiotherapy
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Covid19
DNA Damage and Oxidative Stress in Hospitalized COVID-19 Patients
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic challenging health systems worldwide.
- Trial name
- ABCD (NCT04784468)
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Fear of Falling, Pelvic Joint/Ligament Damage
Impact of Pelvic Joint Stiffness on the Fear of Falling in Subjects Aged Over 75 Years
The pelvic girdle is the mechanical structure at the center of the balance and walking systems. The lack of amplitude of the joints that compose it could induce a fear of falling, common in the geriatric population and often…
- Trial name
- RAAPC (NCT07023718)
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Sud Ile-de-France
Skin Barrier Disruption and Recovery
Evaluation of a Peptide Cream on the Forearm Skin Recovery of Healthy Volunteers
The goal of this clinical trial is to evaluate the efficacy of a topical peptide-based formulation containing Acetyl Hexapeptide-37 in promoting skin barrier recovery after controlled disruption in healthy adult participants.
- Trial name
- NCT07614698
- Testing
- Acetyl Hexapeptide-37
- Where
- Croatia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Covid19, Angiogenesis
Endothelial Damage and Angiogenesis Biomarkers During COVID-19
Severe SARS-CoV-2 disease is characterized by a progressive hypoxemic respiratory failure. Autopsies from these patients show severe endothelial damage with extensive vascular thrombosis, microangiopathy, and occlusion of…
- Conditions
- Covid19, Angiogenesis, Endothelial Dysfunction, Cardiovascular Morbidity
- Trial name
- NCT04609332
- Testing
- Endothelial damage and angiogenic biomarkers
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chile
Exercise Recovery
Post-exercise Therapeutic Modalities on Functional Performance, Muscle Damage and Oxidative Stress of CrossFit® Athletes
Crossfit® is a training modality that consists in functional movements, constantly varied and executed at high intensity. Both training sessions and competitions involve physically demanding activities, which in addition to being…
- Trial name
- NCT06628609
- Testing
- Passive recovery, PBMT-sMF, Shock wave
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Intubation; Difficult or Failed, Sore-throat
Intubation with Different Angled Intubation Tubes Using C-macr D Blade Videolaringoscope;
In this study we compared post-operative sore throat, ease and time of intubation, hoarseness, subglottic damage and hemodynamic changes to orotracheal intubation using three different intubation stylets with C-MAC R…
- Conditions
- Intubation; Difficult or Failed, Sore-throat, Hoarseness
- Trial name
- NCT06011967
- Testing
- Intubation using C-MAC D blade videolariyngoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Muscle Damage
The Effects of Protein Supplementation in Females and Males Following Acute Eccentric Exercise
Examine the impact of the protein supplements leucine, HMB and BCAA on muscle recovery and inflammatory response following acute exercise.
- Trial name
- NCT04679519
- Testing
- Drop Jumps
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Cerebral Palsy
HMB Cerebral Palsy Pilot Study
This is a pilot study of β-hydroxy-β-methylbutyrate (HMB) + Vitamin D3 supplementation in adolescents with cerebral palsy. The primary objective is to quantify safety, compliance, and acceptability of daily combined HMB + Vitamin…
- Trial name
- NCT05384951
- Testing
- HMB + Vitamin D3
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Gillette Children's Specialty Healthcare
Glycogen Storage Disease, McArdle Disease
Carbon-13 Magnetic Resonance Spectroscopy in Glycogen Storage Diseases
The project will use carbon-13 magnetic resonance spectroscopy to assess whether high glycogen levels in skeletal muscle of patients with Glycogen Storage Diseases is a prelude for muscle damage.
- Conditions
- Glycogen Storage Disease, McArdle Disease, Pompe Disease (Late-onset)
- Trial name
- NCT04929002
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cerebral Palsy, Spastic
Associated Disorders of Locomotion and Postural Control of Axial Segments in Cerebral Palsy
Gait abnormalities, which occur in Cerebral Palsy (CP), are characterized usually by a toe-to-floor or a plantar-to-floor initial contact (equinus gait), followed by an early braking of the tibia's forward progression (during…
- Trial name
- NCT04287673
- Testing
- Rehabilitation involving strongly the trunk
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Muscle Damage, Inflammation
Protein and Recovery From Exercise-induced Muscle Damage
Intense, eccentric resistance exercise causes muscle damage, soreness, inflammation, and a loss of muscle function. Protein-amino acid supplementation before, during, and following damaging resistance exercise may reduce muscle…
- Trial name
- NCT02034721
- Testing
- Protein supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Appalachian State University