Clinical trials: Tissue Grafts
Complications of Transplanted Organs and Tissue, Diabetes Mellitus Nos New Onset
Diabetogenicity of Cyclosporine and Tacrolimus
Cyclosporine (CsA) and Tacrolimus (Tac) are immunosuppressive agents comprising the cornerstone of treatment among organ transplant recipients.
- Trial name
- CSATAC (NCT00766909)
- Testing
- cyclosporine, tacrolimus, Capsules and isotonic saline
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gingival Thickness
Soft Tissue Augmentation Using CAF With Either SCTG and Vitamin C Versus SCTG Alone in Management of RT1 Gingival Recession
Compare gingival thickness following CAF With SCTG and Vitamin C Versus SCTG Alone in Management of RT1 Gingival Recession.
- Trial name
- NCT04632693
- Testing
- CAF with SCTG and Vitamin C injection, CAF with SCTG alone
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Edentulous Alveolar Ridge Atrophy, Soft Tissue Augmentation At Dental Implants
Cross-linked Volume-stable Collagen Matrix Versus Connective Tissue Graft At Implant Site.
Recent data suggested that an adequate volume of Keratinized Tissue (KT) around dental implant is a key factor to obtain aesthetic outcomes and to support easy long-term maintenance.
- Trial name
- NCT05458271
- Testing
- VCMX, CTG
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Florence
Anterior Cruciate Ligament Injuries
Comparative Study of the Inclination Angle and Complications of Eccentric Grafts Position in ACL Reconstruction and Normal ACL: Retrospective Cohort
The anatomic ACL reconstruction aims at functional restoration of the ACL to its native dimensions, collagen orientation and insertion sites.
- Trial name
- NCT04188704
- Testing
- Interference screw
- Volunteers
- 108 people
- Sponsor
- Ramathibodi Hospital
Vitiligo
Punch Minigraft Versus Transverse Needling or Combination of Both in Treatment of Non-Segmental Vitiligo
This study is to evaluate the effectiveness and tolerability of autologous punch minigraft, transverse needling technique or combination of both followed by narrow band ultraviolet B phototherapy (311 nm) in the treatment of…
- Trial name
- NCT03872804
- Testing
- Autologous punch mini grafts:, Transverse needling, Punch minigrafts followed by transverse needling
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Coronary Heart Disease, Surgical Wound Infection
Antibiotic Concentration in Internal Mammary Graft Preparation
The negative effect of internal mammary harvesting on sternal perfusion is well known, especially in diabetic subjects. Microdialysis previously showed increased lactate tissue concentration after mammary artery preparation.
- Trial name
- NCT01324804
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Gingival Recession, Localized
Effect of Restoration Margin Level in the Treatment of Gingival Recession Associated With Non-carious Cervical Lesion
The aim of this randomized, parallel-group clinical trial was to compare the 1-year periodontal, root coverage, esthetic, and patient-centered outcomes of the partial restoration placement with different apical margin levels…
- Trial name
- NCT05682274
- Testing
- Partial restoration approach combined with CAF+CTG
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Gingival Recession, Periodontal Diseases
The Effect of Enamel Matrix Derivatives on Root Coverage Esthetic Score
Subepithelial connective tissue grafts (SCTG) are accepted as the gold standard in covering denuded root surfaces. Combining enamel matrix derivatives (EMD) with periodontoplasic surgical operations is another method in covering…
- Trial name
- NCT03197610
- Testing
- enamel matrix derivatives
- Volunteers
- 19 people
- Sponsor
- Yuzuncu Yil University
Recessive Dystrophic Epidermolysis Bullosa
Clinical Trial to Assess Safety and Efficacy of Autologous Cultured Epidermal Grafts Containing Epidermal Stem Cells Genetically Modified in Patients With RDEB.
Prospective open-label, uncontrolled clinical study to assess the safety and efficacy of autologous cultured epidermal grafts containing epidermal stem cells genetically modified with the aid of a gamma-retroviral vector carrying…
- Trial name
- HOLOGENE7 (NCT02984085)
- Testing
- Genetically corrected cultured epidermal autograft (ATMP)
- Where
- Austria
- Volunteers
- 3 people
- Sponsor
- Holostem s.r.l.
Cutaneous Ulcer, Trauma Injury
Reconstruction of Skin Substance Loss With "Micro-grafts" Obtained by Mechanical Disintegration
The etiology of non-healing ulcers depends on both systemic and local factors. The introduction of advanced dressing, negative wound therapy and compression therapy have undoubtedly improved clinical outcomes.
- Trial name
- MG-1 (NCT04030832)
- Where
- 4 sites in Italy
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Gingival Recession
To Compare Two Commonly Used Soft Tissue Grafting Techniques to Achieve Coronal Flap Advancement and Root Coverage
This study will compare two incision designs to allow for coronal gingival/mucosal flap advancement and tissue augmentation with acellular dermal matrix (ADM) graft around teeth with gingival recession and a lack of adequate…
- Trial name
- VISTA (NCT03566108)
- Testing
- VISTA, STA
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Epidermolysis Bullosa Dystrophica, Recessive
Ex Vivo Gene Therapy Clinical Trial for RDEB Using Genetically Corrected Autologous Skin Equivalent Grafts
This phase I/II clinical trial aims to treat 3 adult subjects with Recessive Dystrophic Epidermolysis Bullosa, expressing residual C7 levels, by genetically corrected autologous skin equivalent grafts on selected areas (up to 300…
- Trial name
- EBGraft (NCT04186650)
- Testing
- COL7A1-SIN retroviral vector engineered autologous tissue-engineered skin
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Esthetic Zone
Evaluation of Patient Morbidity and Root Coverage Outcomes of VISTA Versus CAF in Treating Gingival Recession
To evaluate and compare Vestibular Incision Subperiosteal Tunnel Access (VISTA) technique,with connective tissue graft; versus Coronally Advanced Flap (CAF) technique;with connective tissue graft, in treating gingival recession…
- Trial name
- VISTA (NCT06723314)
- Testing
- Vestibular Subperiosteal Tunnel Access vista
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Misr International University
Gingival Recession
PRF for Treating Maxillary Gingival Recession
This is a split-mouth, randomized, controlled clinical trial that aims to evaluate the clinical efficacy of platelet-rich fibrin (PRF) membranes in conjunction with coronally advanced flap (CAF) in treating maxillary gingival…
- Trial name
- NCT05267015
- Testing
- Gingival coverage using coronally advanced flap and a connective tissue graft, Gingival coverage using coronally advanced flap and platelet rich fibrin membranes
- Where
- Palestinian Territories
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Arab American University (Palestine)
Facial Injuries, Adipose Tissue
Structural Fat Grafting for Craniofacial Trauma: Repeat Fat Grafting Injection-5 Subject Cohort
Fat grafting represents a technique with great potential to improve outcomes in minimally invasive facial reconstruction. Fat grafting has already been demonstrated as a safe and minimally invasive technique over decades of…
- Trial name
- BTIPlusUp (NCT01822301)
- Testing
- Repeat Fat grafting
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pittsburgh
Cancer
Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant
RATIONALE: Methotrexate and glucocorticoid therapy, such as prednisone or methylprednisolone, may be an effective treatment for acute graft-versus-host disease caused by a donor stem cell transplant.
- Trial name
- NCT00357084
- Testing
- methotrexate, methylprednisolone, prednisone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Variation of Keratinized Mucosa After Implant Surgery
Keratized Mucosa in CG Implant Placement: CTG vs Flapless
The present study will evaluate the difference in terms of keratinazed mucosa (KM) in computer guided implant placement with immediate loading, comparing a flapless approach to flap surgery with connective tissue graft.
- Trial name
- NCT05073952
- Testing
- Connective tissue graft, Flapless
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Milan
Gingival Recession
Collagen Matrix With Tunnel Technique Compared to CTG for the Treatment of Periodontal Recessions
The aim of this study is to compare the efficacy of dental root coverage using the tunnel technique with connective tissue graft (CTG) and the same technique with collagen matrix for treatment of multiple gingival recessions…
- Trial name
- NCT02632240
- Testing
- Surgery:The tunnel technique for covering gingival recession
- Where
- Poland
- Volunteers
- 28 people
- Sponsor
- Medical University of Silesia
Breast Neoplasms, Carcinoma, Ductal, Breast
Study of Autologous Fat Enhanced w/ Regenerative Cells Transplanted to Reconstruct Breast Deformities After Lumpectomy
A post-marketing study evaluating the transplantation of autologous fat augmented with Adipose Derived Regenerative Cells (ADRCs), in patients with functional and cosmetic breast deformities post segmental mastectomy or…
- Conditions
- Breast Neoplasms, Carcinoma, Ductal, Breast, Mammaplasty, Mastectomy, Segmental, Lumpectomy, Breast Reconstruction,
- Trial name
- RESTORE-2 (NCT00616135)
- Testing
- ADRC-Enhanced Autologous Fat Transplant
- Where
- 5 sites in Belgium, Italy and 2 more
- Volunteers
- 71 people
- Sponsor
- Cytori Therapeutics
Gingival Recession, Gingival Recession, Generalized
Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Adjunctive Therapies
The aim of this study was to evaluate the effect of two different treatment agents used in conjunction with subepithelial connective graft technique on root coverage outcomes in multiple recession defects.
- Trial name
- NCT03462368
- Testing
- Control, antimicrobial photodynamic therapy, Photobiomodulation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo