Clinical trials: Tissue Grafts
Cruciate Ligament Reconstruction
Comparison of Tendon and Muscle-Tendon Semitendinosus Grafts After ACL Reconstruction
Aim: Comparison of tendon to bone ingrowth in bone tunnels and intra-articular remodeling of the graft after anterior cruciate ligament surgery with a muscle-tendon graft and those with a tendon graft.
- Trial name
- CandyStripe (NCT07404046)
- Testing
- ACL reconstruction
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University Hospital Dubrava
Tooth Fractures
Immediate Implant Placement With Connective Tissue Graft or Socket Shield
The present study aims to evaluate the clinical outcomes of immediate implant placement with connective tissue graft or socket shield.
- Trial name
- NCT03594019
- Testing
- Connective tissue graft, socket shield technique, Immediate implant placement
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Cleft Lip and Palate
Alveolar Cleft Hard- and Soft Tissue Reconstruction With an Autogenous Tooth Derived Particulate Graft
The present study aims at clinical and radiographic evaluation of the safety and efficacy of Bonmaker ATB powder combined with a novel split thickness papilla curtain flap in the treatment of alveolar cleft defects.
- Trial name
- NCT05971914
- Testing
- Autogenous tooth derived particulate graft and a novel split thickness papilla curtain flap
- Where
- Hungary
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Breast Cancer, Chronic Myeloproliferative Disorders
Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant
RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00900406
- Testing
- gene expression analysis, microarray analysis, polymorphism analysis
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Gingival Recession
CAF With or Without CTG for the Treatment of Single Maxillary Gingival Recession With NCCL
This studies evaluate the efficacy of the coronally advanced flap (CAF) with or without connective tissue graft (CTG) for the treatment of single maxillary recession associated to non carious cervical lesion (NCCL).
- Trial name
- NCT03862534
- Testing
- CAF, CAF + CTG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florence
Chronic Diabetic Foot Ulcer
Clinical Evaluation of DCB-WH1 in Healing of Chronic Diabetic Foot Ulcers
The primary objective of this Phase 2 study is to evaluate the efficacy of DCB-WH1 ointment in wound closure as compared to vehicle control when applied topically to chronic diabetic foot ulcers for 12 weeks.
- Trial name
- NCT00709514
- Testing
- DCB-WH1 ointment
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Oneness Biotech Co., Ltd.
Metastatic Breast Cancer, Malignant Melanoma
Activated Allogeneic Lymphocytes for Induction Graft Versus Tumor Effect in Metastatic Solid Tumors
The present protocol is a phase 2 study designed to investigate the potential application of allogeneic cell-mediated immunotherapy in metastatic solid tumors, similarly to the well established graft versus leukemia (GVL)…
- Conditions
- Metastatic Breast Cancer, Malignant Melanoma, Renal Cell Cancer, Gastrointestinal Cancer
- Trial name
- rIL-2(LAK) (NCT00855452)
- Testing
- one - three cycles of cell therapy during 4-6 weeks (3-5x10^7 cells/kg will be given through IV systemically
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
GINGIVAL RECESSION
Growth Factor Enhanced Matrix With Subepithelial Connective Tissue Graft or Collagen Membrane in Treatment of Gingival Recession
The study aimed to compare, the effectiveness of Growth Factor Enhanced Matrix (GEM 21s) ® combined either with free connective tissue graft or collagen membrane in the treatment of Miller class II gingival recession.
- Trial name
- NCT05782751
- Testing
- GROUPI, GROUP II
- Where
- 2 sites in Egypt
- Volunteers
- 10 people
- Sponsor
- Tanta University
Gingival Recession, Plastic Surgery
Clinical Evaluation of (TCAF) Versus (CAF) Combined With Connective Tissue Graft in the Treatment of Multiple RT2 Gingival Recession Sites
the aim of the study is to evaluate the changes in gingival recession depth reduction following, treatment of multiple RT2 recession with tunnel coronal advanced flap in comparison to coronal advanced flap, both combined with…
- Trial name
- NCT07064603
- Testing
- TCAF
- Volunteers
- 22 people
- Sponsor
- Cairo University
Craniofacial Microsomia
Fat Grafts With Adipose-derived Regenerative Cells for Soft Tissue Reconstruction in Children
Although first reports of the clinical use of adipose-derived regenerative cells (ADRC) suggest that this approach may be feasible and effective for soft tissue augmentation, there is a lack of randomized, controlled clinical…
- Trial name
- NCT03806361
- Testing
- Fat grafts supplemented with ADRC, Structural fat grafting
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital Sirio-Libanes
Wound Healing, Palatal Wound
The Effectiveness of Nano Bio Fusion Gingival Gel (NBF) on Wound Healing at the Palate (Donor Site) After Soft Tissue Graft Surgery Compared to Placebo Gel.
The goal of this clinical trial is to assess the effect of Nano-biofusion gingival gel (NBF) on wound healing at the palatal donor site following soft tissue graft surgery and compare it to placebo gel.
- Conditions
- Wound Healing, Palatal Wound, Donor Site Complication, Inflammatory Cytokines
- Trial name
- NCT07330154
- Testing
- Application of NBF gel after soft tissue graft surgery
- Where
- Jordan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Gingival Recession, Plastic Surgery
Non-Inferiority of Fibroguide Collagen Membrane Compared to Autologous Connective Tissue Graft for Coverage of Multiple Adjacent Recession. Multicenter Trial.
This study deals with coverage of multiple denuded roots. The current standard treatment requires surgical correction and uses soft tissue taken from the roof of the mouth to enhance results.
- Trial name
- NCT07083050
- Testing
- Volume stable collagen matrix, Autologous Connective Tissue Graft from the Hard Palate
- Where
- 2 sites in Italy, Spain
- Volunteers
- 160 people
- Sponsor
- Maurizio Tonetti
Gingival Recession
A New Therapeutic Approach for Root Coverage
Different surgical techniques have been proposed for root coverage, showing varying results especially in areas of deep recessions.
- Trial name
- NCT01143610
- Testing
- Newly forming bone technique for root coverage, Subepithelial connective tissue graft for root coverage.
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Implants, Peri-Implantitis
Increased Peri-implant Keratinized Mucosal Thickness at Different Operative Times
Keratinized mucosa, which is composed of free gingiva and attached gingiva, is a barrier against bacterial invasion in oral cavity and provides good tissue sealing for periodontal environment.
- Trial name
- NCT04683991
- Testing
- Subepithelial connective tissue graft
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gingival Recession
Use of Platelet Rich Fibrin in Addition to CAF and SCTG for Treatment of Gingival Recession
This research will be conducted in an attempt to achieve complete root coverage with physiologic probing depth and a harmonious view with the adjacent tissues using Platelet rich fibrin in conjunction with Coronally advanced flap…
- Trial name
- NCT03199118
- Testing
- CAF +SCTG, platelet rich fibrin
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Primary Immune Deficiency Disorders, Hemophagocytic Lymphohistiocytosis
Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases
The purpose of this study is to determine a safe dose of BPX-501 gene modified T cells infused after a haplo-identical stem cell transplant to facilitate engraftment and the safety of Rimiducid (AP1903) on day 7 to prevent GVHD.
- Conditions
- Primary Immune Deficiency Disorders, Hemophagocytic Lymphohistiocytosis, Inherited Bone Marrow Failure Syndrome, Hemoglobinopathies
- Trial name
- NCT02231710
- Testing
- BPX-501 and Rimiducid
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Bellicum Pharmaceuticals
Soft Tissue Thickness Arround Implants
Implants Placement with Simultaneous Soft Tissue Augmentation Using a Collagen Matrix Compared to Connective Tissue Graft: a Pilot Study
Background: To our knowledge, no study evaluated the use of VCMX at multiple implant sites and compared its efficacy and safety to a SCTG with the same dimensions.
- Trial name
- NCT06585813
- Testing
- dental implant, Fibrogide membrane, connective tissue graft
- Where
- Lebanon
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Necrotizing Soft Tissue Infection
Negative Pressure Wound Therapy and Allogeneic Human Skin Grafts for Wound Bed Preparation
Introduction Necrotising soft tissue infections (NSTI) incorporate a spectrum of pathologies, all characterized by an infectious state, typically arising after a penetrating trauma or a surgical procedure and an expeditious…
- Trial name
- NPWTvsGPA (NCT02314468)
- Testing
- Negative pressure wound therapy, Glycerol Preserved Allografts (GPA)
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Horizontally Deficient Alveolar Ridges, Hard and Soft Tissue Augmentation During Delayed Implant Placement
Effectiveness of Subepithelial Connective Tissue Graft as an Autogenous Barrier Membrane for Hard and Soft Tissue Augmentation in Horizontally Deficient Ridges During Delayed Implant Placement
This study evaluates the clinical effectiveness of using a patient's own subepithelial connective tissue graft as a natural barrier membrane during simultaneous hard and soft tissue augmentation in areas of the jawbone with…
- Trial name
- CBCT-GBR-SECTG (NCT07861724)
- Testing
- Subepithelial Connective Tissue Graft as an Autogenous Barrier Membrane for Hard and Soft Tissue Augmentation in Horizontally Deficient Ridges during delayed implant placement
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Wound Healing
Manuka Honey for Wound Care
Since antiquity, honey has been recognized for its healing properties. Literature about the use of medicinal honey for wound care dates back centuries with recent data suggesting its use in patients suffering from burns or…
- Trial name
- NCT02259491
- Testing
- Manuka Honey Dressing
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai