Clinical trials: Tobacco Consumption
HIV/AIDS, Smoking Cessation
Learn to Quit-HIV Pilot Study
The study team will conduct a feasibility, acceptability, and preliminary efficacy trial comparing Learn to Quit-HIV (n=30) to an app based on U.S.
- Conditions
- HIV/AIDS, Smoking Cessation, Tobacco Use Disorder
- Trial name
- NCT04609514
- Testing
- Learn to Quit-HIV, QuitGuide, Nicotine patch
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Duke University
Cigarette Smoking
Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity
The central objective of this project is to obtain proof-of-concept data demonstrating the effects of propranolol (a beta-adrenergic antagonist) on neurobiological responses to personal smoking environments and behavioral…
- Trial name
- ProCue (NCT03309943)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
Cigarette Smoking
Cognitive and Emotional Skills to Aid Smoking Cessation
Cigarette smoking is a leading cause of morbidity and mortality in the United States. Among individuals who engage in smoking cessation treatment, attrition rates remain high.
- Trial name
- NCT03148652
- Testing
- Enhanced Intervention Condition
- Where
- United States
- Sponsor
- Boston University Charles River Campus
Multiple Sclerosis
The Effect of Cigarette Smoke on Sleep Quality and Physical Activity in People With Multiple Sclerosis
Current evidence suggests that cigarette smoke increases disease progression in people with multiple sclerosis (PwMS) and worsen their symptoms. 70% of PwMS report sleep disturbances that negatively affects their quality of life.
- Trial name
- Smoke-MS (NCT05046535)
- Testing
- Sleep quality and physical activity, Nicotine dependence, Nicotine and cotinine serum levels
- Where
- Jordan
- Volunteers
- 72 people
- Sponsor
- University of Jordan
Nicotine Use Disorder
Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity
The primary goal will be to identify the optimal pulse protocol by systematically measuring the efficacy of various theta burst stimulation and repetitive rTMS protocols to increase and decrease the reward positivity in dependent…
- Trial name
- NCT06695884
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Rutgers, The State University of New Jersey
Smoking Cessation, Smoking, Tobacco
Contingency Management for Smoking Cessation
The prevalence of smoking in the homeless population (70%) is over 4 times that of the general population (15%). Homeless adults have not experienced similar declines in tobacco use as the general population has over the past…
- Conditions
- Smoking Cessation, Smoking, Tobacco, Smoking Reduction
- Trial name
- NCT04982952
- Testing
- Contingency Management - Increasing, Fixed payments
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking, Cigar
Cigarillo Warnings Image Sorting Study
The goal of this study is to examine the impact of repeated exposure to cigarillo warnings on cigarillo users' intentions and behaviors for cigarillo smoking.
- Trial name
- NCT05838378
- Testing
- Package image sorting with pictorial warnings, Package image sorting with Surgeon General text-only warnings, Package image sorting with FDA text-only warnings
- Where
- United States
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- Boston University
Nicotine Dependence, Tobacco Smoking
Effects of Intranasal Oxytocin on Cigarette Smoking
Socioemotional processing dysfunctions (i.e., disruptions in affective, cognitive, and neural processes that encode, interpret, and respond to socially and emotionally relevant stimuli) have been implicated in tobacco smoking and…
- Trial name
- NCT02595749
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Tobacco Dependence
Varenicline for Long-term Nicotine Replacement Therapy (NRT) Users
Primary aim: Will varenicline be better than placebo to get long-term users of NRT to stop? Secondary aim: To assess in details some side effects of varenicline i.e. nausea and abnormal dreams.
- Trial name
- NCT00977249
- Testing
- support and visits, varenicline
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Cone Beam Computed Tomography, Periodontitis
Evaluation of the Effects of Smoking on Trabecular Bone Microarchitecture Using CBCT in Periodontal Disease
The purpose of this cross-sectional study is to evaluate the morphometric properties of trabecular bone quality using Cone-beam computed tomography in periodontal disease at different stages, comparing smokers and non-smokers.
- Conditions
- Cone Beam Computed Tomography, Periodontitis, Diagnosis of Bone Quality, Diagnosis, Oral
- Trial name
- NCT06676358
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Okan University
Nicotine Dependence
IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior
Clinical studies are proposed to analyze the interactions between nicotine, alterations in endocrine hormones, mood and cardiovascular measures.
- Trial name
- NCT01589055
- Testing
- Intravenous Nicotine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Tobacco Use Disorder/Cigarette Smoking, HIV
Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial
Cigarette smoking is an important cause of illness and death among persons with HIV (PWH). This project will study the impact of adding contingency management (use of financial rewards) to receiving medications and counseling on…
- Trial name
- NCT07835555
- Testing
- nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster
- Where
- 5 sites in United States
- Volunteers
- 794 people
- Sponsor
- Yale University
Tobacco Use Disorder, Bone Fractures
Smoking Cessation and a Teachable Moment in Patients With Acute Fractures
Patients who smoke and suffer from fractures are worse off than those who do not smoke. Orthopaedic patients represent a group that can benefit from physician contributions to smoking cessation, and a special opportunity to cue…
- Trial name
- NCT02781038
- Testing
- Teaching intervention, Control
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use Disorder, Alcohol Use Disorder
Cytisine for Smoking Cessation
The goal of this clinical trial is to evaluate the safety and effectiveness of cytisine as a smoking cessation treatment in individuals with concurrent alcohol use disorder.
- Conditions
- Tobacco Use Disorder, Alcohol Use Disorder, Smoking Cessation
- Trial name
- NCT05729243
- Testing
- Cytisine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Tabacco Use Disorder, rTMS
Personalized Brain Stimulation to Help Veterans Quit Smoking
Cigarette smoking is a significant public health concern for Veterans. Encouraging smoking cessation continues to be a top priority for the Veterans' Administration as Veterans who use tobacco experience negative health effects…
- Trial name
- VICTOR (NCT07050862)
- Testing
- Transcranial Magnetic Stimulation, Personalized-image-guided and E-field-modeling dose rTMS (precision TMS)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- VA Office of Research and Development
Smoking, Tobacco
Smoking Reduction Intervention for Smoking Parents of Paediatric Patients in Hong Kong
A randomized controlled trial to evaluate the effectiveness of smoking reduction interventions for smoking parents in paediatric hospital setting in Hong Kong.
- Trial name
- NCT03879889
- Testing
- Nicotine patch
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- Chinese University of Hong Kong
Current Smoker, Tobacco Smoking
Project MARS: Mobile-Assistance for Regulating Smoking
This study aims to investigate approaches to capitalize on states of vulnerability and receptivity to deliver real-time self-regulation prompts among smokers.
- Trial name
- MARS (NCT04376489)
- Testing
- Messages recommending low effort strategies (participants experiencing negative affect & cigarettes are available), Messages recommending low effort strategies (participants not experiencing negative affect & cigarettes are available), Messages recommending low effort strategies (participants experiencing negative affect & cigarettes are not available)
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Utah
Tobacco Use in Childbirth, Smoking Cessation
Fish Oil to Reduce Tobacco Use iN Expectant Mothers Study
The purpose of this feasibility study is to obtain pilot data in preparation for an upcoming R01 submission. The goals of that submission will be to conduct a clinical trial of n-3 LCPUFAs for smoking cessation in pregnant women.
- Conditions
- Tobacco Use in Childbirth, Smoking Cessation, Pregnancy Related
- Trial name
- FORTUNE (NCT03077724)
- Testing
- Fish oil
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Smokeless Tobacco Use
A Pilot Study Evaluating Nicotine Lozenges and Self Help
The investigators are hypothesizing that by offering both self-help materials and mailed nicotine lozenges we will be able to help increase tobacco abstinence rates among ST users, as well as decrease tobacco withdrawal.
- Trial name
- NCT00888459
- Testing
- nicotine replacement therapy
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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