Clinical trials: Tobacco-Related Disorders
Addictive Behavior, Alcohol Use Disorder (AUD)
Volitional Dysfunction in Self-control Failures and Addictive Behaviors
The aim of this project is to elucidate whether impairments of cognitive control, performance-monitoring, and value-based decision-making and dysfunctional interactions between underlying brain systems are mediating mechanisms…
- Conditions
- Addictive Behavior, Alcohol Use Disorder (AUD), Tobacco Use Disorder, Self-Control
- Trial name
- NCT04498988
- Testing
- Observational study without interventions
- Where
- Germany
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Drug Addiction, Nicotine Dependence
Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray
Background: Smoking is the leading cause of preventable death in the United States, and researchers are interested in gaining a better understanding of the perceived beneficial effects of nicotine to help improve treatment…
- Trial name
- NCT01136642
- Testing
- Nicotrol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Transcranial Direct Current Stimulation in a Smoking Cessation Trial
The purpose of this study is to determine the effectiveness of transcranial direct current stimulation (tDCS) plus nicotine patch as a viable smoking cessation program for nicotine dependent smokers.
- Trial name
- tDCS (NCT01710410)
- Testing
- active transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use Disorder
A Bioequivalence Study of Three, 2 mg Nicotine Chewing Gums (Two Tests and One Reference) in Healthy Adult Smokers
This is a randomized, open-label, single-dose, three-period, crossover, single-center comparative bioavailability (BA) study under fasting condition in Chinese healthy male adult participants with a history of cigarette smoking.
- Trial name
- NCT02688374
- Testing
- Treatment A: Nicorette 2 mg coated mint gum, Treatment B: Nicotinell 2 mg coated mint gum, Treatment C: Nicotinell 2 mg coated fruit flavor gum
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tobacco Dependence
Low Nicotine Cigarettes Plus Electronic Cigarettes
This study aims to determine the health effects of very low nicotine content in cigarettes, in conjunction with the availability of nicotine-containing electronic cigarettes (e-cigs) among smokers with mental health conditions…
- Trial name
- NCT04058717
- Testing
- Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Dependence
Smoking Cessation With Smokeless Tobacco, Nicotine Tablets and Nicotine Patches
To test if smokeless tobacco is more effective than nicotine buccal tablets in smoking cessation compared with a control group with low dose nicotine patches.
- Trial name
- NCT00313105
- Testing
- Smokeless tobacco (Oliver Twist pellets), smoking cessation counseling
- Where
- Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Alcohol Use Disorder, Cigarette Smoking
Semaglutide for Alcohol Use Disorder
This is an early-Phase II human laboratory trial using a randomized, placebo-controlled, dose-ranging design to investigate the effects of semaglutide, a GLP-1 receptor agonist, on alcohol-related outcomes in adults with alcohol…
- Trial name
- NCT05520775
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Insomnia, Nicotine Dependence
Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation.
- Trial name
- NCT00511134
- Testing
- Eszopiclone, Bupropion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
Little Cigars and Cigarillos (LCC) Use
Little Cigar and Cigarillo Warnings for Youth
This study explores the effect of the little cigars and cigarillos (LCC) warnings on youth who currently use, have ever used, or are susceptible to using LCCs.
- Trial name
- NCT06413797
- Testing
- FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings
- Where
- United States
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Tobacco Use Disorder
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the…
- Trial name
- NCT03713424
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Cannabis Use Disorder, Tobacco Use Disorder
Clinical Trial Tobacco Marijuana
Approximately 50% of persons seeking treatment for cannabis-use disorders (CUDs) regularly smoke tobacco. Combining tobacco with cannabis has become a common method of smoking cannabis.
- Trial name
- RCTTM (NCT02277665)
- Testing
- CUD Treatment, Tobacco Treatment
- Where
- 3 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Nicotine Dependence
Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers
The purpose of this study is to evaluate reactions to, and choices to self-administer, cigarette smoke with varying nicotine content among low-frequency, non-dependent adolescent/young adult smokers between the ages of 15-25…
- Trial name
- NicRed (NCT02989038)
- Testing
- Very Low Nicotine Content Cigarettes, Intermediate Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Duke University
Nicotine Dependence
Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity
Background: Smoking is a difficult habit to quit, and some people find it more difficult to quit than others do. Nicotine is the substance in cigarettes that makes smoking so addictive.
- Trial name
- NCT01867411
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder, Smoking
A Pilot Study to Evaluate the Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge
This is a study to determine the safety and effectiveness of silver salt in Ariva® Silver Wintergreen Lozenge on discouraging smoking, by its imparting an unfavorable taste to the smoker when tobacco is smoked.
- Trial name
- NCT01336816
- Testing
- Ariva Silver Wintergreen
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Star Scientific, Inc
Smoking Cessation
Treatment of Smoking Lapses and Relapses
Many smokers who try to stop smoking with nicotine medications (NM) such as gum, lozenge and patch, go back to smoking (i.e., a slip or lapse).
- Trial name
- NCT01807871
- Testing
- nicotine patch, experimental use, nicotine patch, labeled use
- Where
- United States
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Smoking, Smoking Behaviors
Human Perception of Odors and Odor Blockers
The goal of this clinical trial is to determine whether blockers of perception of key odorants in cigarette smoke have any utility in smoking cessation.
- Trial name
- NCT06191419
- Testing
- Odorants
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Tim McClintock
Anxiety Disorders, Depression
Personalized Feedback for Distress Intolerant Smokers
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and distress tolerance.
- Conditions
- Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence
- Trial name
- NCT03918031
- Testing
- PFI for Smoking & Distress Tolerance, PFI for Smoking Only
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Houston
Tobacco Dependence, Tobacco Smoking
Smoke-free Home Study in Subsidized Housing
Comprehensive smoke-free policies have the potential to substantially reduce tobacco-related disparities among populations in subsidized housing.
- Trial name
- NCT06170437
- Testing
- Smoke-free home resident intervention, Lay Health Worker coaching
- Where
- United States
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use, Nicotine Dependence, Other Tobacco Product
A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers
A Study to Characterize Puff Topography with Use of a JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers
- Conditions
- Tobacco Use, Nicotine Dependence, Other Tobacco Product, Tobacco Smoking
- Trial name
- NCT03596034
- Testing
- JUUL 5%, Virginia Tobacco, ENDS product
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Nicotine Dependence, Cigarettes
Penn State TXT2Quit Study
This study is evaluating the feasibility and short term smoking cessation outcomes of an automated smoking cessation intervention delivered via mobile phone text messaging as an adjunct to Varenicline in a primary care setting.
- Trial name
- NCT02367391
- Testing
- Motivational Text Messages, Control
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center