Clinical trials: Tolerance
Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus
Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)
A diagnosis of gestational diabetes mellitus (GDM)has significant implications for the future health of the mother. GDM is often the culmination of years of unrecognized and unmodified diabetes risk factors that lead to overt and…
- Conditions
- Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT01234649
- Testing
- Metformin XR plus liraglutide
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Woman's
Diabetes Mellitis Type 2
A Study to Characterize the Pharmacokinetics/Pharmacodynamics and Effect of Food of DA-1229 in Healthy Male Subjects
This is a dose block-randomized, double-blind, placebo-controlled, single/multiple dosing, dose-escalation study. The study is designed to describe the relationship between multiple doses and pharmacokinetic/pharmacodynamic…
- Trial name
- NCT00961025
- Testing
- DA-1229
- Where
- South Korea
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Dong-A Pharmaceutical Co., Ltd.
Overdose
Does a Soft Drink Mixture Improve Tolerance of Activated Charcoal in the Adult Poisoned Patient Without Affecting Efficacy
Activated charcoal (AC) is an established, effective means of gastrointestinal decontamination. Providers give it to patients who have ingested something that is thought to be potentially poisonous to prevent it from being…
- Trial name
- NCT06219967
- Testing
- Activated Charcoal
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Dysmorphic Disorder (BDD), Congenital Labia Majora Hypotrophy
To Assess The Performance And Tolerance Of Janesse 20 In The Volume Restoration Of Labia Majora
The use of hyaluronic acid (HA)-based fillers administered by injection to obtain Labia Majora augmentation is performed by many surgeons and gynaecologists in Europe, US and other countries, but few studies have investigated the…
- Conditions
- Dysmorphic Disorder (BDD), Congenital Labia Majora Hypotrophy, Post-menopausal Labia Majora Hypotrophy
- Trial name
- NCT04936763
- Testing
- Janesse 20 (Cross-linked Hyaluronic Acid)
- Where
- 2 sites in Italy, Romania
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- I.R.A. Istituto Ricerche Applicate S.p.A.
Age-Related Memory Disorders
A Study to Evaluate The Effects Of a Multivitamin/Mineral With Ginko In Subjects With Age Associated Memory Impairment
A Study to evaluate the cognitive effects and tolerance of a Multi-Vitamin/Mineral Preperation containing Gingko in elderly subjects with age associated memory impairment.
- Trial name
- NCT01160692
- Testing
- Multivitamin/Multimineral/Ginkgo (BAY 81-2775)
- Where
- United Kingdom
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Bayer
Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy
Non-Immunoglobulin E-mediated Food Allergies in Children
Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFA) are an evolving web of clinical conditions characterized by subacute and/or chronic symptoms and include food protein-induced enterocolitis syndrome (FPIES), food…
- Conditions
- Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy, Food Protein-Induced Proctocolitis, Food Protein-Induced Enterocolitis Syndrome
- Trial name
- NIGEFA (NCT04462978)
- Testing
- Non IgE-mediated food allergy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy Subjects
A Study to Evaluate the Similarity in Pharmacokinetics and Safety of IBI310 and Ipilimumab（YERVOY）in Adult Healthy Chinese Male Volunteers
This trail will investigate the pharmacokinetics and safety of IBI310 and establish pharmacokinetics biosimilarity of IBI310 to ipilimumab （YERVOY）
- Trial name
- NCT04868760
- Testing
- Ipilimumab, IBI310
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Growth & Development, Formula Feeding of Healthy Full Term Infants
Evaluation of Different Protein Content of Formulas on Nutrition Status of Infants.
Human milk (HM) is the gold standard of early infant nutrition. The World Health Organization (WHO) recommend that newborns be exclusively breastfed for the first 6 months of life.
- Conditions
- Growth & Development, Formula Feeding of Healthy Full Term Infants, Breast Feeding of Healthy Full Term Infants
- Trial name
- NCT03513991
- Testing
- Infant formula
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Queretaro
Atherosclerosis, Impaired Glucose Tolerance
The Study of Atherosclerosis With Ramipril and Rosiglitazone
The purpose of this study is to determine if ramipril and/or rosiglitazone retard the progression of atherosclerosis as evaluated by serial carotid intermedial thickness measurements.
- Conditions
- Atherosclerosis, Impaired Glucose Tolerance, Isolated Impaired Fasting Glucose, Cardiovascular Disease
- Trial name
- NCT00140647
- Testing
- Ramipril, Rosiglitazone
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gerstein, Hertzel, MD
Healthy
A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers
Exosomes are naturally occurring nanosized vesicles and comprised of natural lipid bilayers with the abundance of adhesive proteins that readily interact with cellular membranes.
- Trial name
- NCT04313647
- Testing
- 1X level of MSCs-Exo, 2X level of MSCs-Exo, 4X level of MSCs-Exo
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Healthy, Adult
Understanding Effects of Calcium on the Gut-Bone Axis
The study team is inviting 13 healthy people to complete a study to explore how calcium affects hormones and bones after eating. Participants will be asked to complete two study visits within eight weeks.
- Conditions
- Healthy, Adult, Calcium, Bone Resorption
- Trial name
- NCT06383117
- Testing
- Calcium carbonate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Cancer
Therapeutic Play on Pain Tolerance and Emotion Regulation in Children
The research is a randomized controlled experimental study. The population of the research will consist of 10-18 year old children who were diagnosed with acute lymphoblastic leukemia and received chemotherapy, who were admitted…
- Trial name
- NCT06368947
- Testing
- Therapeutic Play
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Brain Death
Brain Death: Inflammatory Response, Apoptosis, and Endotoxin Tolerance
We hypothesized that brain death is associated with an early systemic inflammatory response, possibly combined with activation of apoptotic cell death, two events that may contribute to induce rapid organ dysfunction.
- Trial name
- NCT00615225
- Testing
- Muscle biopsy
- Where
- 3 sites in Belgium, France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Delafontaine Hospital
Potential Abnormality of Glucose Tolerance, Appetitive Behavior
Effects of Traditional Greek Meals on Glycemic Responses
This study investigated the effects of Greek traditional meals in dehydrated form consumed after reconstitution with water on glycemic responses
- Trial name
- NCT04831268
- Testing
- Glucose as reference food, Lentils and lupins mixed meal, Trahanas with tomato sauce mixed meal
- Where
- Greece
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Healthy
Study of CM326 Injection in Healthy Subjects
This study is a single-center, randomized, double-blind, placebo-controlled, dose-increasing phase I clinical study.
- Trial name
- NCT05715333
- Testing
- CM326
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Keymed Biosciences Co.Ltd
Kidney Transplantation, Liver Transplantation
Cytokine Kinetics Test to Assess the Presence or Absence of Tolerance in Organ Transplant
The purpose of this pilot study is to determine if there is clinical correlation between the CKT and transplant recipients who are known to be on minimal or no immunosuppression (presumed tolerant) and those who are on…
- Trial name
- NCT00585858
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Dietary Habits
Can Food Timing Reduce Your Diabetes Risk?
The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants. Participants will: complete 2 inpatient stays be provided with test meals have frequent blood draws
- Trial name
- NCT05862818
- Testing
- Day shift protocol - Diet order A-B, Day shift protocol - Diet order B-A, Night shift protocol - Diet order A-B
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy
Food Effects of Single Oral Dose of 600mg TR-701
This is an evaluation of the safety, tolerance, and pharmacokinetics of single oral doses of TR-701 given to normal, healthy, adult volunteers in the fed and fasted state.
- Trial name
- NCT00671359
- Testing
- TR-701 600mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Depression
A Study of HR071603(Ketamine Nasal Spray) in Healthy Subjects
The study is being conducted to evaluate the safety and pharmacokinetics of HR071603 in healthy subjects.
- Trial name
- NCT04108234
- Testing
- HR071603
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy
Safety and PK of Nikkomycin Z in Healthy Subjects
The purpose of this study is to determine if nikkomycin Z is safe when administered at different dose levels for 14 days. The study will also determine blood levels and urinary excretion of nikkomycin Z in relation to dose…
- Trial name
- NCT00834184
- Testing
- nikkomycin Z
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
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