Clinical trials: Tolerance
Acne Vulgaris
A Study to Evaluate the Effectiveness and Tolerance of Two Acne Treatments on Subjects With Mild to Moderate Acne.
This study will compare two different acne treatments for the treatment of acne. Half of the participants will receive two marketed acne products (cleanser and leave-on topical treatment), while the other half of the participants…
- Trial name
- TIGER (NCT02698436)
- Testing
- Acne Mask, 2.5% Benzoyl Peroxide Treatment
- Where
- 2 sites in United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Diabetes Mellitus
Vascular Markers During OGTT in Diabetics and First-degree Relatives
Arterial stiffness is associated with increased risk for cardiovascular disease. Moreover, the integrity of endothelial glycocalyx plays a vital role in vascular permeability, inflammation and elasticity.
- Trial name
- NCT02244736
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Athens
Diabetes, Sugar; Blood, High
The Efficacy of White Kidney Bean on Oral Glucose Tolerance Test
The goal of this randomized, double-blind, cross-over inverventional study is to evaluate the efficacy of white kidney bean on OGTT (oral glucose tolerance test).
- Trial name
- NCT05756712
- Testing
- Phase 1 Wonderlab Product, Phase 2 Wonderlab Product
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Shenzhen Precision Health Food Technology Co. Ltd.,
Gastroesophageal Reflux Disease, Reflux, Gastroesophageal
A Study To Investigate The Effectiveness Of AH234844 (Lavoltidine) Compared With NEXIUM And Ranitidine.
Current treatment for gastroesophageal reflux disease (GERD) confirms an unmet need in patients, based on slow onset of action and an inability to provide 24-hour gastric-acid suppression.
- Trial name
- NCT00405119
- Testing
- AH23844 (lavoltidine), NEXIUM (esomeprazole), ZANTAC (ranitidine)
- Where
- 2 sites in Australia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes
The Finnish Diabetes Prevention Study
The aim of this study is to clarify whether lifestyle intervention provided to people with high type 2 diabetes risk will lower the cumulative incidence of diabetes.
- Trial name
- DPS (NCT00518167)
- Testing
- Intensive lifestyle counselling
- Where
- 4 sites in Finland
- Volunteers
- 522 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Healthy, Abdominal Obesity
Intestinal Tolerance & Health Effects of Daily Consumption of Two Eggs With Fatty Acid Profile Related to Metabolic Disorders
This study has two objectives: 1) to check that the daily consumption of two eggs with a particular fatty acid pattern rich in n-3 polyunsaturated fatty acids (α-linolenic acid, docosahexaenoic acid), conjugated-linoleic acid and…
- Conditions
- Healthy, Abdominal Obesity, Sedentary Behavior
- Trial name
- Oil4Egg (NCT04583657)
- Testing
- Eggs
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Obesity, Diabetes
Fuel Utilization, Diet Composition, and Exercise in African American Women
African American women have a high prevalence of obesity and type 2 diabetes and do not optimally burn fat and carbohydrates in response to changes in these nutrients in their diets.
- Conditions
- Obesity, Diabetes, Insulin Resistance
- Trial name
- NCT04293367
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Type 2 Diabetes, Impaired Glucose Tolerance
Effects of Pinitol on Hidrocarbonated Metabolism Parameters in Diabetic, Impaired and Normal Fasting Glucose Subjects
The purpose of this study was to assess whether pinitol improves hidrocarbonated metabolism parameters, and evaluate its effect on oxidative stress and endothelial function in diabetic, impaired and normal fasting glucose…
- Conditions
- Type 2 Diabetes, Impaired Glucose Tolerance, Healthy
- Trial name
- NCT01754792
- Testing
- Pinitol
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Pregnancy, Obesity
Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn
The purpose of the study is to investigate if the probiotics Vivomixx® can affect gestational weight gain, microbiota and pregnancy complications in pregnant obese women and birth weight body composition of their infants.
- Conditions
- Pregnancy, Obesity, Gestational Diabetes Mellitus
- Trial name
- POP (NCT02508844)
- Testing
- Vivomixx®
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Nutrition, Healthy, Weight Loss
Effect of a Postbiotic Supplementation in Overweight and Obese Subjects: A Randomized Controlled Trial (PARABIOTICS-2).
The principal objective of this project is to evaluate the effect of a postbiotic supplement (inactivated microorganism) on body composition and other physiological and metabolic parameters related to excess body weight in…
- Conditions
- Nutrition, Healthy, Weight Loss, Overweight and Obesity
- Trial name
- PARABIOTICS-2 (NCT07165431)
- Testing
- Postbiotic + nutritional recommendations
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Human Immunodeficiency Virus (HIV)
SPL7013 Gel - Male Tolerance Study
The purpose of this study is to determine if SPL7013 Gel (VivaGel™) is safe when applied topically once a day for seven consecutive days to the shaft and glans of the penis in healthy male volunteers.
- Trial name
- NCT00370357
- Testing
- 3% w/w SPL7013 Gel (VivaGel™)
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Starpharma Pty Ltd
Post Bariatric Surgery, Gastric Bypass
The Effects of Bariatric Surgeries on Glucose Metabolism
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
- Conditions
- Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass
- Trial name
- NCT02823665
- Testing
- Exendin-(9-39), Atropine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes Mellitus, Cardiovascular Diseases (CVD)
Da Qing Offspring Study
This is an observational study tracking families and offspring of three cohorts from the 1986 Da Qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups.
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases (CVD), Offspring, Adult, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- NCT06958640
- Testing
- Lifestyle interventions
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- China-Japan Friendship Hospital
Type 2 Diabetes, Healthy
Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Pioglitazone, a drug used in treatment of type 2 diabetes has been shown to improve insulin sensitivity in skeletal muscle, liver, and fat cells.
- Conditions
- Type 2 Diabetes, Healthy, Impaired Glucose Tolerance
- Trial name
- PIO-EX (NCT00845182)
- Testing
- Pioglitazone, Exenatide, Pioglitazone and Exenatide
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Lentigo, Solar Lentigo
Evaluation of the Tolerance (Main Objective) and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-inflammatory Hyperpigmentation) on the Face
The goal of this clinical trial is to compare the 3 different prototype of cyto-selective cryotherapy devices (name of the devices : CRYONOVE) use in brown spots on the face of subject from different ethnicities.
- Conditions
- Lentigo, Solar Lentigo, Post Inflammatory Hyperpigmentation
- Trial name
- CS5_10B (NCT06305897)
- Testing
- CRYONOVE (EC14_4osc), CRYONOVE (EC+05_1osc), CRYONOVE (EC+05_2osc)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cryonove Pharma
Population With Self-perceived Gastro-intestinal Sensitivity to Fibers
Tolerance Profile of Soluble Fibers in Individuals With Self-perceived GI Sensitivity to Fibers (Tarine)
The purpose of this study is to determine the optimal dose of soluble fibers that induces tolerable gastrointestinal symptoms.
- Trial name
- Tarine (NCT06877013)
- Testing
- Fiber's mix (among 4 doses)
- Where
- France
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Muscle Stretching Exercises, Pain Threshold
Muscle Stretching - the Potential Role of Endogenous Pain Inhibitory Modulation on Stretch Tolerance
This study investigates the influence of a remote, painful stimulus on stretch tolerance. Half of the participants will receive a conditioning painful stimulus following static stretching while the other half will rest quietly.
- Trial name
- NCT03713788
- Testing
- Cold pressor test
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University College of Northern Denmark
Type 2 Diabetes
Preprandial Ghrelin Effect
Background and Significance: The peptide hormone ghrelin drives hunger and feeding behavior, making it a focus of obesity research.
- Trial name
- NCT02913703
- Testing
- Ghrelin, Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jenny Tong, MD, MPH
Type 2 Diabetes Mellitus, PreDiabetes
Glucagon-like Peptide-1 Levels, Insulin Resistance and Insulin Sensitivity Index in Type 2 Diabetes Mellitus
This study is conducted to examine GLP-1, insulin resistance and insulin sensitivity portfolio in Malay, Chinese and Indian populations in Malaysia and to study the effect of DPPIV inhibitor in T2DM patients with different…
- Trial name
- GLP-1 (NCT03659461)
- Testing
- Sitagliptin
- Where
- Malaysia
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Healthy, Hyperalgesia
A Safety Tolerance and Experimental Hyperalgesia Study of Oral NGX426 in Healthy Male Voluneteers
The purpose of this study is to determine the effects of NGX426 on intradermal capsaicin induced pain in hyperalgesia.
- Trial name
- NCT00832546
- Testing
- Oral NGX426 (Powder in solution)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- TorreyPines Therapeutics
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