Clinical trials: Tooth, Impacted
Dental Pain
Single Dose Study of N1539 in the Treatment of Pain Secondary to Dental Impaction Surgery
To evaluate the safety and efficacy of single IV doses of N1539 after dental impaction surgery.
- Trial name
- NCT00945763
- Testing
- N1539, Motrin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Pain, Postoperative, Post Operative Swelling
Effect Of Autologous Platelet Rich Fibrin On Post-Operative Complications And Healing Following The Extraction
As post-operative pain, infection inflammation and infections are the main complications after the surgical extraction of the lower third molar the aim of this study is to compare the healing effects of PRF administered…
- Conditions
- Pain, Postoperative, Post Operative Swelling, Trismus, Soft Tissue Healing
- Trial name
- PRF (NCT06609967)
- Testing
- application of PRF, application of conventional surgicel
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Malaria
Impact of Malaria Mass Drug Administration on Malaria Prevalence in Under 15 Children and Pregnant Women
This is a clinical trial being done to find better ways to reduce malaria in the community. Malaria is caused by a parasite that is spread by mosquitoes.
- Trial name
- NCT07358767
- Testing
- Artemether-lumefantrine (AL)
- Where
- Ghana
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Noguchi Memorial Institute for Medical Research
Enamel Hypomineralization, Dental
Esthetic Impact of Different Minimally Invasive Approaches on Hypomineralized Permanent Anterior Teeth
The aim of the study is to determine the effectiveness of minimally invasive treatments in reducing the visible enamel opacities on permanent anterior teeth in children aged from seven to twelve years with hypomineralized…
- Trial name
- NCT07906236
- Testing
- ICON® resin infiltration, Opalustre® enamel microabrasion, Antivet® enamel micro-abrasion
- Where
- Egypt
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Shaimaa Abdelrahman
Third Molar Surgery, Postoperative Complications
Effect of Irrigation Solution Temperature on Clinical Outcomes and Salivary CRP After Impacted Mandibular Third Molar Surgery
Surgical extraction of impacted mandibular third molars often requires bone removal using rotary instruments, in which friction between the bur and bone generates heat.
- Conditions
- Third Molar Surgery, Postoperative Complications, C-REACTIVE PROTEIN
- Trial name
- NCT07243210
- Testing
- Cold Saline Irrigation, Room-Temperature Saline Irrigation (Control)
- Where
- Vietnam
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Alveolar Bone Loss, Sinus Floor Augmentation
Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation: A 10-year Retrospective Radiographical Study
This research aims to investigate the influence of alveolar ridge preservation, after extraction of maxillary posterior teeth, on the potential need of sinus floor augmentation procedures (that include lateral or crestal sinus…
- Conditions
- Alveolar Bone Loss, Sinus Floor Augmentation, Sinus Pneumatization, Alveolar Bone Atrophy
- Trial name
- NCT07526129
- Testing
- Alveolar ridge preservation using bony biomaterials
- Where
- Lebanon
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Third Molar Surgery, Impacted Third Molar Tooth
Impact of 3D Intraoral Scanning on Postsurgical Evaluation of Mandibular Third Molar Surgery
The aim of this study was to analyze the effectiveness of piezoelectric surgery and traditional rotating device in reducing perioperative sequelae after impacted mandibular third molar surgery in 56 subjects.
- Trial name
- NCT05684601
- Testing
- Third molar surgery
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Catania
Impacted Third Molar, Postoperative Pain
Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery
A prospective cohort of 40 consecutive patients with bilateral impacted mandibular third molars underwent two sequential surgical extractions separated by a two-week interval.
- Conditions
- Impacted Third Molar, Postoperative Pain, Neuroinflammation, Anxiety
- Trial name
- KYNA-3M (NCT07644065)
- Testing
- Ibuprofen, Ibuprofen + Gabapentin
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Impacted Third Molar Tooth
Trapezoidal Flap vs. Envelope Flap in Mandibular Third Molar Extraction.
the purpose of this study was to test the effectiveness of the envelope flap compared to trapezoidal flap in impacted mandibular third molar extractions.
- Trial name
- NCT02120131
- Where
- Italy
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Firenze and Siena, Napoli, Italy
Periodontitis, Bruxism
Impact of Subgingival Instrumentation on Jaw Symptoms of Probable Bruxers Among Patients With Periodontitis
This study aims to explore the mechanisms by which periodontal disease affects the bruxers and to assess the impact of subgingival instrumentation on jaw symptoms of probable bruxers among patients with periodontitis .
- Trial name
- NCT06429917
- Testing
- Subgingival instrumentation
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Lingual Nerve Injuries
Removal of Impacted Molars With Lingual Split Technique
This research assesses removal of mandibular third molars by the lingual split technique with using Walter's lingual retractor for retracting lingual flap, and evaluates the lingual nerve injury that may result after applying…
- Trial name
- NCT05946317
- Testing
- Lingual nerve function assessed after removal of mandibular third molar with lingual split technique
- Where
- Syria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Latakia University
Brain Injuries, Traumatic
Traumatic Brain Injury Positive Strategies
This study evaluates the effectiveness of The Traumatic Brain Injury Positive Strategies (TIPS) program, a comprehensive educational and training resource to help families improve their knowledge and skills in supporting a child…
- Trial name
- TIPS (NCT03867968)
- Testing
- TIPS Intervention, Control
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Attachment Loss, Periodontal, Teeth, Impacted
Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar Extraction
Background: Prevention of periodontal defects after the extraction of lower third molars remains a challenge. Various methods have been proposed in the literature, but there are no studies which evaluated the effectiveness of…
- Trial name
- NCT04314726
- Testing
- Amelogenin
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Quality of Life, Pediatric Cancer
Intervention Development and Evaluation to Reduce Disparities in Quality of Life for Latino Families Impacted by Cancer
The purpose of this study is to determine if a culturally relevant caregiver intervention is effective in decreasing stress and improving quality of life in Spanish speaking Latino caregivers of children diagnosed with cancer…
- Conditions
- Quality of Life, Pediatric Cancer, Caregiver Burden
- Trial name
- NCT06622252
- Testing
- 13-week session program
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Impacted Mandibular Third Molar Extraction
Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Morbidity After Mandibular Third Molar Surgery
This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical…
- Trial name
- NCT07748585
- Testing
- Titanium-Prepared Platelet-Rich Fibrin (T-PRF), Low-Level Laser Therapy (LLLT)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cyprus Health and Social Sciences University
Pain
Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1940
The primary aim of this study is to investigate if AZD1940 can relieve the pain induced by the surgical removal of one lower wisdom-tooth.
- Trial name
- NCT00659490
- Testing
- AZD1940, Naproxen
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Bleeding, Tooth Extraction
Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery
Tranexamic acid (TXA) is an effective hemostatic agent used to reduce blood loss and the need for transfusion. It is a relatively safe drug with minimal significant side effects.
- Trial name
- NCT06806241
- Testing
- Tranexamic acid, saline irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Third Molar Surgery
A-PRF AND HA AFTER IMPACTED THIRD MOLAR SURGERY
This randomized controlled clinical trial evaluated the effects of advanced platelet-rich fibrin (A-PRF) and hyaluronic acid (HA) on healing after surgical removal of impacted mandibular third molars.
- Trial name
- NCT07835373
- Testing
- Advanced Platelet-Rich Fibrin, Sodium hyaluronate
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Inonu University
Healthy Subjects, Hyperalgesia
Effect of High-dose Naloxone Following Third Molar Extraction
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Healthy Subjects, Hyperalgesia, Inflammations, Endodontic, Pain, Acute
- Trial name
- TME (NCT02976337)
- Testing
- Naloxone, Normal Saline
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- mads u werner
Dental Caries
Impact of Detecting Initial and Active Caries Lesions in Primary Teeth
The present study aims to evaluate the impact of detecting active initial caries lesions in primary teeth regarding effectiveness, cost-effectiveness, applicability (acceptability and satisfaction) and quality of life.
- Trial name
- NCT02473107
- Testing
- Advanced caries lesions detection (no activity assessment), All caries lesions detection (+activity assessment)
- Where
- Brazil
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo