Clinical trials: Tooth Erosion
Tooth Erosion, Tooth Wear
Association Between Erosive Tooth Wear Progression and Dietary Risk Factors.
Study to determine if whether or not exist an association between the tissue loss (ETW progression) and the frequency of an acidic diet.
- Conditions
- Tooth Erosion, Tooth Wear, Erosion, Dental Erosion
- Trial name
- NCT04586322
- Testing
- No intervention, (observational study).
- Where
- Belgium
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Ghent
Caries, Erosive Tooth Wear
New In Situ Model Design for Caries and Erosion
This study will test simultaneously and independently two novel in situ models, one for caries and one for erosive tooth wear (ETW), based on the simulation of these dental conditions on enamel specimens placed on 3D-printed…
- Trial name
- NCT07849270
- Testing
- 0 ppm fluoride toothpaste, 250 ppm fluoride toothpaste (dose-response control), 1150 ppm fluoride toothpaste
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dental Erosion
Effect of Smoking on Saliva Composition and the Development of Dental Erosion
The aim of this study is to investigate whether smoking is associated with changes in salivary composition and/or predisposition to erosion.
- Trial name
- NCT04208802
- Testing
- Use of fluoridated toothpaste, Wearing of an intraoral device with bovine tooth samples, Wearing of an intraoral device with resin samples
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Göttingen
Oral Diseases
Carnosine Supplementation on Quantity/Quality of Oral Salivae.
The aim of this study is to elucidate the mutual relationship between salivae characteristics and oral microbiome and to compare them with common oral disease; furthermore, by using specific bioinformatic tools to analyse the…
- Trial name
- PHoral (NCT04295525)
- Testing
- 400 mg mucoadhesive oral tablet
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Milan
Tooth Abnormality
Evaluation of a Low-fluoride Anticaries Toothpaste
The purpose of this trial is to evaluate the anticaries remineralizing potential of a toothpaste containing 500 ppm fluoride plus fTCP technology relative to a commercially available toothpaste via a double-blind cross-over in…
- Trial name
- NCT01094210
- Testing
- Fluorides, Topical
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana Nanotech, LLC
Dental Caries, Dental Erosion
Maintaining Oral Health With Bio-products
This study will follow a randomised, double-blind, cross-over design. Participants will use mouth rinses containing plant extracts and/or fluoride, as well as a mouth rinse containing only water (placebo).
- Trial name
- NCT04033263
- Testing
- Mouth rinse 1, Mouth rinse 2, Mouth rinse 3
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Bern
Non-carious Cervical Lesions
Evaluation of Double Layer Application Using a Universal Adhesive in the Quality of Cervical Lesions Restorations
The aim of this study will be to evaluate the effect of a double layer application of a universal adhesive system used as etch-and-rinse application mode in non-carious cervical lesions (NCCLs), on the 6- and 12-months clinical…
- Trial name
- NCT06474494
- Testing
- Application of one layer, Application of double layer, Etch-and-rinse application mode
- Where
- Chile
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Dental Erosion
The Effect of Chlorhexidine on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when the teeth lose some of their parts because of acid from the things people eat and/or drink or even from stomach. It can make teeth hurt and become sensitive.
- Trial name
- NCT06171594
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Tooth Wear, Attrition
Prevalence of Tooth Wear and Its Association with Oral Health-related Quality of Life
The aim of this study is to detect the prevalence of tooth wear (All forms of cumulative surface loss of mineralized tooth substance loss due to physical and chemico-mechanical process according to the definition of the European…
- Conditions
- Tooth Wear, Attrition, Erosion
- Trial name
- NCT06665191
- Testing
- No Intervention: Observational study for prevalence of dental wear and its association with quality of life
- Volunteers
- 1,011 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Erosion
Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study
Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion.
- Trial name
- NCT02780973
- Testing
- Wearing of an intraoral device with bovine tooth samples
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Göttingen
Tooth Erosion
An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel
The purpose of this study is to investigate the ability of an experimental dentifrice containing 1150 parts per million (ppm) fluoride to remineralize acid-softened dental enamel and help prevent further demineralization compared…
- Trial name
- NCT06242444
- Testing
- Experimental Dentifrice, Reference Dentifrice
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- HALEON
Tooth Wear
Timing of Dietary Acid Intake, Brushing Teeth and Acid Erosion.
This is a questionnaire based study investigating the relationship between the timing of dietary acid intake toothbrushing and erosive tooth wear.
- Trial name
- NCT02449434
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- King's College London
Dental Erosion
Casein Phosphopeptide--amorphous Calcium Phosphate on Human Enamel Subjected to in Vivo Acid Attacks
40 specimens were prepared from fresh-extracted human molars and further embedded using the acrylic resin. Specimens were randomly divided into 2 groups according to the treatment before in vivo erosion (n=20): CPP-ACP for 3 min…
- Trial name
- NCT03426150
- Testing
- CPP-ACP
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Dental Erosion
Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
The purpose of this study is to determine whether an experimental fluoridated dentifrice is effective in the treatment of dental caries
- Trial name
- NCT00752089
- Testing
- NaF/ KNO3/isopentane Dentifrice, NaF/KNO3 Dentifrice, NaF Dentifrice
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Erosion
In Vivo Investigation of Initial Stages of Enamel Erosion
This exploratory study is designed to help develop a clinical model to measure the earlier stages of dietary acid medicated enamel loss. The study will use fluoride as positive control to explore the validity of this design.
- Trial name
- NCT02533466
- Testing
- Sodium fluoride + potassium nitrate, Potassium nitrate
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Erosion
The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when teeth lose some of their parts because of acid from the things people eat and/or drink or even from their stomach. It can make their teeth hurt and become sensitive.
- Trial name
- NCT06156618
- Testing
- Nitrate
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Tooth Erosion
In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste
This will be a randomized, controlled, single center, single- blind, 3 period, 3 treatment, cross-over, in situ design which consists of placing pre-eroded bovine enamel specimens intra orally using a palatal appliance and…
- Trial name
- NCT03296072
- Testing
- 0.254% w/w sodium fluoride and 5% KNO3, 0.454% w/w stannous fluoride, 5% KNO3
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Erosion, Erosive Tooth Wear
Quantitative In Vivo Monitoring of Early Erosion-Associated Enamel Optical Changes Using Swept-Source Optical Coherence Tomography.
This study aims to evaluate the ability of swept-source optical coherence tomography (SS-OCT) to detect early enamel optical changes associated with erosive tooth wear under clinically relevant in vivo conditions.
- Trial name
- NCT07690644
- Testing
- Swept-Source Optical Coherence Tomography (SS-OCT), Orange Juice Erosive Challenge, Sugar-Free Chewing Gum Stimulation
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Primary Ciliary Dyskinesia, Caries,Dental
Assessment of Oral Health Status of Children With Primary Ciliary Dyskinesia
The aim of this study is to compare the oral health findings, salivary parameters and pediatric oral health related quality of life of children with Primary Ciliary Dyskinesia (PCD) with healthy children
- Conditions
- Primary Ciliary Dyskinesia, Caries,Dental, Quality of Life, Saliva Altered
- Trial name
- NCT06618209
- Testing
- physical and chemical methods, biochemical methods, Oral Findings
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Marmara University
Gastroesophageal Reflux, Dental Erosion
Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease
This study investigates the prevalence and pathophysiology of dental and periodontal involvement in pediatric patients with symptomatic or asymptomatic gastroesophageal reflux (GER) or gastroesophageal reflux disease (GERD).
- Trial name
- NCT01167543
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco