Clinical trials: Topical Anaesthesia
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04513652
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Pain
The Effect of Microneedle Pretreatment on Topical Anesthesia
This study evaluates the role of microneedle pretreatment in the speed at which anesthesia develops after application of topical 4% lidocaine.
- Trial name
- NCT02596750
- Testing
- Microneedle Roller
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Local Anesthesia of the Skin.
Fractional Laser Assisted Delivery of Anesthetics
The purpose of this study is to assess the efficacy of fractional CO2 laser assisted delivery of topically applied anesthetics (articaine hydrochloride 40 mg/ml and epinephrine 10 μg/ml solution and EMLA cream) regarding to…
- Trial name
- NCT02246179
- Testing
- AFXL, AHES, EMLA cream
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Metal Staple Removal After Total Knee Replacement
Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Lidocaine patch is a safe and effective topical anesthetic agent for removal of metal staples after total knee replacement
- Trial name
- NCT02812602
- Testing
- Lidocaine patch
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04829344
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Pain
Comparison Between the Analgesic Effectiveness of Virtual Reality and Topical Anesthesia: A Clinical Study
A split-mouth, controlled trial aimed to clinically compare and evaluate the effectiveness of virtual reality versus topical anesthesia gel prior to administration of dental anesthesia injection in reducing the perceived pain and…
- Trial name
- NCT04919421
- Testing
- Dental injection and topical gel application, Dental injection and virtual reality device
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Gastroscopy
Topical Pharyngeal Anesthesia With Articaine for Gastroscopy
Topical Pharyngeal anesthesia (TPA) is widely used during upper endoscopy. Articaine is local anaesthetic that have not been previously evaluated in pharyngeal anesthesia for upper endoscopy.
- Trial name
- NCT01350050
- Testing
- articaine, 9% Sodium Chloride solution for injection
- Where
- Finland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Healthy, Anesthesia
A Study to Compare the Efficacy of Rapydan Versus Tetracaine Gel
Tetracaine gel 4% is a topical anaesthetic gel commonly used in the UK that contains 40 mg of tetracaine base per gram. Adequate anaesthesia can usually be achieved following a 30 minute application time for venopuncture and a 45…
- Trial name
- NCT00670696
- Testing
- Rapydan, tetracaine gel
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals
Topical Anesthetic Applied With Sonophoresis
The Effect of Sonophoresis on Topical Anesthesia: A Pilot Study
The Dental Anesthesia Sonophoresis Device (DASD) is a novel device that is intended to reduce the discomfort associated with puncturing the oral mucosa.
- Trial name
- NCT01283490
- Testing
- DASD Group, Sonic Vibration (SV)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Anesthesia; Hypothermia, Injection Site Irritation
Topical Ice-therapy for Intravitreal Injections
Purpose: To examine the difference in patient's pain experience in the setting of intravitreal anti-VEGF injections with pretreatment of topical ice-therapy compared with no-ice.
- Trial name
- NCT05269823
- Testing
- Ice-therapy, No Ice-therapy
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Local Anesthesia Infiltration
Efficacy of Facial Massager in Reducing Intra Oral Injection Pain in Pediatric Patients
Abstract Background: Local anesthesia is a primary source of anxiety in pediatric dentistry. Objective: To evaluate if mechanical vibration from a low-cost facial massager reduces pain and anxiety during injections using the Gate…
- Trial name
- NCT07682181
- Testing
- Facial T massager, Topical Benzocaine 20%
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Hospital, India
Topical Anaesthesia
A Study of the Use of Microneedle Patches to Deliver Topical Lidocaine in the Oral Cavity
To look at the effect on patient perceived pain resulting from infiltration injection with local anaesthetic in a dental syringe with prior application of topical anaesthetic to the oral mucosa on a microneedle patch compared to…
- Trial name
- NCT03629041
- Testing
- Microneedle Patch, Patch with no microneedles
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Innoture Ltd
Local Anesthesia of the Skin
Fractional Laser Assisted Delivery of Anesthetics III
The purpose of this study is to compare the effect of pretreatment with two different ablative laser modalities, a CO2 laser and an Er:YAG laser, and to assess the role of laser density in fractional laser assisted topical…
- Trial name
- NCT02938286
- Testing
- Fractional CO2 laser, 2.5 mJ, 5% density, Fractional CO2 laser, 2.5 mJ, 15% density, Fractional Er:YAG laser, 9 mJ, 5% density
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Lentigo
The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser
This study will conduct a split-face and -body randomized control trial to compare lidocaine 2.5%/prilocaine 2.5% topical anesthetic (LPTA), lidocaine 7%/tetracaine 7% topical anesthetic (LTTA), and placebo vechicle (PV) on…
- Trial name
- NCT02427724
- Testing
- lidocaine 2.5%/prilocaine 2.5% topical anesthetic, lidocaine 7%/tetracaine 7% topical anesthetic, Q-switched 532nm Laser
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Local Anesthesia of the Skin
Fractional Laser Assisted Delivery of Anesthetics IIIb
The purpose of this study are to compare the efficacy of two different commercially available local anesthetics on AFXL pretreated skin and to assess the role of the application time in this technique.
- Trial name
- NCT03279757
- Testing
- AHES 5 minutes, AHES 15 minutes, AHES 25 minutes
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Dental Fear, Anesthesia, Local
Effectiveness of Synapse Transcutaneous Electronic Nerve Stimulation (TENS) During Dental Procedures Among Children
Dental Fear and Anxiety (DFA) are at higher levels among children and often leads to avoidance of dental treatment. Negative experiences in the early years such as experience of pain during injections, fillings, or extractions…
- Conditions
- Dental Fear, Anesthesia, Local, Pediatric Dentistry
- Trial name
- NCT03779659
- Testing
- Synapse TENS device, Topical anesthetic gel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston University
Anesthesia of Mucous Membrane
Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
The efficacy of the topical anesthetics will be determined by how much pain the patient felt (using a Heft-Parker pain analog scale) upon needle penetration.
- Trial name
- NCT01951820
- Testing
- Pliaglis, Benzocaine, Articaine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Esophagogastroduodenoscopy
Topical Pharyngeal Anesthesia in Sedated Esophagogastroduodenoscopy
At recent, the number of patients who underwent sedated esophagogastroduodenoscopy has been on the increase. For such patients, whether topical pharyngeal anesthesia is needed remains to be controversial.
- Trial name
- NCT03070379
- Testing
- Topical lidocaine pharyngeal anesthesia
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Anesthesia
Liposomal Lidocaine Gel for Oral Topical Anesthesia
This blinded cross-over study aimed to evaluate the efficacy of topical liposome-encapsulated lidocaine on oral mucosa.
- Trial name
- NCT01425840
- Testing
- Lidocaine
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Anesthesia
Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections
The aim of this randomized controlled trial. is to test the efficacy of topical anesthesia against the use of no topical agent during buccal infiltration in maxillary anterior teeth.
- Trial name
- NCT03261115
- Testing
- No topical anesthesia
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nurain Rehman