Clinical trials: Topical Anesthetic
Normal Tension Glaucoma
IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic
The primary purpose of this study is to determine whether topical ophthalmic anesthetics lower the intraocular pressure in the eye.
- Trial name
- NCT01254149
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Anesthesia
Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
The purpose of the study is to compare two modalities of local anesthetic administration prior to the placement of cosmetic facial injectable fillers.
- Trial name
- NCT02379221
- Testing
- Injectable, Topical
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Oral Anxiolytic, Phacoemulsification
Anxiety and Surgery Satisfaction for Cataract Patient With Different State Anxiety
This study aims to explore the effects of anxiety traits on pain, anxiety, and anesthesia satisfaction in patients undergoing cataract surgery under topical anesthesia.
- Conditions
- Oral Anxiolytic, Phacoemulsification, Cataract Surgery, Satisfaction Survey
- Trial name
- NCT06826417
- Testing
- Xanax
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Oral Cavity Disease
Microneedle Pretreatment as a Strategy to Improve the Effectiveness of Topical Anesthetics Formulations
A randomized, crossover, double-blind, two-sessions clinical trial with 30 male volunteers was performed to access pain of local anesthesia after using a topical anesthetic associated or not with prior application of microneedles…
- Trial name
- NCT05267938
- Testing
- Topical Anesthetic, Local anesthetic
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04829344
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Dental Trauma, Local Anesthesia
Clinical Efficiency of Xanthan Hydrogels Containing Local Anesthetics Encapsulated in Nanostructured Lipid Carries
In a crossover, randomized, placebo-controlled, double-blind study, 40 volunteers will receive the following formulations: hydrogels containing LAs (local anesthetic) - lidocaine and prilocaine (both at 2.5%) encapsulated in CLN…
- Conditions
- Dental Trauma, Local Anesthesia, Oral Cavity Disease
- Trial name
- NCT05912335
- Testing
- Topical anesthetic
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Pain
Efficacy of Ametop Cream in Reducing Pain of Local Anesthetic Infiltration
Ametop is a numbing cream used to ease the pain of having blood drawn or an IV inserted. It is safe and virtually none enters the blood stream.
- Trial name
- Ametop (NCT01864213)
- Testing
- Ametop cream
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Lentigo
The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser
This study will conduct a split-face and -body randomized control trial to compare lidocaine 2.5%/prilocaine 2.5% topical anesthetic (LPTA), lidocaine 7%/tetracaine 7% topical anesthetic (LTTA), and placebo vechicle (PV) on…
- Trial name
- NCT02427724
- Testing
- lidocaine 2.5%/prilocaine 2.5% topical anesthetic, lidocaine 7%/tetracaine 7% topical anesthetic, Q-switched 532nm Laser
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Lip Augmentation
A Multicenter, Double-blind, Randomized, Controlled, Roll-over Retreatment Study of the Safety and Pain Associated With Injections of PN40082, RV001 With Topical Anesthetic or RV001 for Lip Augmentation
The purpose of this study is to evaluate the safety of repeat injections and pain associated with injection of PN40082 and comparative pain associated with RV001 with a topical anesthetic and RV001 for lip augmentation.
- Trial name
- NCT04029545
- Testing
- PN40082
- Where
- 5 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Prollenium Medical Technologies Inc.
Corneal Diseases, Effectiveness of Microdrops
Efficacy of Nanodropper-mediated Topical Anesthetic
The goal of this clinical trial is to compare the onset and duration of numbness of the surface of the eye following the administration of numbing drops, called proparacaine, using either a standard eye drop bottle or a…
- Trial name
- NCT06636708
- Testing
- Nanodropper and Proparacaine HCl 0.5%, Standard Eye Drop Bottle with Proparacaine HCl 0.5%
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pharyngitis
Safety, Tolerability, and Pharmacokinetic Profile of Grammidin With Anesthetic, a Metered Dose Topical Spray in Healthy Volunteers
This study aims to evaluate the safety, tolerability, and pharmacokinetic profile of the Grammidin with anesthetic, a metered dose topical spray, compared to Grammidin with anesthetic neo, lozenges following single administration…
- Trial name
- NCT06857890
- Testing
- Grammidin with anesthetic neo, Grammidin with anesthetic, a metered dose topical spray
- Where
- Russia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Glaucoma, Intraocular Pressure
The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops
Pediatric glaucoma is a rare but potentially blinding condition where the pressure in the eye is too high. Diagnosis is based on intraocular pressure (IOP) and assessment of the optic nerve, cornea and other structures.
- Conditions
- Glaucoma, Intraocular Pressure, Anesthesia
- Trial name
- IOP (NCT01925391)
- Testing
- Tono-pen XL Applanation tonometer + Ocu-film +
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Miami
Anesthesia, Local
A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population
A Phase 3, randomized, active-controlled, study in pediatric subjects. It is designed to evaluate the safety and anesthetic efficacy of one dose of AG-920 ophthalmic solution compared to Proparacaine Hydrochloride Ophthalmic…
- Trial name
- NCT05325853
- Testing
- AG-920, Proparacaine Ophthalmic
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Premature Ejaculation
A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation
A phase I, single-center, double-blind, randomized, placebo-controlled, safety and pharmacokinetic study to evaluate systemic and local vaginal exposure to lidocaine and prilocaine and the metabolites, 2,6-dimethylaniline…
- Trial name
- NCT01184105
- Testing
- Intervention A, Intervention B
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Plethora Solutions Ltd
Local Anesthesia of the Skin.
Fractional Laser Assisted Delivery of Anesthetics
The purpose of this study is to assess the efficacy of fractional CO2 laser assisted delivery of topically applied anesthetics (articaine hydrochloride 40 mg/ml and epinephrine 10 μg/ml solution and EMLA cream) regarding to…
- Trial name
- NCT02246179
- Testing
- AFXL, AHES, EMLA cream
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Pain, Anxiety
Randomized Control Trial of a Topical Anesthetic to Evaluate Pain and Anxiety During Venipuncture
The purpose of this study is to evaluate the amount of anxiety and pain felt by children during procedures that require a needle stick after using a topical anesthetic or placebo cream.
- Trial name
- NCT00676364
- Testing
- 4% lidocaine topical anesthetic cream
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Jenny Boucher, PharmD
Circumcision, Male
Unicirc vs Open Surgical Circumcision
RCT of Unicirc under topical anesthetic w/ cyanoacrylate wound sealing vs. open surgical circumcision under local anesthetic with suturing.
- Trial name
- Unicirc004 (NCT02443792)
- Testing
- Unicirc with tissue adhesive, Open Surgical
- Where
- South Africa
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Simunye Primary Health Care
Anxiety
COMPARISON OF THE TOPICAL ANAESTHETIC EFFICACY OF VARIOUS AGENTS WITH ANAESTHETIC EFFECTS IN CHILDREN
The purpose of the study is to compare the effectiveness of natural methods-such as basil oil, chamomile oil, and ice-with synthetic topical anesthetics, such as topical anesthetic sprays and topical anesthetic creams, and to…
- Trial name
- NCT07849192
- Testing
- Vemcaine, Essences and Essential Oils, VISION
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Uşak University
Topical Anesthesia
Pharmacokinetic Study of Nanoencapsulated Gel of Lidocaine, Prilocaine and Combination of Lidocaine and Prilocaine
This trial evaluated the pharmacokinetic interaction between fixed doses of lidocaine (2.5%), prilocaine (2.5%) or the association of both (Nanorap®) in healthy volunteers. The drug safety and tolerability was also evaluated.
- Trial name
- NCT03441841
- Testing
- Lidocaine + Prilocaine, Lidocaine, Prilocaine
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Pain
A Study of the Effect of Time on Topical Anesthetic Efficacy.
This is a study of the effect of time on the effectiveness of topical anesthetics in the mouth. The Null Hypothesis is: Regardless of the time of application over a 10-minute period, there is no difference in the clinical…
- Trial name
- NCT00353041
- Testing
- lidocaine topical
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Toronto