Clinical trials: Topical Anesthetic
Procedural Pain
Comparison of Compounded Topical Anesthetics
The primary objective for this pilot study is to evaluate the efficacy of the compounded topical anesthetic Benzocaine 20%/ Lidocaine 8%/Tetracaine 4% (BLT) compared to 4% Lidocaine topical in providing relief of pain during IPL…
- Trial name
- NCT06569537
- Testing
- Lidocaine topical, BLT
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Healthy, Topical Anesthesia
Cryotherapy as a Topical Anesthetic in Healthy Children
In this study, the investigators aimed to compare the effects of topical anesthetic materials and cold application on pain perception.
- Conditions
- Healthy, Topical Anesthesia, Pediatric Dentistry, Cryotherapy
- Trial name
- NCT07198022
- Testing
- Cryotherapy, topical anesthetic, Topical anesthetic gel
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Application Site Discomfort
Clinical Trial With Bupivacaine Lozenges as Local Anaesthesia Under Upper Gastrointestinal Endoscopy
In this project the investigators want to compare a new anaesthetic method during upper gastroscopic endoscopy, compared to the traditional used method in a private clinic.
- Trial name
- NCT01832675
- Testing
- Xylocain, cutaneous spray, solution, Bupivacaine lozenge
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Ove Andersen
Neuralgia, Neuropathic Pain
PK of Lidocaine/Tetracaine and PD Derived From a New Topical Formulation for Treatment of Neuropathic Pain.
Post-herpetic neuralgia (PHN) is the most frequent complications related to herpes zoster, and can persist for months or even years, and require extensive treatment.
- Conditions
- Neuralgia, Neuropathic Pain, Local Anesthetic Complication, Lidocaine Adverse Reaction
- Trial name
- PK/PDLido (NCT06171243)
- Testing
- Lidocaine topical
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Administration, Topical Drug, Administration, Topical
Topical Formulations of Liposomal Local Anesthetics
This blinded cross-over study aim to evaluate the efficacy of topical liposome-encapsulated ropivacaine formulations.
- Conditions
- Administration, Topical Drug, Administration, Topical, Anesthetic Drugs
- Trial name
- NCT01054547
- Testing
- Ropivacaine
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Anesthesia, Dental
Using Anesthetic Gel Patches to Reduce Pain of Palatal Injection
Local anesthetic administration step is mandatory step for controlling pain before dental procedures. The aim of this study was to compare effectiveness of topical Benzocaine 18% gel patch form and Benzocaine 20% topical gel in…
- Trial name
- NCT04317508
- Testing
- Topicale GelPatch (Benzocaine 18%), Benzocaine oral gel 20%
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Dina Youssef Attia
Intravitreal Injections, IVI
Control of Pain in Intravitreal Injections Using Topical NSAIDs
Intravitreal injections (IVI) are a common form of treatment for multiple retinal pathologies. The investigators hypothesize that an intervention with a topical NSAID will alleviate pain experienced at intravitreal injection…
- Trial name
- COPIVIN (NCT04343222)
- Testing
- Bromfenac, Artificial tears
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Wisconsin, Madison
Pain
Patient Assessment of Topical Anesthetic Effectiveness for Intravitreal Injections
There are currently several different commercially available topical eye drops and gels used to reduce eye discomfort (topical anesthetics) during and after eye injections. Dr.
- Trial name
- NCT01027611
- Testing
- proparacaine HCL 0.5%, proparacaine HCL 0.5% + 4% lidocaine solution, 3.5% viscous lidocaine gel
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Illinois Retina Associates
Itch
Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens
With this experiment, we want to use to investigate whether repeated application of EMLA cream as a tool to modulate non-histaminergic itching, which is produced using small needles from the plant mucuna pruriens (it is known…
- Trial name
- NCT04858360
- Testing
- Emla 1 hour, EMLA 3 hours, Vehicle cream for 1 hour
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Topical Anaesthesia, General Anesthetic Drug Adverse Reaction
Evaluation of Postoperative Pain in Cases Undergoing Cataract Surgery Under Topical Versus General Anesthesia
Comparison between cataract surgery under local versus general anesthesia regarding postoperative pain, complications and patient satisfaction and need for rescue analgesic intake after surgery The results will be followed up at…
- Conditions
- Topical Anaesthesia, General Anesthetic Drug Adverse Reaction, Cataract
- Trial name
- NCT07287683
- Testing
- Topical Anaesthesia group, General Anaesthesia group
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Pain
A Study of the Effect of Time on Topical Anesthetic Efficacy.
This is a study of the effect of time on the effectiveness of topical anesthetics in the mouth. The Null Hypothesis is: Regardless of the time of application over a 10-minute period, there is no difference in the clinical…
- Trial name
- NCT00353041
- Testing
- lidocaine topical
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pain
Topical Anesthetic Use In Pessary Management
The purpose of this study is to evaluate if lidocaine-prilocaine (EMLA 5%) cream can reduce pain and discomfort at the time of vaginal pessary removal and insertion.
- Trial name
- NCT02380742
- Testing
- lidocaine-prilocaine cream
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Loyola University
Lidocaine Adverse Reaction, Prilocaine Adverse Reaction
Efficacy of a Topical Anesthetic Containing Lidocaine and Prilocaine in Treatment With CO2 Fractional Laser
This is a study aimed at evaluating the efficacy of a topical anesthesia (test product) compared to placebo in adult patients of phototypes I to III, with indication of treatment of CO2 fractional laser in the forehead.
- Trial name
- CO2 (NCT03366246)
- Testing
- Lidocaine / Prilocaine Cream
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
IUD
Use of Cervical Cap and Menstrual Disc for Application of Topical Anesthetic Prior to IUD Insertion
This prospective, open label, double arm, feasibility group study will recruit participants planning to undergo office intrauterine device (IUD) placement without sedation or anxiolysis at the Center for Women's Health.
- Trial name
- NCT06891794
- Testing
- Menstrual disc with EMLA cream, Cervical cap with EMLA cream
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Cutaneous Abscess
Conservative Management of Cutaneous Abscess
This is a single center non-blinded randomized trial of topical anesthetic cream to usual care (warm compresses and time) for superficial, non-perianal abscesses in children under 18 years of age.
- Trial name
- NCT05461053
- Testing
- LMX 4 Topical Cream
- Where
- United States
- Sponsor
- Rush University Medical Center
Circumcision, Male
Unicirc vs Open Surgical Circumcision
RCT of Unicirc under topical anesthetic w/ cyanoacrylate wound sealing vs. open surgical circumcision under local anesthetic with suturing.
- Trial name
- Unicirc004 (NCT02443792)
- Testing
- Unicirc with tissue adhesive, Open Surgical
- Where
- South Africa
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Simunye Primary Health Care
Pain, Acute
Bupivacaine vs Oxybuprocaine Topical Anesthesia in IVI
comparing two local anaesthetic agents, Bupivacaine 0.5% versus Oxybuprocaine used topically to provide surface anaesthesia before IVI procedures.
- Trial name
- NCT05069350
- Testing
- bupivacaine 0.5% and oxubuprocaine
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Research Institute of Ophthalmology, Egypt
Investigate the Efficacy of Sucrose During Eye Examination
Efficacy of Oral Sucrose and Topical Anesthetics to Reduce Pain During Eye Examination for Retinopathy of Prematurity
Oral sucrose reduces pain during heel sticks and venipunctures in preterm infants. The purpose of this study was to determine the effectiveness of local anesthetic eye drops and a pacifier, plus repeated doses of 24% sucrose, to…
- Trial name
- NCT01811979
- Testing
- Oral sucrose solution, Steril water
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr. Sami Ulus Children's Hospital
Dental Trauma, Local Anesthesia
Clinical Efficiency of Xanthan Hydrogels Containing Local Anesthetics Encapsulated in Nanostructured Lipid Carries
In a crossover, randomized, placebo-controlled, double-blind study, 40 volunteers will receive the following formulations: hydrogels containing LAs (local anesthetic) - lidocaine and prilocaine (both at 2.5%) encapsulated in CLN…
- Conditions
- Dental Trauma, Local Anesthesia, Oral Cavity Disease
- Trial name
- NCT05912335
- Testing
- Topical anesthetic
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Hemorrhoids
The Use of Topical Anaesthetic in the Banding of Internal Haemorrhoids
The investigators' aim is to assess if they can complete a study measuring the effect of local anaesthetic gel (Instillagel) on reducing pain experienced by patients undergoing a common treatment for haemorrhoids (piles).
- Trial name
- TAB (NCT04031131)
- Testing
- Instillagel, KY Gel
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Julie Dawson