Clinical trials: Total Blood Loss
Osteoarthritis, Knee
Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty
Our purpose of this study is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of this two topical hemostatic agents in primary TKA procedures in patients with a risk of…
- Trial name
- NCT02865174
- Testing
- Topical tranexamic acid, Floseal®, Enoxaparin
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Knee
Postoperative Drainage in Total Knee Arthroplasty in the Presence of Tranexamic Acid
The investigator's aim with this study is to address, with the new paradigm of tranexamic acid, the role of wound drainage following total knee arthroplasty in blood loss, blood transfusion requirements and functional recovery
- Trial name
- NCT03915756
- Testing
- Drainage of surgical wound
- Where
- Portugal
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Beatriz Ângelo
Osteoarthritis
Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine
This study involves research. The purpose of this research is to formally investigate the hemostatic efficacy of epinephrine to minimize blood loss after total joint arthroplasty.
- Trial name
- NCT00737139
- Testing
- Peri-articular injection of marcaine/epinephrine, Peri-articular injection of marcaine alone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Uterine Fibroids, Abnormal Uterine Bleeding
Does 3D Laparoscopy Improve Vaginal Cuff Suture Time?
The objective aim is to evaluate whether the use of 3D laparoscopy facilitates the vaginal cuff closure of the vaginal cuff during a total laparoscopic hysterectomy among novice laparoscopists (PGY 2-4, Fellow).
- Conditions
- Uterine Fibroids, Abnormal Uterine Bleeding, Pelvic Pain, Adenomyosis
- Trial name
- 3DRCT (NCT02192606)
- Testing
- Storz 3D Laparoscopy System, 2D Laparoscopy
- Where
- 2 sites in United States, Denmark
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Total Blood Loss
Reducing Blood Loss Using Tisseel in TKA
The purpose of this study is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of the topical hemostatic agents in patients receiving primary TKA procedures.
- Trial name
- NCT03310060
- Testing
- Tisseel, Tranexamic Acid
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Tourniquets, Knee Arthroplasty, Total
Tourniquet Pressure in Primary Total Knee Arthroplasty
This proposed novel randomized control trial (RCT) seeks to address this gap in TKA protocol by gaining a better understanding of the relationship between tourniquet pressure and time, and intraoperative performance and…
- Conditions
- Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
- Trial name
- NCT02830087
- Testing
- Tourniquet Cuff Pressure
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Infection, Bleeding
Effects of Microcrystalline Titanium Dioxide With Covalently Linked Monovalent Silver Ions on Complications After Total Hysterectomy ( ISTIAB-0)
Total hysterectomy is one of the most performed surgical procedures in the world and it is associated with post-operative complications.
- Conditions
- Infection, Bleeding, Complication, Postoperative
- Trial name
- ISTIAB-0 (NCT03791294)
- Testing
- TIAB: microcrystalline titanium dioxide with covalently linked monovalent silver ions
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Postoperative Hemorrhage
Efficacy of Intra-auricular Tranexamic Acid in Total Knee Arthroplasty
Tranexamic acid an antifibrinolytic that develops its anti-haemorrhagic action by inhibiting fibrinolytic activities of plasmin and many studies confirms its effectiveness in decreasing blood loss.
- Trial name
- NCT04085575
- Testing
- Acide Tranexamique
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Montauban
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Post Operative Blood Loss
Role of Topical Tranexamic Acid in Total Hip Arthroplasty
Total hip arthroplasty (THA) is a procedure associated with perioperative blood loss, requiring blood transfusions in some patients.
- Trial name
- TXA (NCT01866943)
- Testing
- Tranexamic Acid, Normal Saline Solution
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Tranexamic Acid, Blood Loss, Surgical
Intravenous vs. Topical Tranexamic Acid in Revision THA (VITALITY-X)
The objective of this study is to evaluate and compare the effects of intravenous and topical administration of tranexamic acid during revision hip arthroplasty on blood loss, allogenic blood transfusion rates, length of hospital…
- Conditions
- Tranexamic Acid, Blood Loss, Surgical, Arthroplasty, Replacement, Hip
- Trial name
- VITALITY-X (NCT02938962)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Intraoperative Bleeding, Post-operative Bleeding
Study to Compare the Addition of Floseal to Our Standard of Care to Control Post Operative Bleeding in TKR
The purpose of this study is to compare Floseal to our standard of care (SOC) to decrease intraoperative and immediate post-operative bleeding.
- Trial name
- NCT01891461
- Testing
- Floseal
- Where
- Canada
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Abnormal Uterine Bleeding, Uterine Bleeding
Outcomes on Abdominal Versus Vaginal Morcellation At Time of Hysterectomy
The purpose of the study is to investigate differences in perioperative and postoperative outcomes between the abdominal (AM) versus vaginal (VM) routes of contained morcellation in participants undergoing laparoscopic total…
- Conditions
- Abnormal Uterine Bleeding, Uterine Bleeding, Fibroid Uterus, Surgery
- Trial name
- NCT04434066
- Testing
- Total Laparoscopic Hysterectomy
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Osteoarthritis, Knee
Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty
Our purpose of this study therefore is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of combined topical application of these two hemostatic agents in different time during…
- Trial name
- NCT03328832
- Testing
- Topical tranexamic acid, Floseal®, rivaroxaban (10mg)
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Hematoma, Arthroplasty Complications
The Effect of Releasing the Tourniquet in Total Knee Replacement Before Closure on the Blood Loss , Joint Effusion , Hematoma Formation and Wound Complication
The study , observe the effect of releasing the Tourniquet in total knee replacement surgery before closure in comparison with releasing it after wound closure The effect was assessed by Hb drop post operative and Hematoma…
- Trial name
- NCT04810000
- Testing
- tourniquet
- Where
- Jordan
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Yazan Saleh Rajab Hammad
Osteoarthritis, Intraoperative Bleeding
Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Applying a fibrin spray, after knee device implantation, will help in reducing patient blood loss and decrease the drop in both hemoglobin and hematocrit levels.
- Trial name
- NCT01656759
- Testing
- Evicel Fibrin Spray
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days)
The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle
The investigators propose to test the hypothesis that the use of a prostaglandin inhibitor will result in premature luteolysis (ovulation failure) in women.
- Conditions
- Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days), Gonadotropin and Ovarian Hormone Levels (FSH, LH, E2, P)
- Trial name
- NCT00614406
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Total Blood Loss, Arthropathy of Knee Joint
Kaolin-based Hemostatic Gauze in Total Knee Arthroplasty
This study is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of combination of intravenous TXA and QCG in a primary TKA procedure.
- Trial name
- NCT05504577
- Testing
- Tranexamic acid injection, apply the QCG, apply surgical gauze
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Postoperative Bleeding
Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty
Tranexamic acid (TXA) is an anti-fibrinolytic agent developed in the 1960s that has been safely used to reduce blood loss, transfusion rates and bleeding-associated mortality in trauma, obstetrics and orthopedic surgery…
- Trial name
- TXA (NCT06208267)
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Blood Loss After a Total Hip Replacement
Evaluating the Effectiveness of Intramuscular Versus Intravenous Tranexamic Acid for Minimizing Blood Loss After Total Hip Arthroplasty: A Randomized Controlled Trial
Intramuscular vs. Intravenous Tranexamic Acid for Total Hip Arthroplasty
- Trial name
- NCT07817537
- Testing
- Tranexamic Acid (TXA) intarmuscular, Tranexamic Acid (TXA) intravenous
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Alexandria University