Clinical trials: Total Joint Arthroplasty
Total Knee Arthroplasty
Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty.
Total knee arthroplasty (TKA) is one of the most common orthopedic surgical procedures and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.
- Trial name
- LIAQ (NCT07477730)
- Testing
- Surgical local infiltration, Obturator nerve block, Femoral nerve block
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CMC Ambroise Paré
Total Knee Arthroplasty
Oral Tranexamic Acid After Total Knee Arthroplasty
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA).
- Trial name
- NCT06894719
- Testing
- tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm
- Volunteers
- 351 people
- Sponsor
- Rush University Medical Center
Osteoarthritis
The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty
The purpose of this study is to use a new combination of anesthesia techniques in an attempt to minimize early pain after surgery and improve the patient's ability to participate more fully with physical therapy.
- Trial name
- NCT00620828
- Testing
- Ropivicaine 0.5%
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Duke University
Arthroplasty Replacement, Knee, Gonarthrosis; Primary
The Effect of Intraoperative Findings Shown to the Patient on Early Postoperative Clinical Outcomes in Primary Total Knee Arthroplasty
The Effect of Showing Intraoperative Cartilage Damage and Post-Implantation Range of Motion Photos to Patients on Early Clinical and Functional Outcomes in Patients Undergoing Total Knee Arthroplasty Objective: The aim of this…
- Trial name
- NCT07364812
- Testing
- The Effect of Showing Intraoperative Cartilage Damage and Post-Implantation Range of Motion Photos to Patients on Early Clinical and Functional Outcomes in Patients Undergoing Total Knee Arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bezmialem Vakif University
Pain, Postoperative
Combination Effects of Pregabalin and Dexmedetomidine on Postoperative Pain
Pregabalin and dexmedetomidine have been introduced to manage postoperative pain. The present study aimed to evaluate the effect of the combination of two drugs on pain relief in patients undergoing total knee or hip arthroplasty…
- Trial name
- NCT03512574
- Testing
- Pregabalin, Dexmedetomidine, Pregabalin and dexmedetomidine
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Rheumatoid Arthritis, Osteoarthritis
G7 BiSpherical Acetabular Shell PMCF Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available G7 BiSpherical Acetabular Shell.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis
- Trial name
- NCT03266874
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 160 people
- Sponsor
- Zimmer Biomet
Anesthesia, Conduction, Osteoarthritis, Hip
Pain and Sensation After Regional Anesthesia - Pilot Study
This study aims to determine spinal resolution and pain levels after the placement of a lumbar plexus block (LPB) and spinal for total hip replacement procedure.
- Trial name
- NCT03623035
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Pain, Postoperative
Posterior Pericapsular Deep-gluteal Block
The goal of this clinical trial is to determine whether adding a posterior pericapsular deep-gluteal (PPD) block to pericapsular nerve group (PENG) and lateral femoral cutaneous nerve (LFCN) blocks improves pain control after…
- Trial name
- NCT07891013
- Testing
- PENG (Pericapsular nerve group) block, LFCN (Lateral femoral cutaneous nerve) block, PPD (Posterior pericapsular deep gluteal) block
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Knee Osteoarthritis, Knee Arthritis
Comparison of Two Robotic-Assisted Total Knee Arthroplasty Systems
The goal of this prospective study is to compare two different knee replacement robots. This study will look at patient reported outcome measures and data collected during the operation.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Disease
- Trial name
- NCT06284824
- Testing
- Stryker Triathlon with MAKO Robotic-Arm, DePuy Attune with VELYS Robotic-Assistance
- Volunteers
- 120 people
- Sponsor
- Southeast Orthopedic Specialists
Opioid Use, Pain, Musculoskeletal
Naloxone Education in Total Joint Patients
This study examines the efficacy of a brief pre-hospital naloxone education module added to the standard "Total Joint Class" curriculum on patient safety and experience.
- Conditions
- Opioid Use, Pain, Musculoskeletal, Surgery, Overdose of Opiate
- Trial name
- NCT04868552
- Testing
- Pre-hospital naloxone education
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Carilion Clinic
Total Knee Replacement Revision
LEGION™ Revision Metal Hypersensitivity Study
This is a prospective, randomized, multi-center, metal hypersensitivity study comparing OXINIUM and cobalt chrome femoral components in subjects with failed total knee arthroplasty (TKA).
- Trial name
- NCT02412813
- Testing
- LEGION OXINIUM, LEGION Cobalt Chrome
- Where
- 3 sites in United States, Canada
- Sponsor
- Smith & Nephew, Inc.
Fasting
Effect of Drinking Carbohydrate-containing Fluids on Gastric Residual Volume in Elderly Patients
In the past, some guidelines advised no oral intake for at least 8 hours before any surgery. However, research has shown risks associated with excessive fasting, such as postoperative insulin resistance, and advantages in shorter…
- Trial name
- NCT04514380
- Testing
- Carbohydrate fluid, Non-carbohydrate fluid
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Bundang Hospital
Prosthetic Joint Infection
Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee Arthroplasty
The purpose of this study is to investigate whether there are quantifiable differences in the level of calprotectin in the synovial fluid that allow separation of different modes of joint implant failure (e.g.
- Trial name
- NCT03694925
- Testing
- Calprotectin test
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- The Cleveland Clinic
Osteoarthritis, Hip, Osteoarthritis, Knee
Total Joint Arthroplasty (TJA) Weight Loss Study
This is a randomized clinical trial (RCT) to assess the efficacy of bariatric surgery vs medical weight loss vs. the "usual standard of care" to optimize a morbidly obese patient with end-stage osteoarthritis of the hip or knee…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Obesity, Morbid
- Trial name
- NCT05156762
- Testing
- Bariatric surgery, Medical weight loss, Patient research surveys
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston Medical Center
Osteoarthritis, Intraoperative Bleeding
Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Applying a fibrin spray, after knee device implantation, will help in reducing patient blood loss and decrease the drop in both hemoglobin and hematocrit levels.
- Trial name
- NCT01656759
- Testing
- Evicel Fibrin Spray
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Distal Humerus Fracture
Elbow Hemiarthroplasty Versus Total Elbow Arthroplasty for Irreparable Distal Humeral Fractures
Distal humeral fractures can be difficult to treat, in particular when the joint surface is affected (intra-articular fractures).
- Trial name
- NCT03596736
- Testing
- Elbow Hemiarthroplasty, Total Elbow Arthroplasty
- Where
- 3 sites in Sweden
- Volunteers
- 42 people
- Sponsor
- Linkoeping University
Knee Osteoarthritis, Knee Pain Chronic
The Effect of RF Genicular Nerve Block Applied in the Preoperative Period on Fast-track Total Knee Arthroplasty
In our study, investigators plan to compare the preoperative RF and genicular nerve ablation approach in patients who underwent TKA(Total Knee Arthroplasty) using the Fast-Track protocol in terms of meeting postoperative pain…
- Trial name
- NCT06239649
- Testing
- Genicular nerve Radiofrequency Ablation block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Femoral Head Size, Cup Size THP
Correlation Between Femoral Head and Cup Size and Postoperative Pain in Total Hip Arthroplasty
We want to investigate the correlation between the native femoral head and the implanted cup in Total hip arthroplasty. As second parameter to investigate we believe an oversized cup will cause groin pain.
- Conditions
- Femoral Head Size, Cup Size THP, Postoperatie Groin Pain
- Trial name
- jantje (NCT04637958)
- Testing
- THA
- Where
- Belgium
- Volunteers
- 463 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteo Arthritis Knee
Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty
An observational study of the effect of femoral nerve block in addition to an adductor canal block for pain following total knee arthroplasty.
- Trial name
- NCT03395990
- Testing
- Active comparator: chloroprocaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
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