Clinical trials: Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty
Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at…
- Trial name
- NCT06640491
- Testing
- IO Administration of Cefazolin, IO Administration of Vancomycin, IV Administration of Cefazolin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Knee Osteoarthritis
Kinematics of Contemporary Knee Arthroplasty
Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship.
- Trial name
- NCT02965690
- Testing
- Zimmer Biomet NexGen CR, Medacta International GMK Sphere
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Hip and Knee Osteoarthritis
Recovery After Fast Track THA / TKA
The development and implementation of "fast-track" principles in total knee and hip arthroplasty have resulted in early recovery and rehabilitation alongside a reduced length of hospital stay.
- Trial name
- 0-21 (NCT02137655)
- Where
- 2 sites in Denmark
- Volunteers
- 112 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Arthroplasty, Replacement
Evaluate the Performance of JOURNEY II CR and JOURNEY II BCS in TKA Populations
Background: The JOURNEY II BCS Total Knee System (JOURNEY II Bi-cruciate Stabilized Total Knee System) consists of femoral component made from oxidized zirconium (OXINIUM) The JOURNEY II CR Total Knee System (JOURNEY II Cruciate…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- JIICRBCSTKA (NCT04822259)
- Testing
- JOURNEY II BCS Total Knee System, JOURNEY II CR Total Knee System
- Where
- 5 sites in China, India and 1 more
- Sponsor
- Smith & Nephew, Inc.
Joint Diseases, Arthritis Knee
Anterior Knee Pain in Mobile Bearing Versus Fixed Bearing in TKA
Osteoarthritis is the most common cause of chronic joint disease, and its incidence has increased due to the high average life expectancy, in addition to the high incidence of obesity.
- Conditions
- Joint Diseases, Arthritis Knee, Arthroplasty Complications
- Trial name
- NCT05696418
- Testing
- Total knee arthroplasty with a Mobile Bearing system., Total knee arthroplasty with a Fixed Bearing system.
- Where
- Syria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Damascus University
Severe Knee Pain, Severe Knee Disability
Zimmer POLAR Persona - TKA (EMEA Study)
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona knee implants used in primary total knee arthroplasty. The assessment will include: 1.
- Conditions
- Severe Knee Pain, Severe Knee Disability, Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT02337244
- Testing
- Zimmer Persona Total Knee System
- Where
- 12 sites in Austria, France and 4 more
- Volunteers
- 777 people
- Sponsor
- Zimmer, GmbH
Postoperative Pain
Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement
The objectives in this study are to evaluate: (1) efficacy of buprenorphine transdermal system (BTDS, Butrans™) on postoperative pain following total knee replacement surgery; (2) the impact of BTDS on functional rehabilitative…
- Trial name
- NCT00403234
- Testing
- Buprenorphine transdermal patch
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Purdue Pharma LP
Arthroplasty Complications, Pain, Joint
Efficacy of iPACK After Unilateral TKA
Total knee arthroplasty (TKA) is a common orthopedic procedure associated with severe postoperative pain which may limit patient rehabilitation and hospital discharge.
- Conditions
- Arthroplasty Complications, Pain, Joint, Arthritis Knee, Regional Anesthesia Morbidity
- Trial name
- NCT04565093
- Testing
- iPACK, Periarticular local infiltration analgesia (LIA)
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Khalid University Hospital
Knee Osteoarthritis
A Prospective, Randomized Study Comparing Cemented and Cementless Total Knee Replacement
The purpose of this study is to compare the the Nexgen knee replacement system using cementless fixation with the same system using cemented fixation.
- Trial name
- NCT01194817
- Testing
- High-Flexion Knee Replacement System using Cemented Fixation, High-Flexion Knee Replacement System using Cementless Fixation
- Volunteers
- 100 people
- Sponsor
- Anderson Orthopaedic Research Institute
Total Knee Arthroplasty
Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA）
This is a randomized, double-blind, active-controlled, multicenter, phase II clinical study designed to evaluate the efficacy and safety of BT-114143 Injection in the perioperative treatment of unilateral total knee arthroplasty.
- Trial name
- TKA (NCT07127042)
- Testing
- Low-dose BT-114143, High-dose BT-14143, Tranexamic Acid (IV)
- Where
- China
- Volunteers
- 270 people
- Sponsor
- ScinnoHub Pharmaceutical Co., Ltd.
Knee Pain Swelling
Painful Total Knee Replacement (TKA) and I-one Therapy
Arthroplasty operations are very frequent and their number is constantly increasing. The success of prosthetic surgery is linked to surgical factors (prosthesis type, prosthesis design, prosthesis material, surgical hand) and…
- Trial name
- NCT06330454
- Testing
- I-ONE
- Where
- 7 sites in Italy
- Volunteers
- 237 people
- Sponsor
- University Hospital of Ferrara
Knee Arthropathy
Effects of Virtual Reality in TKA Patients
The goal of this clinical trial] is to investigate the effects of virtual reality (VR) in patients undergoing total knee arthroplasty (TKA).
- Trial name
- TKA (NCT05875324)
- Testing
- virtual reality application, exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Kırklareli University
Knee Osteoarthritis
ROM Outcomes in Patients Undergoing a Primary TKA
The goal of this prospective, randomized study is to compare the outcomes of patients undergoing primary TKA after photographing final knee range of motion immediately post-operatively and sharing these photographs with patients…
- Trial name
- NCT04217486
- Testing
- Patient will be shown a photograph of their knee at 2 weeks postop, Patient will not be shown a photograph of their knee at 2 weeks postop
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Louisville
Anesthesia, Local, Pain, Postoperative
Pain Management After TKA: Comparison of Short- and Long-term Nerve Blocks
The purpose of this study is to determine if there is any significant difference between using a short-term ON-Q nerve block (which is applied prior to surgery and maintained in place until the medication in the initial balls…
- Trial name
- NCT03245359
- Testing
- Short-term ON-Q, Long-term ON-Q
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- AdventHealth
Arthropathy of Hip, Arthropathy of Knee
Evaluation of Weight Bearing After Total Hip and Knee Replacement
The regime in the aftercare after total hip and knee arthroplasty(THA/TKA) differs a lot between orthopedic surgeons concerning weight bearing. The type of implant and the way of implants' anchoring are considered.
- Trial name
- NCT01135160
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Kantonsspital Münsterlingen
Total Knee Replacement
Kinematic Versus Mechanical Alignment in Total Knee Replacement
This prospective controlled double-blind randomized study compares kinematic and mechanical alignment in TKA (Total knee arthroplasty).
- Trial name
- KAvsMA (NCT04384913)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Hannover Medical School
Knee Osteoarthritis
Metal Ion Concentration Between Coated and Uncoated TKA
Metal ion release from metal implants may have side effects. It can be reduced by coating of the implant. This study compares coated and uncoated TKA.
- Trial name
- NCT03047564
- Testing
- Coated Total Knee Arthroplasty, Standard Total Knee Arthroplasty
- Volunteers
- 120 people
- Sponsor
- Technische Universität Dresden
Knee Osteoarthristis, Total Knee Anthroplasty
Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System
In an effort to satisfy regulatory requirements for post-market surveillance of product safety and efficacy, a representative sample of patients will be recruited for prospective monitoring.
- Trial name
- NCT06627699
- Testing
- Total Knee Arthroplasty
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Maxx Orthopedics Inc
Total Knee Arthroplasty, Robotic
Early Radiographic and Clinical Outcomes of Robotic-Arm-Assisted Versus Conventional TKA
Purpose: A robotic system was recently introduced to improve prosthetic alignment during total knee arthroplasty (TKA). The purpose of this multicenter prospective randomized controlled trial (RCT) study was to determine whether…
- Trial name
- TKA (NCT05987839)
- Testing
- robotic system
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University Third Hospital
Arthritis Knee, Gait Biomechanics
Muscles Strength and Gait Parameteres After TKA
Total Knee Arthroplasty (TKA) is actually the most effective treatment option for patients with end-stage osteoarthritis (OA). However, nearly 20% of patients who underwent TKA remain unsatisfied with their clinical outcome.
- Conditions
- Arthritis Knee, Gait Biomechanics, Total Knee Arthroplasty, Muscle Strength
- Trial name
- NCT06061367
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw