Clinical trials: Total Knee Replacement Surgeries
Postsurgical Pain
Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery
The objectives of this study are to evaluate the safety and analgesic efficacy of a single preoperative intrathecal administration of AYX1 Injection at two dose/volume levels.
- Trial name
- NCT02081703
- Testing
- AYX1 Injection 660 mg / 6 mL, AYX1 Injection 1100 mg / 10 mL
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Adynxx, Inc.
Osteoarthritis, Knee, Joint Diseases
Comparative Study of Navigation-assisted OrthoPilot® Elite and Robotic-assisted MAKO® Total Knee Arthroplasty
Randomized, controlled, single center observational study to compare the safety and performance of navigation-assisted OrthoPilot Elite and robotic-assisted MAKO total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Joint Diseases, Rheumatoid Arthritis of Knee, Posttraumatic Arthropathy
- Trial name
- ORMAK (NCT05980442)
- Testing
- Navigated total knee arthroplasty, Robot assisted total knee arthroplasty
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Aesculap AG
Blood Loss, Surgical
Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty
The purpose of this study is to compare blood loss between using low dose (500 mg) and high dose (3 g) topical intra-articular tranexamic acid after total knee arthroplasty in double-blind RCT
- Trial name
- NCT03044041
- Testing
- Tranexamic Acid
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Thammasat University
Prehabilitation, Preoperative Care
Preoperative Optimization Before Total Hip or Knee Replacement Surgery
Preoperative Optimisation prior to Hip and Knee Arthroplasty (PrOpE) Many patients scheduled for planned hip or knee replacement surgery have health conditions that may affect recovery, such as reduced physical fitness…
- Trial name
- PrOpE (NCT07394582)
- Testing
- Prehabilitation
- Where
- Austria
- Volunteers
- 180 people
- Sponsor
- Medical University Innsbruck
Total Knee Replacement, Postoperative Recovery
Efficacy of Kinesiotaping During Rehabilitation Following Total Knee Replacement Surgery
The aim of this study was to examine the efficacy of Kinesiotaping (KT) within postoperative rehabilitation after Total Knee Replacement (TKR) surgery by determining whether KT enhances early postoperative outcomes, in terms of…
- Conditions
- Total Knee Replacement, Postoperative Recovery, Rehabilitation Outcome
- Trial name
- KT-TKR (NCT06831682)
- Testing
- Kinesiotaping (KT), Standard Rehabilitation
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- SRH Gesundheitszentrum Bad Herrenalb
Unicompartmental Knee Replacement, Osteo Arthritis Knee
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control.
- Conditions
- Unicompartmental Knee Replacement, Osteo Arthritis Knee, Surgery
- Trial name
- NCT04095637
- Testing
- Medial knee arthroplasty
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University College, London
Knee Osteoarthritis
SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty
This randomized controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under…
- Trial name
- NCT07449442
- Testing
- sodium Chloride, Ropivacaine Hydrocloride
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Knee Arthropathy
Laser + Cryo-thermal Therapy Following Total Knee Replacement Surgery
Objective To investigate the effectiveness of the use of the QMD Helios Laser device in association with standard rehabilitation therapy in reducing inflammatory symptoms in patients following total knee replacement.
- Trial name
- NCT04183673
- Testing
- Laser therapy-cryo thermal therapy, Usual care
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Pain, Postoperative, Surgery
The Effect of Baduanjin on Patients Undergoing Knee Replacement Surgery
This randomized controlled trial aims to evaluate the effects of Baduanjin, a traditional Chinese mind-body exercise, on pain, comfort, and quality of recovery in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Pain, Postoperative, Surgery, Knee Replacement, Nurse's Role
- Trial name
- NCT07109557
- Testing
- Baduanjin
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Niran Çoban
Arthroplasty, Replacement, Knee
Silkeborg Knee Replacement Cohort Study
In this cohort study, we will investigate short and long term outcomes after knee replacement surgery and identify preoperative and early postoperative factors associated with long term outcome.
- Trial name
- NCT03411083
- Testing
- Total or unicompartmental knee replacement
- Where
- Denmark
- Volunteers
- 1,225 people
- Sponsor
- Central Jutland Regional Hospital
Osteoarthritis
Functional Outcome in Two Types of Total Knee Replacement Surgery for People With Osteoarthritis
When performing total knee replacement surgery, the surgeon has a choice as to which type of surgical technique to use. The standard technique at the Royal Infirmary in Edinburgh is the so-called 'medial parapatellar' exposure.
- Trial name
- NCT01576445
- Testing
- Mid-vastus approach, medial parapatellar approach
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Margaret University
Arthroplasty, Replacement, Knee, Hip
Prospective Randomized Controlled Trial of Impact of Enhanced Recovery After Surgery(ERAS) for Outcomes of Total Knee and Hip Arthroplasty
The purpose of this study is to analyze the effect of the ERAS(early recovery after surgery) protocol on total knee and hip arthroplasty compared to conventional standard protocol.
- Trial name
- NCT03869203
- Testing
- Enhanced recovery after surgery (ERAS)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Knee Pain Swelling
Role of Two Rehabilitative Treatments and Diet in the Modulation of Inflammation in Patients With Knee Prosthesis.
The investigators studied the influence of two aproved rehabilitative treatments, connective tissue techniques and lymphatic drainage, on acute inflammation markers.
- Trial name
- NCT04580069
- Testing
- Lymphatic drainage
- Where
- 2 sites in Italy
- Volunteers
- 34 people
- Sponsor
- Presidio Ospedaliero di Asiago
Arthroplasty, Knee Replacement
Neurostimulation an Adjuvant Postoperative Analgesic in Total Knee Replacement (TKR) Surgeries
To study and evaluate the effect of using the Primary Relief PENS treatment as adjuvant analgesia for reducing pain in total knee replacement (TKR) patients.
- Trial name
- TKR (NCT05416294)
- Testing
- Primary Relief, Inactive Primary Relief
- Sponsor
- DyAnsys, Inc.
Knee Osteoarthritis, Total Knee Arthroplasty
Improved Pain Management in Knee Osteoarthritis-related Surgeries
In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects.
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty, High Tibial Osteotomy
- Trial name
- NCT06124170
- Testing
- Preoperative pain managment, Intraoperative pain managment, Postoperative pain managment
- Where
- China
- Volunteers
- 714 people
- Sponsor
- Peng Liu
Knee Arthroplasty, Total, Post Operative Pain, Acute
Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery
The purpose of this research is to see if a person having an outpatient total knee replacement will have a difference in their pain and the amount of pain medication (opioids) used after discharge if they are given suzetrigine (a…
- Conditions
- Knee Arthroplasty, Total, Post Operative Pain, Acute, Opioid Consumption, Postoperative
- Trial name
- NCT07796152
- Testing
- Suzetrigine, Opioid standard care pain medicine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Endeavor Health
Knee Injuries
Femoral/Sciatic Block for Knee Surgery
Knee arthroplasty has a high potential for postoperative pain. This study compares analgesia and postoperative bleeding from intrathecal morphine with the continuous femoral and a single-shot sciatic nerve blockades.
- Trial name
- NCT02882152
- Testing
- femoral nerve blockade, morphine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Total Knee Arthroplasty, Fracture of Head of Femur Articular Displaced
Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved.
- Conditions
- Total Knee Arthroplasty, Fracture of Head of Femur Articular Displaced, Protrusion of Intervertebral Disc
- Trial name
- NCT04423276
- Testing
- Donepezil
- Where
- China
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Knee Replacement Arthroplasty
Effect of Adductor Canal Block vs. Placebo on Muscle Strength, Mobilisation and Pain After Total Knee Arthroplasty
The purpose of this study is to evaluate the effect of adductor canal block (ACB) vs. placebo on muscle strength, mobility and pain on the first postoperative day after total knee alloplastic (TKA).
- Trial name
- NCT02242591
- Testing
- Ropivacaine 7,5 mg/ml, Saline
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Ulrik Grevstad
Knee Osteoarthritis, Knee Disease
The Effect of Motor Imagery and Motion Observation Training on Pain, Functionality, Balance, and Anxiety After Knee Replacement Surgery: A Randomized Controlled Study
This single-center randomized controlled trial aims to evaluate the effects of motor imagery and action observation training on pain, functionality, balance, and fear of movement in patients after total knee arthroplasty (TKA).
- Trial name
- NCT07327190
- Testing
- Traditional Physiotherapy, Motor imagery training, Action observation training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kutahya Health Sciences University