Clinical trials: Toxicity
Gadolinium Toxicity
In Vitro Study of the Effect of Gadolinium Contrast on Fibrocytes
Gadolinium contrast agents are frequently administered for MRI imaging. Very little is known of its toxicity outside of patients with reduced renal function.
- Trial name
- NCT02512796
- Testing
- Gadolinium contrast dye
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Arthralgia, Breast Neoplasms
Omega-3 Supplementation in Prevention of Aromatase Inhibitor-Induced Toxicity in Patients With Stage I-III Breast Cancer
This clinical trial studies the use of omega-3 fatty acid supplementation in preventing aromatase inhibitor-induced toxicity in patients with stage I-III breast cancer.
- Trial name
- NCT02831582
- Testing
- Omega-3 Fatty Acid
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Spinal Anesthetic Toxicity, Hypotension Drug-Induced
Comparison of Two Different Norepinephrine Bolus Doses for Management of Spinal Anesthesia-Induced Maternal Hypotension
In this study the investigators will compare two doses of norepinephrine bolus (6 mcg and 8 mcg) in management of maternal hypotensive episode after spinal block during cesarean delivery.
- Conditions
- Spinal Anesthetic Toxicity, Hypotension Drug-Induced, Cesarean Section Complications
- Trial name
- NCT05502146
- Testing
- Noradrenaline Bitartrate, Bupivacaine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mersin University
Toxic Leadership Styles
The Efficacy of the iWork.COMP Among Health Care Professionals
According to the literature, the prevalence of anxiety, depression, and/or burnout symptoms among healthcare workers is high. There are several factors than can, directly or indirectly, be related to these symptoms, being the…
- Trial name
- iWorkCOMP (NCT07018089)
- Testing
- iWork.Comp
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Plaque, Gingivitis
A Pilot Study to Evaluate a Method for Plaque When Comparing Stannous Fluoride Toothpaste to a Regular Dentifrice
This study will evaluate the sensitivity of an assay and its ability to split a marketed stannous fluoride toothpaste versus a negative control.
- Trial name
- NCT02543060
- Testing
- stannous fluoride toothpaste, cavity protection toothpaste
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
MEK Inhibitor-Associated Serous Retinopathy
Investigation of Potential Retinal Toxicity Associated With Hair Dye Products Containing pPD Type Aromatic Amines
Hair dye products could induce minimal forms of MEKAR retinopathies (Mitogen-activated Extracellular signal-regulated Kinase - inhibitors associated retinopathies).
- Trial name
- CAPITOX (NCT04222387)
- Testing
- OCT-B scan
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity
Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
The MyBrain study investigates the brain function of children, adolescents and young adults during and after chemo treatment for cancer.
- Conditions
- Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity, Chemo-brain, Cancer
- Trial name
- MyBrain (NCT05840575)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Brain Tumor
Creating a Decision Support System for the Corporate Management of Physical Therapy
The purpose of this study is to create a software product on the basis of the support technologies for making decisions for the collaboration of the different specialists, the family and the patient himself in the process of…
- Conditions
- Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Brain Tumor, Physical Activity, Physical Disability
- Trial name
- NCT03586401
- Where
- Russia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Healthy Participants
A Study to Investigate the Effect of AZD0780 on Metformin Pharmacokinetics in Healthy Adult Volunteers Aged 18 to 55 Years
The purpose of this study is to determine how the experimental medication AZD0780 impacts the pharmacokinetics (PK) of metformin, a common medication used to treat type 2 diabetes mellitus, when given together in healthy…
- Trial name
- NCT07216131
- Testing
- AZD0780, Metformin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
HIV Infections
Effects of Maternal Anti-HIV Treatment on Infants Born to HIV-Infected Women
In clinical trials being conducted throughout the world, pregnant HIV-infected women are given anti-HIV drugs before, during, and after they give birth to prevent mother-to-child transmission of HIV.
- Trial name
- NCT00100867
- Where
- 23 sites in Botswana, Brazil and 6 more
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Death, Sudden, Cardiac, Arrythmia
Monitoring of Arrhythmias in Patients Treated With Antipsychotics
Antipsychotics may be associated to life-threatening arrhythmias and sudden cardiac death. This is the fist study to estimated the arrhythmic burden using long-term monitoring by implantable loop recorder in patients treated with…
- Conditions
- Death, Sudden, Cardiac, Arrythmia, Antipsychotics and Neuroleptics Toxicity
- Trial name
- MAPP (NCT04575103)
- Testing
- Antipsychotic
- Where
- 18 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Acetaminophen Toxicity
Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing
A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the…
- Trial name
- APAPII (NCT02322879)
- Testing
- First Treatment Period, Washout, Second Treatment Period
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Dental Caries
Nanosilver Fluoride to Prevent Dental Biofilms Growth
This study aims to evaluate the effectiveness of nanosilver fluoride for controlling the growth of S. mutans present in dental plaque of children.
- Trial name
- NSFCT (NCT01950546)
- Testing
- nanosilver fluoride
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Consumption, Toxicity
Assessment of Peroxide Level in Saliva During Teeth Bleaching With 9.5% Hydrogen Peroxide Gel
Assessment of peroxide level in saliva during teeth bleaching with 9.5% hydrogen peroxide gel using a tray with reservoir versus a tray without reservoir. A randomized clinical trial
- Trial name
- NCT05605834
- Testing
- 9.5% hydrogen peroxide bleaching (POLA DAY advanced tooth whitening system, SDI) using a tray with reservoir, 9.5% hydrogen peroxide bleaching (POLA DAY advanced tooth whitening system, SDI) using a tray without reservoir.
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Depressive Symptoms, Anxiety Disorders and Symptoms
Pregnancy Without Psychosocial Stress
The project is aimed at children who are exposed to the toxic psychosocial stress present in their mothers during pregnancy or after childbirth.
- Conditions
- Depressive Symptoms, Anxiety Disorders and Symptoms, Depression, Postpartum
- Trial name
- NCT04853693
- Testing
- Mom´s Supporting Mom, Enhanced Treatment As Usual
- Where
- Czechia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Non Toxic Multinodular Goiter, High Intensity Focused Ultrasound
HIFU Ablation vs Fixed-dose RAI-131 Therapy in Moderate-sized Non-toxic MNG
After obtaining informed consent, eligible subjects will be assigned randomly into either High intensity focused ultrasound group (HIFU) or Radioactive iodine (131I) therapy group (RAIT).
- Conditions
- Non Toxic Multinodular Goiter, High Intensity Focused Ultrasound, RAI
- Trial name
- NCT04009863
- Testing
- Echopulse, Radioactive iodine (Radioidine i131)
- Where
- Hong Kong
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Toxic Shock Syndrome Staphylococcal
Phase I STEBVax in Healthy Adults
The main purpose of this study is to test the safety of a new vaccine, STEBVax, which may lead to a useful treatment for toxic shock syndrome.
- Trial name
- NCT00974935
- Testing
- Aluminum hydroxide, STEBVax vaccine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nicotine Dependence, Tobacco Toxicity
Cigarette Harm Reduction With Electronic Cigarette Use
This is an observational, crossover study that will be examine use behaviors, chemical exposures, and biological effects of SREC compared to TC use in subjects confined to a research ward setting.
- Conditions
- Nicotine Dependence, Tobacco Toxicity, Nicotine Dependence, Cigarettes, Cardiovascular Risk Factor
- Trial name
- NIDA-SREC (NCT03473483)
- Testing
- SREC
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Frailty, Fall
Frailty Status and Increased Risk for Falls
We hypothesized that the use of anticholinergic medications may precipitate falls differently by frailty status in older adults.
- Conditions
- Frailty, Fall, Anticholinergic Toxicity
- Trial name
- NCT04233541
- Testing
- Fall assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Organophosphate Poisoning
Paraoxonase-1 Pseudo Cholinesterase Organophosphate Toxicity Enzyme in Prediction the Severity and Outcome of Acute Organophosphate Poisoning and Its Correlation With Pseudo Cholinesterase Enzyme Level.
The aim of the present study is to: Evaluate the serum Paraoxonase-1 level in cases with organophosphate compounds poisoning and to correlate it᾿s level with the severity, outcome of acutely organophosphate poisoned cases .
- Trial name
- NCT06108557
- Testing
- Serum Pararoxonase -1 level, Diagnostic Test: Serum pseudocholinesterase enzyme level
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University