Clinical trials: Tracheobronchomalacia
Tracheobronchomalacia, Excessive Dynamic Airway Collapse
Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC
The purpose of this protocol is to perform a prospective, randomized, double-blinded, pacebo-controlled clinical trial to determine the influence of a non-invasive positive pressure ventilation device on exercise capacity and…
- Trial name
- NCT04217603
- Testing
- Continuous positive airway pressure (CPAP) device
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Beth Israel Deaconess Medical Center
Tracheobronchomalacia
Bioresorbable Airway Splint Pivotal Clinical Trial
The purpose of this study is to learn if a three-dimensional (3D) printed airway splint device made to hold open a collapsing airway is a safe and effective treatment of Tracheobronchomalacia (TBM) in children.
- Trial name
- NCT06406452
- Testing
- Bioresorbable Tracheobronchial Splint
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Tracheobronchomalacia, Excessive Dynamic Airway Collapse
Airway Stents for Excessive Dynamic Airway Collapse
Airway stents are used as standard of care to identify which patients with excessive dynamic airway collapse will benefit from a definitive surgical treatment.
- Trial name
- NCT02982876
- Testing
- Dynamic Flexible Bronchoscopy, Rigid Bronchoscopy, Stent placement
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Tracheobronchomalacia
The Effect of Bethanechol on Tracheobronchomalacia
The primary aim of this study is to determine if work of breathing estimated using swing Edi will be improved following initiation of bethanechol in infants with tracheobronchomalacia.
- Trial name
- NCT05299008
- Testing
- Bethanechol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Excessive Central Airways Collapse, Respiratory Disease
Portable Continuous Positive Airways Pressure (CPAP) in Excessive Central Airway Collapse (ECAC) Study
This study will investigate the role of a portable Continues Positive Airway Pressure device (pCPAP) in management of patients with symptomatic Excessive Central Airway Collapse (ECAC).
- Conditions
- Excessive Central Airways Collapse, Respiratory Disease, Tracheobronchomalacia, Excessive Dynamic Airway Collapse
- Trial name
- NCT06072872
- Testing
- Use of portable CPAP
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Tracheobronchomalacia
PEEP Mask for Tracheobronchomalacia-Induced Cough
This study aims to determine if an expiratory resistance device that delivers non-invasive positive expiratory pressure (nPEP) will reduce or stop coughing, reduce airway resistance and improve quality of life in patients with…
- Trial name
- NCT04169282
- Testing
- nPEP (non-invasive positive expiratory pressure) mask
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Airway Disease
Characterisation of Large Airway Collapse During Exercise (LACE)
The large central airways (i.e. trachea and bronchi) act as a conduit to enable lower airway ventilation but also facilitate airway clearance during dynamic manoeuvres, such as coughing.
- Trial name
- LACE (NCT04264052)
- Testing
- CBE & MRI
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Excessive Dynamic Airway Collapse, Tracheobronchomalacia
Symptomatic Treatment of Excessive Dynamic Airway Collapse Using Daytime Portable Continuous Positive Airway Pressure
The aim of this study is to assess the benefit of a portable ventilator generating positive end-expiratory pressure on exercise tolerance in patients with Excessive dynamic airway collapse (EDAC) and tracheobronchomalacia (TBM).
- Trial name
- EPOC (NCT02763631)
- Testing
- Experimental: Treatment, Experimental: Run In Phase
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Trachebronchomalacia (TBM), Hyper Dynamic Airway Collapse (HDAC)
Correlation Between Trachebroncho Malacia/Hyperdynamic Airway Collapse And Obstructive Sleep Apnea
The investigators hypothesize that there is a strong correlation between OSA and TBM/HDAC. Our hypothesis is based on the similarities in mechanism (airway collapse), symptoms (daytime and nocturnal dyspnea) predisposing…
- Conditions
- Trachebronchomalacia (TBM), Hyper Dynamic Airway Collapse (HDAC), Obstructive Sleep Apnea (OSA)
- Trial name
- NCT02097212
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Jewish Health
Tracheobronchomalacia, Tracheal Stenosis
Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis
It is not clearly understood what causes tracheobronchomalacia (weakening of the windpipe and airways) or tracheal stenosis (narrowing of the windpipe).
- Trial name
- NCT00705848
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
Tracheomalacia, Tracheobronchomalacia
Tracheal Mechanics During Bronchoscopy
The main purpose of this study is use a new type of measurement to help decide what kind of therapy would help people with a collapsing windpipe or tracheomalacia.
- Trial name
- NCT00536315
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Tracheomalacia, Tracheobronchomalacia
Tracheobronchomalacia: Treatment Outcomes
The purpose of this study is to evaluate respiratory symptoms and their impact in the quality of life and after treatment of the respiratory condition (tracheobronchomalacia - TBM).
- Trial name
- NCT00550602
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Beth Israel Deaconess Medical Center
Tracheobronchomalacia
Efficacy and Safety Evaluation of HCPA-1 Silicone Stent in the Treatment of Central Airway Obstructions
The aim of the study is, primarily, evaluate the safety of the use of the silicone stent HCPA-1 in patients with clinically significant tracheal and/or bronchial stenosis.
- Trial name
- NCT01389531
- Testing
- Rigid bronchoscopy
- Where
- 9 sites in Brazil
- Volunteers
- 110 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Tracheobronchomalacia
Pressure Dependent Tracheal Obstruction in Copd Patients
Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study.
- Trial name
- PDTO (NCT01679808)
- Where
- Norway
- Volunteers
- 104 people
- Sponsor
- LHL Helse