Clinical trials: Transbronchial Lung Cryobiopsy
Hemorrhage Lung, Endobronchial Mass
Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy
Transbronchial cryobiopsies are common procedures used to obtain tissue samples from airways for diagnostic purposes. While these procedures are safe, there is a risk of bleeding from the biopsy site.
- Trial name
- CRYOTXA (NCT06266546)
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Youssef Yammine
Lung Cancer
Safety of Lung Cryobiopsy in People With Cancer
The purpose of this study is to find out whether a biopsy technique called transbronchial cryobiopsy (TBCB) is a safe alternative to the standard biopsy procedure (transbronchial forceps biopsy; TBFB).
- Trial name
- NCT04548830
- Testing
- Transbronchial cryobiopsy
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Interstitial Lung Disease (ILD)
Confocal Laser Endomicroscopy Guided Cryobiopsy in the Diagnosis of Interstitial Lung Disease
This prospective, single-center, randomized controlled trial compares pCLE-guided TBLC with conventional TBLC in patients with suspected interstitial lung disease.
- Trial name
- NCT06741826
- Testing
- pCLE-guided transbronchial lung cryobiopsy, Fluoroscopy-guided transbronchial lung cryobiopsy
- Where
- China
- Volunteers
- 430 people
- Sponsor
- China-Japan Friendship Hospital
Interstitial Lung Diseases (ILD), Hypersenstivity Pneumonitis
Diagnostic Yield and Safety of Lung Biopsy Techniques in Interstitial Lung Diseases
This study aims to evaluate the diagnostic yield and safety of different lung biopsy techniques in patients with interstitial lung diseases (ILD).
- Trial name
- DYSAFE-ILD (NCT07432503)
- Testing
- Transbronchial forceps biopsy, transbronchial cryobiopsy, thoracoscopic lung biopsy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Diagnosis, Complication Rate
The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in The Pulmonary Periphral Nodule
Transbronchial cryobiopsy under the guidance of endobronchial ultrasound is performed in patients with pulmonary peripheral nodule, and assess the diagnostic yield and safety.
- Trial name
- NCT04661956
- Testing
- Transbronchial cryobiopsy/Transbronchial lung biopsy (forcep)
- Where
- 24 sites in China
- Volunteers
- 300 people
- Sponsor
- ShiYue Li
Lung Cancer (NSCLC)
Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes
EBUS-guided cryobiopsy of mediastinal and hilar lymph nodes has shown to be a useful diagnostic tool to obtain tissue for histological analysis and further targeted therapies in lung malignancies.
- Trial name
- NCT06921681
- Testing
- Cryobiopsy of lymph nodes group 6 sec, Cryobiopsy lymphnode group 3 sec
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University of Zurich
Lung Transplant Rejection, Lung Transplant Failure and Rejection
Comparison of Transbronchial Cryobiopsy and Forceps Biopsy in Lung Transplant Recipients
CLAD is defined as loss of lung function after other factors, particularly infections have been excluded. Readily accessible diagnostic procedures to detect acute cellular rejection at the earliest possible occasion is crucial…
- Trial name
- Kryo-LUTPL (NCT05006742)
- Testing
- CB study arm, FB-CB study arm
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Interstitial Lung Disease (ILD), Bronchoscopy
Safety of Bronchoscopy in Patients With Interstitial Lung Disease
Bronchoscopy is an essential technique, routinely used in the differential diagnosis workup of many Interstitial Lung Diseases (ILDs) and in referral centres is a common procedure.
- Conditions
- Interstitial Lung Disease (ILD), Bronchoscopy, Bronchoalveolar Lavage (BAL), Acute Exacerbation
- Trial name
- SaBrILD (NCT07627594)
- Where
- 11 sites in France, Italy
- Volunteers
- 427 people
- Sponsor
- University of Milan
Pulmonary Fibrosis, Transbronchial Cryobiopsy
A Retrospective Study of Transbronchial Cryobiopsy in the Diagnosis of Progressive Pulmonary Fibrosis
The goal of this observational study is to learn about the diagnostic effectiveness, safety, and influencing factors of transbronchial cryobiopsy（TBLC） in progressive pulmonary fibrosis.
- Trial name
- NCT06275295
- Volunteers
- 300 people
- Sponsor
- China-Japan Friendship Hospital
Lung Diseases
Defining a Technique for the Use of Cryogenic Catheters for Biopsy and Ablation for the Diagnostic and Treatment of Pulmonary Lesions: An Ex-Vivo Human Lung Model Study.
Developing a standardized methodology for the use of novel cryogenic catheters for transbronchial cryobiopsy and cryoablation of pulmonary lesions.
- Trial name
- CT0129 (NCT05948904)
- Testing
- Cryo Ex Vivo
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Lung Transplantation
Transbronchial Cryobiopsy in Lung Transplant Patients
Cryobiopsy has displaced the transbronchial biopsy (BTB) with forceps because it allows to obtain samples of more representative pulmonary parenchyma with more alveoli, less artifacts and a greater diagnostic yield.
- Trial name
- NCT03090594
- Testing
- Biopsy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pulmonary Fibrosis, Transbronchial Cryobiopsy
Application of Transbronchial Cryobiopsy in the Diagnosis of Progressive Pulmonary Fibrosis
The goal of this clinical study is to learn about the diagnostic effectiveness, safety, and influencing factors of transbronchial cryobiopsy（TBLC）in progressive pulmonary fibrosis.
- Trial name
- NCT06251687
- Testing
- Transbronchial Cryobiopsy，TBLC, Transbronchial Lung Biopsy，TBLB
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Transbronchial Cryobiopsy
EBUS Guided Cryobiopsies With Ultrathin Cryoprobe in Patients With Peripheral Pulmonary Nodules - a Feasibility Study
The standard procedure in the diagnosis of peripheral round foci is bronchoscopy with transbronchial forceps biopsy (TBB). Despite the simultaneous application of X-ray fluoroscopy, the diagnostic value of this method depends…
- Trial name
- NCT04471324
- Testing
- EBUS cryo probe
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Thoraxklinik-Heidelberg gGmbH
Interstitial Lung Disease
Diagnostic Value of Transbronchial Lung Cryobiopsy
Evaluating the diagnostic value of transbronchial lung cryobiopsy (TBLC) as well as its procedural feasibility and safety in a prospective series of 20 patients with diffuse interstitial lung diseases (DILD) who are referred for…
- Trial name
- NCT02579304
- Testing
- transbronchial lung cryobiopsy
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- KU Leuven
Interstitial Lung Diseases (ILD)
TBLC vs NIVATS in Interstitial Lung Disease
Patients with suspected interstitial lung disease (ILD) may require a lung biopsy when clinical and imaging findings are inconclusive.
- Trial name
- NCT07910448
- Testing
- NIVATS biopsy, TBLC biopsy
- Where
- Portugal
- Volunteers
- 74 people
- Sponsor
- Rita Alexandra Afonso da Costa