Clinical trials: Transbronchial Lung Cryobiopsy
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Cryobiopsy Versus Forceps Biopsy for Pulmonary Lesions
Purpose: Patients with peripheral lung nodules require evaluation for lung cancer. Our aim is to assess the diagnostic yield of a new technique, transbronchial cryobiopsies, in patients at risk for lung cancer.
- Trial name
- NCT02983903
- Testing
- transbronchial biopsy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Pennsylvania
Interstitial Lung Disease
Prospective, Randomised Multicenter Study Comparing the Efficacy of Transbronchial Forceps Biopsy With Cryobiopsy to Diagnose Interstitial Lung Disease.
The use of cryoprobes improves the diagnostic yield in transbronchial biopsies compared to forceps biopsies to diagnose an interstitial lung disease
- Trial name
- TRABIS (NCT01894113)
- Testing
- transbronchial lung biopsy
- Where
- Germany
- Volunteers
- 382 people
- Sponsor
- University Hospital Tuebingen
Lung Ground-Glass Opacity
The Efficacy and Safety of TBCB vs TBFB in Diagnosis of GGO
The aim of this study is to investigate the difference of efficacy and safety between transbronchial cryobiopsy (TBCB) and transbronchial forceps biopsy (TBFB) in the diagnosis of lung ground-glass opacity.
- Trial name
- NCT04727190
- Testing
- Transbronchial Cryobiopsy, Transbronchial Forceps Biopsy
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Shanghai Chest Hospital
Lung Diseases, Interstitial
Cryobiopsy Study to Assess Drug Distribution in Subjects With Suspected Interstitial Lung Disease
Interstitial lung disease (ILD) often affects distal lung, and the evaluation of drug distribution to the relevant lung compartments is essential for development of new treatment options.
- Trial name
- NCT03136120
- Testing
- Ipratropium Bromide, Flexible Bronchoscopy/Biopsy
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
Lung Carcinoma
Three-Dimensional Fluoroscopic Guidance During Transbronchial Cryobiopsy
This study assesses the effectiveness of transbronchial cryobiopsy guided by 3-dimensional fluoroscopy. Transbronchial cryobiopsy is a procedure to collect lung tissue.
- Trial name
- NCT05059691
- Testing
- Electronic Health Record Review, Transbronchial Cryobiopsy Guided by Three-Dimensional Fluoroscopy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center
Interstitial Lung Disease
Study Comparing Two Different Methods of Cryobiopsy in the Interstitial Lung Diseases
Interstitial lung diseases (ILD) are a heterogeneous collection of more than 100 different pulmonary disorders. Surgical lung biopsie in combination with multidisciplinary discussion is recommend in combination to reach a…
- Trial name
- NCT03727568
- Testing
- Cryobiopsy
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- University Hospital, Essen
Lung Cancer
EBUS-TBNA vs Transbronchial Mediastinal Cryobiopsy for Adequacy of Next Generation Sequencing
This is a multi-center clinical trial evaluating the effect of transbronchial mediastinal cryobiopsy for its ability to improve the likelihood of obtaining tissue sufficient for molecular analysis.
- Trial name
- FROSTBITE-3 (NCT06105801)
- Testing
- Endobronchial ultrasound with transbronchial needle aspiration, Bronchoscopy, Cryobiopsy
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Transbronchial Lung Cryobiopsy
The Role of Standardized Training in the Diagnosis of Interstitial Lung Disease by Transbronchial Lung Cryobiopsy
The aim of this study was to conduct a prospective randomized controlled trial to design simulator and in vitro lung standardized training, to perform a learning curve evaluation of transbronchial lung cryobiopsy (TBLC) operating…
- Trial name
- NCT06245954
- Testing
- simulated training, traditional bedside teaching
- Where
- China
- Volunteers
- 20 people
- Sponsor
- China-Japan Friendship Hospital
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Transbronchial Lung Cryobiopsy in Undiagnosed Acute Respiratory Failure
In patients with acute hypoxemic respiratory failure whose diagnosis is not established after initial evaluation, obtaining a histopathological diagnosis may improve the patients' prognosis.
- Trial name
- NCT05754866
- Testing
- Transbronchial lung cryobiopsy, Transbronchial lung biopsy
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Lung Diseases, Interstitial Disease
Cryoprobe Transbronchial Lung Biospy in Patients With Mechanical Ventilation
The purpose of this study is to evaluate the the diagnostic yield and safety of transbronchial lung biopsies (TBLB) with cryoprobe in patients with mechanical ventilation.
- Trial name
- NCT02611297
- Testing
- Cryoprobe
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Lung Transplant Rejection
Study of Transbronchial Cryobiopsy in Monitoring Complications of Lung Transplantation
The goal of this randomized controlled trial is to compare the diagnostic efficacy and safety of transbronchial cryobiopsy (TBCB) and traditional transbronchial lung biopsy for diagnosing the lung transplantation rejection , so…
- Trial name
- NCT05792384
- Testing
- transbronchial lung cryobiopsy with a 1.1 mm flexible cryoprobe, transbronchial lung biopsy with biopsy forceps
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Transbronchial Cryobiopsy, Anesthesia
The Impacts of the Different Anesthesia Methods on Patients of Transbronchial Cryobiopsy
to evaluate the difference between the tracheal intubation (TI) and rigid bronchoscopy (RB) under general anesthesia on patients with transbronchial cryobiopsy.
- Conditions
- Transbronchial Cryobiopsy, Anesthesia, Tracheal Intubation, Rigid Bronchoscopy
- Trial name
- NCT04099069
- Testing
- anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Lung Diseases, Interstitial
Diagnostic Yield and Safety of Transbronchial Lung Biopsy Using Cryoprobes Versus Conventional Forceps. A Multicenter Study
The purpose of this study is to evaluate the diagnostic yield and safety of transbronchial lung biopsies (TBLB) with cryoprobe versus conventional forceps in patients with diffuse lung disease.
- Trial name
- NCT02464592
- Testing
- Transbronchial lung biopsy.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Transbronchial Lung Cryobiopsy
Defining Optimal Settings for Transbronchial Lung Cryobiopsy II: An Ex-Vivo Human Lungs Model Study for Improvement of Specimen Quality
Diffuse parenchymal lung disease (DPLD) or Interstitial Lung Disease (ILD) comprises a broad variety of lung pathologies in which accurate diagnosis is crucial given to the different prognosis and therapeutic approaches…
- Trial name
- NCT04285463
- Testing
- Transbronchial Lung Cryobiopsy (TBLC)
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Sarcoidosis, Pulmonary
Diagnostic Value of EBUS-Guided Transbronchial Mediastinal Cryobiopsy Versus Conventional Bronchoscopic Approaches for Stage I/II Sarcoidosis
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and/or transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal…
- Trial name
- NCT07246876
- Testing
- EBUS-TBNA-based sampling methods, EBUS-TBMC based sampling method
- Where
- China
- Volunteers
- 469 people
- Sponsor
- China-Japan Friendship Hospital
Interstitial Lung Disease
Diagnostic Yield of Transbronchial Cryobiopsy in Diagnosis of Interstitial Lung Diseases
Evaluation of diagnostic yield, feasibility and safety of transbronchial lung cryobiopsies done via bronchoscopy in the investigation of interstitial lung disease in comparison with videothoracoscopy-assisted surgical lung biopsy.
- Trial name
- NCT02235779
- Testing
- Transbronchial lung cryobiopsy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Bronchoalveolar Lavage (BAL), Transbronchial Cryobiopsy
BAL Contribution to Lung Cryo-TBB in ILD
The goal of this observational study is to evaluate whether performing bronchoalveolar lavage (BAL) simultaneously with transbronchial lung cryobiopsy (c-TBB) can improve diagnostic yield in adult patients with suspected…
- Conditions
- Bronchoalveolar Lavage (BAL), Transbronchial Cryobiopsy, Interstitial Lung Disease (ILD)
- Trial name
- NCT07130110
- Testing
- Transbronchial cryobiopsy, Bronchoalveolar Lavage
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Saglik Bilimleri Universitesi
Transbronchial Cryobiopsy, Freezing Time
The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in Different Freezing Time in the Diffuse Parenchymal Lung Diseases
Transbronchial cryobiopsy in different freezing time is performed in patients with undefined diffuse parenchymal lung diseases, and assess the diagnostic yield and safety.
- Conditions
- Transbronchial Cryobiopsy, Freezing Time, Diagnostic Yield, Safety
- Trial name
- NCT03927235
- Testing
- Transbronchial Cryobiopsy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Diffuse Parenchymal Lung Diseases
The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Diseases
The Diagnostic yield and Safety of transbronchial cryobiopsy in the diagnosis of diffuse parenchymal lung diseases are investigated in this multicenter, prospective and real world study.
- Trial name
- NCT03704233
- Testing
- Transbronchial cryobiopsy
- Where
- 26 sites in China
- Volunteers
- 350 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Surgical Lung Biopsy, Transbronchial Lung Cryobiopsy
The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy in the Diagnosis of Interstitial Lung Disease
To compariing the uniportal and tubeless video assisted thoracic surgery and trnsbronchial lung cryobiopsy within the multidisciplinary discussion context in the diagnosis of interstitial lung disease，and assess the safety and…
- Conditions
- Surgical Lung Biopsy, Transbronchial Lung Cryobiopsy, Interstitial Lung Disease
- Trial name
- NCT03958162
- Testing
- lung biopsy
- Volunteers
- 60 people
- Sponsor
- Guangzhou Institute of Respiratory Disease