Clinical trials: Transcranial Ultrasound Stimulation
Transcranial Direct Current Stimulation
Exploring the Possible Beneficial Impact of Non-invasive and Invasive Neuromodulation on Freezing of Gait in Parkinson's Disease During Different Ambulatory Complexities: An Electrophysiological and fMRI Study
Freezing of gait (FOG) stands out as a devastating symptom of Parkinson's disease (PD), where patients may become momentarily glued to the ground, rendering them incapable of walking efficiently.
- Trial name
- NCT06505460
- Testing
- Transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Cognitive Enhancement
Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants
This study examines the impact of theta-burst transcranial focused ultrasound stimulation (tFUS) on cognitive performance in healthy participants, specifically focusing on both acute and post-stimulation effects on visual working…
- Trial name
- NCT06829368
- Testing
- Transcranial Focused Ultrasound Stimulation
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Participants
Functional Roles of Dorsolateral Prefrontal Cortex
Dorsolateral prefrontal cortex (DLPFC) has been found to be involved in cognitive functions such as executive function, response selection, and working memory.
- Trial name
- NCT03882931
- Testing
- Theta Burst Transcranial Magnetic Stimulation, Focused Ultrasound
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy Participants
Ultrasound Effects on Human Motor Cortical Plasticity
The purpose of this study is to test the duration and effect of single element focused ultrasound to the primary motor cortex on healthy human participants with the use of transcranial focused ultrasound and transcranial magnetic…
- Trial name
- NCT04168762
- Testing
- Transcranial Ultrasound Magnetic Stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Mild Neurocognitive Disorder, Healthy Aging
tFUS for Memory in mNCD and Healthy Adults
Dementia is an ongoing and growing public health crisis in the US and worldwide. The purpose of this study is to examine a form of noninvasive brain stimulation called transcranial focused ultrasound (tFUS) to the hippocampus…
- Trial name
- NCT06718140
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Development of LIFU for Clinical Purposes
Investigation of Low-intensity Focused Ultrasound Parameters
This project examines the effects of different brain stimulation settings on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the…
- Trial name
- NCT05134233
- Testing
- Low-intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Development of LIFU for Clinical Purposes
Investigation of the Duration of Low-intensity Focused Ultrasound
This project examines the effects of various durations of noninvasive neuromodulation on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may…
- Trial name
- NCT05147103
- Testing
- Low-Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Healthy Participants
Cerebellar Functions in Visuomotor Adaptation
Transcranial focused ultrasound stimulation (tFUS) will be used in this study to functions of the cerebellum in human motor learning. Participants will complete a visuomotor task while receiving stimulation pulses from tFUS.
- Trial name
- NCT04168086
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Parkinson Disease, Freezing of Gait Symptoms in Parkinson Disease
Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease
This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease.
- Trial name
- NCT07695233
- Testing
- Excitatory Stimulation, Inhibitory Stimulation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Robert Chen
Healthy Volunteers, no Condition, Basic Science
Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans
There are a number of disorders of the brain that have limited treatment options, such as chronic pain, addiction, and major depression.
- Trial name
- NCT07508722
- Testing
- Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology
Pain, Acute, Pain, Chronic
Noninvasive Brain Stimulation for Pain Relief
Non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial focused ultrasound (FUS), is be applied to healthy human subjects, acute pain patients, and chronic pain patients to investigate…
- Conditions
- Pain, Acute, Pain, Chronic, Pain, Experimental
- Trial name
- NCT04283643
- Testing
- Transcranial Focused Ultrasound, Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Sleep Disturbance, Stress, Psychological
Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement
This study evaluates a wearable system (NEUSleeP) that combines overnight EEG recording with transcranial focused ultrasound (tFUS) targeted to deep brain structures involved in REM sleep regulation (e.g., subthalamic nucleus).
- Conditions
- Sleep Disturbance, Stress, Psychological, REM Sleep Measurement
- Trial name
- NEUSleeP (NCT07190287)
- Testing
- NEUSleeP system (FUS-EEG wearable device), BrainSonix Pulsar 1002
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Essential Tremor
Cerebellar Research in Ultrasound Stimulation
Experiment 1: Modulation of Physiological Tremor in Healthy Volunteers Thirty healthy volunteers will undergo TUS targeting the dentate nucleus in a randomized, double-blinded crossover design.
- Trial name
- CERBERUS (NCT07508696)
- Testing
- Transcranial focused ultrasound delivered to the dentate nucleus using the NeuroFUS Pro by Brainbox, Transcranial focused ultrasound delivered to the ventricles (control) using the NeuroFUS Pro by Brainbox
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy
Safety Assessment of Central Medial Thalamus Stimulation Using Transcranial Focused Ultrasound
The purposes of this research study are to investigate closed-loop and personalized focused ultrasound as a technique to study how the brain works and to evaluate the safety and effectiveness of the Attune ATTN201 device.
- Trial name
- NCT05895474
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Closed-loop Brain Stimulation
Closed-loop tES-non-invasive Stimulation
The goal of this study is to establish if non-invasive closed-loop neuromodulation is an effective approach to enhance cognitive function in healthy 18-40 years old volunteers.
- Trial name
- CLIBM (NCT07671079)
- Testing
- Transcranial low intensity focused ultrasound (FUS), transcranial electrical stimulation, Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sub-cortical Stimulation
Ultrasound in Deep Brain Stimulation
It is the purpose of this proposal to apply tFUS to the ventral posterior lateral (VPL) nucleus of the thalamus in humans.
- Trial name
- NCT02382965
- Testing
- transcranial focused ultrasound
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota