Clinical trials: Transdiagnostic
Emotion Regulation, Relationship Conflict
Get Better Together: Relationship Education For Military Couples
This study is testing a program called Get Better Together, a relationship education program designed to help military couples effectively navigate life stressors as a team.
- Conditions
- Emotion Regulation, Relationship Conflict, Suicide Risk, Alcohol Use
- Trial name
- GBT RCT (NCT07096271)
- Testing
- Get Better Together (GBT)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Death Anxiety, Depression
Death Anxiety, Depression and Anxiety: An Experimental Study
The goal of this experimental study is to investigate the transdiagnostic role of death anxiety in depression and anxiety symptoms in participants from the general population. The main questions it aims to answer are: 1.
- Conditions
- Death Anxiety, Depression, Anxiety
- Trial name
- NCT07201480
- Testing
- Mortality Salience Prompts, Dental Pain Prompts
- Where
- Romania
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Pain, Depression
Transdiagnostic Cognitive Biomarkers
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across…
- Trial name
- NCT04864080
- Testing
- Computer game/task, Health surveys online
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Anorexia Nervosa, Obsessive-Compulsive Disorder
Radical Openness for Adolescents Pilot
Heightened performance monitoring and overcontrol (HPM/OC) is characterized by inflexibility, a need for control, perfectionism, anxious apprehension and high error monitoring.
- Conditions
- Anorexia Nervosa, Obsessive-Compulsive Disorder, Social Phobia, Depression, Anxiety
- Trial name
- ROA (NCT05913557)
- Testing
- Radically Open Dialectical Behavior Therapy (RO DBT)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Depression, Anxiety
Preliminary Testing and Development of a Short Digital Intervention for Patients on Waiting Lists for Psychological Treatment
The goal of this randomized pilot feasibility trial is to assess the feasibility and further develop a single-session digital mental health intervention for patients on waiting lists for psychological treatment.
- Trial name
- NCT07499219
- Testing
- Digital therapy program (short), Digital therapy program (long), Mental health advice
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Healthy Participants Study
ACT-based EMI in College Students
This study aims to evaluate the acceptability and effectiveness of a transdiagnostic, Acceptance and Commitment Therapy (ACT)-based ecological momentary intervention (EMI) among college students.
- Trial name
- NCT06843395
- Testing
- ACT-based ecological momentary intervention, Mood monitoring
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Transdiagnostic, Depression - Major Depressive Disorder
Open-Label Psilocybin Study in Transdiagnostic Population
The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms.
- Conditions
- Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms
- Trial name
- NCT06442423
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Learning, taVNS
Learning and Ear Stimulation
This study aims to determine how non-invasive ear stimulation affects learning. During this study, participants will be asked to complete surveys and come to a lab for about 2.5 hours.
- Trial name
- NCT04812015
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS) 15 minutes, taVNS 30 minutes, taVNS 45 minutes
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Sleep Disorder, Circadian Dysregulation
NIA_Improving Function and Well-being by Improving Patient Memory: Transdiagnostic Sleep and Circadian Treatment
Mental illness is often chronic, severe, and difficult to treat. Though there has been significant progress towards establishing effective and efficient interventions for psychological health problems, many individuals do not…
- Conditions
- Sleep Disorder, Circadian Dysregulation, Memory Impairment
- Trial name
- NCT05986604
- Testing
- Memory Support Intervention, Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Social Anxiety Disorder, Generalized Anxiety Disorder
Where We All Meet: ACT Approach to Adolescents Anxiety Disorders
Transdiagnostic approaches have been proposed as more truthfully representing mental health problems. Acceptance and Commitment Therapy (ACT) is a transdiagnostic approach that proposes Psychological Inflexibility/Flexibility…
- Trial name
- NCT05906849
- Testing
- ACT for anxiety disorders
- Where
- Portugal
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Emotional Disorder, Trauma and Stressor Related Disorders
Efficacy of a Transdiagnostic Guided Internet-Delivered Intervention for Emotional, Trauma and Stress-Related Disorders.
Emotional, trauma and stress-related disorders show high incidence, prevalence, morbidity, and comorbidity rates in Mexico. In recent decades, research findings indicate that cognitive behavioral interventions, from a…
- Conditions
- Emotional Disorder, Trauma and Stressor Related Disorders, Anxiety Disorders, Depression
- Trial name
- NCT05225701
- Testing
- Transdiagnostic guided internet-delivered intervention with synchronous assistance, Transdiagnostic self-guided internet-delivered intervention
- Where
- 6 sites in Mexico
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Behavior, Addictive, Adolescent - Emotional Problem
"Juego de LLaves": Study Protocol of a Universal School-based Drug Use Prevention Program (PSIDUP)
"Juego de Llaves" is a universal school-based drug prevention program for adolescents aged 12-15 years. The outcome evaluation is critical to determine the quality of preventive interventions.
- Conditions
- Behavior, Addictive, Adolescent - Emotional Problem, Alcohol Abuse, Smoking Behaviors
- Trial name
- PSIDUP (NCT05442294)
- Testing
- Juego de Llaves
- Where
- Spain
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Susana Al-Halabí
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts"
The investigators are examining whether difficulties with cognitive control (i.e., the ability to stop one's thought process and shift attention) is a common problem across three types of repetitive, negative thinking: obsessions…
- Conditions
- Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT03414619
- Testing
- Cognitive Control Tasks and Script Driven Imagery
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV/AIDS, Violence
Effectiveness of Transdiagnostic Cognitive Behavioral Therapy for Improving HIV Treatment Outcomes in South Africa
This study will evaluate the impact of the Common Elements Treatment Approach (CETA), an evidence-based intervention comprised of cognitive-behavioral therapy elements, at improving HIV treatment outcomes among women with HIV who…
- Trial name
- CETA (NCT04242992)
- Testing
- CETA, Short Message Service (SMS) text reminders
- Where
- South Africa
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- Boston University
Mental Health, Depression
rTMS for Emotional Difficulties in Verterans
Mental illness rarely occurs as a single, easily categorized condition. Instead, multiple disorders often co-occur. This complicates the treatment plan for many Veterans, especially those suffering the most severe dysfunction.
- Conditions
- Mental Health, Depression, rTMS, Anxiety
- Trial name
- rTMS (NCT03749967)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Intervention, Life Style
A Transdiagnostic Intervention for Health-related Habits (LEV)
Research problem and specific questions: Health-related habits influences mental and physical health. Still, screening and treatment of health-related habits, which can help to remedy health problems, is not done at all or very…
- Conditions
- Intervention, Life Style, Health-Related Behavior, Feasibility
- Trial name
- NCT05889936
- Testing
- Lev
- Where
- Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Neurodevelopmental Disorder (Diagnosis), Epilepsy
Characterization of Neurocognitive Profiles in Neurodevelopmental Disorders and Epilepsy: a Transdiagnostic Approach
Neurodevelopmental disorders (NDDs) are early-onset conditions affecting personal, social, and academic functioning, with high comorbidity rates and shared neurobiological traits.
- Trial name
- DIS-Neurodev (NCT06877260)
- Testing
- Computer based task with EEG
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Panic Disorder, Generalized Anxiety Disorder
False Safety Behavior Elimination Therapy: A Randomized Study of a Brief Individual Transdiagnostic Treatment for Anxiety Disorders
The aim of the current study was to test the efficacy of an individually administered, brief (5-session) transdiagnostic treatment for anxiety disorders.
- Conditions
- Panic Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder
- Trial name
- NCT02082561
- Testing
- Transdiagnostic Treatment (F-SET)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Florida State University
Anxiety, Depression
Up-regulating Positive Affect in Emotional Disorders
The aim of this study is to assess the differential effect of two transdiagnostic treatment protocols for emotional disorders (ED) (depression and anxiety disorders) using a randomized pilot study design: a) a transdiagnostic…
- Trial name
- NCT02790398
- Testing
- Transdiagnostic treatment protocol, Transdiagnostic treatment protocol + PA regulation component
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I