Clinical trials: Transfusion Requirements
Complex Valvular Heart Surgery
Effect of Perioperative Iron Isomaltoside 1000 Administration on Transfusion Requirements in Patients Undergoing Complex Valvular Heart Surgery: a Randomized Clinical Trial
In complex cardiac surgery with prolonged cardiopulmonary bypass, allogeneic blood products transfusions are often necessary to control intraoperative and postoperative bleeding.
- Trial name
- NCT02862665
- Testing
- iron isomaltoside 1000 (Monofer®), normal saline 100 ml
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Yonsei University
Infant, Newborn, Infant, Low Birth Weight
The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants
This study tested the safety and efficacy of transfusing erythropoietin (Epo) and iron in infants of <1,250g birth weight. For infants 401-1,000g birth weight, we tested whether early erythropoietin (Epo) and iron therapy would…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- EPO (NCT01203514)
- Testing
- Erythropoietin
- Where
- 9 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Transfusions, Cystectomy
Robot-assisted Cystectomies With Regard to Blood Loss, Pain and Transfusions.
What influence does robot-assisted surgical treatment in the sense of a radical cystectomy and possibly bladder reconstruction have on blood loss, pain and transfusion requirements? We intend to conduct a corresponding…
- Conditions
- Transfusions, Cystectomy, Blood Loss Requiring Transfusion, Anaemia
- Trial name
- NCT07008261
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Goethe University
Hepatic Carcinoma, Hepatic Metastasis
Efficacy and Safety of Octreotide in Laparoscopic Hepatectomy Surgery: Effect on Blood Loss, Need for Vasoactive Drugs, Transfusion Requirements.
The goal of this double-blind clinical trial is to compare the efficacy of octreotide versus placebo in laparoscopic hepatectomy surgery in patients diagnosed with resectable hepatocarcinoma or liver metastases.
- Trial name
- NCT06085976
- Testing
- Octreotide
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cardiac Surgery, Cardiopulmonary Bypass
Clinical Trial Comparing Heparin and Protamine Fixed and Titrated Doses in Cardiac Surgery With Cardiopulmonary Bypass
There are currently several schemes described for anticoagulation with heparin and its reversal with protamine during cardiac surgery with CPB.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Anticoagulation
- Trial name
- NCT01267487
- Testing
- Heparin fixed doses, PO continuous infusion of Protamine, Heparin and protamine titration
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- SANE-Society of Anesthesiology
Hepatectomy, Surgical Blood Loss, Terlipressin
Effects of Terlipressin on Blood Loss and Transfusion Requirements During Major Liver Resection.
To evaluate the effects of Terlipressin infusion on blood loss \& transfusion requirements in cirrhotic patients undergoing major liver resections.
- Trial name
- NCT02588716
- Testing
- Terlipressin, normal saline
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Anemia
A Study to Evaluate the Safety and Efficacy of Epoetin Alfa Versus Placebo to Reduce the Need for Blood Transfusions and Reduce the Occurrence of Severe Anemia During the Time Period Surrounding Total Hip Replacement Surgery
The purpose of this study is to evaluate the safety and effectiveness of two different dosing schedules of epoetin alfa versus placebo for decreasing the need for blood transfusions and preventing the occurrence of severe anemia…
- Trial name
- NCT00269958
- Testing
- epoetin alfa
- Volunteers
- 208 people
- Sponsor
- Janssen-Ortho Inc., Canada
Cardiac Surgery
TRACS STUDY: Transfusion Requirements After Cardiac Surgery
Blood transfusion is related to worse outcomes and the triggers for red blood cells transfusion are not well defined in cardiac surgery.
- Trial name
- TRACS (NCT01021631)
- Testing
- Red blood cell transfusion
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Instituto do Coracao
Surgical Blood Loss, Transfusion-dependent Anemia
Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery
The goal of this clinical trial is to learn if the administration of tranexamic acid can reduce the necessity of blood transfusions in adult patients undergoing major abdominal surgery. .
- Conditions
- Surgical Blood Loss, Transfusion-dependent Anemia, Abdomen Disease
- Trial name
- TATRA (NCT06414031)
- Testing
- Tranexamic Acid
- Where
- 2 sites in Germany
- Volunteers
- 892 people
- Sponsor
- Ulrich Ronellenfitsch, MD
Craniosynostosis
Amicar Pharmacokinetics of Children Having Craniofacial Surgery
Craniofacial reconstruction surgery involves a surgical approach to the craniofacial region to repair cranial vault and facial deformities.
- Trial name
- NCT00912119
- Testing
- Epsilon-Aminocaproic Acid
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Paul Stricker
Sickle Cell Disease
Alternative Dosing And Prevention of Transfusions (ADAPT)
ADAPT is a prospective cohort study at Jinja Regional Referral Hospital (JRRH) primarily to assess the effect of hydroxyurea on blood transfusion utilization and secondarily to determine the feasibility of PK-guided hydroxyurea…
- Trial name
- NCT05662098
- Testing
- Hydroxyurea
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Blood Loss, Surgical, Postoperative Hemorrhage
Effect of Aprotinin on Transfusion Requirements in Patients Undergoing Elective Spinal Fusion Surgery
The objective of this study is to evaluate the safety and efficacy of aprotinin as compared to placebo, in reducing the need for blood transfusion in adult subjects undergoing elective spinal fusion surgery involving 3 to 7…
- Trial name
- NCT00327379
- Testing
- Trasylol (Aprotinin, BAYA0128)
- Where
- 14 sites in Canada, Germany and 1 more
- Volunteers
- 54 people
- Sponsor
- Bayer
Disorder, Heart
Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery
TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on…
- Conditions
- Disorder, Heart, Postoperative, Cardiac Surgery
- Trial name
- TRICS-IV (NCT04754022)
- Testing
- Restrictive Transfusion Strategy, Liberal transfusion strategy
- Where
- 54 sites in United States, Australia and 14 more
- Volunteers
- 1,440 people
- Sponsor
- Unity Health Toronto
Systemic Inflammatory Response Syndrome, Sepsis
Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients
Acute inflammation induced by surgery and sepsis is complicated by the development of iron-restricted anemia due to the up-regulation of hepcidin.
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Surgical Injuries
- Trial name
- DEHEPTRA (NCT03001687)
- Testing
- enteral supplementation with vitamin D, blood collection 3mL
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Anemia
Transfusion Requirements After Orthotopic Liver Transplantation
The objective of this trial is to evaluate different transfusion strategies in patients after liver transplantation. Patients in the experimental arm will be given red blood cell (RBC) transfusion according to a liberal strategy…
- Trial name
- TROLL (NCT01435746)
- Testing
- Red blood cell transfusion
- Where
- Germany
- Sponsor
- University Medical Center Goettingen
Coronary Artery Disease
Antegrade Autologous Blood Reinfusion After CPB
This prospective observational study aims to evaluate the effect of antegrade pump blood reinfusion using the crystalloid "chase" technique on postoperative transfusion requirements in adult patients undergoing cardiac surgery…
- Trial name
- NCT07420582
- Testing
- Antegrade Pump Blood Reinfusion, No Anterograde Pump Blood Reinfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Kocaeli City Hospital
Cardiac Surgery
Transfusion Requirements in Cardiac Surgery
This is a multi-centre randomized controlled pilot trial of two transfusion strategies in high risk patients having cardiac surgery. This study will be conducted in 7 Canadian centers and 1 American centre.
- Trial name
- TRICSII (NCT01484639)
- Testing
- Liberal transfusion triggers, Restrictive transfusion triggers
- Where
- 8 sites in United States, Canada
- Volunteers
- 208 people
- Sponsor
- Nadine Shehata
Blood Loss, Surgical, Postoperative Hemorrhage
Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectomy
The purpose of this study is to assess if aprotinin (BAYA0128), given intravenously during your surgery, is safe and can help reduce the need for a blood transfusion during bladder surgery.
- Trial name
- NCT00306150
- Testing
- Trasylol (Aprotinin, BAYA0128)
- Where
- 37 sites in United States, Belgium and 5 more
- Volunteers
- 57 people
- Sponsor
- Bayer
Traumatic Brain Injury
Transfusion Requirements After Head Trauma
TRAHT is a pilot randomized clinical trial designed to evaluate safety and feasibility of two red blood cells transfusion thresholds in moderate or severe traumatic brain injured patients
- Trial name
- TRAHT (NCT02203292)
- Testing
- Liberal transfusion strategy, Restrictive transfusion strategy
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Anemia
Transfusion Requirements in Critically Ill Oncologic Patient
Blood transfusion in critical ill patients has been associated to several complications and worse outcome. Particularly in oncologic patients, red blood cell transfusion has been investigated as a factor of worse outcome and…
- Trial name
- TRICCOP (NCT01648946)
- Testing
- Red blood cell transfusion
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo