Clinical trials: Transfusions
Hemorrhage, Trauma
Empiric Calcium in Massive Transfusion
Calcium helps blood to clot and thereby stop bleeding. Trauma patients who experience large volume blood loss often require blood transfusions and bleeding is the most common cause of death.
- Conditions
- Hemorrhage, Trauma, Hypocalcemia, Shock, Hemorrhagic
- Trial name
- NCT05953376
- Testing
- Calcium Gluconate
- Sponsor
- University of California, Irvine
Iron Overload
Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload
The purpose of this study is to investigate the effects of iron chelation using deferasirox in patients who show signs of iron overload after an allogeneic stem cell transplantation The iron overload must be due to blood…
- Trial name
- NCT00654589
- Testing
- Deferasirox
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Novartis Pharmaceuticals
Coronavirus
Anti-SARS-CoV-2 Inactivated Convalescent Plasma in the Treatment of COVID-19
There is still no effective antiviral drugs and vaccines against SARS-CoV-2 yet now. This is an obsevational study, the investigators collected the clinical information and clinical outcomes of the COVID-19 patients using…
- Trial name
- NCT04292340
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Public Health Clinical Center
Myelodysplastic Syndrome, Thalassemia
This Study Will Evaluate Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndromes (MDS), Thalassemia and Rare Anemia Types Having Transfusion-induced Iron Overload.
This study will evaluate the efficacy and safety of deferasirox in patients with MDS, thalassemia and rare anemia patients with transfusion iron overload.
- Trial name
- NCT01250951
- Testing
- Deferasirox
- Where
- 2 sites in Russia
- Volunteers
- 111 people
- Sponsor
- Novartis Pharmaceuticals
Hemorrhagic Shock, Acute Blood Loss Anemia
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1.
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Trial name
- NCT05081063
- Testing
- Routine labs
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Loma Linda University
Thalassemia, Iron Overload
Combined Chelation Therapy in Patients With Transfusion Dependent Thalassemia and Iron Overload
This is a pilot study looking at the safety and efficacy of giving combination chelation with deferasirox and deferoxamine. The hypothesis is that combination chelation is safe in decreasing overall iron in patients with…
- Trial name
- NCT00901199
- Testing
- Combo Chelation with Deferasirox (Exjade) and Deferoxamine (DFO)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Elliott Vichinsky
Hemorrhage, Blood Component Transfusion
Prehospital Transfusion Strategy in Bleeding Patients
The aim of study is to compare clinical and biochemical effect of three different transfusion strategies among patients with major hemorrhage requiring prehospital transfusion.
- Trial name
- NCT04879485
- Testing
- Blood products
- Where
- 2 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Transfusion-dependent Anemia
Machine Learning-Based Prediction of Major Perioperative Allogeneic Blood Requirements in Cardiac Surgery
Cardiac surgery is one of the clinical surgical specialties that carries a particularly high risk for patients to suffer from severe bleeding perioperatively and consequent anemia, which subsequently requires transfusion of…
- Trial name
- PREMATRICS (NCT04856618)
- Testing
- Massive Transfusion of Allogeneic Blood
- Where
- Austria
- Volunteers
- 3,782 people
- Sponsor
- Kepler University Hospital
Heart Surgery, Blood Transfusion
Modeling Blood Management and Hemolytic Risk in Pediatric Heart Surgery
This study aims to learn more about blood management in children undergoing heart surgery, such as the right amounts, and the best blood products, to administer.
- Conditions
- Heart Surgery, Blood Transfusion, Hemolysis
- Trial name
- NCT06721455
- Testing
- blood sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Transfusion-related Acute Lung Injury, Chronic Liver Disease
Predicting Lung Injury From Transfusion in Patients With Liver Disease
A certain molecule floating in the blood may represent a risk of lung injury after a transfusion. We are determining whether detection of this molecule on a simple blood clotting test will predict the development of lung injury…
- Conditions
- Transfusion-related Acute Lung Injury, Chronic Liver Disease, Gastrointestinal Bleeding
- Trial name
- NCT01756690
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Iron Deficiency
Delayed Cord Clamping and Infant Brain Study
The purpose of this study is to determine if delaying cord clamping at the birth of term infants effects the early brain development (myelin deposition)as determined by quantitative MRI at 4 and 10 months and developmental…
- Trial name
- IBS (NCT01620008)
- Testing
- Delayed Cord Clamping
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Traumatic Shock
AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
Trauma patients, who are transfused with multiple blood products to treat shock due to blood loss, frequently develop inappropriately low vasopressin levels.
- Trial name
- AVERTShock (NCT01611935)
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Pennsylvania
Myelodysplastic Syndromes
ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions
The purpose of the study is to compare the efficacy and safety of Luspatercept vs epoetin alfa in the treatment of anemia in adults due to IPSS-R very low, low, intermediate-risk MDS in ESA-naïve participants who are…
- Trial name
- ELEMENT-MDS (NCT05949684)
- Testing
- Luspatercept, Epoetin Alfa
- Where
- 144 sites in United States, Argentina and 17 more
- Volunteers
- 402 people
- Sponsor
- Bristol-Myers Squibb
Anemia, Neoplasms
Asses the Impact of Early Starting Erythropoetin in the Reduction of Transfusions Blood in Childrens
Anemia is a frequent complication among cancer patients, both as a result of the malignancy of the disease and the aggressiveness of the treatment.
- Conditions
- Anemia, Neoplasms, Chemotherapeutic-Induced Anemia
- Trial name
- NCT05704894
- Testing
- Erythropoietin
- Volunteers
- 320 people
- Sponsor
- Blau Farmaceutica S.A.
Complications, Bleeding
Fibrinogen and Bleeding After Cardiac Surgery
The study hypothesis is that prophylactic fibrinogen infusion reduces postoperative bleeding and transfusion requirements after coronary artery bypass surgery (CABG) in patients with endogenous fibrinogen levels in the lower…
- Conditions
- Complications, Bleeding, Coronary Artery Disease
- Trial name
- Fibro-3 (NCT00968045)
- Testing
- Fibrinogen
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Sahlgrenska University Hospital
Femoral Neck Fractures, Hemiarthroplasty
Efficacy of Intraoperative Periarticular Injections in Hip Fracture Hemiarthroplasty
The objective of this study was to assess the effectiveness of the intraoperative periarticular solution in reducing blood loss and minimizing transfusion requirements in patients with femoral neck fractures who underwent…
- Conditions
- Femoral Neck Fractures, Hemiarthroplasty, Blood Loss Requiring Transfusion
- Trial name
- NCT06701695
- Testing
- Periarticular Injection (PAI), Control (Standard treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara City Hospital Bilkent
Infant, Extremely Premature, Erythrocyte Transfusion
Red Blood Cells From Umbilical Cord for Transfusion of Preterm Infants
This study has been designed to demonstrate that red blood cell from umbilical cord blood (UCB-RBC) is a safe and available product for extremely preterm infants (EPI) transfusion and that transfusion of UCB-RBC is non-less…
- Conditions
- Infant, Extremely Premature, Erythrocyte Transfusion, Umbilical Cord Issue
- Trial name
- NCT05612919
- Testing
- Red blood cell from umbilical cord blood, Red blood cell from adult donor
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Hospital Clinic of Barcelona
Alzheimer&Amp;#39;s Disease
Phosphorylated Tau Levels in Donated Blood
Alzheimer's disease (AD) is characterized by the accumulation of tau pathology, and blood-based biomarkers such as phosphorylated tau-217 (pTau217) have been identified as sensitive and specific predictors of AD risk.
- Trial name
- pTIDB (NCT07157839)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Femur Fracture
Post-operative Anemia in Lateral Fractures of the Femur.
It was conducted a prospective study with a series of 45 patients with lateral fragility fractures of the femur treated by three different intramedullary nails.
- Trial name
- NCT05225753
- Testing
- hemoglobin serum value
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Anemia, Red Blood Cell Transfusion
Detection of Anemizations in Primary Care.
Objective: To evaluate the effect of the use of the hemoglobinometer in primary care on the clinical results of patients with chronic anemia.
- Trial name
- ANHEMOG (NCT04757909)
- Testing
- Monthly Haemoglobinometry
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
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