Clinical trials: Transfusions
Hematologic Neoplasms, Hemorrhage
TRial to EvaluAte Tranexamic Acid Therapy in Thrombocytopenia
The purpose of this study is to test whether giving tranexamic acid to patients receiving treatment for blood cancers reduces the risk of bleeding or death, and the need for platelet transfusions.
- Conditions
- Hematologic Neoplasms, Hemorrhage, Hematopoietic Stem Cell Transplantation
- Trial name
- TREATT (NCT03136445)
- Testing
- Tranexamic acid (TXA).
- Where
- 27 sites in Australia, United Kingdom
- Volunteers
- 616 people
- Sponsor
- NHS Blood and Transplant
Transfusion Dependent Thalassemia
Evaluation of Recombinant Humanized Anti-CD25 Monoclonal Antibody for Preventing Graft-versus-host Disease After Haploidentical/matched Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients with Transfusion-dependent Thalassemia
Graft-versus-host disease (GVHD) is a major factor affecting the efficacy and quality of life of alternative donor transplantation in thalassemia major (TM), severely limiting the clinical application of alternative donor…
- Trial name
- NCT06657391
- Testing
- recombinant humanized anti-CD25 monoclonal antibody
- Where
- 5 sites in China
- Volunteers
- 396 people
- Sponsor
- Rongrong Liu
Chikungunya Virus Infection, Neonatal
Against Chikungunya Virus and Neonatal Infection
The goal of this clinical trial is to learn if administration of plasma, from a whole blood donation from an individual who has declared a Chikungunya infection for less than 6 months , to a newborn, whose mother has a peripartum…
- Conditions
- Chikungunya Virus Infection, Neonatal, Transfusion, Encephalopathy
- Trial name
- ConvictionCHIK (NCT07190560)
- Testing
- plasma transfusion : PC-CHIK-V
- Where
- 3 sites in France, French Guiana and 1 more
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Hypertension, Pulmonary, Hemolysis
Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion
The objective of this study is to assess if prolonged storage time of a packed red blood cell unit may cause pulmonary vasoconstriction after transfusion, in a susceptible population such as cardiac surgery patients.
- Trial name
- NCT02217683
- Testing
- Nitric Oxide
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Transfusion-dependent Thalassemia
Efficacy of Combination of Hdroxyurea and Thalidomide Over Hydroxyurea or Thalidomide in the Treatment of Transfusion Dependent Thalassemia in Children
The goal of this clinical trial is to find out the efficacy of combined Hydroxyurea and thalidomide transfusion dependent thalassemia patients.
- Trial name
- NCT06299670
- Testing
- Thalidomide, Hydroxy Urea, Combinations
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Organophosphorus Poisoning
Fresh Frozen Plasma Transfusion in Acute Organophosphate Poisoning
this study clinical trial to assess the role of fresh frozen plasma as a novel available and easy to be applied rather than conventional therapy on organophosphate poisoned patients and prediction of it is prognosis on selected…
- Trial name
- NCT06256796
- Testing
- fresh frozen plasma
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ain Shams University
Preterm Infants
Intravenous Immunoglobin Transfusion in Preterm Infants With Encephalopathy of Prematurity
Infection and inflammation is related to increased encephalopathy of prematurities.
- Trial name
- NCT02822027
- Testing
- human gamma globulin, non-human gamma globulin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Patients With Advanced Solid Tumors With Liver Metastases Who Have Failed Standard Treatments
Hepatic Artery Transfusion of NKG2D CAR-NK Cells Followed by Intravenous Infusion of NKG2D CAR-T Cells to Treat Patients With Advanced Solid Tumors With Liver Metastases Who Have Failed Standard Treatments: a Phase I Exploratory Clinical Trial
This is a single-center, single-arm, open-label, dose-escalation clinical study to evaluate the safety and preliminary efficacy of NKG2D CAR-NK cells followed by NKG2D CAR-T cells in patients with advanced solid tumors…
- Trial name
- NCT07021534
- Testing
- NKG2D CAR NK and NKG2D CAR T cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zhejiang University
Coronary Artery Bypass
Microparticles in Stored RBC as Potential Mediators of Transfusion Complications
INTRODUCTION. Cell-derived microparticles (MP) are released in cell activation, apoptosis and other processes. MP derived from red cells (RMP) are known to be released from stored packed red blood cells (PRBC), and their number…
- Trial name
- NCT01185600
- Testing
- Washed RBC, Unwashed RBC
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Miami
Adolescent Idiopathic Scoliosis
Intraoperative Cell Salvage and Hemodilution Technique in Scoliosis Surgery
Surgical correction of scoliosis with instrumentation carries significant blood loss and needs for blood transfusion with its inherent risk and cost.
- Trial name
- NCT02112409
- Testing
- cell salvage technique, acute normovolemic hemodilution
- Where
- Malaysia
- Volunteers
- 44 people
- Sponsor
- University of Malaya
Gynecologic Cancer
Intravenous Iron in Gynecologic Cancer Patients Receiving Chemotherapy
Can intravenous iron lower the rate of blood transfusion in gynecologic cancer patients receiving platinum based chemotherapy than oral iron?
- Trial name
- NCT01435200
- Testing
- Intravenous iron
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Chulalongkorn University
Covid19, Coronavirus Infection
TranSfUsion of coNvalescent plAsma for the Early Treatment of pneuMonIa in COVID-19 Patients
This is a multicenter open-label randomized study for the early treatment of pneumonia due to SARS-COV2 with transfusion of convalescent plasma.
- Conditions
- Covid19, Coronavirus Infection, Pneumonia, Viral
- Trial name
- NCT04716556
- Testing
- Convalescent plasma
- Where
- 48 sites in Italy
- Volunteers
- 474 people
- Sponsor
- Istituto Superiore di Sanità
Thalassemia
T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients
The purpose of this study is to provide accurate prognostic data linking cardiac complications to myocardial T2* values (A measure of iron levels in the heart using MRI)in patients predisposed to heart iron overload.
- Trial name
- NCT00520559
- Volunteers
- 652 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Aortic Dissection Type A, Transfusions
Use of PRP in Open Surgery for Type A Aortic Dissection
The goal of this clinical trial is to determine if autologous platelet rich plasma (PRP) can reduce the need for blood transfusions in patients undergoing open surgery for Type A aortic dissection.
- Conditions
- Aortic Dissection Type A, Transfusions, Platelet Rich Plasma (PRP), Organ Protection
- Trial name
- NCT07005661
- Testing
- Autologous Platelet Rich Plasma, Standard Blood Management
- Volunteers
- 250 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Surgery
Erythrocyte Transfusion Based on the Measurement of Central Venous Oxygen Saturation in Postoperative Cardiac Surgery
Postoperative erythrocytes transfusion is associated with morbidity and excess mortality, which should lead to ask the indication for RBC transfusions only on metabolic needs.
- Trial name
- PITT (NCT02963883)
- Testing
- SVO2 group / control group
- Where
- 2 sites in France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hemorrhage
Finnish Prehospital Whole Blood Study
Up-to-date evidence suggests that blood transfusion initiated as early as possible reduces the likelihood of death from hemorrhagic shock, and the sooner replacement therapy with blood products is initiated, the greater the…
- Trial name
- FinnPHWB (NCT05744583)
- Testing
- Packed red cell transfusion, Whole blood transfusion
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- Finnish Red Cross Blood Service
Avascular Necrosis of Hip, Degenerative Hip Joint Disease
Revision Total Hip Replacement Arthroplasty and Hematologic Variables
Revision total hip replacement arthroplasty is a surgery having intra- and postoperative substantial blood loss. The investigators will investigate the relationship between the various hematologic variables and postoperative…
- Trial name
- NCT02951741
- Testing
- RTHRA group
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Seoul National University Bundang Hospital
Hip Fractures, Surgical Blood Loss
Tranexamic Acid in Intertrochanteric and Subtrochanteric Femur Fractures
The objective of this study is to evaluate the effect of Tranexamic Acid (TXA) on blood loss and need for perioperative blood transfusion following intertrochanteric and subtrochanteric femur fractures.
- Trial name
- NCT02580227
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Good Samaritan Regional Medical Center, Oregon
Wounds and Injuries
Effect of Leukoreduced Blood Transfusions on Infection Following Trauma
The purpose of this study is to determine if leukoreduced blood transfusions reduce the risk of infection following trauma. Specifically, the investigators intend to evaluate whether there are clinically relevant differences in…
- Trial name
- NCT00135291
- Testing
- Leukoreduced blood transfusion
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Leukemia
Prophylactic White Cell Transfusions Versus Therapeutic White Cell Transfusions in Patients With Leukemia
Patients with leukemia often have low white blood cell counts after chemotherapy, which puts them at greater risk for infection.
- Trial name
- NCT01204788
- Testing
- Prophylactic White Cell Transfusion, Therapeutic White Cell Transfusion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center
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