Clinical trials: Transfusions
Hip Fracture, Anemia
IV Iron in Association With Tranexamic Acid for Hip Fracture
It is a prospective randomized controlled study aiming to test if tranexamic acid combined to intravenous iron before and after surgery for hip fracture in elderly can decrease peri-operative red cell transfusion.
- Trial name
- NCT02428868
- Testing
- tranexamic acid (Exacyl®), intravenous iron (Ferroven®), Saline
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Institut Kassab d'Orthopédie
MDS, AML, Adult
Quality of Life-Guided Transfusion in Refractory MDS or AML
Patients with refractory myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) in exclusive palliative care frequently receive red blood cell transfusions based on hemoglobin thresholds, despite limited evidence of…
- Conditions
- MDS, AML, Adult, Anemia
- Trial name
- Q-TRANS (NCT07328191)
- Testing
- Red blood cell transfusions based on EQ-5D-5L questionnaire
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Thromboembolus, Massive Blood Transfusion; Thrombocytopenia
Comparative Outcomes of PCC and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion
This study aims to compare the incidence of thromboembolic complications among trauma patients receiving PCC, rFVIIa, both agents, or neither during massive transfusion.
- Conditions
- Thromboembolus, Massive Blood Transfusion; Thrombocytopenia, Trauma
- Trial name
- NCT07290634
- Testing
- Number of Participants with massive blood transfusion
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Zeliha Alicikus
Cardiac Surgery
Transfusion Triggers in Cardiac Surgery
A high proportion of patients having cardiac surgery receive red cell transfusions. Yet, the investigators do not know whether transfusions are beneficial and they may be associated with harm.
- Trial name
- TTRICS (NCT00470444)
- Testing
- Transfusion with Red Blood Cells, 1 unit of donated red blood cells
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Anemia
Transfusion Requirements in Critically Ill Oncologic Patient
Blood transfusion in critical ill patients has been associated to several complications and worse outcome. Particularly in oncologic patients, red blood cell transfusion has been investigated as a factor of worse outcome and…
- Trial name
- TRICCOP (NCT01648946)
- Testing
- Red blood cell transfusion
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Burns
Tranexamic Acid in Debridement Surgery of Burns on the Volume of Bleeding in Transfusion Requirements
Tranexamic acid in debridement surgery of burns on the volume of bleeding in transfusion requirements
- Trial name
- NCT05855590
- Testing
- Tranexamic acid, 0.9% isotonic saline solution
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto Mexicano del Seguro Social
Myelodysplastic Syndromes
An Efficacy and Safety Study of Luspatercept (ACE-536) for the Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in Japanese Subjects Who Are Not Requiring Red Blood Cell Transfusion
The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory…
- Trial name
- NCT03900715
- Testing
- Luspatercept
- Where
- 19 sites in Japan
- Volunteers
- 21 people
- Sponsor
- Celgene
Myelodysplastic Syndrome, Anemia
A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Lower Risk Myelodysplastic Syndromes (LR-MDS) Who Need Regular Blood Transfusions
The main aim of this study is to assess how much elritercept reduces the need for RBC (red blood cell) transfusions and improves hemoglobin blood values in addition to how safe elritercept is when compared with epoetin alfa.
- Trial name
- ELRiSE MDS (NCT07422480)
- Testing
- Elritercept, Epoetin Alfa
- Where
- 162 sites in United States, Argentina and 26 more
- Volunteers
- 300 people
- Sponsor
- Takeda
Cancer, Anaemia
Optimal Transfusion in Anaemic Cancer Patients Treated With Chemotherapy (HaemOPtimal)
This an open two-arm interventional randomised feasibility study in anaemic patients treated with chemotherapy. Randomisation is performed between two transfusion thresholds: Haemoglobin < 6.0 mmol/l (9.9 g/dL) versus haemoglobin…
- Trial name
- HaemOPtimal (NCT01116479)
- Testing
- Blood transfusion
- Where
- 2 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Coagulopathy
Comparison of Rapid Thrombelastography and Conventional Coagulation Testing for Haemostatic Resuscitation in Trauma
The purpose of this study is to compare rapid thrombelastography (r-TEG) with conventional coagulation testing for diagnosing and treating coagulation abnormalities in severely injured patients who are likely to require…
- Trial name
- NCT01536496
- Testing
- Blood product transfusion based on conventional coagulation tests., Blood product transfusion based on rapid thrombelastography (r-TEG) results.
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Denver Health and Hospital Authority
Myelodysplastic Syndromes
A Study to Investigate the Efficacy and Safety of Roxadustat (FG-4592) for Treating Anemia in Participants With Myelodysplastic Syndromes (MDS)
The study is designed to determine the efficacy and safety of roxadustat for the treatment of anemia due to very low, low, or intermediate risk MDS in participants with high transfusion burden (HTB).
- Trial name
- NCT07722988
- Testing
- Roxadustat
- Volunteers
- 201 people
- Sponsor
- Kyntra Bio
Myelodysplastic Syndromes
Lenalidomide Versus Placebo in Myelodysplastic Syndromes With a Deletion 5q[31] Abnormality
The purpose of this study was to compare 2 doses (10 mg and 5 mg) of lenalidomide to that of placebo in subjects with red blood cell (RBC) transfusion-dependent low- or intermediate-1-risk IPSS MDS associated with a deletion…
- Trial name
- NCT00179621
- Testing
- Lenalidomide 5 mg, Lenalidomide 10 mg
- Where
- 38 sites in Belgium, France and 7 more
- Volunteers
- 205 people
- Sponsor
- Celgene Corporation
Very Preterm and Extremely Preterm Birth, Anemia
Clinical Characterization of Very and Extremely Preterm Infants Who Received Excess Erythrocyte Transfusions With Respect to HAS 2014 Recommendations
Prematurity affects around 60,000 births a year in France. Extremely premature babies are particularly fragile and require multiple erythrocyte transfusions to maintain an effective hemoglobin level for metabolism and continued…
- Conditions
- Very Preterm and Extremely Preterm Birth, Anemia, Erythrocyte Transfusion, Excess Transfusion
- Trial name
- CGR EXCESS (NCT06909487)
- Where
- France
- Volunteers
- 201 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cancer, Surgery
Unmodified Versus Leuko-reduced Allogeneic Red Blood Cells Transfusion in Cancer Patients
There is evidence to suggest that red blood cell concentrate (RBC) transfusion may have immunomodulatory effects. The aim of this randomized single-center trial is to compare immune responses in patients undergoing cancer surgery…
- Trial name
- NCT00180869
- Testing
- transfusion of allogeneic red blood cell concentrate, transfusion of leuko-reduced red blood cell concentrate
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Patient Blood Management, Blood Product Transfusion for All Conditions
Patient Blood Management in Obstetrics
Obstetric anemia and hemorrhage are major causes of maternal morbidity and increased healthcare utilization. Although red blood cell (RBC) transfusion is commonly used, it is associated with higher rates of postpartum…
- Trial name
- PBM (NCT07544017)
- Where
- United Arab Emirates
- Volunteers
- 44,000 people
- Sponsor
- Corniche Hospital
Traumatic Brain Injury, Blunt Abdominal Trauma
Impact of Traumatic Brain Injury on Hemodynamic Instability in Patients With Blunt Bowel and Mesenteric Injuries
This retrospective cohort study aims to evaluate the impact of traumatic brain injury (TBI) on hemodynamic status in trauma patients with surgically confirmed blunt bowel and mesenteric injuries (BBMI).
- Conditions
- Traumatic Brain Injury, Blunt Abdominal Trauma, Hemodynamic Instability, Shock
- Trial name
- NCT06942091
- Testing
- Traumatic Brain Injury (TBI)
- Volunteers
- 169 people
- Sponsor
- Chang Gung Memorial Hospital
Surgery
Validation of Noninvasive Hemoglobin, Comparison of PVI to Standard Methods, and Validation of Clinical Efficacy of ORI
The study goal is to establish the correlation of hemoglobin values determined by the noninvasive pulse oximetry-determined hemoglobin (SpHb) system with hemoglobin as measured by other validated devices.
- Trial name
- NCT02841397
- Testing
- Masimo Pulse CO-Oximeter
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Masimo Corporation
Hip Fracture
Postoperative Blood Transfusion for Frail Elderly With Hip Fracture
Elderly with hip fractures are often frail and discharged from hospital after few days of hospitalisation. Hip fracture surgery is often associated with blood loss, where the patient is at risk of developing anaemia.
- Trial name
- NCT01102010
- Testing
- Blood transfusion
- Where
- Denmark
- Volunteers
- 284 people
- Sponsor
- University of Aarhus
Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage
INR-Triggered Transfusion In GI Bleeders From ER
Transfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related morbidity and mortality in the United States.
- Conditions
- Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage, Liver Diseases, Transfusion Related Lung Injury
- Trial name
- I-TRIGER (NCT01461889)
- Testing
- Transfuse plasma to High INR target, Transfuse plasma to Low INR target
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Red Blood Cell Transfusions
Implementation of Red Blood Cell Transfusion Recommendations in the Pediatric Intensive Care Unit
Evidence demonstrates that the risks of red blood cell transfusions outweigh benefits in many patients who are hospitalized in the pediatric intensive care unit with increased risk of organ dysfunction, infection, delirium, and…
- Trial name
- TRIP (NCT07108374)
- Testing
- Implementation strategies to increase use of transfusion recommendations
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
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