Clinical trials: Transfusions
Thromboembolic Event, FDP
Safety And Field Evaluation of Plasma Lyophilized for Acute and Surgical Management Applications
The purpose of this study is to compare the safety of freeze-dried plasma (FDP), known as EZPLAZ, with conventional plasma in adults who need a plasma transfusion.
- Trial name
- SAFE-PLASMA (NCT07840352)
- Testing
- Freeze-Dried Plasma, Conventional Plasma
- Volunteers
- 867 people
- Sponsor
- Teleflex
Thrombocytopenia
Romiplostim in Thoracic Transplantation
The investigators developed a platelet transfusion saving strategy based on thrombopoietin administration in heart or lung transplantation (HLT) patients or assist device implantation in bridge-to-transplantation (BTT) or bridge…
- Trial name
- N-PLATE (NCT03515447)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Anemia
ENTRUST, a 5 Year Surveillance of Children Aged 2 to <6 Years With Transfusional Iron Overload Treated With Deferasirox
This registry will evaluate long-term safety and efficacy of deferasirox in children with transfusional iron overload.
- Trial name
- NCT00466063
- Testing
- Deferasirox
- Where
- 23 sites in United States
- Volunteers
- 108 people
- Sponsor
- Novartis Pharmaceuticals
Iron Deficiency, Child Development
Infant Brain Study Follow-Up at 3 and 4 Years of Age
When immediate clamping of the umbilical cord (ICC) occurs at birth, 20 to 30% of the fetal-placental blood volume is left behind in the placenta.
- Trial name
- NCT02619006
- Testing
- Delayed Cord Clamping or Cord Milking
- Volunteers
- 10 people
- Sponsor
- University of Rhode Island
Anemia
Age of Blood in Children in Pediatric Intensive Care Units
ABC PICU is a randomized clinical trial that will compare the clinical consequences of RBC storage duration in 1538 critically ill children.
- Trial name
- ABC-PICU (NCT01977547)
- Testing
- Short storage RBC age
- Where
- 37 sites in United States, Canada and 3 more
- Volunteers
- 1,538 people
- Sponsor
- Washington University School of Medicine
Thalassemia
A Study of SNH-119014 in Adult Participants With Non-transfusion-dependent Thalassemia (NTDT)
This study is a multicenter study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of treatment with SNH-119014 in adult participants with non-transfusion-dependent thalassemia.
- Trial name
- NCT07579949
- Testing
- SNH-119014 dose 1, SNH-119014 dose 2
- Where
- 8 sites in China
- Volunteers
- 30 people
- Sponsor
- ScinnoHub Pharmaceutical Co., Ltd.
Hemorrhagic Shock
Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage
Study Design: Single-center, not-randomized, open-label, two-arms controlled pilot clinical trial. Health Condition: Patients with severe trauma with a need for transfusion and categorized as priority 0 or 1 according to the…
- Trial name
- NCT04149171
- Testing
- with red blood cells (RBC), Tranexamic acid (TXA) and Fibrinogen Concentrate (FC),administration of Crystalloids and TXA., conventional treatment
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Cristina Martinez
Myelodysplastic Syndromes, Leukemia, Myelomonocytic, Chronic
Study of Lonafarnib Versus Placebo in Subjects With Either Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML) (Study P02978AM3)(TERMINATED)
The purpose of this study is to assess the benefit of lonafarnib (versus placebo) in patients with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML).
- Conditions
- Myelodysplastic Syndromes, Leukemia, Myelomonocytic, Chronic, Myelodysplasia, Myelomonocytic
- Trial name
- NCT00109538
- Testing
- Lonafarnib
- Volunteers
- 47 people
- Sponsor
- Merck Sharp & Dohme LLC
Major Trauma
Calcium Levels in Major Trauma
To assess and treat The calcium level abnormalities in major trauma pre and post receiving blood transfusions .
- Trial name
- NCT06103292
- Testing
- ionized calcium levels
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hossam Abdel Rahman Ahmed Ismail
Transfusion-dependent Anemia
Knowledge and Attitude in Perioperative Erythrocyte Transfusion in Medical Personnel in Siriraj Hospital
This study is designed to explore the correlation between knowledge and attitude in perioperative erythrocyte transfusion in medical personnel.
- Trial name
- NCT04155021
- Where
- Thailand
- Volunteers
- 250 people
- Sponsor
- Siriraj Hospital
Anemia, Sickle Cell, Complex and Transfusion-dependent Hemoglobinopathies
Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies
The goal of this research study is to establish chimerism and avoid graft-versus-host disease in patients with hemoglobinopathies.
- Conditions
- Anemia, Sickle Cell, Complex and Transfusion-dependent Hemoglobinopathies, Thalassemia, Diamond-Blackfan Anemia
- Trial name
- NCT01419704
- Testing
- Enriched Hematopoetic Stem Cell Infusion
- Where
- 3 sites in United States
- Sponsor
- Talaris Therapeutics Inc.
Postpartum Hemorrhage
Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery
The aim of this study is to evaluate the impact of a rotational thromboelastometry (ROTEM®)-based transfusion protocol during postpartum hemorrhage (PPH) after vaginal or cesarean delivery.
- Trial name
- NCT03064152
- Testing
- Rotational Thromboelastometry
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cardiac Surgery-CABG, Cardiac Valve Replacement
EPOgen and Restrictive Transfusions in Patients Undergoing Cardiac Surgery (EPORT)
EPOgen and Restrictive Transfusions in Patients Undergoing Cardiac Surgery (EPORT)
- Trial name
- EPORT (NCT02802592)
- Testing
- Epogen, Normal Saline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Dengue Fever
Adult Dengue Platelet Study
Retrospective data in children with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), and in adults with dengue fever (DF), suggested a lack of benefit from prophylactic platelet transfusion for severe…
- Trial name
- ADEPT (NCT01030211)
- Testing
- Platelet transfusion, Supportive care
- Where
- 2 sites in Malaysia, Singapore
- Volunteers
- 372 people
- Sponsor
- Tan Tock Seng Hospital
Cardiopulmonary Bypass, Obesity
Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery
Standard Heparin management, based on total body weight, is not well established for obese patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Trial name
- NCT03302195
- Testing
- Heparin, cardiopulmonary bypass pump flow rate
- Where
- Canada
- Volunteers
- 410 people
- Sponsor
- Laval University
Thrombocytopenia, Platelet Transfusion
Role of Viscoelastometric Testing in the Development and Validation of a Clinical-biological Score for Predicting Bleeding in Patients With Malignant Haematological Disorders and Severe Thrombocytopenia
The goal of this single-center, non-controlled, non-randomized exploratory clinical trial is To develop and validate a clinical-biological score (VISCOTHEM score) incorporating viscoelastometric tests parameters; based on an…
- Conditions
- Thrombocytopenia, Platelet Transfusion, Haemorrhage, Hematologic Malignancies
- Trial name
- VISCOTHEM-2 (NCT07653672)
- Testing
- Additional blood sample
- Where
- France
- Volunteers
- 410 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure)
SvO2 Trigger in Transfusion Strategy After Cardiac Surgery
Current international guidelines suggest a restrictive transfusion strategy, setting that Hb level at 7 g/dl is a reasonable threshold.
- Conditions
- Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure), Anemia (<9g/dL) Requiring Blood Transfusion, Hemodynamic and Respiratory Stability
- Trial name
- ReTSEACS (NCT02761564)
- Testing
- Red blood cell tranfusion, ScvO2 measure
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Neoplasms, Gynecologic
rhTPO Mobilized Auto Cryo Platelets For GYN Patients Receiving Carboplatin
A Pilot Study of Transfusion of rhTPO-Derived Autologous Platelets Cryopreserved with ThromboSol and 2% DMSO in Patients with Gynecologic Malignancy Receiving Carboplatin
- Trial name
- NCT00038012
- Testing
- Thrombopoietin, Platelet-pheresis, Carboplatin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- M.D. Anderson Cancer Center
Knee Osteoarthritis, Blood Clot
Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement.
This study compares two oral medications (tranexamic acid and aminocaproic acid) as hemostatic agent administered in patients undergoing total knee replacement.
- Conditions
- Knee Osteoarthritis, Blood Clot, Transfusion Related Complication, Blood Loss
- Trial name
- NCT03365999
- Testing
- Oral Tranexamic Acid, Oral Aminocaproic Acid
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Iron Deficiency
Neuroimaging of Donor Iron Deficient Study
This pilot study is designed to investigate (1) whether getting iron treatment affects iron in the brain and (2) how getting iron treatment affects brain functions when it is performing specific cognitive tasks.
- Trial name
- NCT02990559
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Columbia University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.