Clinical trials: Transfusions
Polytrauma, Traumatic Hemorrhage
Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage at Pre-hospital Phase of Care.
This is a single-center, not-randomized, open-label, controlled pilot clinical trial. This study compares presence of Trauma Induced Coagulopathy (TIC) and acute traumatic hemorrhage treatment at pre-hospital phase of care with…
- Trial name
- PRETIC (NCT03780894)
- Testing
- Fibrinogen Concentrate (Human) 1 MG [RiaSTAP], Red blood cells concentrate, Tranexamic Acid
- Where
- Spain
- Volunteers
- 79 people
- Sponsor
- Banc de Sang i Teixits
Thalassemia Major, Covid19
Frequency of COVID-19 Antibodies in Patients With Hereditary Hematological Diseases
In Italy there are about 5000 patients with dependent transfusion thalassemia (source Italian Thalassemia and Hemoglobinopathies - SITE) and a smaller number, currently not definable, of patients with sickle cell anemia in…
- Trial name
- ThalaCoV (NCT04526405)
- Testing
- SARS-CoV-2 S1/S2 IgG
- Where
- Italy
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Pediatric Patients Who Need Liver Transplantation
Transfusion Strategies for Pediatric Liver Transplantation
The patients assigned to the restrictive group will receive transfusion once the hemoglobin concentration falls below 6.0 g per deciliter, with a target hemoglobin range of 7.5 to 8.0 g per deciliter.
- Trial name
- NCT02951013
- Testing
- restrictive transfusion, liberal transfusion
- Where
- China
- Volunteers
- 488 people
- Sponsor
- RenJi Hospital
Blood Transfusion Complication, Oxidative Stress
Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative…
- Trial name
- NCT03767361
- Testing
- packed red blood cells transfusion
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Rania Ali El-Farrash
Blood Transfusion Complication, Wrong Blood in Tube
Proficiency Based Training to Investigate Blood Sampling Errors Including WBIT
The objective of this study is to determine the effectiveness of a Proficiency Based Progression training programme, together with evidence based individual feedback for any residual errors, which has been specifically developed…
- Conditions
- Blood Transfusion Complication, Wrong Blood in Tube, Pre Analytical Blood Sample Errors
- Trial name
- NCT03577561
- Testing
- Proficiency Based Progression Training in Phlebotomy
- Where
- Ireland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Patrick Henn
5q Minus Syndrome, Myelodysplastic Syndrome
Leucovorin for the Treatment of 5 q Minus Syndrome
The 5 q minus syndrome is a condition that occurs due to a missing segment of chromosome 5 in the normal genetic make-up of the cells responsible for forming blood cells.
- Trial name
- NCT00004997
- Testing
- Leucovorin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Transfusion-dependent Anemia
Prediction of Transfusion-Associated Complications
Currently, about 350000 red blood cell concentrates are produced from blood donations in Austria every year. In addition to the main effect of replacing lost blood, red blood cell concentrates also have many undesirable effects …
- Trial name
- PRETRACO (NCT05466370)
- Testing
- Transfusion of Allogeneic Blood
- Where
- Austria
- Volunteers
- 3,366 people
- Sponsor
- Kepler University Hospital
Beta Thalassemia Transfusion Dependent
Gene Therapy for Patients With Transfusion-Dependent β-Thalassemia
Thalassemia is a group of recessively inherited hemoglobin disorders characterized by reduced or no production of hemoglobin and chronic anemia of varying severity.
- Trial name
- NCT07721480
- Testing
- HGI-001 Injection
- Volunteers
- 6 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Acquired Immunodeficiency Syndrome, Blood Transfusion
Effectiveness of AIDS Antibody Screening
To determine the effectiveness of efforts to eliminate the human immunodeficiency virus (HIV) from whole blood and blood components in the blood supply.
- Conditions
- Acquired Immunodeficiency Syndrome, Blood Transfusion, HIV Infections
- Trial name
- NCT00005303
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Trauma Associated Hemorrhage
Prehospital Transfusion Outcomes in Traumatic Hemorrhage: a Prospective Cohort Study
Traumatic injuries can cause severe bleeding, which causes a lot of deaths worldwide that could be prevented. Starting treatment as early as possible has been shown to improve survival, which makes fast care very important.
- Trial name
- PRONTO (NCT07883252)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Erasmus Medical Center
Multifocal Motor Neuropathy (MMN), Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Do IgG Level Variations in CIDP and MMN Patients Following Initial Intravenous IVIg Treatment Correlate With Ultimate Dosing
CIDP and MMN are part of a group of chronic inflammatory conditions that affect the peripheral nervous system. In CIDP, there is chronic inflammation of the peripheral nerves and nerve roots leading to demyelination.
- Trial name
- digG (NCT04356781)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Walton Centre NHS Foundation Trust
Surgical Blood Loss, Transfusion-dependent Anemia
Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery
The goal of this clinical trial is to learn if the administration of tranexamic acid can reduce the necessity of blood transfusions in adult patients undergoing major abdominal surgery. .
- Conditions
- Surgical Blood Loss, Transfusion-dependent Anemia, Abdomen Disease
- Trial name
- TATRA (NCT06414031)
- Testing
- Tranexamic Acid
- Where
- 2 sites in Germany
- Volunteers
- 892 people
- Sponsor
- Ulrich Ronellenfitsch, MD
Blood Loss Following Open Femur Fracture Surgery
The Effect of Tranexamic Acid on Blood Loss and Transfusion Requirements Following Open Femur Fracture Surgery
The purpose of this study is to determine the effect of tranexamic acid (TXA) on blood loss and transfusion requirements in patients with femur fractures requiring open surgical approaches.
- Trial name
- NCT03679481
- Testing
- Tranexamic acid (TXA), Normal saline
- Sponsor
- The University of Texas Health Science Center, Houston
Hemorrhage
The Effect of Tranexamic Acid for Total Hip Arthroplasty
The aim of this study is to investigate the effects of tranexamic acid on hemorrhage, blood transfusion, fibrin degradation products and kidney functions for total hip arthroplasty.
- Trial name
- NCT02094066
- Testing
- tranexamic acid, serum physiologic
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Diamond Blackfan Anemia, Pure Red Cell Aplasia
The Use of Trifluoperazine in Transfusion Dependent DBA
Diamond Blackfan anemia (DBA) is a rare inherited pure red cell aplasia. The two main non-stem cell transplant therapeutic options are corticosteroids and red blood cell (RBC) transfusions.
- Trial name
- DBA (NCT03966053)
- Testing
- Trifluoperazine
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Adrianna Vlachos, MD
Thoracic Surgery, Blood Transfusion; Hemoglobinemia
Cardiac Surgery Outcomes in Blood-transfusion Acceptors and no Acceptors
The primary objective of this study is to analyze mortality after cardiac surgery in blood-transfusion non-acceptors (BTNA), and the secondary one to perform an adjusted comparison with a blood-transfusion acceptors (BTA) matched…
- Conditions
- Thoracic Surgery, Blood Transfusion; Hemoglobinemia, Cardiac Disease
- Trial name
- NCT04609228
- Testing
- Non-acceptance of blood-transfusions, Acceptance of blood-transfusions
- Where
- Spain
- Volunteers
- 1,911 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Platelet Transfusion
Pathogen-Reduced Platelet Concentrates: Experience in Routine Practice in Germany
Overall objective: to accumulate further experience with the use of pathogen-reduced platelet concentrates throughout the entire process chain from manufacture to clinical use of pathogen-reduced platelet concentrates and their…
- Trial name
- INITIATE (NCT07354672)
- Testing
- Pathogen-Reduced Platelet Concentrates
- Where
- Germany
- Volunteers
- 850 people
- Sponsor
- Deutsches Rotes Kreuz DRK-Blutspendedienst Baden-Wurttemberg-Hessen
Beta-Thalassemia
Vitamin E Supplementation for Children With Transfusion Dependent Beta Thalassemia on Different Iron Chelation Regimen
repeated transfusions are the mainstay of disease management in most patients with transfusion dependent beta thalassemia.iron overload predispose to oxidative stress and tissue injury.
- Trial name
- NCT06509581
- Testing
- vitamin E
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Anemia, Red Blood Cell Transfusion
A Trial to Assess the Effect of Transfusion Strategies on Fatigability Levels After Hospital Discharge
This study is a randomized controlled trial in which hospitalized patients with anemia are randomized to receive transfusion at: a) Hb<9g/dL (liberal transfusion strategy), or b) Hb<7g/dL (restrictive transfusion strategy).
- Conditions
- Anemia, Red Blood Cell Transfusion, Fatigability, Fatigue
- Trial name
- EToF (NCT04920045)
- Testing
- Red blood cell transfusion
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Chicago
Sickle Cell Disease
Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent Transfusions
The objective of this proposal is to test the feasibility of red blood cell (RBC) rejuvenation to chronic transfusion in sickle cell disease (SCD) and the potential benefit of RBC rejuvenation in this population to determine if a…
- Trial name
- NCT02731157
- Testing
- Rejuvesol, Blood transfusion
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Duke University
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